Original Papaya Leaf Extract 600 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Original Papaya Leaf Extract 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Original Papaya Leaf Extract 600 mg is a dietary supplement by Herbal Goodness with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Original Papaya Leaf Extract 600 mg by Herbal Goodness
Ask about any prescription or over-the-counter medication and we check it for interactions with Original Papaya Leaf Extract 600 mg by Herbal Goodness — and tell you which ingredient is responsible.
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HelloPharmacist Scorecard of Original Papaya Leaf Extract 600 mg by Herbal Goodness
Four independent checks of what is known — a summary of the available information, not a grade of the product itself.
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
The stated purpose hasn't been mapped to our evidence data yet.
Why this rating?
- We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Every active ingredient lists its own amount on the label.
Why this rating?
- The label discloses an exact amount for 1 of its 1 active ingredient.
- No proprietary blends here — you can verify the dose of every single component.
The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.
Why this rating?
- 1 of the 1 matched ingredient can interact with medications — Papaya.
- The most serious interaction on file is rated Moderate.
- Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
- For scale: 92 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.
Why this rating?
- We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
- Pregnancy & breastfeeding safety ratings cover 1 of 1.
- General safety write-ups exist for 1 of 1.
- Remember: this measures how much safety information exists. Thin data is not the same as being safe.
HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Original Papaya Leaf Extract 600 mg, straight from the product label.
| Brand | Herbal Goodness |
|---|---|
| Barcode (UPC) | 798304169072 |
| Net contents | 60 Capsule(s) |
| Market status | Off market |
| Date entered into DSLD | Feb 26, 2020 |
| DSLD ID | 214444 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Original Papaya Leaf Extract 600 mg by Herbal Goodness, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Papaya leaf extract | 600 mg | -- |
Other ingredients: Veggie Capsules, Microcrystalline Cellulose, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Papaya leaves contain the enzymes papain, chymopapain and fibrin which supports healthy digestion, aids immune system and improves blood platelet function.
General Statements
100% women owned, we give 10% of profits to support education of girls in Africa. Women owned 10% of profits go to WAAW Foundation Visit herbalgoodnessco.com for a complete line of products.
Nature's superfruits pure & simple
100% Satisfaction guaranteed
Seals/Symbols
Packaged in the USA
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Precautions
Keep out of reach of children.
Warning: If pregnant or have a medical condition, consult your physician before using this product.
Do not use if inner seal or tamper evident wrap is broken.
Storage
Store tightly closed in a cool dry place.
Formulation
Promotes healthy blood and immune system functions
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Serving Size: One capsule, two times daily
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Original Papaya Leaf Extract 600 mg by Herbal Goodness label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Original Papaya Leaf Extract 600 mg by Herbal Goodness
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Papaya leaf extract
Interacts with92 drugs
Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...
Papaya leaf extract monograph & interactionsOther (inactive) ingredients: Veggie Capsules, Microcrystalline Cellulose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
Original Papaya Leaf Extract 600 mg by Herbal Goodness Drug Interactions
Original Papaya Leaf Extract 600 mg contains a single active ingredient, and it has known interactions with 92 medications. Here’s the picture, then you can look up your own drug.
Want to check YOUR meds against Original Papaya Leaf Extract 600 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Original Papaya Leaf Extract 600 mg interact with 92 drugs. Click any drug to see the details.
1 of the 1 ingredient in Original Papaya Leaf Extract 600 mg interact with drugs. Each result below shows which ingredient is responsible. Papaya leaf extract
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Alogliptin, Pioglitazone interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAmiodarone (cordarone) Moderate
Interaction Summary
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Read the full Papaya Leaf Extract + Amiodarone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
How Canagliflozin interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Chlorpropamide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Dasiglucagon Hydrochloride interactionDulaglutideTrulicity
How Dulaglutide interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Dulaglutide interactionEmpagliflozinJardiance
How Empagliflozin interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
How Exenatide interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Exenatide Synthetic interactionGliclazideDiamicron
How Gliclazide interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Original Papaya Leaf Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Papaya Leaf ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Papaya Leaf Extract + Glipizide, Metformin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Original Papaya Leaf Extract 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Papaya leaf extract
Amiodarone (Cordarone)
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.
Antidiabetes Drugs
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.
Levothyroxine (Synthroid, Others)
Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.
Warfarin (Coumadin)
Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for Original Papaya Leaf Extract 600 mg, from the product label.
Herbal Goodness
See all Herbal Goodness products- Name
- Herbal Goodness
- Street Address
- 2150 S. Central Expressway, Suite 200
- City
- McKinney
- State
- TX
- ZipCode
- 75070
- Phone Number
- 800-820-4829
- Web Address
- herbalgoodnessco.com
Original Papaya Leaf Extract 600 mg by Herbal Goodness: Common Questions
Does Original Papaya Leaf Extract 600 mg by Herbal Goodness interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Original Papaya Leaf Extract 600 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Original Papaya Leaf Extract 600 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Original Papaya Leaf Extract 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Papaya 14 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
- Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
- Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
- Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
- Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
- Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
- Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
- Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
- Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
- Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC