Original Green Papaya 4:1 Fruit Extract 600 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Original Green Papaya 4:1 Fruit Extract 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Original Green Papaya 4:1 Fruit Extract 600 mg is a dietary supplement by Herbal Goodness with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Green Papaya Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Original Green Papaya 4:1 Fruit Extract 600 mg by Herbal Goodness
Ask about any prescription or over-the-counter medication and we check it for interactions with Original Green Papaya 4:1 Fruit Extract 600 mg by Herbal Goodness — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Original Green Papaya 4:1 Fruit Extract 600 mg by Herbal Goodness
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: green papaya fruit extract at 600 mg per capsule in a 4:1 concentration, meaning four pounds of raw fruit are condensed into one pound of extract. The capsule also contains pullulan, an inactive ingredient used as a binder.
Does it work?
Not established
The evidence for green papaya extract's effectiveness isn't established in the data we hold. The supplement has been studied for aging skin, hair loss, gallbladder cancer, colorectal cancer, and diabetes, but all those ratings show insufficient reliable evidence to rate — meaning we don't have enough good-quality research to say whether it works for any of those uses.
How safe is it?
Well-documented data
Ripe papaya fruit eaten as food is generally well tolerated, but concentrated supplements are less well studied. This product is made from green papaya extract, and the safety data advises caution: unripe papaya, papaya latex, and seeds should be avoided, and large amounts during pregnancy warrant caution from some sources.
The most common side effects from papaya leaf extract are nausea and vomiting. Allergic reactions occur in sensitive people — including itchy watery eyes, runny nose, sneezing, abdominal cramps, sweating, and diarrhea — and are more common in those allergic to latex.
Rare serious allergic reactions have been reported.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before using this product if you take warfarin or other blood thinners, diabetes medications, amiodarone, or levothyroxine. All four drug types have moderate-severity interactions documented with green papaya extract.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
Green papaya extract is best approached cautiously if you take blood thinners, diabetes medications, heart rhythm drugs, or thyroid replacement — all have documented interactions. If you're on any prescription medication, check with your doctor or pharmacist before starting.
The evidence for what it actually does isn't established in our data, and concentrated supplements are less well studied than eating ripe papaya as food.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Original Green Papaya 4:1 Fruit Extract 600 mg, straight from the product label.
| Brand | Herbal Goodness |
|---|---|
| Barcode (UPC) | 798304381849 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 11, 2022 |
| DSLD ID | 261378 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher, Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Original Green Papaya 4:1 Fruit Extract 600 mg by Herbal Goodness, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Green Papaya Fruit Extract | 1200 mg | -- |
Other ingredients: Pullulan
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Our Green Papaya 4:1 fruit extract comes from organic unripe papayas. It contains digestive enzymes papain and chymopapain which aids healthy enzyme levels and digestion. Green papaya helps maintain strong spinal, nervous and immune systems.
Approved Keto Friendly
Certified Kosher by Orthodox Union
Brand IP Statement(s)
100% Women Owned, 10% of Profits & Ethical trade Quality We Only Use the Best Made from the highest quality herbs, our products are tested to the highest standard by 3rd party certifiers. Impact We Do Right By Others We believe in business for social good and give 10% of profits to support the education of African girls. Sustainability We Respect Mother Earth We believe in the environment and fairtrade practices.
Seals/Symbols
Packaged in the USA
OU (Kosher)
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formulation
Made with Organic Green Papaya Fruit Extract
Digestion & Enzyme Level Support
Certified Organic by OTCO
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Take 2 capsules with meal or as directed by a qualified health care professional.
Precautions
Warning: Do not use if inner seal or tamper evident seal is broken.
If pregnant or have a medical condition, consult your physician before using this herbal product.
General Statements
Instagram @herbalgoodnessco Twitter @herbal_goodness Visit herbalgoodnessco.com to learn more
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Original Green Papaya 4:1 Fruit Extract 600 mg by Herbal Goodness label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Original Green Papaya 4:1 Fruit Extract 600 mg by Herbal Goodness
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Green Papaya Fruit Extract
Interacts with92 drugs
Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...
Green Papaya Fruit Extract monograph & interactionsOther (inactive) ingredients: Pullulan. These complete the product’s ingredient list but are not active constituents.
Original Green Papaya 4:1 Fruit Extract 600 mg by Herbal Goodness Drug Interactions
HelloPharmacist Interaction Report
Herbal Goodness Original Green Papaya 4:1 Fruit Extract contains green papaya fruit extract, which interacts with several important medication types.
The most serious documented concern is a moderate-severity interaction with blood thinners (anticoagulants) like warfarin — papaya extract may increase warfarin's effects and side effects, and at least one case report linked a papaya supplement to dangerously elevated blood-thinning levels in a previously stable patient.
Read the full breakdown — every affected drug type, severity by severity
Other moderate-severity interactions affect antidiabetes drugs (the extract may add to their blood-sugar-lowering effect, though evidence is limited to fermented papaya), amiodarone (a heart rhythm medication that papaya may cause to build up in your system), and levothyroxine (thyroid hormone replacement, which papaya may reduce). One case involved a patient who developed hypothyroidism after eating 5–6 papaya fruits daily for two weeks.
Additionally, we could not check for interactions with every medication type. Altogether, these interactions span 92 individual medications.
If you take warfarin, any diabetes medication, amiodarone, levothyroxine, or other prescription drugs, use the interaction checker below with your exact medications before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Original Green Papaya 4:1 Fruit Extract 600 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Original Green Papaya 4:1 Fruit Extract 600 mg interact with 92 drugs. Click any drug to see the details.
1 of the 1 ingredient in Original Green Papaya 4:1 Fruit Extract 600 mg interact with drugs. Each result below shows which ingredient is responsible. Green Papaya Fruit Extract
AcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Acarbose interactionAcetohexamideDymelor
How Acetohexamide interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Acetohexamide interactionAlbiglutideTanzeum
How Albiglutide interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Alogliptin, Pioglitazone interactionAmiodaroneCordarone, Pacerone
How Amiodarone interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAmiodarone (cordarone) Moderate
Interaction Summary
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Read the full Green Papaya Fruit Extract + Amiodarone interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionCanagliflozinInvokana
How Canagliflozin interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Canagliflozin, Metformin Hydrochloride interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Chlorpropamide interactionDapagliflozinFarxiga
How Dapagliflozin interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Dapagliflozin interactionDapagliflozin Propanediol, MetforminXigduo XR
How Dapagliflozin Propanediol, Metformin interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Dapagliflozin Propanediol, Metformin interactionDapagliflozin Propanediol, Saxagliptin HydrochlorideQtern
How Dapagliflozin Propanediol, Saxagliptin Hydrochloride interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Dapagliflozin Propanediol, Saxagliptin Hydrochloride interactionDapagliflozin, Metformin Hydrochloride, Saxagliptin HydrochlorideQternmet XR
How Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Dapagliflozin, Metformin Hydrochloride, Saxagliptin Hydrochloride interactionDasiglucagon HydrochlorideZegalogue
How Dasiglucagon Hydrochloride interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Dasiglucagon Hydrochloride interactionDulaglutideTrulicity
How Dulaglutide interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Dulaglutide interactionEmpagliflozinJardiance
How Empagliflozin interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Empagliflozin interactionEmpagliflozin, Linagliptin, Metformin HydrochlorideTrijardy XR
How Empagliflozin, Linagliptin, Metformin Hydrochloride interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Empagliflozin, Linagliptin, Metformin Hydrochloride interactionEmpagliflozin, MetforminSynjardy
How Empagliflozin, Metformin interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Empagliflozin, Metformin interactionEmpagliflozin, Metformin HydrochlorideSynjardy XR
How Empagliflozin, Metformin Hydrochloride interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Empagliflozin, Metformin Hydrochloride interactionErtugliflozinSteglatro
How Ertugliflozin interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Ertugliflozin interactionErtugliflozin, Metformin HydrochlorideSegluromet
How Ertugliflozin, Metformin Hydrochloride interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Ertugliflozin, Metformin Hydrochloride interactionExenatideBydureon, Byetta
How Exenatide interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Exenatide interactionExenatide SyntheticBydureon BCISE
How Exenatide Synthetic interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Exenatide Synthetic interactionGliclazideDiamicron
How Gliclazide interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Gliclazide interactionGlimepirideAmaryl
How Glimepiride interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Glimepiride interactionGlipizideGlucotrol, Glucotrol XL
How Glipizide interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Glipizide interactionGlipizide, MetforminMetaglip
How Glipizide, Metformin interacts with Original Green Papaya 4:1 Fruit Extract 600 mg — through 1 ingredient. Tap an ingredient for the detail:
Green Papaya Fruit ExtractAntidiabetes Drugs Moderate
Interaction Summary
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects.
Read the full Green Papaya Fruit Extract + Glipizide, Metformin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Original Green Papaya 4:1 Fruit Extract 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Green Papaya Fruit Extract
Amiodarone (Cordarone)
Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.
Antidiabetes Drugs
Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.
Levothyroxine (Synthroid, Others)
Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.
Warfarin (Coumadin)
Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for Original Green Papaya 4:1 Fruit Extract 600 mg, from the product label.
Herbal Goodness
See all Herbal Goodness products- Name
- Herbal Goodness
- Street Address
- 2150 S. Central Expressway Suite 200
- City
- McKinney
- State
- TX
- ZipCode
- 75070
- Phone Number
- 1-800-820-4829
- Web Address
- www.herbalgoodnessco.com
Original Green Papaya 4:1 Fruit Extract 600 mg by Herbal Goodness: Common Questions
Does Original Green Papaya 4:1 Fruit Extract 600 mg by Herbal Goodness interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is green papaya safe during pregnancy?
Can I take this if I'm breastfeeding?
What are the most common side effects?
Is this product good for blood sugar control?
Why does this product warn against large amounts during pregnancy if it's otherwise 'Likely Safe'?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Original Green Papaya 4:1 Fruit Extract 600 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Original Green Papaya 4:1 Fruit Extract 600 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Original Green Papaya 4:1 Fruit Extract 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Papaya 14 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
- Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
- Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
- Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
- Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
- Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
- Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
- Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
- Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
- Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC