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Dietary supplement

Original Papaya Leaf Extract 600 mg Ingredients & Drug Interactions

by Herbal Goodness

Original Papaya Leaf Extract 600 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Original Papaya Leaf Extract 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Original Papaya Leaf Extract 600 mg is a dietary supplement by Herbal Goodness with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Original Papaya Leaf Extract 600 mg by Herbal Goodness

Ask about any prescription or over-the-counter medication and we check it for interactions with Original Papaya Leaf Extract 600 mg by Herbal Goodness — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Original Papaya Leaf Extract 600 mg by Herbal Goodness

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: papaya leaf extract at 600 mg per capsule. Papaya leaf extract is a concentrated form derived from the leaves of the papaya plant.

The capsule itself is made from pullulan (a plant-based material) and rice hull concentrate, which are inactive ingredients that help form and fill the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Papaya's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: blood platelet support, immunity and digestion.
  • We looked for evidence on: Thrombocytopenia, Intestinal parasite infection, Wound healing, platelet count, immune function, digestive health.
  • The closest evidence on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection (Natural Medicines).
  • Also on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Thrombocytopenia, Wound healing.

The evidence for papaya leaf extract isn't established for the conditions listed in our data — aging skin, hair loss, colorectal cancer, and diabetes all show insufficient reliable evidence to rate how well it works. This doesn't mean it doesn't work; it means the studies to prove it aren't solid enough yet for us to say.

The evidence, ingredient by ingredient Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papaya leaf extract itself is generally well tolerated, though nausea and vomiting have been reported in some people taking it. Ripe papaya fruit eaten as food is safe, but the supplement form and unripe papaya are less well studied.

You should avoid unripe (green) papaya, papaya latex, and papaya seeds. There isn't enough safety data on file about this ingredient during breastfeeding to know either way — talk with your doctor or pharmacist for personalized advice.

A small number of people may have allergic reactions, especially those with a latex allergy.

Side effects, ingredient by ingredient Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papaya.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 92 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting this product, double-check with your doctor or pharmacist if you take blood thinners like warfarin, diabetes medications, amiodarone (a heart rhythm drug), or levothyroxine (thyroid replacement) — all have documented Moderate interactions with papaya leaf extract.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This single-ingredient papaya leaf supplement is generally well tolerated, but it interacts with a wide range of medications — most notably blood thinners, diabetes drugs, and thyroid replacements. If you take any prescription medication, particularly for your heart, blood sugar, bleeding risk, or thyroid, check with your doctor or pharmacist before adding this product.

The evidence for what it treats isn't solid yet, so weigh that against the interaction risk for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 11, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Original Papaya Leaf Extract 600 mg, straight from the product label.

Brand Herbal Goodness
Barcode (UPC) 798304495386
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Apr 11, 2022
DSLD ID 261295
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Original Papaya Leaf Extract 600 mg by Herbal Goodness, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
798304495386
IngredientAmount% DV
Papaya leaf extract600 mg--

Other ingredients: Pullulan Capsule, Rice hull concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Papaya Leaf contains papain, chemopapain and fibrin enzymes which help maintain healthy blood platelets, boost autoimmune functions and support healthy digestion.

Certified Kosher by Orthodox Union

General Statements

100% Women Owned, 10% of Profits & Ethical trade Quality We Only Use the Best Made from the best quality herbs, our products are tested to the highest standard by 3rd party certifiers. Impact We Do Right By Others We believe in business for social good and give 10% of profits to support the education of African girls. Sustainability We Respect Mother Earth We believe in the environment and support our farmers through fairtrade practices.

Seals/Symbols

Packaged in the USA

OU (Kosher)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Made with Organic Papaya Leaf Extract

Blood Platelet Support, Immunity & Digestion Aid Concentrated 10x Extra Strength

Certified Organic by OTCO

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules with meal or as directed by a qualified health care professional.

Precautions

Warning: Do not use if inner seal or tamper evident seal is broken.

If pregnant or have a medical condition, consult your physician before using this herbal product.

Brand IP Statement(s)

Instagram @herbalgoodnessco Twitter @herbal_goodness Visit HerbalGoodnessCo.com to learn more

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Original Papaya Leaf Extract 600 mg by Herbal Goodness label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Original Papaya Leaf Extract 600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Original Papaya Leaf Extract 600 mg by Herbal Goodness

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Papaya leaf extract

Interacts with
92 drugs
600 mg per serving

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Papaya leaf extract monograph & interactions

Other (inactive) ingredients: Pullulan Capsule, Rice hull concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Original Papaya Leaf Extract 600 mg by Herbal Goodness Drug Interactions

Want to check YOUR meds against Original Papaya Leaf Extract 600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
92Drugs
92 Moderate

Ingredients driving the most interactions

Papaya leaf extract 92

Individual Drug Interactions

The ingredients in Original Papaya Leaf Extract 600 mg interact with 92 drugs. Click any drug to see the details.

1 of the 1 ingredient in Original Papaya Leaf Extract 600 mg interact with drugs. Each result below shows which ingredient is responsible. Papaya leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Original Papaya Leaf Extract 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papaya leaf extract4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papaya leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Original Papaya Leaf Extract 600 mg, from the product label.

Herbal Goodness

See all Herbal Goodness products
Name
Herbal Goodness
Street Address
2150 S. Central Expressway Suite 200
City
McKinney
State
TX
ZipCode
75070
Phone Number
1-800-820-4829
Web Address
www.herbalgoodnessco.com
Pharmacist Counseling Corner

Original Papaya Leaf Extract 600 mg by Herbal Goodness: Common Questions

Does Original Papaya Leaf Extract 600 mg by Herbal Goodness interact with any medications?
Yes. Based on its ingredients, Original Papaya Leaf Extract 600 mg has a known interaction with 92 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Original Papaya Leaf Extract 600 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Our data shows mixed safety ratings for papaya during pregnancy — some sources say it's likely safe, others say it's possibly unsafe. Because of that split, talk with your doctor or pharmacist before taking it while pregnant; they can weigh the specific risks and benefits for you.
Does papaya leaf extract actually work for diabetes?
The evidence isn't established yet in our data. There's one small, low-quality study showing a fermented papaya prep may lower blood sugar in people with type 2 diabetes, but we don't have enough reliable evidence to say papaya leaf extract works for that purpose.
What side effects might I have?
The most common ones reported in studies are nausea and vomiting. Allergic reactions are rare but possible, especially if you have a latex allergy. If you notice itchy watery eyes, sneezing, abdominal cramps, or a rash, stop taking it and talk with your pharmacist or doctor.
Is this safe to take long-term?
There's little reliable safety information for how well this supplement form works or how safe it is over the long term. Ripe papaya fruit eaten as food is well tolerated, but concentrated supplements haven't been studied as thoroughly.
Why does the ingredient list say this interacts with 92 medications?
Papaya leaf extract can affect several different drug types — blood thinners, diabetes drugs, heart medications, and thyroid drugs — and each category includes many individual medications. That's why the total count is high even though there are only four main drug types involved.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Original Papaya Leaf Extract 600 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Original Papaya Leaf Extract 600 mg label
Go deeper

The Full Monographs Behind Original Papaya Leaf Extract 600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Original Papaya Leaf Extract 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papaya 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

See these in context on the Papaya monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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