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Dietary supplement

Body Detox + Ingredients & Drug Interactions

by Herbal Goodness

Body Detox + label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Body Detox + against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Body Detox + is a dietary supplement by Herbal Goodness with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya Seed Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Body Detox + by Herbal Goodness

Ask about any prescription or over-the-counter medication and we check it for interactions with Body Detox + by Herbal Goodness — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Body Detox + by Herbal Goodness

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

Body Detox + is a liquid containing one active ingredient: papaya seed extract. The inactive ingredients are glycerin and purified water—both common in liquid supplements.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Papaya's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: gently cleanse body and support digestive health.
  • We looked for evidence on: Intestinal parasite infection, Wound healing, digestion, constipation, indigestion.
  • The closest evidence on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection (Natural Medicines).
  • Also on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Wound healing.

The evidence on papaya seed extract for its claimed uses isn't established in the data we hold. The product lists several possible purposes—aging skin, hair loss, gallbladder cancer, colorectal cancer, and diabetes—but all of them carry a rating of insufficient reliable evidence.

That means the studies either don't exist, are too small or weak, or are too limited to draw firm conclusions. This doesn't mean it doesn't work; it means we don't have the science to say either way.

The evidence, ingredient by ingredient Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ripe papaya fruit eaten as food is generally well tolerated. Concentrated supplements are much less studied, and unripe (green) papaya, papaya latex, and papaya seeds should be avoided.

The most common side effects from papaya leaf extract are nausea and vomiting. Rare but serious allergic reactions have been reported, and people with a latex allergy may be at higher risk for hypersensitivity reactions to papaya because of cross-reactivity.

Regarding pregnancy, some sources caution against large amounts during pregnancy, though the safety data is mixed. For lactation, the limited data suggests likely safety, but talk with your doctor or pharmacist for personalized advice about use during pregnancy or while breastfeeding.

Side effects, ingredient by ingredient Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papaya.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 92 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check this product against antidiabetes drugs (blood sugar medications)—papaya extract may lower blood sugar additively and raise the risk of dangerously low levels. Also flag amiodarone (Cordarone), warfarin (Coumadin), and levothyroxine (Synthroid) with your pharmacist, as documented interactions or case reports exist for all three.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood sugar medications, heart rhythm drugs, blood thinners, or thyroid medication, run this product through the medication checker below first. Papaya supplements are less studied than whole ripe fruit, and the interactions documented here are real concerns.

Talk with your pharmacist before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Body Detox +, straight from the product label.

Brand Herbal Goodness
Barcode (UPC) 850035852576
Net contents 12 Ounce(s); 354 Milliliter(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 303484
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Body Detox + by Herbal Goodness, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
15 mL
Maximum serving Sizes:
15 mL
Servings per container
23
UPC/BARCODE
850035852576
IngredientAmount% DV
Papaya Seed Extract0 NP--

Other ingredients: Glycerin, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Papaya seed extract helps to gently cleanse the body and support a healthy digestive system.

Papaya seed extract

Certified Kosher by Earth Kosher EarthKosher

General Statements

100% Women owned, 10% of profits support female education

Quality We only use the best Made from the highest quality herbs, our products are tested to the highest standard by 3rd party certifiers Impact We do right by others We believe in business for social good and give 10% of profits to support the education of African girls. Sustainability We respect mother earth We believe in the environment and support our farmers through fairtrade practices. Women owned

YouTube herbalgoodness Facebook Herbal Goodness

Instagram herbalgoodnessco Twitter herbal_goodness

Formulation

Packaged in the USA

Supports health colon and kidney cleanse 15x Concentrated extra strength

Certified Organic by Oregon Tilth

Storage

Warning: Store tightly closed in a cool dry place.

Precautions

Do not use if inner seal or tamper evident seal is broken.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

USDA Organic

EarthKosher

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 1 tablespoon, 2 to 3 times a day with food. May be diluted with water or juice.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Body Detox + by Herbal Goodness label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Body Detox + label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Body Detox + by Herbal Goodness

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size15 mL Dosage formLiquid Servings per container23 Amounts shown are per serving.

Papaya Seed Extract

Interacts with
92 drugs
0 NP per serving

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Papaya Seed Extract monograph & interactions

Other (inactive) ingredients: Glycerin, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Body Detox + by Herbal Goodness Drug Interactions

Want to check YOUR meds against Body Detox +?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
92Drugs
92 Moderate

Ingredients driving the most interactions

Papaya Seed Extract 92

Individual Drug Interactions

The ingredients in Body Detox + interact with 92 drugs. Click any drug to see the details.

1 of the 1 ingredient in Body Detox + interact with drugs. Each result below shows which ingredient is responsible. Papaya Seed Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Body Detox + with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papaya Seed Extract4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papaya Seed Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Body Detox +, from the product label.

Herbal Goodness

See all Herbal Goodness products
Name
Herbal Goodness
Street Address
2150 S. Central Expressway, Suite 200
City
McKinney
State
TX
ZipCode
75070
Phone Number
800-820-4829
Web Address
herbalgoodnessco.com
Pharmacist Counseling Corner

Body Detox + by Herbal Goodness: Common Questions

Does Body Detox + by Herbal Goodness interact with any medications?
Yes. Based on its ingredients, Body Detox + has a known interaction with 92 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Body Detox + contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is papaya seed extract safe if I'm not taking any medications?
Ripe papaya fruit eaten in food amounts is generally well tolerated. Concentrated supplements are less studied, and nausea and vomiting have been reported with papaya leaf extract in clinical trials. If you have a latex allergy, you're at higher risk for allergic reactions to papaya. Talk with your pharmacist if you have any concerns about your health or allergies.
Can I take this while pregnant or breastfeeding?
The safety data is mixed. Some sources caution against large amounts during pregnancy, though limited data suggests lactation may be safe. Since this is a supplement—not a studied drug—there isn't enough reliable information to say either way. Talk with your doctor or pharmacist for personalized advice before using it during pregnancy or while breastfeeding.
What exactly is papaya seed extract, and why is it in a detox product?
Papaya seed extract comes from papaya seeds. Papaya has been used traditionally in herbal medicine, but the evidence for its use in 'detox' products specifically isn't established in the data we hold. The product lists several possible purposes, but none of them have sufficient reliable evidence to support the claims.
Why is unripe papaya listed as something to avoid?
Unripe papaya, papaya latex, and papaya seeds contain higher levels of papain and other compounds that are less studied and carry more risk. They've been linked to allergic reactions and other adverse effects. This product is a seed extract, so talk with your pharmacist about whether this applies to what you're taking.
Could this lower my blood sugar if I'm taking diabetes medication?
Yes—that's one of the documented interactions. A clinical study found that fermented papaya can lower blood sugar additively with diabetes drugs like glibenclamide, which could cause dangerously low blood sugar. It's unclear if other papaya forms have the same effect. If you take any diabetes medication, check with your pharmacist before you start this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Body Detox + is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Body Detox + label
Go deeper

The Full Monographs Behind Body Detox +’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Body Detox +'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papaya 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

See these in context on the Papaya monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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