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Dietary supplement

Organic Papaya Leaf Liquid Extract Ingredients & Drug Interactions

by Herbal Goodness

Organic Papaya Leaf Liquid Extract label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Papaya Leaf Liquid Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Papaya Leaf Liquid Extract is a dietary supplement by Herbal Goodness with 1 active ingredient. Its ingredients are commonly taken for digestive upset and indigestion, constipation, wound and skin care (topical).Based on those ingredients, 92 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papaya leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Papaya Leaf Liquid Extract by Herbal Goodness

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Papaya Leaf Liquid Extract by Herbal Goodness — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Papaya Leaf Liquid Extract by Herbal Goodness

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: papaya leaf extract. It's been used traditionally for various purposes, though the evidence supporting many of those uses isn't well established yet in our data.

The inactive ingredients are vegetable glycerin, papaya, and purified water — these are the carrier and base for the liquid extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Papaya's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: digestive, immune and blood platelet support.
  • We looked for evidence on: Intestinal parasite infection, Thrombocytopenia, Wound healing, indigestion, constipation.
  • The closest evidence on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Intestinal parasite infection (Natural Medicines).
  • Also on file: Papaya is rated "Insufficient Reliable Evidence To Rate" for Thrombocytopenia, Wound healing.

The effectiveness of papaya leaf extract for aging skin, hair loss, gallbladder cancer, colorectal cancer, and diabetes all carry a rating of insufficient reliable evidence in our data. That means the science isn't there yet to say whether it works for these purposes.

If you're considering it for one of these uses, talk with your pharmacist or doctor about what the current evidence actually shows.

The evidence, ingredient by ingredient Papaya

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Papaya leaf extract is generally well tolerated when used as a supplement, though nausea and vomiting have been reported in clinical research. Ripe papaya fruit is safe as food, but concentrated supplements are less well studied.

You should avoid unripe (green) papaya, papaya latex, and papaya seeds — some sources also caution against large amounts during pregnancy. Rare serious allergic reactions have been reported, and people with latex allergies may be at higher risk for hypersensitivity reactions to papaya.

Side effects, ingredient by ingredient Papaya

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Papaya.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 92 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications before starting, especially: blood thinners like warfarin (Moderate severity), diabetes drugs (Moderate), amiodarone for heart rhythm (Moderate), and levothyroxine for thyroid (Moderate).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood thinners, diabetes medications, heart rhythm drugs, or thyroid medication, check with your pharmacist before using this product. Papaya leaf extract is generally well tolerated in supplement amounts, but the safety data for concentrated extracts is still limited.

Your pharmacist can tell you whether it's right for you and your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Papaya Leaf Liquid Extract, straight from the product label.

Brand Herbal Goodness
Barcode (UPC) 798304262032
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 261266
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Papaya Leaf Liquid Extract by Herbal Goodness, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1.2 mL
Maximum serving Sizes:
1.2 mL
Servings per container
24
UPC/BARCODE
798304262032
IngredientAmount% DV
Papaya leaf extract2.4 mL--

Other ingredients: Vegetable Glycerin, Papaya, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Papaya leaves include the enzymes papain, chymopapain and fibrin which support healthy digestive, immune and blood platelet functions.

Approved Keto Friendly

Certified Kosher by Earth Kosher

General Statements

100% Women Owned, 10% of Profits & Ethical trade

Fairly Traded

Questions or comments? Instagram herbalgoodnessco Twitter herbal_goodness

Formulation

Made with Non-GMO Ingredients

Blood Platelet Support, Immunity & Digestion Aid

Certified Organic by Oregon Tilth

Seals/Symbols

Packaged in the USA

USDA Organic

EarthKosher

Storage

Warning: Store tightly closed in a cool dry place.

Precautions

Do not use if inner seal or tamper evident seal is broken.

If pregnant or have a medical condition, consult your physician before using this herbal product.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested use: Take 1/4 tsp (1.2ml) 2-3 times a day with food.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Papaya Leaf Liquid Extract by Herbal Goodness label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Papaya Leaf Liquid Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Papaya Leaf Liquid Extract by Herbal Goodness

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1.2 mL Dosage formLiquid Servings per container24 Amounts shown are per serving.

Papaya leaf extract

Interacts with
92 drugs
2.4 mL per serving

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and m...

Papaya leaf extract monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, Papaya, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Papaya Leaf Liquid Extract by Herbal Goodness Drug Interactions

Want to check YOUR meds against Organic Papaya Leaf Liquid Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
92Drugs
92 Moderate

Ingredients driving the most interactions

Papaya leaf extract 92

Individual Drug Interactions

The ingredients in Organic Papaya Leaf Liquid Extract interact with 92 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Papaya Leaf Liquid Extract interact with drugs. Each result below shows which ingredient is responsible. Papaya leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Papaya Leaf Liquid Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papaya leaf extract4 drug types · 92 drugs

Amiodarone (Cordarone)

Theoretically, papaya extract may increase the levels and clinical effects of amiodarone.
Animal research in rats shows that a single oral dose of papaya extract, as well as multiple doses of papaya extract daily over 14 days, prior to a single dose of amiodarone delays the time to maximum amiodarone concentration. However, only the 14-day papaya extract regimen increases systemic amiodarone exposure by 60% to 70%. This interaction has not been reported in humans.

Likelihood Probable Evidence D
Antidiabetes Drugs

Concomitant use of antidiabetic drugs with fermented papaya can produce additive effects. It is unclear if other forms of papaya have the same effect.
A small low-quality clinical study in patients with type 2 diabetes who are taking glibenclamide shows that taking a fermented papaya preparation 3 grams daily for 2 months decreases fasting and postprandial blood glucose levels when compared to baseline. Additionally, of the 25 patients in the study, 9 required a reduction in glibenclamide dose.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Theoretically, consuming large quantities of papaya fruit can reduce the clinical effects of levothyroxine.
In one case-report, a 37-year-old male with a history of thyroidectomy who was stabilized on levothyroxine for 5 years presented with hypothyroidism after consuming 5-6 papaya fruits daily for 14 days during vacation. In a controlled re-challenge test involving 5-6 papayas daily, the patient remained euthyroid for 7 days, but developed mild hypothyroidism after 14 days. Both times, thyroid levels normalized 40-45 days after discontinuing papaya.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, concomitant use of warfarin with papain-containing papaya extract might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papaya leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Papaya Leaf Liquid Extract, from the product label.

Herbal Goodness

See all Herbal Goodness products
Name
Herbal Goodness
Street Address
2150 S. Central Expressway, Suite 200
City
McKinney
State
TX
ZipCode
75070
Phone Number
800-820-4829
Web Address
herbalgoodnessco.com
Pharmacist Counseling Corner

Organic Papaya Leaf Liquid Extract by Herbal Goodness: Common Questions

Does Organic Papaya Leaf Liquid Extract by Herbal Goodness interact with any medications?
Yes. Based on its ingredients, Organic Papaya Leaf Liquid Extract has a known interaction with 92 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Papaya Leaf Liquid Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What's actually in this liquid extract?
It's papaya leaf extract mixed with vegetable glycerin and purified water. The papaya leaf is the active part; the glycerin and water are there to carry it and keep it stable as a liquid.
Is papaya leaf extract safe to take every day?
The leaf extract itself is generally well tolerated, though nausea and vomiting have shown up in clinical research. But safety data for concentrated supplements is still limited compared to eating ripe papaya fruit as food, so talk with your pharmacist about whether daily use is right for you.
Can I take this if I'm pregnant?
We don't have specific safety data on file for papaya leaf extract during pregnancy. Some sources caution against large amounts of papaya during pregnancy, so it's best to talk with your doctor or pharmacist for personalized advice before use.
Will this help with my diabetes?
The evidence for papaya leaf extract in diabetes is insufficient to say it works. One small study of a fermented papaya form showed it might lower blood sugar, but the science isn't there yet for a clear answer — your doctor or pharmacist can discuss other options with you.
What if I'm allergic to latex?
You may be at higher risk for a hypersensitivity reaction to papaya, since some people with latex allergies react to papaya as well. It's worth mentioning this to your pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Papaya Leaf Liquid Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Papaya Leaf Liquid Extract label
Go deeper

The Full Monographs Behind Organic Papaya Leaf Liquid Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Papaya

Interacts with 92 drugs

Papaya is a tropical fruit that is nutritious and generally safe to eat as food, and it contains an enzyme called papain used as a digestive aid and meat tenderizer. Papaya leaf extract is b...

Read the full Papaya monograph →
Sources

Sources & How We Checked

Organic Papaya Leaf Liquid Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Papaya 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  3. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Blanco C, Diaz-Perales A, Collada C, et al. Class I chitinases as potential panallergens involved in the latex-fruit syndrome. J Allergy Clin Immunol 1999;103(3 Pt 1):507-13. PubMed
  6. Diaz-Perales A, Collada C, Blanco C, et al. Cross-reactions in the latex-fruit syndrome: A relevant role of chitinases but not of complex asparagine-linked glycans. J Allergy Clin Immunol 1999;104:681-7. PubMed
  7. Castillo, R., Delgado, J., Quiralte, J., Blanco, C., and Carrillo, T. Food hypersensitivity among adult patients: epidemiological and clinical aspects. Allergol.Immunopathol.(Madr.) 1996;24(3):93-97.
  8. Oderinde, O., Noronha, C., Oremosu, A., Kusemiju, T., and Okanlawon, O. A. Abortifacient properties of aqueous extract of Carica papaya (Linn) seeds on female Sprague-Dawley rats. Niger.Postgrad.Med J 2002;9(2):95-98. DOI
  9. Danese, C., Esposito, D., D'Alfonso, V., Cirene, M., Ambrosino, M., and Colotto, M. Plasma glucose level decreases as collateral effect of fermented papaya preparation use. Clin Ter. 2006;157(3):195-198.
  10. Iliev, D. and Elsner, P. Generalized drug reaction due to papaya juice in throat lozenges. Dermatology 1997;194(4):364-366. PubMed
  11. Andersen HA, Bernatz PE, Grindlay JH. Perforation of the esophagus after use of a digestant agent: report of case and experimental study. Ann Otol Rhinol Laryngol 1959;68:890-6. PubMed
  12. Deiana L, Marini S, Mariotti S. Ingestion of large amounts of papaya fruit and impaired effectiveness of levothyroxine therapy. Endocr Pract 2012;18(1):98-100. PubMed
  13. Rodrigues M, Alves G, Francisco J, Fortuna A, Falcão A. Herb-drug pharmacokinetic interaction between Carica papaya extract and amiodarone in rats. J Pharm Pharm Sci 2014;17(3):302-15. PubMed
  14. Rajapakse S, de Silva NL, Weeratunga P, Rodrigo C, Sigera C, Fernando SD. Carica papaya extract in dengue: a systematic review and meta-analysis. BMC Complement Altern Med. 2019;19(1):265. PubMed

See these in context on the Papaya monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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