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Dietary supplement

Original Graviola Leaf Liquid Extract Ingredients & Drug Interactions

by Herbal Goodness

Original Graviola Leaf Liquid Extract label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Original Graviola Leaf Liquid Extract against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Original Graviola Leaf Liquid Extract is a dietary supplement by Herbal Goodness with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Graviola leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Original Graviola Leaf Liquid Extract by Herbal Goodness

Ask about any prescription or over-the-counter medication and we check it for interactions with Original Graviola Leaf Liquid Extract by Herbal Goodness — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Original Graviola Leaf Liquid Extract by Herbal Goodness

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: organic graviola leaf extract. Graviola is a tropical plant traditionally used in herbal medicine, though the science behind most of its claimed uses remains incomplete.

The liquid extract also includes organic vegetable glycerin, organic graviola, and purified water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports healthy cell regeneration and calm relaxation.
  • We looked for evidence on: stress, anxiety, relaxation.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence we hold on graviola leaf extract is not established for any of its common uses. The data rates it as having insufficient reliable evidence for human papillomavirus (HPV) infection, headache, male infertility, and insect repellent purposes — which means there simply isn't enough solid human research to say whether it works or doesn't.

If you're considering this product for a specific health goal, talk it over with your doctor or pharmacist to explore what the science actually supports.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Here's what you need to know: regular graviola consumption may not be safe long-term. The most common side effects reported in studies are nausea and burning pain in the upper belly (epigastrium), and a small number of people have experienced serious effects like movement disorders and nerve damage (myeloneuropathy) that resemble Parkinson disease symptoms.

One large study found that even low cumulative amounts of graviola fruit, juice, or herbal tea worsened motor and cognitive symptoms in people who already had Parkinson disease. The safety data are limited overall, and lab work raises concerns about possible nerve toxicity with continued use.

This product should be avoided during pregnancy and breastfeeding. The safety information is too sparse to know whether it's safe for either, and the data that does exist advises against it.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take carbamazepine (Tegretol) for seizures or nerve pain, do not use this product without checking with your doctor first — graviola may reduce how well the medication works. No other medication interactions are documented in our data for the ingredients we could check, but that does not mean none exist; use the search tool on this page to verify your exact drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a single-ingredient supplement with very limited human safety and effectiveness data behind it. It's not recommended during pregnancy or breastfeeding, and it can lower levels of the seizure drug carbamazepine, making that medication less effective.

Before you take it — especially if you're on any prescription medication or have Parkinson disease or movement concerns — talk with your doctor or pharmacist to make sure it's right for your individual situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Original Graviola Leaf Liquid Extract, straight from the product label.

Brand Herbal Goodness
Barcode (UPC) 798304441550
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Feb 26, 2020
DSLD ID 214391
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Organic
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Original Graviola Leaf Liquid Extract by Herbal Goodness, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
15 mL
Maximum serving Sizes:
15 mL
Servings per container
2
UPC/BARCODE
798304441550
IngredientAmount% DV
organic Graviola leaf extract15 mL--

Other ingredients: organic Vegetable Glycerin, organic Graviola, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Graviola leaves, cultivated for centuries for its amazing health benefits to the body and mind, supports healthy cell regeneration and aids calm relaxation.

Certified Kosher by Earth Kosher.

General Statements

100% women owned, we give 10% of profits to support education of girls in Africa. Women Owned 10% of profits go to WAAW Foundation

Visit herbalgoodnessco.com for a complete line of products.

Nature's superfruits pure and simple

100% Satisfaction guaranteed

Seals/Symbols

Packaged in the USA

USDA Organic Non GMO Project Verified nongmoproject.org

EarthKosher

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Keep out of reach of children.

Warning: If pregnant or have a medical condition, consult your physician before using this product.

Do not use if tamper evident wrap is broken

Storage

Store tightly closed in a cool, dry place.

Formulation

Vegan

Non GMO Project Verified nongmoproject.org

Helps promote cell regeneration

Certified Organic by Oregon Tilth.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 1 tbsp (15 mL) 2 to 3 times a day with food. May be diluted with water or juice.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Original Graviola Leaf Liquid Extract by Herbal Goodness label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Original Graviola Leaf Liquid Extract label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Original Graviola Leaf Liquid Extract by Herbal Goodness

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size15 mL Dosage formLiquid Servings per container2 Amounts shown are per serving.

Organic Graviola leaf extract

Interacts with
1 drug
15 mL per serving

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

Organic Graviola leaf extract monograph & interactions

Other (inactive) ingredients: Organic Vegetable Glycerin, Organic Graviola, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Original Graviola Leaf Liquid Extract by Herbal Goodness Drug Interactions

Want to check YOUR meds against Original Graviola Leaf Liquid Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

organic Graviola leaf extract 1

Individual Drug Interactions

The ingredients in Original Graviola Leaf Liquid Extract interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Original Graviola Leaf Liquid Extract interact with drugs. Each result below shows which ingredient is responsible. organic Graviola leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Original Graviola Leaf Liquid Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Graviola leaf extract1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
organic Graviola leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Original Graviola Leaf Liquid Extract, from the product label.

Herbal Goodness

See all Herbal Goodness products
Name
Herbal Goodness
Street Address
2150 S. Central Expressway, Suite 200
City
McKinney
State
TX
ZipCode
75070
Phone Number
800-820-4829
Web Address
herbalgoodnessco.com
Pharmacist Counseling Corner

Original Graviola Leaf Liquid Extract by Herbal Goodness: Common Questions

Does Original Graviola Leaf Liquid Extract by Herbal Goodness interact with any medications?
Yes. Based on its ingredients, Original Graviola Leaf Liquid Extract has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Original Graviola Leaf Liquid Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
No. The safety data are insufficient, and what information exists advises against use during both pregnancy and breastfeeding. Talk with your doctor or pharmacist before taking it if you're pregnant, planning to become pregnant, or nursing.
What side effects should I watch for?
The most common are nausea and burning pain in the upper belly. Rarely, people have reported serious nerve and movement problems that look like Parkinson disease symptoms. If you develop any unusual muscle movements, stiffness, or cognitive changes, stop and contact your doctor right away.
Does graviola actually work for HPV, headaches, or male fertility?
The human evidence isn't there yet. We rate all of those uses as having insufficient reliable evidence — meaning the research just hasn't been done or isn't strong enough to say yes or no. If you're using it for one of those reasons, talk with your doctor about proven options too.
Is this safe to use long-term?
The data suggest caution with regular use. Lab studies raise concerns about possible nerve damage with continued consumption, and human safety information is limited. It's not something to take indefinitely without checking with your doctor first.
What's actually in the bottle?
The active ingredient is organic graviola leaf extract. It also contains organic vegetable glycerin, organic graviola, and purified water as the liquid base and other inactive ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Original Graviola Leaf Liquid Extract is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Original Graviola Leaf Liquid Extract label
Go deeper

The Full Monographs Behind Original Graviola Leaf Liquid Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Original Graviola Leaf Liquid Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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