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Dietary supplement

Original Graviola Leaf (Soursop) Extract 700 mg Ingredients & Drug Interactions

by Herbal Goodness

Original Graviola Leaf (Soursop) Extract 700 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Original Graviola Leaf (Soursop) Extract 700 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Original Graviola Leaf (Soursop) Extract 700 mg is a dietary supplement by Herbal Goodness with 1 active ingredient. Its ingredients are commonly taken for cancer support (unproven), infections, inflammation.Based on those ingredients, 1 medication has a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Graviola (Soursop) leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Original Graviola Leaf (Soursop) Extract 700 mg by Herbal Goodness

Ask about any prescription or over-the-counter medication and we check it for interactions with Original Graviola Leaf (Soursop) Extract 700 mg by Herbal Goodness — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Original Graviola Leaf (Soursop) Extract 700 mg by Herbal Goodness

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: graviola (soursop) leaf extract at 700 mg per capsule. Graviola is a tropical plant traditionally used in herbal medicine.

The capsule itself is made with hypromellose and rice hull concentrate as inactive ingredients.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Graviola's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: cell regeneration and stress relief.
  • We looked for evidence on: Diabetes, Inflammation, Immune function, General wellness.
  • The closest evidence on file: Graviola is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).

The evidence we hold doesn't establish that graviola leaf extract works reliably for any condition. The data rates its use for HPV infection, headache, male infertility, and insect repellent as having insufficient reliable evidence — meaning the studies aren't there yet or aren't conclusive enough to say whether it actually helps.

The evidence, ingredient by ingredient Graviola

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Regular use of graviola raises safety concerns. The most common side effects reported are stomach pain and nausea.

Rarely, people have experienced movement disorders and nerve damage (myeloneuropathy) resembling Parkinson disease symptoms. One clinical study of 300 mg daily noted nausea and burning stomach pain in some participants.

Lab studies also raise concerns about possible nerve toxicity with long-term use. Graviola is not recommended during pregnancy or breastfeeding — there isn't enough safety data, and traditional use has avoided it in these situations.

If you're pregnant, planning pregnancy, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Graviola

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Graviola.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take carbamazepine (Tegretol), a seizure medication, check with your doctor or pharmacist before adding this product — graviola may lower your carbamazepine level and reduce seizure control.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take carbamazepine (Tegretol) for seizures, you should check with your doctor or pharmacist before using this product, since graviola may reduce how well the medication works. Because we don't have strong evidence that graviola is effective for any condition, and because regular use carries real safety concerns including possible nerve damage, this is worth discussing with your healthcare provider before starting.

They can help you weigh whether it makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Original Graviola Leaf (Soursop) Extract 700 mg, straight from the product label.

Brand Herbal Goodness
Barcode (UPC) 798304395105
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2022
DSLD ID 261306
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Original Graviola Leaf (Soursop) Extract 700 mg by Herbal Goodness, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
798304395105
IngredientAmount% DV
Graviola (Soursop) leaf extract1400 mg--

Other ingredients: Hypromellose, Rice hull concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Graviola Leaves, cultivated for centuries for its amazing health benefits to the body and mind, supports healthy cell regeneration and aids calm relaxation.

Approved Keto Friendly

Certified Kosher by Orthodox Union

General Statements

100% Women Owned, 10% of Profits & Ethical trade Quality We Only Use the Best Made from the highest quality herbs, our products are tested to the highest standard by 3rd party certifiers. Impact We Do Right By Others We believe in business for social good and give 10% of profits to support the education of African girls. Sustainability We Respect Mother Earth We believe in the environment and fairtrade practices.

Instagram @herbalgoodnessco Twitter @herbal_goodness Visit herbalgoodnessco.com to learn more

Seals/Symbols

Packaged in the USA

OU (Kosher)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Cell Regeneration & Stress Relief

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 capsules with meal or as directed by a qualified health care professional.

Storage

Warning: Store tightly closed in a cool dry place.

Precautions

Do not use if inner seal or tamper evident seal is broken.

If pregnant or have a medical condition, consult your physician before using this herbal product.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Original Graviola Leaf (Soursop) Extract 700 mg by Herbal Goodness label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Original Graviola Leaf (Soursop) Extract 700 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Original Graviola Leaf (Soursop) Extract 700 mg by Herbal Goodness

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Graviola (Soursop) leaf extract

Interacts with
1 drug
1400 mg per serving

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Afri...

Graviola (Soursop) leaf extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice hull concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Original Graviola Leaf (Soursop) Extract 700 mg by Herbal Goodness Drug Interactions

Want to check YOUR meds against Original Graviola Leaf (Soursop) Extract 700 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1Drugs
1 Moderate

Ingredients driving the most interactions

Graviola (Soursop) leaf extract 1

Individual Drug Interactions

The ingredients in Original Graviola Leaf (Soursop) Extract 700 mg interact with 1 drug. Click any drug to see the details.

1 of the 1 ingredient in Original Graviola Leaf (Soursop) Extract 700 mg interact with drugs. Each result below shows which ingredient is responsible. Graviola (Soursop) leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Original Graviola Leaf (Soursop) Extract 700 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Graviola (Soursop) leaf extract1 drug type · 1 drug

Carbamazepine (Tegretol)

Theoretically, graviola might decrease concentrations of carbamazepine when used concomitantly.
A study in rats shows that graviola extract reduces the area under the curve of carbamazepine by 46% and maximum concentration by 35% when compared with carbamazepine alone.

Likelihood Possible Evidence D
Graviola (Soursop) leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Original Graviola Leaf (Soursop) Extract 700 mg, from the product label.

Herbal Goodness

See all Herbal Goodness products
Name
Herbal Goodness
Street Address
2150 S. Central Expressway Suite 200
City
McKinney
State
TX
ZipCode
75070
Phone Number
1-800-820-4829
Web Address
www.herbalgoodnessco.com
Pharmacist Counseling Corner

Original Graviola Leaf (Soursop) Extract 700 mg by Herbal Goodness: Common Questions

Does Original Graviola Leaf (Soursop) Extract 700 mg by Herbal Goodness interact with any medications?
Yes. Based on its ingredients, Original Graviola Leaf (Soursop) Extract 700 mg has a known interaction with 1 medication. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Original Graviola Leaf (Soursop) Extract 700 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — graviola is rated possibly unsafe in pregnancy, and there isn't enough safety data for breastfeeding. Traditional use has avoided it in both situations. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing.
What are the side effects?
The most common ones are stomach pain and nausea. Rarely, people have reported movement disorders or nerve damage that can look like Parkinson disease. Lab studies also raise concerns about possible nerve toxicity with long-term use.
Does this actually work for anything?
The evidence we have doesn't show it works reliably for any condition — we rate HPV, headache, male infertility, and insect repellent all as having insufficient reliable evidence. More research is needed.
Is it safe to take regularly?
Regular consumption of graviola may be unsafe, which is why we flag the nerve toxicity concerns and rare serious side effects. This isn't a casual daily supplement — it's worth talking through with your doctor or pharmacist if you're considering ongoing use.
What is graviola, and why would someone take it?
Graviola (soursop) is a tropical fruit, and people have traditionally used the leaves and fruit in herbal medicine. This product is the leaf extract. But we don't have solid evidence it works for the conditions people typically try it for.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Original Graviola Leaf (Soursop) Extract 700 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Original Graviola Leaf (Soursop) Extract 700 mg label
Go deeper

The Full Monographs Behind Original Graviola Leaf (Soursop) Extract 700 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Graviola

Interacts with 1 drug

Graviola (soursop) is a tropical fruit tree whose leaves, fruit, and bark are used in traditional medicine, especially in parts of South America, Africa, and Asia. Despite popular online cla...

Read the full Graviola monograph →
Sources

Sources & How We Checked

Original Graviola Leaf (Soursop) Extract 700 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Graviola 4 references
  1. Caparros-Lefebvre D, Elbaz A. Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group. Lancet 1999;354:281-6. PubMed
  2. Gavamukulya Y, Wamunyokoli F, El-Shemy HA. Annona muricata: Is the natural therapy to most disease conditions including cancer growing in our backyard? A systematic review of its research history and future prospects. Asian Pac J Trop Med. 2017;10(9):835- PubMed
  3. Abu Soukhon AA, Abu-Qatouseh L, Mansoor K, et al. Cytotoxicity Activity of Graviola Fruit Extract with Carbamazepine and Valproic Acid Show Antagonistic and Indifferent Effects. Asian Pac J Cancer Prev 2023;24(6):1869-1875. PubMed
  4. Cleret de Langavant L, Roze E, Petit A, et al. Annonaceae Consumption Worsens Disease Severity and Cognitive Deficits in Degenerative Parkinsonism. Mov Disord 2022;37(12):2355-2366. PubMed

See these in context on the Graviola monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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