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Dietary supplement

Ostivone Ipriflavone Ingredients & Drug Interactions

by Nature's Way

Ostivone Ipriflavone label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Ostivone Ipriflavone against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Ostivone Ipriflavone is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for bone density and osteoporosis, postmenopausal bone loss, athletic performance.Based on those ingredients, 391 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ipriflavone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Ostivone Ipriflavone by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Ostivone Ipriflavone by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Ostivone Ipriflavone by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Ostivone Ipriflavone contains one active ingredient: ipriflavone, a compound used to support bone health. The product is made up of inactive ingredients—a plant-derived capsule, cellulose, magnesium stearate, and silica—that serve as the capsule structure and binders.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports healthy bone mineral density and calcium absorption.
  • We looked for evidence on: Osteoporosis, bone health, postmenopausal bone loss, fracture prevention.
  • The strongest evidence on file: Ipriflavone is rated "Likely Effective" for Osteoporosis (Natural Medicines).

Ipriflavone is rated likely effective for osteoporosis and Paget disease (a bone disorder involving abnormal bone remodeling). These ratings reflect clinical evidence supporting its use in these conditions.

The evidence, ingredient by ingredient Ipriflavone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ipriflavone is generally well tolerated when taken by mouth, though some people report stomach pain, diarrhea, and dizziness. There is concern that long-term use (6 months or longer) can lower white blood cell counts, so caution is warranted with extended use.

The safety data during pregnancy is not sufficient—possible estrogen-like effects mean pregnancy should be avoided. There is no reliable safety information during breastfeeding, so it's best avoided while nursing.

Talk with your doctor or pharmacist about whether this product is right for your situation.

Side effects, ingredient by ingredient Ipriflavone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ipriflavone.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 391 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Ostivone Ipriflavone, check with your doctor or pharmacist if you take immunosuppressant drugs (used to prevent organ rejection or treat certain autoimmune conditions); theophylline (for breathing problems); or drugs metabolized by the liver enzymes CYP1A2 or CYP2C9, which include certain muscle relaxers, antidepressants, and blood pressure or seizure medications. Ipriflavone can raise their levels and increase the risk of side effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Ostivone Ipriflavone may be worth considering if you have osteoporosis or Paget disease and your doctor approves it. Because it interacts with a large number of medications—especially immunosuppressants, certain blood pressure and seizure drugs, and theophylline—you'll need to check your exact prescriptions with your doctor or pharmacist before starting.

Avoid it if you're pregnant or breastfeeding. Long-term use requires monitoring for drops in white blood cell counts.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Ostivone Ipriflavone, straight from the product label.

Brand Nature's Way
Barcode (UPC) 763948076598
Net contents 90 Veg Capsule(s)
Market status On market
Date entered into DSLD Mar 25, 2021
DSLD ID 246235
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Ostivone Ipriflavone by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
763948076598
IngredientAmount% DV
Ipriflavone200 mg--

Other ingredients: plant-derived Capsule, Cellulose, Magnesium Stearate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Supports healthy bone mineral density and calcium absorption

Nature’s Way Since 1969

Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Warning: Ostivone (ipriflavone) has the potential to interact with some prescription drugs, including theophylline. If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Formulation

Gluten free. No yeast-derived ingredients, wheat, corn, soy, dairy, or artificial colors, flavors, or preservatives.

Vegetarian

Enhances calcium absorption Bone health

Brand IP Statement(s)

Ostivone is a registered trademark of Technical Sourcing International, Inc.

2021 Nature's Way Brands, LLC

Seals/Symbols

Ostivone A foundation for healthy bones Quality Global Sourcing Bottled & Tested In the USA

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 capsule three times daily with meals. For best results, take in conjuction with a multinutrient bone supplement with high potency calcium such as Enzymatic Therapy OsteoPrime.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Ostivone Ipriflavone by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Ostivone Ipriflavone label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Ostivone Ipriflavone by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Ipriflavone

Interacts with
391 drugs
200 mg per serving

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably preven...

Ipriflavone monograph & interactions

Other (inactive) ingredients: Plant-derived Capsule, Cellulose, Magnesium Stearate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Ostivone Ipriflavone by Nature's Way Drug Interactions

Want to check YOUR meds against Ostivone Ipriflavone?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
391Drugs
391 Moderate

Ingredients driving the most interactions

Ipriflavone 391

Individual Drug Interactions

The ingredients in Ostivone Ipriflavone interact with 391 drugs. Click any drug to see the details.

1 of the 1 ingredient in Ostivone Ipriflavone interact with drugs. Each result below shows which ingredient is responsible. Ipriflavone

Each ingredient & the kinds of drugs it affects

For each ingredient in Ostivone Ipriflavone with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ipriflavone4 drug types · 391 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Ipriflavone is thought to competitively inhibit cytochrome P450 1A2 (CYP1A2). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP1A2 include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), Pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline (Slo-bid, Theo-Dur, others), zileuton (Zyflo), Zolmitriptan (Zomig), and others.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9). Theoretically, concurrent use of ipriflavone and drugs metabolized by these enzymes might result in decreased drug elimination, increased serum levels, and potential toxicity. Some drugs metabolized by CYP2C9 include amitriptyline (Elavil), diazepam (Valium), estradiol (Estrace), tacrine (Cognex), verapamil (Calan), warfarin (Coumadin), zileuton (Zyflo), and others.

Likelihood Possible Evidence D
Immunosuppressants

Concurrent use of ipriflavone and immunosuppressant drugs might have additive effects on inhibiting immune function. Some patients taking ipriflavone experience subclinical lymphocytopenia; avoid concurrent use. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), and other corticosteroids (glucocorticoids).

Likelihood Possible Evidence A
Theophylline

Concomitant use of theophylline and ipriflavone can increase serum theophylline levels. Increased theophylline levels have occurred in two cases after patients started taking ipriflavone. Ipriflavone is thought to decrease theophylline metabolism through competitive inhibition of the cytochrome P450 1A2 (CYP1A2) enzyme.

Likelihood Probable Evidence D
Ipriflavone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Ostivone Ipriflavone, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC (previously branded Enzymatic Therapy, LLC)
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Ostivone Ipriflavone by Nature's Way: Common Questions

Does Ostivone Ipriflavone by Nature's Way interact with any medications?
Yes. Based on its ingredients, Ostivone Ipriflavone has a known interaction with 391 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Ostivone Ipriflavone contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is ipriflavone and what does it do?
Ipriflavone is a compound used to support bone health. It's rated likely effective for osteoporosis and Paget disease, a condition involving abnormal bone remodeling. It's derived from a flavone, a type of plant compound.
Can I take this if I'm pregnant or nursing?
No. The product should be avoided during pregnancy due to possible estrogen-like effects and insufficient safety data. There's also no reliable safety information during breastfeeding, so it's best to avoid it while nursing. Talk with your doctor or pharmacist about whether this product is appropriate for you.
What side effects might I experience?
Ipriflavone is generally well tolerated, but some people report stomach pain, diarrhea, and dizziness. With long-term use (6 months or longer), there's concern it can lower white blood cell counts, so caution and monitoring are warranted if you take it for an extended period.
How many active ingredients does this product have?
Ostivone Ipriflavone contains one active ingredient: ipriflavone. The other ingredients listed on the label are inactive—fillers and capsule material.
Does ipriflavone interact with a lot of medications?
Yes. Altogether, these interactions span 391 individual medications. Ipriflavone slows how your liver breaks down certain drugs, particularly those processed by two liver enzymes (CYP1A2 and CYP2C9). It also has a concerning interaction with immunosuppressant drugs. You'll need to check your specific prescriptions with your doctor or pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Ostivone Ipriflavone is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Ostivone Ipriflavone label
Go deeper

The Full Monographs Behind Ostivone Ipriflavone’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ipriflavone

Interacts with 391 drugs

Ipriflavone is a synthetic isoflavone studied mainly for bone health and osteoporosis, but high-quality research has not shown that it reliably prevents fractures or builds strong bone. Beca...

Read the full Ipriflavone monograph →
Sources

Sources & How We Checked

Ostivone Ipriflavone's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ipriflavone 6 references
  1. Agnusdei D, Bufalino L. Efficacy of ipriflavone in established osteoporosis and long-term safety. Calcif Tissue Int 1997;61,Suppl 1:S23-7. PubMed
  2. Alexandersen P, Toussaint A, Christiansen C, et al. Ipriflavone in the treatment of postmenopausal osteoporosis: A randomized controlled trial. JAMA 2001;285:1482-8.
  3. Agnusdei D, Camporeale A, Gonnelli S, et al. Short-term treatment of Paget's disease of bone with ipriflavone. Bone Miner 1992;19 Suppl 1:S35-42. PubMed
  4. Monostory K, Vereczkey L, Levai F, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol 1998;123:605-10. PubMed
  5. Takahashi J, Kawakatsu K, Wakayama T, Sawaoka H. Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur J Clin Pharmacol 1992;43:207-8. PubMed
  6. Hu Q, Long C, Wu D, et al. The efficacy and safety of ipriflavone in postmenopausal women with osteopenia or osteoporosis: A systematic review and meta-analysis. Pharmacol Res. 2020;159:104860. PubMed

See these in context on the Ipriflavone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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