Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Panplex 2-Phase Ingredients & Drug Interactions

by Integrative Therapeutics

Panplex 2-Phase label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Panplex 2-Phase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Panplex 2-Phase is a dietary supplement by Integrative Therapeutics with 5 active ingredients. Its ingredients are commonly taken for low stomach acid (hypochlorhydria), bloating and gas, indigestion.Based on those ingredients, 36 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Betaine HCl. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Panplex 2-Phase by Integrative Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Panplex 2-Phase by Integrative Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Panplex 2-Phase by Integrative Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 4 of its 7 active ingredients.
  • “Pancreatin USP” is listed as a grouped ingredient — the label gives one combined amount (168 mg) without saying how much of each component you get.
  • “Phase I” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Phase II” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Panplex 2-Phase is a 7-ingredient digestive enzyme blend designed to support your stomach and small intestine during digestion. It contains proteolytic enzymes — specifically protease and pepsin concentrate — along with lipase and amylase to break down proteins, fats, and carbohydrates.

It also includes betaine hydrochloride to support stomach acid, L-glutamic acid, ox bile extract to help with fat digestion, and pancreatin USP, a blend of multiple digestive enzymes from pork pancreas. The tablet also contains several inactive ingredients like cellulose and magnesium stearate to hold it together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Gastric and intestinal digestive support.
  • We looked for evidence on: Dyspepsia, Indigestion, Bloating, Pancreatic enzyme insufficiency.
  • The closest evidence on file: Lipase is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia (Natural Medicines).
  • Also on file: Betaine Hydrochloride is rated "Insufficient Reliable Evidence To Rate" for Dyspepsia.

The evidence for most ingredients in this product isn't established in our data. Lipase, betaine hydrochloride, and protease have been studied for conditions like indigestion (dyspepsia) and inflammatory bowel disease, but we have insufficient reliable evidence to rate how well they work for these uses.

That doesn't mean they don't work — it means the research we hold doesn't prove effectiveness yet.

The evidence, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

The digestive enzymes in this product — protease and pepsin concentrate — are generally well tolerated, though some people report digestive upset or allergic reactions. Rarely, occupational exposure to airborne pepsin has caused allergic rhinitis or asthma symptoms, though this is uncommon with supplement use.

Betaine hydrochloride can irritate your stomach and isn't safe if you have ulcers, gastritis, or true acid reflux — it may cause heartburn. During pregnancy, betaine hydrochloride should be avoided because there isn't enough safety data; the safety data for the enzymes is also limited, so talk with your doctor before use.

During breastfeeding, these ingredients also lack sufficient safety data, so check with your healthcare provider first.

Side effects, ingredient by ingredient Betaine Hydrochloride Proteolytic Enzymes (proteases)

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 3 matched ingredients can interact with medications — Betaine Hydrochloride.
  • The most serious interaction on file is rated Minor.
  • For scale: 36 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use H2-blockers (like famotidine), antacids (like calcium carbonate or magnesium hydroxide), or proton pump inhibitors such as omeprazole. Betaine hydrochloride in this formula increases stomach acid and can reduce how well these medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Panplex 2-Phase is a broad-spectrum digestive enzyme formula with betaine hydrochloride, generally well tolerated by healthy adults. If you take acid-reducing medications — H2-blockers, antacids, or PPIs — you need to check with your doctor or pharmacist first, because this product could interfere with how those drugs work.

If you're pregnant, breastfeeding, or have a history of ulcers or reflux, talk it over with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Panplex 2-Phase, straight from the product label.

Brand Integrative Therapeutics
Barcode (UPC) 871791001787
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Oct 23, 2019
DSLD ID 206825
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Panplex 2-Phase by Integrative Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
UPC/BARCODE
871791001787
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Betaine HCl320 mg--
L-Glutamic Acid200 mg--
Ox Bile extract130 mg--
Pepsin Concentrate220 mg--
Pancreatin USP168 mg--
Phase I0 NP--
Phase II0 NP--

Other ingredients: Dicalcium Phosphate, Modified Cellulose, Stearic Acid, Calcium Carbonate, Cellulose, Cottonseed Oil, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no sugar, salt, yeast, wheat, gluten, corn, soy, dairy products, artificial colors, flavors or preservatives.

Brand IP Statement(s)

2015

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Gastric and intestinal digestive support

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 or 2 tablets three times daily with meals, or as recommended by your healthcare professional. Do not chew.

Precautions

Do not chew. Not recommended for use if peptic ulcer, gastritis or heartburn is present.

If pregnant, nursing, or taking prescription drugs, consult your healthcare professional prior to use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Panplex 2-Phase by Integrative Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Panplex 2-Phase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Panplex 2-Phase by Integrative Therapeutics

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Ox Bile extract

130 mg per serving

Phase I

0 NP per serving

Phase II

0 NP per serving
  • › Pancreatin USP

Other (inactive) ingredients: Dicalcium Phosphate, Modified Cellulose, Stearic Acid, Calcium Carbonate, Cellulose, Cottonseed Oil, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Panplex 2-Phase by Integrative Therapeutics Drug Interactions

Want to check YOUR meds against Panplex 2-Phase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
36Drugs
36 Minor

Ingredients driving the most interactions

Betaine HCl 36

Individual Drug Interactions

The ingredients in Panplex 2-Phase interact with 36 drugs. Click any drug to see the details.

1 of the 5 ingredients in Panplex 2-Phase interact with drugs. Each result below shows which ingredient is responsible. Betaine HCl

Each ingredient & the kinds of drugs it affects

For each ingredient in Panplex 2-Phase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Betaine HCl3 drug types · 36 drugs

Antacids

Betaine hydrochloride increases stomach acidity and could decrease the effects of antacids.
In human research, betaine hydrochloride increases stomach acidity. Antacids are taken to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with antacids might decrease the effects of the antacids.

Likelihood Possible Evidence D
H2-Blockers

Betaine hydrochloride increases stomach acidity and could decrease the effects of H2-blockers.
In human research, betaine hydrochloride increases stomach acidity. H2-blockers are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with H2-blockers might decrease the effects of H2-blockers.

Likelihood Possible Evidence D
Proton Pump Inhibitors (Ppis)

Betaine hydrochloride increases stomach acidity and could decrease the effects of PPIs.
In human research, betaine hydrochloride increases stomach acidity. PPIs are used to decrease stomach acidity. Theoretically, taking betaine hydrochloride along with PPIs might decrease the effects of PPIs

Likelihood Possible Evidence D
Betaine HCl full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Panplex 2-Phase, from the product label.

Integrative Therapeutics

See all Integrative Therapeutics products
Name
Integrative Therapeutics, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1.800.931.1709
Web Address
www.integrativeinc.com
Pharmacist Counseling Corner

Panplex 2-Phase by Integrative Therapeutics: Common Questions

Does Panplex 2-Phase by Integrative Therapeutics interact with any medications?
Yes. Based on its ingredients, Panplex 2-Phase has a known interaction with 36 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Panplex 2-Phase contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The safety data for these ingredients isn't strong enough during pregnancy. Betaine hydrochloride should be avoided, and the digestive enzymes also have limited safety information. Talk with your doctor before taking this product if you're pregnant.
What if I'm breastfeeding?
There isn't enough safety data on these ingredients during breastfeeding. Check with your healthcare provider first to see if it's right for you.
Can this cause allergic reactions?
Yes. The protease and pepsin concentrate in this product may cause digestive upset or allergic reactions in some people. Rarely, occupational exposure to pepsin has caused allergic rhinitis or asthma, though that's uncommon with supplement use. If you have enzyme allergies, talk with your pharmacist before taking it.
Is this safe if I have acid reflux or stomach ulcers?
No. Betaine hydrochloride increases stomach acid and can irritate ulcers or make heartburn worse. If you have ulcers, gastritis, or true acid reflux, avoid this product and talk with your doctor about alternatives.
Will this work for my indigestion?
The evidence for these enzymes in indigestion isn't established in our data yet. We have insufficient reliable evidence to say how well they work for that purpose, so results vary.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Panplex 2-Phase is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Panplex 2-Phase label
Go deeper

The Full Monographs Behind Panplex 2-Phase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Betaine Hydrochloride

Interacts with 36 drugs

Betaine hydrochloride is a supplement used to temporarily increase stomach acid in people who may have low acid levels. Evidence for its benefits is limited and mostly based on tradition rat...

Read the full Betaine Hydrochloride monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph →
Sources

Sources & How We Checked

Panplex 2-Phase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Betaine Hydrochloride 2 references
  1. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. AAPS J. 2014 PubMed
  2. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013 Nov 4;10(11):4032-7. PubMed

See these in context on the Betaine Hydrochloride monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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