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Dietary supplement

Pepto Herbal Blends Peppermint & Caraway Ingredients & Drug Interactions

by Pepto Bismol

Pepto Herbal Blends Peppermint & Caraway label
See full label image
Softgel Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pepto Herbal Blends Peppermint & Caraway against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pepto Herbal Blends Peppermint & Caraway is a dietary supplement by Pepto Bismol with 2 active ingredients. Its ingredients are commonly taken for irritable bowel syndrome (ibs), indigestion and gas, nausea.Based on those ingredients, 1,062 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Peppermint Aerial Oil, Caraway Seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pepto Herbal Blends Peppermint & Caraway by Pepto Bismol

Ask about any prescription or over-the-counter medication and we check it for interactions with Pepto Herbal Blends Peppermint & Caraway by Pepto Bismol — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pepto Herbal Blends Peppermint & Caraway by Pepto Bismol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active herbal ingredients: peppermint aerial oil and caraway seed oil, both concentrated botanical extracts meant to settle the stomach. The capsule also holds several inactive ingredients — sunflower oil, gelatin, glycerin, and other binders and thickeners — that help deliver the oils.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Relief of occasional indigestion, abdominal discomfort, and bloating.
  • We looked for evidence on: Abdominal pain, Dyspepsia, Flatulence, Irritable bowel syndrome (IBS), Gas, Stomach upset — and 1 related terms.
  • The strongest evidence on file: Peppermint is rated "Likely Effective" for Irritable bowel syndrome (IBS) (Natural Medicines).
  • Also on file: Caraway is rated "Possibly Effective" for Dyspepsia.
  • Also on file: Peppermint is rated "Possibly Effective" for Dyspepsia.

Peppermint is likely effective for irritable bowel syndrome (IBS) and possibly effective for indigestion, nausea from chemotherapy, colon spasms before medical imaging, and side effects from endoscopy. Caraway is possibly effective for indigestion but has insufficient evidence for amenorrhea, asthma, constipation, or gas.

The product pairs them for digestive comfort, though the combined effect isn't separately rated in the data we hold.

The evidence, ingredient by ingredient Peppermint Caraway

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, peppermint oil is generally well tolerated, though side effects in trial participants included belly pain, anal burning, belching, diarrhea, dry mouth, heartburn, nausea, and vomiting. Rare allergic reactions — including anaphylaxis with throat swelling and breathing trouble — have been reported, and there's one documented case of an allergic reaction when peppermint and caraway were used together in someone with asthma.

For caraway combined with peppermint, substernal burning, belching, nausea, and vomiting have been noted, though it's unclear which ingredient caused them. Peppermint is rated likely safe in pregnancy.

Caraway is rated possibly unsafe in pregnancy, and safety data during breastfeeding for both ingredients are limited. If you're pregnant or nursing, talk to your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Peppermint Caraway

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Caraway, Peppermint.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,063 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your medications if you take blood pressure drugs or other medicines metabolized by CYP3A4, CYP2C9, or CYP2C19 (peppermint); diabetes medications, sleeping pills or tranquilizers, water pills, or lithium (caraway); or tuberculosis drugs like isoniazid or rifampin (caraway). If you're unsure whether your drug falls into these categories, use the checker on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is intended to ease indigestion and IBS symptoms using established herbal remedies. If you take any medications — especially for blood pressure, diabetes, asthma, sleep, or seizures — check them against our interaction tool first.

Pregnant or nursing? Run it by your provider.

Anyone with a known peppermint or caraway allergy should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pepto Herbal Blends Peppermint & Caraway, straight from the product label.

Brand Pepto Bismol
Barcode (UPC) 301490002063
Net contents 14 Softgel Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 291987
Product type Botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pepto Herbal Blends Peppermint & Caraway by Pepto Bismol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel Capsule(s)
Maximum serving Sizes:
1 Softgel Capsule(s)
Servings per container
14
UPC/BARCODE
301490002063
IngredientAmount% DV
Peppermint Aerial Oil90 mg--
Caraway Seed Oil50 mg--

Other ingredients: Sunflower Oil, Gelatin, Glycerin, Water, Ethyl Cellulose, Sodium Alginate, Ammonium Hydroxide, Triglycerides, Oleic Acid, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

From the makers of Pepto Bismol, a trusted brand for the treatment of upset stomachs.

Drug-free Gluten-free Taste-free

Drug-free relief to help occasional indigestion & abdominal discomfort

General Statements

Healthy adults can occasionally experience indigestion, abdominal discomfort, or bloating.

Paper box Plastic bottle how2recycle.info

Formula

Pepto herbal blends contains 100% naturally-sourced peppermint & caraway to provide drug-free relief to help soothe occasional indigestion, abdominal discomfort, and bloating. The clinically-tested dose of peppermint and caraway provides soothing relief within an enteric-coated softgel designed to withstand strong stomach acid.

Pepto Herbal Blends with 100% natural peppermint & caraway

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: To relieve indigestion and abdominal discomfort: For adults: Swallow with water, do not chew. Take 1 softgel twice daily, 30-60 minutes before a meal; do not take more than 2 softgels in 24 hours.

Storage

Store at no greater than 25 degrees C.

Brand IP Statement(s)

Patents: www.pg.com/patents

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Consult a healthcare professional before use if you are pregnant, nursing, taking any supplements and/or medications, or have a medical condition such as gallbladder problems or a liver disorder.

Use as directed, discontinue use if you experience heartburn.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pepto Herbal Blends Peppermint & Caraway by Pepto Bismol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pepto Herbal Blends Peppermint & Caraway label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pepto Herbal Blends Peppermint & Caraway by Pepto Bismol

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel Capsule(s) Dosage formSoftgel Capsule Servings per container14 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Peppermint Aerial Oil

Interacts with
796 drugs
90 mg per serving

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated f...

Peppermint Aerial Oil monograph & interactions

Caraway Seed Oil

Interacts with
413 drugs
50 mg per serving

Caraway is a common cooking spice that has long been used to ease gas, bloating, and indigestion. Some evidence suggests caraway oil—often combined wi...

Caraway Seed Oil monograph & interactions

Other (inactive) ingredients: Sunflower Oil, Gelatin, Glycerin, Water, Ethyl Cellulose, Sodium Alginate, Ammonium Hydroxide, Triglycerides, Oleic Acid, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pepto Herbal Blends Peppermint & Caraway by Pepto Bismol Drug Interactions

Want to check YOUR meds against Pepto Herbal Blends Peppermint & Caraway?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,062Drugs
1,017 Moderate 45 Minor

Ingredients driving the most interactions

Peppermint Aerial Oil 796
Caraway Seed Oil 413

Individual Drug Interactions

The ingredients in Pepto Herbal Blends Peppermint & Caraway interact with 1,062 drugs. Click any drug to see the details.

2 of the 2 ingredients in Pepto Herbal Blends Peppermint & Caraway interact with drugs. Each result below shows which ingredient is responsible. Peppermint Aerial Oil Caraway Seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Pepto Herbal Blends Peppermint & Caraway with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Peppermint Aerial Oil5 drug types · 796 drugs

Cyclosporine (Neoral, Sandimmune)

Theoretically, peppermint oil might increase the levels and adverse effects of cyclosporine.
In animal research, peppermint oil inhibits cyclosporine metabolism and increases cyclosporine levels. Inhibition of cytochrome P450 3A4 (CYP3A4) may be partially responsible for this interaction. An interaction between peppermint oil and cyclosporine has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, peppermint might increase the levels of CYP2C19 substrates.
In vitro research shows that peppermint oil inhibits CYP2C19. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, peppermint might increase the levels of CYP2C9 substrates.
In vitro research shows that peppermint oil inhibits CYP2C9. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, peppermint might increase the levels of CYP3A4 substrates.
Clinical research in healthy volunteers shows that a single dose of peppermint oil 600 mg inhibits CYP3A4 enzymes and increases the AUC of felodipine, a CYP3A4 substrate. However, in vitro research suggests that peppermint oil only inhibits CYP3A4 at very high concentrations.

Likelihood Possible Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, peppermint might increase the levels of CYP1A2 substrates.
In vitro and animal research shows that peppermint oil and peppermint leaf inhibit CYP1A2. However, in clinical research, peppermint tea did not significantly affect the metabolism of caffeine, a CYP1A2 substrate. It is possible that the 6-day duration of treatment may have been too short to identify a difference.

Likelihood Possible Evidence B
Peppermint Aerial Oil full monograph & interactions

Caraway Seed Oil7 drug types · 413 drugs

Antidiabetes Drugs

Theoretically, caraway might increase the risk of hypoglycemia when used with antidiabetes drugs.
Animal research suggests that caraway can reduce blood glucose levels. Monitor blood glucose levels closely. Medication dose adjustments may be necessary.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, caraway might increase the effects and adverse effects of CNS depressants.
Animal research suggests that (S)-(+)-carvone, a major constituent of caraway seed extract, has sedative effects.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, caraway might increase the risk of hypokalemia when used with diuretics that deplete potassium.
Animal research suggests that a single dose of caraway fruit extract can promote diuresis and increase the urinary excretion of sodium and potassium. However, sub-chronic use of caraway fruit extract does not seem to significantly increase potassium excretion, although urine output continues to be increased for up to 6 days.

Likelihood Possible Evidence D
Lithium

Theoretically, caraway might reduce excretion and increase levels of lithium due to diuretic effects.
Animal research suggests that caraway fruit extract has diuretic properties.

Likelihood Possible Evidence D
Isoniazid

Theoretically, caraway might increase the effects and adverse effects of isoniazid.
Animal research suggests that a specific fraction of caraway seed extract (CC-1a) can increase plasma levels of isoniazid when administered concomitantly. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Pyrazinamide

Theoretically, caraway might increase the effects and adverse effects of pyrazinamide.
Animal research suggests that a specific fraction of caraway seed extract (CC-1a) can increase plasma levels of pyrazinamide when administered concomitantly. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Rifampin (Rifadin)

Theoretically, caraway might increase the effects and adverse effects of rifampin.
Animal research suggests that a specific fraction of caraway seed extract (CC-1a) can increase plasma levels of rifampin when administered concomitantly. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Caraway Seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pepto Herbal Blends Peppermint & Caraway, from the product label.

Pepto Bismol

See all Pepto Bismol products
Name
Procter & Gamble
City
Cincinnati
State
OH
ZipCode
45202
Web Address
www.pg.com
Pharmacist Counseling Corner

Pepto Herbal Blends Peppermint & Caraway by Pepto Bismol: Common Questions

Does Pepto Herbal Blends Peppermint & Caraway by Pepto Bismol interact with any medications?
Yes. Based on its ingredients, Pepto Herbal Blends Peppermint & Caraway has a known interaction with 1,062 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pepto Herbal Blends Peppermint & Caraway contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Peppermint is likely safe in pregnancy, but caraway is rated possibly unsafe — meaning the safety data advises caution. During breastfeeding, there isn't enough data on either ingredient to be certain. Talk with your doctor or pharmacist before taking it.
What are the most common side effects?
The most frequent side effects from peppermint oil are belly pain, anal burning, belching, diarrhea, dry mouth, heartburn, nausea, and vomiting. When peppermint and caraway are used together, substernal (chest) burning, belching, nausea, and vomiting have also been reported, though it's unclear which ingredient causes them.
Is this safe if I have asthma?
One allergic reaction has been reported in someone with bronchial asthma who used peppermint and caraway together — it involved throat tightness and breathing trouble. Talk to your doctor before taking this product if you have asthma.
Does peppermint actually work for IBS?
Yes — peppermint is rated likely effective for irritable bowel syndrome. It's also possibly effective for indigestion, chemotherapy-related nausea, and other digestive issues.
What is caraway supposed to do?
Caraway seed is possibly effective for indigestion. It's often paired with peppermint in digestive products for that reason, though evidence is stronger for peppermint alone.
Can this interact with my blood pressure medication?
Peppermint theoretically may increase the levels of some blood pressure drugs broken down by your liver, particularly those that use the CYP3A4 enzyme pathway. One study showed it slowed the clearance of felodipine. Use the interaction checker to search your exact medication.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pepto Herbal Blends Peppermint & Caraway is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pepto Herbal Blends Peppermint & Caraway label
Go deeper

The Full Monographs Behind Pepto Herbal Blends Peppermint & Caraway’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Peppermint

Interacts with 796 drugs

Peppermint is a popular herb with the best evidence supporting enteric-coated peppermint oil for easing IBS symptoms. It is generally well tolerated for most adults, but it can cause heartbu...

Read the full Peppermint monograph → Herb & supplement monograph

Caraway

Interacts with 413 drugs

Caraway is a common cooking spice that has long been used to ease gas, bloating, and indigestion. Some evidence suggests caraway oil—often combined with peppermint oil—may help with indigest...

Read the full Caraway monograph →
Sources

Sources & How We Checked

Pepto Herbal Blends Peppermint & Caraway's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 52 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Peppermint 41 references
  1. Liu JH, Chen GH, Yeh HZ, et al. Enteric-coated peppermint-oil capsules in the treatment of irritable bowel syndrome: a prospective, randomized trial. J Gastroenterol 1997;32:765-8. PubMed
  2. Pittler MH, Ernst E. Peppermint oil for irritable bowel syndrome: a critical review and metaanalysis. Am J Gastroenterol 1998;93:1131-5. PubMed
  3. Kline RM, Kline JJ, Di Palma J, Barbero GJ. Enteric-coated, pH-dependent peppermint oil capsules for the treatment of irritable bowel syndrome in children. J Pediatr 2001;138:125-8. PubMed
  4. Madisch A, Heydenreich CJ, Wieland V, et al. Treatment of functional dyspepsia with a fixed peppermint oil and caraway oil combination preparation as compared to cisapride. A multicenter, reference-controlled, double-blind equivalence study. Arzneimittel
  5. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  6. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  7. Morton CA, Garioch J, Todd P, et al. Contact sensitivity to menthol and peppermint in patients with intra-oral symptoms. Contact Dermatitis 1995;32:281-4. PubMed
  8. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  9. Nash P, Gould SR, Bernardo DE. Peppermint oil does not relieve the pain of irritable bowel syndrome. Br J Clin Pract 1986;40:292-3. DOI
  10. Rees WD, Evans BK, Rhodes J. Treating irritable bowel syndrome with peppermint oil. Br Med J 1979;2:835-6. PubMed
  11. Davies SJ, Harding LM, Baranowski AP. A novel treatment of postherpetic neuralgia using peppermint oil. Clin J Pain 2002;18:200-2. PubMed
  12. Weston CF. Anal burning and peppermint oil. Postgrad Med J 1987;63:717. PubMed
  13. Dresser GK, Wacher V, Wong S, et al. Evaluation of peppermint oil and ascorbyl palmitate as inhibitors of cytochrome P4503A4 activity in vitro and in vivo. Clin Pharmacol Ther 2002;72:247-55. PubMed
  14. Wacher VJ, Wong S, Wong HT. Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. J Pharm Sci 2002;91:77-90.
  15. Lawson MJ, Knight RE, Tran K, et al. Failure of enteric-coated peppermint oil in the irritable bowel syndrome: a randomized double-blind crossover study. J Gastroenterol Hepatol 1988;3:235-8. DOI
  16. Unger M, Frank A. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. Rapid Commun Mass Spectrom 2004;1 PubMed
  17. Maliakal PP, Wanwimolruk S. Effect of herbal teas on hepatic drug metabolizing enzymes in rats. J Pharm Pharmacol 2001;53:1323-9. PubMed
  18. Rogers SN, Pahor AL. A form of stomatitis induced by excessive peppermint consumption. Dent Update 1995;22:36-7.
  19. Cappello G, Spezzaferro M, Grossi L, et al. Peppermint oil (Mintoil) in the treatment of irritable bowel syndrome: a prospective double blind placebo-controlled randomized trial. Dig Liver Dis 2007;39:530-6. PubMed
  20. Moghadam BK, Gier R, and Thurlow T. Extensive oral mucosal ulcerations caused by misuse of a commercial mouthwash. Cutis 1999;64:131-134.
  21. Andersen, K. E. Contact allergy to toothpaste flavors. Contact Dermatitis 1978;4(4):195-198. PubMed
  22. Barnard, D. R. Repellency of essential oils to mosquitoes (Diptera: Culicidae). J Med Entomol. 1999;36(5):625-629. PubMed
  23. Tamir, S., Davidovich, Z., Attal, P., and Eliashar, R. Peppermint oil chemical burn. Otolaryngol.Head Neck Surg. 2005;133(5):801-802. PubMed
  24. Kalavala, M., Hughes, T. M., Goodwin, R. G., Anstey, A. V., and Stone, N. M. Allergic contact dermatitis to peppermint foot spray. Contact Dermatitis 2007;57(1):57-58. PubMed
  25. Vermaat, H., van Meurs, T., Rustemeyer, T., Bruynzeel, D. P., and Kirtschig, G. Vulval allergic contact dermatitis due to peppermint oil in herbal tea. Contact Dermatitis 2008;58(6):364-365. PubMed
  26. Merat, S., Khalili, S., Mostajabi, P., Ghorbani, A., Ansari, R., and Malekzadeh, R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig.Dis.Sci. 2010;55(5):1385-1390. PubMed
  27. Tran, A., Pratt, M., and DeKoven, J. Acute allergic contact dermatitis of the lips from peppermint oil in a lip balm. Dermatitis 2010;21(2):111-115. DOI
  28. Hitz, Lindenmuller, I and Lambrecht, J. T. Oral care. Curr Probl.Dermatol 2011;40:107-115.
  29. Shavakhi, A., Ardestani, S. K., Taki, M., Goli, M., and Keshteli, A. H. Premedication with peppermint oil capsules in colonoscopy: a double blind placebo-controlled randomized trial study. Acta Gastroenterol Belg 2012;75(3):349-353.
  30. Lech, Y., Olesen, K. M., Hey, H., Rask-Pedersen, E., Vilien, M., and Ostergaard, O. [Treatment of irritable bowel syndrome with peppermint oil. A double- blind study with a placebo]. Ugeskr.Laeger 10-3-1988;150(40):2388-2389.
  31. Parys, B. T. Chemical burns resulting from contact with peppermint oil mar: a case report. Burns Incl.Therm.Inj. 1983;9(5):374-375. PubMed
  32. Bayat R, Borici-Mazi R. A case of anaphylaxis to peppermint. Allergy Asthma Clin Immunol. 2014;10(1):6. PubMed
  33. Rich G, Shah A, Koloski N, et al. A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia. Neurogastroenterol Motil 2 PubMed
  34. Douros A, Bronder E, Andersohn F, et al. Herb-Induced Liver Injury in the Berlin Case-Control Surveillance Study. Int J Mol Sci 2016;17(1). PubMed
  35. Begas E, Tsioutsiouliti A, Kouvaras E, et al. Effects of peppermint tea consumption on the activities of CYP1A2, CYP2A6, Xanthine Oxidase, N-acetyltranferase-2 and UDP-glucuronosyltransferases-1A1/1A6 in healthy volunteers. Food Chem Toxicol 2017;100:80-9 PubMed
  36. Cash BD, Epstein MS, Shah SM. A Novel Delivery System of Peppermint Oil Is an Effective Therapy for Irritable Bowel Syndrome Symptoms. Dig Dis Sci 2016;61(2):560-71. PubMed
  37. Elsaie LT, El Mohsen AM, Ibrahim IM, Mohey-Eddin MH, Elsaie ML. Effectiveness of topical peppermint oil on symptomatic treatment of chronic pruritus. Clin Cosmet Investig Dermatol 2016;9:333-8. PubMed
  38. Wu J, Xu R, Zhan R, et al. Effective symptomatic treatment for severe and intractable pruritus associated with severe burn-induced hypertrophic scars: A prospective, multicenter, controlled trial. Burns 2016;42(5):1059-66. PubMed
  39. Weerts ZZRM, Masclee AAM, Witteman BJM, et al. Efficacy and safety of peppermint oil in a randomized, double-blind trial of patients with irritable bowel syndrome. Gastroenterology. 2020;158(1):123-136. PubMed
  40. Nee J, Ballou S, Kelley JM, et al. Peppermint Oil Treatment for Irritable Bowel Syndrome: A Randomized Placebo-Controlled Trial. Am J Gastroenterol 2021;116(11):2279-2285. PubMed
  41. Ingrosso MR, Ianiro G, Nee J, et al. Systematic review and meta-analysis: efficacy of peppermint oil in irritable bowel syndrome. Aliment Pharmacol Ther 2022;56(6):932-41. PubMed

See these in context on the Peppermint monograph →

Caraway 11 references
  1. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  2. May B, Kuntz HD, Kieser M, Kohler S. Efficacy of a fixed peppermint oil/caraway oil combination in non-ulcer dyspepsia. Arzneimittelforschung 1996;46:1149-53.
  3. Micklefield GH, Greving I, May B. Effects of peppermint oil and caraway oil on gastroduodenal motility. Phytother Res 2000;14:20-3. DOI
  4. Herb Info Canada. Caraway website. www.herb.plant.org/caraway.htm (Accessed 11 September 2000).
  5. May B, Kohler S, Schneider B. Efficacy and tolerability of a fixed combination of peppermint oil and caraway oil in patients suffering from functional dyspepsia. Aliment Pharmacol Ther 2000;14:1671-7. PubMed
  6. Eddouks M, Lemhardri A, Michel JB. Caraway and caper: potential anti-hyperglycaemic plants in diabetic rats. J Ethnopharmacol 2004;94:143-8. PubMed
  7. Sachin BS, Monica P, Sharma SC, et al. Pharmacokinetic interaction of some antitubercular drugs with caraway: implications in the enhancement of drug bioavailability. Hum Exp Toxicol. 2009;28(4):175-84. PubMed
  8. Lahlou, S., Tahraoui, A., Israili, Z., and Lyoussi, B. Diuretic activity of the aqueous extracts of Carum carvi and Tanacetum vulgare in normal rats. J Ethnopharmacol. 4-4-2007;110(3):458-463. PubMed
  9. de Sousa, D. P., Farias Nobrega, F. F., and de Almeida, R. N. Influence of the chirality of (R)-(-)- and (S)-(+)-carvone in the central nervous system: a comparative study. Chirality 5-5-2007;19(4):264-268.
  10. Modu S, Gohla K Umar IA. The hypoglycaemic and hypocholrsterolaemic properties of black caraway (Carum carvi L.) oil in alloxan diabetic rats. Biokemistri (Nigeria) 1997;7:91-97.
  11. Rich G, Shah A, Koloski N, et al. A randomized placebo-controlled trial on the effects of Menthacarin, a proprietary peppermint- and caraway-oil-preparation, on symptoms and quality of life in patients with functional dyspepsia. Neurogastroenterol Motil 2 PubMed

See these in context on the Caraway monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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