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Dietary supplement

Phosphatidylserine 100 mg Ingredients & Drug Interactions

by Nature's Way

Phosphatidylserine 100 mg label
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Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phosphatidylserine 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phosphatidylserine 100 mg is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phosphatidylserine 100 mg by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Phosphatidylserine 100 mg by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phosphatidylserine 100 mg by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: phosphatidylserine, a naturally occurring compound found in cell membranes. It's derived from soy or cabbage sources and is meant to support brain function and memory.

The softgel capsule also contains inactive ingredients—medium-chain triglycerides, gelatin, glycerin, lipids, purified water, ascorbyl palmitate, and mixed tocopherols—which help deliver the phosphatidylserine and keep it stable.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports brain function and healthy nerve function.
  • We looked for evidence on: Age-related cognitive decline, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), memory, mental performance, neurological health.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer's disease, based on available evidence. For athletic performance, ADHD, general cognitive function, and dementia, the evidence isn't established well enough to rate it one way or the other.

If you're taking this for memory or brain health, talk with your doctor about whether it's the right fit for your situation.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety data is limited. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea—especially at higher doses.

Insomnia is more likely at 600 mg per dose, and stomach upset can show up at doses around 200–300 mg daily. During pregnancy, there isn't enough safety information, so avoidance is recommended.

The same goes for breastfeeding—safety data is unknown, so talk with your doctor or pharmacist before using it if you're nursing or planning to become pregnant.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before starting if you take anticholinergic drugs (like certain antihistamines or urinary antispasmodics) or cholinergic drugs (like Parkinson's medications or some glaucoma drops). Both types may have their effects changed by phosphatidylserine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Phosphatidylserine might help with age-related memory loss or early Alzheimer's changes, and it's usually easy on the stomach at this 100 mg dose. If you take anticholinergic or cholinergic medications, you'll need to check with your pharmacist first.

If you're pregnant, breastfeeding, or trying to get pregnant, skip it unless your doctor says otherwise.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phosphatidylserine 100 mg, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674451618
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jul 24, 2025
DSLD ID 333764
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phosphatidylserine 100 mg by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
60
UPC/BARCODE
033674451618
IngredientAmount% DV
Phosphatidylserine100 mg--

Other ingredients: Medium Chain Triglyceride, Gelatin, Glycerin, Lipids, Water, Purified, Ascorbyl Palmitate, Mixed Tocopherols

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Supports brain function Important component of brain cell membranes Needed for nutrient transfer across cells Supports healthy nerve function Made with the quality you trust

Bottled and tested in the USA

Gluten free. No salt, wheat, soy, dairy, or artificial colors.

General Statements

Explore more products at naturesway.com

Bottle made from 50% post-consumer recycled plastic

Precautions

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Storage

Keep tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

Brand IP Statement(s)

Copyright 2024 Sharp-PS Green is a registered trademark of IFF or its affiliates.

Formula

Sharp-PS Green

Phosphatidylserine 100 mg per serving

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommendation: Adults swallow 1 softgel three times daily for one month, then swallow 1 softgel two times daily thereafter, or as recommended by a healthcare professional. Do not chew. Best results are obtained with continuous use.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phosphatidylserine 100 mg by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phosphatidylserine 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phosphatidylserine 100 mg by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: Sunflower Lecithin

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Medium Chain Triglyceride, Gelatin, Glycerin, Lipids, Water, Purified, Ascorbyl Palmitate, Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phosphatidylserine 100 mg by Nature's Way Drug Interactions

Want to check YOUR meds against Phosphatidylserine 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in Phosphatidylserine 100 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Phosphatidylserine 100 mg interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in Phosphatidylserine 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phosphatidylserine 100 mg, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Phosphatidylserine 100 mg by Nature's Way: Common Questions

Does Phosphatidylserine 100 mg by Nature's Way interact with any medications?
Yes. Based on its ingredients, Phosphatidylserine 100 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phosphatidylserine 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is phosphatidylserine used for?
Phosphatidylserine is used to support memory and cognitive function, especially for age-related memory loss and Alzheimer's disease, where it's shown possibly effective in studies. It's also being studied for athletic performance and ADHD, but the evidence isn't strong enough yet to confirm it works for those.
What side effects might I notice?
The most common ones are flatulence, stomach upset, headache, insomnia, and nausea. Insomnia is more likely at higher doses (600 mg), and stomach issues can happen around 200–300 mg per day. At this 100 mg dose, side effects are usually mild.
Can I take this if I'm pregnant or breastfeeding?
During pregnancy, there isn't enough safety data, so avoidance is recommended. If you're breastfeeding, safety is also unknown—talk with your doctor or pharmacist before using it in either situation.
How does phosphatidylserine work?
It's a compound found naturally in your cell membranes. It's thought to support brain cell function and increase acetylcholine, a chemical messenger involved in memory and thinking. That's also why it can interact with certain medications that affect acetylcholine.
Is this a soy product?
Phosphatidylserine is typically sourced from soy or cabbage. If you have a soy allergy, check the label or ask your pharmacist to confirm the source before taking it.
How long does it take to work?
The product facts don't include timing data on when you might notice effects. Talk with your doctor or pharmacist about realistic expectations and how long to take it before reassessing whether it's helping.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phosphatidylserine 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phosphatidylserine 100 mg label
Go deeper

The Full Monographs Behind Phosphatidylserine 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Phosphatidylserine 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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