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Dietary supplement

Phosphatidylserine 100 mg Ingredients & Drug Interactions

by Nature's Way

Phosphatidylserine 100 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phosphatidylserine 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phosphatidylserine 100 mg is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are SerinAid Phosphatidylserine complex. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phosphatidylserine 100 mg by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Phosphatidylserine 100 mg by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Phosphatidylserine 100 mg by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “SerinAid Phosphatidylserine complex” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

This product contains one active ingredient: phosphatidylserine, a naturally occurring compound found in cell membranes. It's derived from soybean in this formula.

The softgel also contains gelatin, glycerin, soybean oil, and purified water as inactive ingredients to hold and deliver the phosphatidylserine.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: brain function and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Dementia, Attention deficit-hyperactivity disorder (ADHD), memory — and 2 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia.

The data shows phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease. For athletic performance, ADHD, general cognitive function, and dementia, the evidence we hold is insufficient to rate whether it works.

If you're considering it for one of those first two uses, talk it over with your doctor to see if it makes sense for your situation.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety hasn't been fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea.

Insomnia is more likely at higher doses (600 mg), and gastrointestinal upset can occur at 200–300 mg daily. The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe.

Talk with your doctor or pharmacist before taking this if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist if you're on anticholinergic drugs (used for urinary symptoms, overactive bladder, eye problems, and other conditions) or cholinergic drugs (such as those for myasthenia gravis or Alzheimer disease). Phosphatidylserine might interfere with how these medications work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Phosphatidylserine may help with age-related cognitive decline or Alzheimer disease, but you'll want to check your medications first—especially any anticholinergic or cholinergic drugs. Most people tolerate it well, though digestive upset and insomnia can happen.

Talk with your doctor or pharmacist before you start, particularly if you're pregnant, breastfeeding, or taking prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phosphatidylserine 100 mg, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674451601
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Jan 25, 2020
DSLD ID 213475
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phosphatidylserine 100 mg by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
033674451601
IngredientAmount% DV
Calories5 Calorie(s)--
Phosphatidylserine100 mg--
SerinAid Phosphatidylserine complex500 mg--

Other ingredients: Gelatin, Glycerin, Soybean Oil, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Brain function

Gluten free. No salt, yeast-derived ingredients, wheat, corn, dairy products, or artificial colors, flavors, or preservatives.

Formula

Phosphatidylserine (PS) helps regulate membrane transfer of nutrients and neurotransmitters necessary for proper brain function. Our PS is carefully tested and produced to superior quality standards.

Phosphatidylserine 100 mg per serving

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Nature’s Way Since 1969

Bottles made from 97% post-consumer recycled plastic

FDA Statement of Identity

Dietary supplement

Suggested/Recommended/Usage/Directions

Recommendation: Take 1 softgel three times daily for one month, then two times daily thereafter. Best results are obtained with continuous use.

Precautions

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Contains soy.

Keep out of reach of children.

Safety sealed with printed inner seal. Do not use if seal is broken or missing.

Brand IP Statement(s)

2019 Distributed by Nature’s Way Brands, LLC

SerinAid and logo are trademarks of Chemi Nutraceuticals, Inc.

Seals/Symbols

Quality Global Sourcing Bottled & Tested In the USA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phosphatidylserine 100 mg by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phosphatidylserine 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phosphatidylserine 100 mg by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

SerinAid Phosphatidylserine complex

Interacts with
219 drugs
500 mg per serving

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

SerinAid Phosphatidylserine complex monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Soybean Oil, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phosphatidylserine 100 mg by Nature's Way Drug Interactions

Want to check YOUR meds against Phosphatidylserine 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

SerinAid Phosphatidylserine complex 219

Individual Drug Interactions

The ingredients in Phosphatidylserine 100 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Phosphatidylserine 100 mg interact with drugs. Each result below shows which ingredient is responsible. SerinAid Phosphatidylserine complex

Each ingredient & the kinds of drugs it affects

For each ingredient in Phosphatidylserine 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

SerinAid Phosphatidylserine complex2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
SerinAid Phosphatidylserine complex full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phosphatidylserine 100 mg, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Phosphatidylserine 100 mg by Nature's Way: Common Questions

Does Phosphatidylserine 100 mg by Nature's Way interact with any medications?
Yes. Based on its ingredients, Phosphatidylserine 100 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phosphatidylserine 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does phosphatidylserine do?
Phosphatidylserine is thought to increase acetylcholine, a brain chemical involved in memory and thinking. It's possibly effective for age-related cognitive decline and Alzheimer disease, but the evidence for other uses like ADHD or general cognitive function is insufficient to say whether it works.
What are the most common side effects?
Flatulence, gastrointestinal upset, headache, insomnia, and nausea are the most commonly reported. Insomnia is more likely at higher doses, and digestive upset can occur at 200–300 mg daily. Most people tolerate it well overall.
Can I take this if I'm pregnant or breastfeeding?
No, the safety data advises against it. There isn't enough information to know it's safe during pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
How much acetylcholine does this increase?
The facts don't specify the amount of increase. What we know is that phosphatidylserine is thought to raise acetylcholine levels, which is why it can interact with drugs that affect acetylcholine.
Is this derived from soy?
Yes, the phosphatidylserine in this product comes from soybean. The softgel capsule also contains soybean oil. If you have a soy allergy, talk with your pharmacist before taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phosphatidylserine 100 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phosphatidylserine 100 mg label
Go deeper

The Full Monographs Behind Phosphatidylserine 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Phosphatidylserine 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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