Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

PhosSerine Complex Ingredients & Drug Interactions

by Allergy Research Group

PhosSerine Complex label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PhosSerine Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PhosSerine Complex is a dietary supplement by Allergy Research Group with 2 active ingredients. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PhosSerine Complex by Allergy Research Group

Ask about any prescription or over-the-counter medication and we check it for interactions with PhosSerine Complex by Allergy Research Group — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of PhosSerine Complex by Allergy Research Group

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

PhosSerine Complex contains 2 active ingredients: phosphatidic acid and phosphatidylserine. Phosphatidylserine is a fatty compound found naturally in cell membranes and is studied primarily for brain function and memory support.

The softgel also contains several inactive ingredients — soybean oil, gelatin, glycerin, and water — that help deliver the actives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Phosphatidylserine's overall clinical evidence instead.

Moderate

Some clinical evidence supports Phosphatidylserine for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Age-related cognitive decline — rated "Possibly Effective" (Natural Medicines).
  • On file: Alzheimer disease — rated "Possibly Effective" (Natural Medicines).

Phosphatidylserine is rated possibly effective for age-related cognitive decline and Alzheimer disease based on available evidence. For athletic performance, attention deficit-hyperactivity disorder (ADHD), general cognitive function, and dementia, the evidence isn't strong enough to rate it — we simply don't hold reliable data showing whether it works for those uses.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety hasn't been fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea.

Higher doses (around 600 mg) are more likely to cause insomnia, and doses of 200–300 mg daily may trigger digestive upset. The safety data advises against use during pregnancy.

Safety while breastfeeding is also unknown, so avoidance is recommended. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, double-check your medications with your doctor or pharmacist if you take anticholinergic drugs (used for conditions like overactive bladder or Parkinson disease) or cholinergic drugs (used for myasthenia gravis, glaucoma, or Alzheimer disease) — phosphatidylserine may interfere with their effectiveness or strengthen their effects more than intended.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

PhosSerine Complex may be worth considering if you're dealing with age-related memory changes or have concerns about cognitive decline, since phosphatidylserine shows some promise there. If you take anticholinergic or cholinergic medications, check with your doctor or pharmacist first — the product could interfere with how these drugs work.

Start with a lower dose if you're concerned about side effects like nausea or insomnia. Your pharmacist can help you weigh whether this fits your personal health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PhosSerine Complex, straight from the product label.

Brand Allergy Research Group
Barcode (UPC) 713947725706
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Dec 23, 2015
DSLD ID 54373
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PhosSerine Complex by Allergy Research Group, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
90
UPC/BARCODE
713947725706
IngredientAmount% DV
Phosphatidic Acid100 mg--
Phosphatidylserine100 mg--

Other ingredients: other Phospholipids, Soybean Oil, Gelatin, Glycerin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Phosphatidylserine is a phospholipid, extracted from soy lecithin with the aid of a cabbage enzyme.

Soy Lecithin Base

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 1 softgel three times daily with meals, or as directed by a healthcare practitioner.

Formulation

This nutrient is of the highest quality and purity obtainable, and does not contain preservatives, diluents, or artificial additives.

Storage

Keep in a cool, dry place, tightly capped.

General

Rev. 004

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PhosSerine Complex by Allergy Research Group label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PhosSerine Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PhosSerine Complex by Allergy Research Group

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Phosphatidic Acid

100 mg per serving

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: Soy

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Other Phospholipids, Soybean Oil, Gelatin, Glycerin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

PhosSerine Complex by Allergy Research Group Drug Interactions

Want to check YOUR meds against PhosSerine Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in PhosSerine Complex interact with 219 drugs. Click any drug to see the details.

1 of the 2 ingredients in PhosSerine Complex interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in PhosSerine Complex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PhosSerine Complex, from the product label.

Allergy Research Group

See all Allergy Research Group products
Name
Allergy Research Group
City
Alameda
State
CA
ZipCode
94502
Phone Number
510-263-2000
Web Address
www.allergyresearchgroup.com
Pharmacist Counseling Corner

PhosSerine Complex by Allergy Research Group: Common Questions

Does PhosSerine Complex by Allergy Research Group interact with any medications?
Yes. Based on its ingredients, PhosSerine Complex has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PhosSerine Complex contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does phosphatidylserine do?
Phosphatidylserine is a natural fatty compound found in cell membranes. It's studied mainly for supporting brain function and memory, especially as people age. The evidence suggests it may help with age-related cognitive decline and Alzheimer disease, but for other uses like ADHD or general brain performance, we don't have strong enough data yet.
What are the most common side effects?
The most frequent side effects are flatulence, stomach upset, headache, insomnia, and nausea. Higher doses (around 600 mg) are more likely to trigger insomnia, and doses in the 200–300 mg range are more likely to cause digestive upset. Most people tolerate it well, but start with a lower dose if you're sensitive.
Can I take this while pregnant or breastfeeding?
No — the safety data advises against it during pregnancy. Safety while breastfeeding is unknown, so avoidance is also recommended. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding to discuss whether this product is right for you.
What's the difference between phosphatidylserine and phosphatidic acid in this product?
Phosphatidylserine is the ingredient we have the most research on — it's studied for cognitive health. Phosphatidic acid is the other active ingredient, but we don't hold interaction data for it. Both are phospholipids, which are natural fatty compounds.
Are there any fillers in this softgel?
Beyond the two active ingredients, the softgel contains soybean oil, gelatin, glycerin, and water as inactive ingredients to deliver the product. These are standard capsule materials and not fillers in the sense of empty bulk — they serve a functional purpose.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PhosSerine Complex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PhosSerine Complex label
Go deeper

The Full Monographs Behind PhosSerine Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

PhosSerine Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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