Pine Bark Extract Pycnogenol 50 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Pine Bark Extract Pycnogenol 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pine Bark Extract Pycnogenol 50 mg is a dietary supplement by Martin Avenue Pharmacy with 1 active ingredient. Its ingredients are commonly taken for circulation and vein health, antioxidant support, skin health and aging.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pine bark extract powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pine Bark Extract Pycnogenol 50 mg by Martin Avenue Pharmacy
Ask about any prescription or over-the-counter medication and we check it for interactions with Pine Bark Extract Pycnogenol 50 mg by Martin Avenue Pharmacy — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pine Bark Extract Pycnogenol 50 mg by Martin Avenue Pharmacy
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: pine bark extract powder, 50 mg per capsule. Pine bark extract (also called maritime pine) is derived from the bark of a specific pine tree species and standardized for its active compounds.
The capsule also contains cellulose as an inactive ingredient to hold it together.
Does it work?
Moderate evidence
Pine bark extract is possibly effective for osteoarthritis and chronic venous insufficiency (heaviness, swelling, or pain in the legs from sluggish blood flow). It's also possibly effective for asthma.
For high cholesterol (hyperlipidemia), the evidence rates it as possibly ineffective. The research supporting these ratings is still growing, and more data would help clarify how well it actually works.
How safe is it?
Well-documented data
Pine bark extract is generally well tolerated, though long-term safety hasn't been fully established in studies. The most common side effects when taken by mouth are stomach upset, dizziness, and vertigo.
Headache has been reported in one trial. A very small number of people have reported chest pain or worsening heart failure, but these cases occurred in patients with existing heart disease, and it's unclear whether the extract was directly responsible.
The safety data during pregnancy advises against it, and there isn't enough data to know if it's safe while breastfeeding—talk with your doctor or pharmacist about your individual situation.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you use blood thinners or antiplatelet drugs (like warfarin or aspirin), diabetes medications, or immunosuppressant drugs. Pine bark extract may increase bleeding risk, lower blood sugar further, or reduce immunosuppressant effectiveness.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Pine bark extract may help with osteoarthritis, leg swelling from poor circulation, or asthma symptoms, though the evidence is still emerging. If you take blood thinners, diabetes medications, or immunosuppressants, check with your doctor or pharmacist first—this product could affect how those drugs work.
Pregnant or breastfeeding? Discuss it with your healthcare provider before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pine Bark Extract Pycnogenol 50 mg, straight from the product label.
| Brand | Martin Avenue Pharmacy |
|---|---|
| Net contents | 30 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Mar 25, 2013 |
| DSLD ID | 19023 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pine Bark Extract Pycnogenol 50 mg by Martin Avenue Pharmacy, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pine bark extract powder | 50 mg | -- |
Other ingredients: Cellulose, May contain one or more of the following:
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
"We Make It Better..."
QUALITY AND POTENCY GUARANTEED
Formulation
Contains No Added sugar, salt, dairy, yeast, wheat, corn, soy, preservatives, artificial colors or flavors.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, adults take one (1) capsule, one (1) to three (3) times daily with meals, or as directed by a health care professional.
Storage
Store in a cool, dry place and away from direct light.
Precautions
Keep out of reach of children.
Brand IP Statement(s)
Our Pycnogenol(R) French Maritime Pine Bark Extract is produced by a European phytopharmaceutical company and is manufactured under strict European quality control standards without the use of harsh solvents.
Pycnogenol(R) is a registered trademark of Horphag Research, Ltd.
Formula
Like all European herbal extracts, the extraction of Pycnogenol(R) is regulated to the same high standards as Over-The-Counter drugs. It is meticulously extracted to provide the optimal level of 90% natural occurring Proanthocyanidins.
General
#10121
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pine Bark Extract Pycnogenol 50 mg by Martin Avenue Pharmacy label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pine Bark Extract Pycnogenol 50 mg by Martin Avenue Pharmacy
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Pine bark extract powder
Interacts with327 drugs
Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...
Pine bark extract powder monograph & interactionsOther (inactive) ingredients: Cellulose, May contain one or more of the following:. These complete the product’s ingredient list but are not active constituents.
Pine Bark Extract Pycnogenol 50 mg by Martin Avenue Pharmacy Drug Interactions
HelloPharmacist Interaction Report
Pine Bark Extract Pycnogenol by Martin Avenue Pharmacy can interact with several medication types through its single active ingredient, pine bark extract.
The most serious concern is with blood thinners and antiplatelet drugs (anticoagulants/antiplatelets)—a Moderate-severity interaction where the extract may increase bleeding risk by inhibiting how your blood cells clump together, though the real-world significance of this effect isn't yet clear.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to watch for interactions with diabetes medications and immunosuppressants (drugs that calm your immune system). With diabetes drugs, the extract may lower your blood sugar further, raising the risk of low blood sugar (hypoglycemia)—one clinical study showed this effect, so if you take diabetes medication, close monitoring and possible dose adjustments may be needed.
With immunosuppressants, the extract's immune-stimulating activity could theoretically reduce how well those drugs work, though this hasn't been confirmed in humans.
Altogether, these interactions span 327 individual medications. Use the interaction checker below to look up your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pine Bark Extract Pycnogenol 50 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pine Bark Extract Pycnogenol 50 mg interact with 327 drugs. Click any drug to see the details.
1 of the 1 ingredient in Pine Bark Extract Pycnogenol 50 mg interact with drugs. Each result below shows which ingredient is responsible. Pine bark extract powder
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pine Bark Extract Powder + 6-mercaptopurine interactionAbciximabReoPro
How Abciximab interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs, Immunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pine Bark Extract Powder + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Acetaminophen, Ibuprofen interactionAcetohexamideDymelor
How Acetohexamide interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pine Bark Extract Powder + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Acetylsalicylic Acid interactionAdalimumabHumira
How Adalimumab interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pine Bark Extract Powder + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pine Bark Extract Powder + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pine Bark Extract Powder + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pine Bark Extract Powder + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pine Bark Extract Powder + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pine Bark Extract Powder + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pine Bark Extract Powder + Adalimumab-fkjp interactionAlbiglutideTanzeum
How Albiglutide interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pine Bark Extract Powder + Albiglutide interactionAlefaceptAmevive
How Alefacept interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pine Bark Extract Powder + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pine Bark Extract Powder + Alemtuzumab interactionAlogliptinNesina
How Alogliptin interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pine Bark Extract Powder + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pine Bark Extract Powder + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full Pine Bark Extract Powder + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Anagrelide interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full Pine Bark Extract Powder + Anifrolumab-fnia interactionAnisindioneMiradon
How Anisindione interacts with Pine Bark Extract Pycnogenol 50 mg — through 1 ingredient. Tap an ingredient for the detail:
Pine Bark Extract PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full Pine Bark Extract Powder + Anisindione interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pine Bark Extract Pycnogenol 50 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Pine bark extract powder
Anticoagulant/Antiplatelet Drugs
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.
Antidiabetes Drugs
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Immunosuppressants
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Pine Bark Extract Pycnogenol 50 mg, from the product label.
Martin Avenue Pharmacy
See all Martin Avenue Pharmacy products- Name
- Martin Avenue Pharmacy, Inc.
- City
- Naperville
- State
- IL
- ZipCode
- 60540
- Phone Number
- (630) 355-6400
Pine Bark Extract Pycnogenol 50 mg by Martin Avenue Pharmacy: Common Questions
Does Pine Bark Extract Pycnogenol 50 mg by Martin Avenue Pharmacy interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on a blood thinner like warfarin or aspirin?
What are the most common side effects?
Does this actually work for joint pain?
Is it safe to take while breastfeeding?
What is pine bark extract used for?
Can I take this if I'm diabetic and on diabetes medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pine Bark Extract Pycnogenol 50 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pine Bark Extract Pycnogenol 50 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pine Bark Extract Pycnogenol 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Maritime Pine 14 references
- Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
- Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
- Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
- Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
- Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
- Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
- Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
- Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
- Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
- Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
- Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
- Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
- Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
- Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC