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Dietary supplement

Pino-Rico Ingredients & Drug Interactions

by Dr. Rico Perez

Pino-Rico label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pino-Rico against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pino-Rico is a dietary supplement by Dr. Rico Perez with 1 active ingredient. Its ingredients are commonly taken for circulation and vein health, antioxidant support, skin health and aging.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pine Bark Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pino-Rico by Dr. Rico Perez

Ask about any prescription or over-the-counter medication and we check it for interactions with Pino-Rico by Dr. Rico Perez — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pino-Rico by Dr. Rico Perez

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Pino-Rico is a single-ingredient supplement: maritime pine bark extract, sourced from a specific pine species. It's the sole active ingredient in each capsule.

The rest — cellulose, gelatin, magnesium stearate, and silicon dioxide — are inactive ingredients that form the capsule and keep the powder stable.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Circulation and vein health support.
  • We looked for evidence on: Chronic venous insufficiency (CVI), Varicose veins, Atherosclerosis, Hypertension, Vascular function, Endothelial health.
  • The strongest evidence on file: Maritime Pine is rated "Possibly Effective" for Chronic venous insufficiency (CVI) (Natural Medicines).
  • Also on file: Maritime Pine is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Hypertension, Varicose veins.

Maritime pine bark extract is possibly effective for osteoarthritis and chronic venous insufficiency (a condition where your leg veins don't pump blood back to your heart efficiently). For asthma, the evidence is also rated possibly effective.

When it comes to cholesterol and fat levels in the blood, though, the extract is rated possibly ineffective — so it's not a reliable choice if that's your goal.

The evidence, ingredient by ingredient Maritime Pine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Maritime pine bark extract is generally well tolerated in the studies we have, but long-term safety hasn't been fully worked out yet. The most common side effects from oral use are stomach complaints, dizziness, and vertigo.

Headache and severe dizziness have also shown up in trials. Very rare cases of chest pain and heart failure worsening have been reported, though it's unclear whether the extract was directly responsible.

During pregnancy, there isn't enough safety data, so the facts advise against use. The same applies to breastfeeding — we don't have enough information to say it's safe, so talk with your doctor or pharmacist about your individual situation.

Side effects, ingredient by ingredient Maritime Pine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Maritime Pine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Pino-Rico, double-check with your pharmacist if you're on blood thinners or antiplatelet drugs (like warfarin or aspirin) — the extract may increase bleeding risk. Also flag diabetes medications and immunosuppressants, as the extract can lower blood sugar and may reduce how well immune-dampening drugs work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pino-Rico may be worth considering if you have osteoarthritis, chronic leg vein problems, or asthma and want to explore herbal options. But if you take blood thinners, diabetes medications, or drugs that suppress your immune system, check with your pharmacist first — the extract can interfere with how they work.

Pregnant or breastfeeding? Skip it unless your doctor says otherwise.

Start here with our medication checker to be sure.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pino-Rico, straight from the product label.

Brand Dr. Rico Perez
Barcode (UPC) 879840000545
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 321013
Product type Botanical
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pino-Rico by Dr. Rico Perez, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
879840000545
IngredientAmount% DV
Pine Bark Extract100 mg--

Other ingredients: Cellulose, Gelatin, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one (1) to two (2) capsules three times daily with any meal or as directed by your healthcare provider. Do not exceed recommended dosage. Individual results may vary.

Precautions

Warning: Consult healthcare provider to use if: pregnant, nursing, on medications, have a medical condition or are planning a medical procedure.

Stop use and contact a physician if adverse reactions occur. Do not use if product appears to be tampered with or seal is broken.

Keep out of reach of children.

Storage

Store at room temperature.

Formulation

Unconditionally guaranteed for purity, freshness and label potency. Manufactured in a cGMP certified facility. Freshness Assured

No added sugar, yeast, preservatives, artificial colors or flavors.

Pino-Rico is a powerful antioxidant and natural anti-inflammatory that protects against free radicals. It may be beneficial for cardiovascular health, cognitive function, diabetes health and menstrual disorders. It may also help with asthma and allergies.

Seals/Symbols

Made in USA from domestic and foreign materials

FDA Statement of Identity

Dietary Supplement

Formula

Pino-Rico contains a concentrated natural extract from the bark of pine trees that grown along costal areas.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pino-Rico by Dr. Rico Perez label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pino-Rico label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pino-Rico by Dr. Rico Perez

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Pine Bark Extract

Interacts with
327 drugs
100 mg per serving Form: Pinus massoniana Bark Extract, Proanthocyanidins

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...

Pine Bark Extract monograph & interactions

Other (inactive) ingredients: Cellulose, Gelatin, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pino-Rico by Dr. Rico Perez Drug Interactions

Want to check YOUR meds against Pino-Rico?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Pine Bark Extract 327

Individual Drug Interactions

The ingredients in Pino-Rico interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pino-Rico interact with drugs. Each result below shows which ingredient is responsible. Pine Bark Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pino-Rico with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pine Bark Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Pine Bark Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pino-Rico, from the product label.

Dr. Rico Perez

See all Dr. Rico Perez products
Name
Rico-Perez Products, Inc.
Street Address
2295 Coral Way
City
Miami
State
FL
ZipCode
33145
Phone Number
(800) 633-6799
Web Address
www.ricoperez.com
Pharmacist Counseling Corner

Pino-Rico by Dr. Rico Perez: Common Questions

Does Pino-Rico by Dr. Rico Perez interact with any medications?
Yes. Based on its ingredients, Pino-Rico has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pino-Rico contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does maritime pine bark extract actually work?
For osteoarthritis, chronic leg vein problems, and asthma, the evidence says it's possibly effective — meaning there's some promising research, but more work is needed to be sure. For cholesterol and fat levels, though, it's rated possibly ineffective, so it's not a strong choice for that goal.
What are the most common side effects?
The main ones are stomach upset, dizziness, and vertigo. Headache and severe dizziness have also been reported in trials. These tend to be mild, but if they're bothersome, let your pharmacist know.
Is it safe to take while pregnant or breastfeeding?
There isn't enough safety data for either. During pregnancy, the advice is to avoid it. For breastfeeding, we also don't have enough information — talk with your doctor or pharmacist about what's right for your situation.
Can I take this with my diabetes medication?
Not without caution. Maritime pine bark extract can lower blood sugar on its own, so combining it with diabetes drugs might drop your glucose too low. Your doctor may need to adjust your medication dose, and you'll need to monitor your blood sugar closely.
What's in the capsule besides the active ingredient?
Cellulose, gelatin, magnesium stearate, and silicon dioxide — these are all inactive ingredients that help form and stabilize the capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pino-Rico is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pino-Rico label
Go deeper

The Full Monographs Behind Pino-Rico’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Maritime Pine

Interacts with 327 drugs

Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research is promising, but many studies are small...

Read the full Maritime Pine monograph →
Sources

Sources & How We Checked

Pino-Rico's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Maritime Pine 14 references
  1. Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
  2. Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
  3. Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
  4. Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
  5. Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
  6. Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
  7. Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
  8. Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
  9. Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
  10. Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
  11. Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
  12. Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
  13. Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
  14. Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.

See these in context on the Maritime Pine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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