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Dietary supplement

Policosanol 20 mg Ingredients & Drug Interactions

by Natural Nutra

Policosanol 20 mg label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Policosanol 20 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Policosanol 20 mg is a dietary supplement by Natural Nutra with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, heart and blood vessel health, leg pain from poor circulation (intermittent claudication).Based on those ingredients, 242 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Policosanol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Policosanol 20 mg by Natural Nutra

Ask about any prescription or over-the-counter medication and we check it for interactions with Policosanol 20 mg by Natural Nutra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Policosanol 20 mg by Natural Nutra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: policosanol 20 mg per capsule. Policosanol is a plant-derived compound used to support heart and circulation health.

The capsule also contains inactive ingredients—cellulose, dicalcium phosphate, magnesium stearate, rice bran, ascorbyl palmitate, and silica—which are fillers and binders that hold the supplement together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Policosanol's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Support healthy cholesterol levels.
  • We looked for evidence on: Hypercholesterolemia, Familial hypercholesterolemia, Coronary heart disease (CHD), Metabolic syndrome, Dyslipidemia, Cardiovascular risk reduction.
  • The closest evidence on file: Policosanol is rated "Insufficient Reliable Evidence To Rate" for Coronary heart disease (CHD) (Natural Medicines).
  • Also on file: Policosanol is rated "Insufficient Reliable Evidence To Rate" for Familial hypercholesterolemia, Metabolic syndrome.

Policosanol is likely effective for intermittent claudication, a condition where leg pain occurs during walking due to poor blood flow. For coronary heart disease and familial hypercholesterolemia (inherited high cholesterol), the evidence in our data is insufficient to make a reliable claim about how well it works.

If you're considering this for heart or cholesterol support, talk with your doctor about whether the evidence fits your situation.

The evidence, ingredient by ingredient Policosanol

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Policosanol is generally well tolerated in studies, though real-world results vary and product quality differs between brands. The most common side effects are uncommon and mild—a small number of trial participants reported headache, dizziness, sleepiness, upset stomach, or skin rash.

Weight loss has been associated with policosanol, but post-market data shows this is rare. During pregnancy, there isn't enough safety information, so the data advises against use.

The same applies to breastfeeding. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this supplement.

Side effects, ingredient by ingredient Policosanol

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Policosanol.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 242 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (moderate risk of bleeding), beta-blockers (moderate risk of blood pressure dropping too far), antidiabetes medications (moderate risk of low blood sugar), or nitroprusside (moderate risk of blood pressure dropping too far). No interactions are documented for the checked ingredients beyond these categories.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Policosanol may help with leg pain from poor circulation, but it interacts with blood thinners, beta-blockers, diabetes drugs, and blood pressure medications. If you take any of those—or any prescription drug—check it against this product's interactions before you start.

Your doctor or pharmacist can help you weigh whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Policosanol 20 mg, straight from the product label.

Brand Natural Nutra
Net contents 60 Vegan Capsule(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 247037
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Policosanol 20 mg by Natural Nutra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Policosanol20 mg--

Other ingredients: Cellulose Capsule, Dicalcium Phosphate, Magnesium Stearate, Rice Bran, Ascorbyl Palmitate, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no artificial colors, flavors or preservatives; no wheat, gluten, milk, eggs, peanuts, tree nuts, soy, crustacean shellfish or fish.

Suitable for vegans.

Extra strength Cholesterol support

Vegan

Gluten free

Purity + potency guaranteed

Formula

Policosanol is a mixture of nine different aliphatic alcohols designed to support healthy cholesterol. Octacosanol, a derivative of the wax from sugar cane plants, is the main ingredient in policosanol and works as a powerful antioxidant to help maintain healthy arteries. This combined with the actions of eight other alcohols, including triacontanol and hexacosanol, can support healthy LDL and HDL levels, and promote cardiovascular health.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take one capsule daily with or without meals.

Precautions

Keep out of reach of children.

General Statements

To report a serious adverse event, call 1-888-710-0006

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Policosanol 20 mg by Natural Nutra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Policosanol 20 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Policosanol 20 mg by Natural Nutra

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Policosanol

Interacts with
242 drugs
20 mg per serving Form: Octacosanol, Sugar Cane

Policosanol is a mix of waxy alcohols (mostly octacosanol) made from sugar cane or other plant waxes, and it is often marketed as a natural way to low...

Policosanol monograph & interactions

Other (inactive) ingredients: Cellulose Capsule, Dicalcium Phosphate, Magnesium Stearate, Rice Bran, Ascorbyl Palmitate, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Policosanol 20 mg by Natural Nutra Drug Interactions

Want to check YOUR meds against Policosanol 20 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
242Drugs
242 Moderate

Ingredients driving the most interactions

Policosanol 242

Individual Drug Interactions

The ingredients in Policosanol 20 mg interact with 242 drugs. Click any drug to see the details.

1 of the 1 ingredient in Policosanol 20 mg interact with drugs. Each result below shows which ingredient is responsible. Policosanol

Each ingredient & the kinds of drugs it affects

For each ingredient in Policosanol 20 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Policosanol6 drug types · 242 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking policosanol with other antiplatelet or anticoagulant drugs might increase the risk of bruising and bleeding.
Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. Although, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to warfarin dosing does not affect warfarin pharmacokinetics or warfarin response. Furthermore, a study in patients undergoing percutaneous coronary intervention with a drug-eluting stent found that taking policosanol 40 mg plus clopidogrel and aspirin daily for 30 days modestly reduced the risk for minor bleeding events when compared with taking clopidogrel and aspirin alone. Until more is known, use with caution.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, policosanol might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
Clinical research shows that policosanol can lower blood glucose levels.

Likelihood Possible Evidence B
Beta-Blockers

Concomitant use of policosanol with beta-blockers can cause additive blood pressure-lowering effects.
Clinical research shows that policosanol 5 mg daily can have additive blood pressure-lowering effects in patients with hypertension who are taking beta-blockers. Also, animal research shows that policosanol can increase the blood-pressure lowering effects of propranolol.

Likelihood Probable Evidence A
Nitroprusside (Nitropress)

Theoretically, concomitant use of policosanol with nitroprusside might cause additive blood pressure-lowering effects.
Animal research shows that taking policosanol along with nitroprusside can increase the blood pressure-lowering effects of nitroprusside.

Likelihood Possible Evidence D
Propranolol (Inderal)

Animal research shows that taking policosanol along with propranolol can increase the blood pressure-lowering effects of propranolol.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, taking policosanol with warfarin might increase the risk of bruising and bleeding.
Some clinical research shows that taking policosanol 10-50 mg daily for 7-15 days can inhibit platelet aggregation in healthy patients. However, one clinical trial shows that taking policosanol 10 mg twice daily for 2 weeks prior to warfarin dosing does not affect warfarin pharmacokinetics or warfarin response.

Likelihood Possible Evidence B
Policosanol full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Policosanol 20 mg, from the product label.

Natural Nutra

See all Natural Nutra products
Name
Hurd Dynamics LLC, DBA Natural Nutra
City
Tampa
State
FL
ZipCode
33615
Phone Number
1-888-710-0006
Web Address
www.natnutra.com
Pharmacist Counseling Corner

Policosanol 20 mg by Natural Nutra: Common Questions

Does Policosanol 20 mg by Natural Nutra interact with any medications?
Yes. Based on its ingredients, Policosanol 20 mg has a known interaction with 242 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Policosanol 20 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is policosanol used for?
Policosanol is used to support heart and circulation health. It's likely effective for intermittent claudication, a condition where your legs hurt when you walk because blood flow is poor. For coronary heart disease and familial high cholesterol, the evidence we have is not yet enough to say how well it works.
Can I take this if I'm pregnant or breastfeeding?
No—there isn't enough safety information about policosanol in pregnancy or while breastfeeding, so it's best to avoid it. Talk with your doctor or pharmacist for guidance if you're pregnant, planning to become pregnant, or breastfeeding.
What are the side effects?
Policosanol is usually well tolerated. In clinical studies, only a small number of people reported mild headache, dizziness, sleepiness, upset stomach, or skin rash. Weight loss has been linked to it, but it's uncommon based on post-market data.
I take a blood thinner—is this safe for me?
Policosanol can affect clotting and might raise your bleeding and bruising risk if you take blood thinners like warfarin or other antiplatelet drugs. Don't start this supplement without talking to your doctor or pharmacist first—they can tell you whether it's safe for your situation.
Does this product have fillers?
Yes, it contains inactive ingredients: cellulose, dicalcium phosphate, magnesium stearate, rice bran, ascorbyl palmitate, and silica. These are standard binders and fillers that help hold the supplement together.
Can I take this with my diabetes medication?
Policosanol can lower blood sugar on its own, so combining it with diabetes drugs might push your blood sugar too low. Talk with your doctor or pharmacist before starting—they'll want to watch your levels if you do take it together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Policosanol 20 mg label
Go deeper

The Full Monographs Behind Policosanol 20 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Policosanol

Interacts with 242 drugs

Policosanol is a mix of waxy alcohols (mostly octacosanol) made from sugar cane or other plant waxes, and it is often marketed as a natural way to lower cholesterol. Early studies from Cuba...

Read the full Policosanol monograph →
Sources

Sources & How We Checked

Policosanol 20 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Policosanol 15 references
  1. Carbajal D, Arruzazabala ML, Valdes S, Mas R. Effect of policosanol on platelet aggregation and serum levels of arachidonic acid metabolites in healthy volunteers. Prostaglandins Leukot Essent Fatty Acids 1998;58:61-4.
  2. Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res 1997;36:293-7. PubMed
  3. Valdes S, Arruzazabala ML, Fernandez L. Effect of policosanol on platelet aggregation in healthy volunteers. Int J Clin Pharmacol Res 1996;16:67-72.
  4. Greyling A, De Witt C, Oosthuizen W, Jerling JC. Effects of a policosanol supplement on serum lipid concentrations in hypercholesterolaemic and heterozygous familial hypercholesterolaemic subjects. Br J Nutr 2006;95:968-75. PubMed
  5. Abdul MI, Jiang X, Williams KM, et al. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. Br J Clin.Pharmacol. 2010;69:508-15. PubMed
  6. Molina, Cuevas, V, Arruzazabala, M. L., Carbajal, Quintana D., Mas, Ferreiro R., and Valdes, Garcia S. Effect of policosanol on arterial blood pressure in rats. Study of the pharmacological interaction with nifedipine and propranolol. Arch Med Res 1998;29
  7. Castano G, Fernandez L, Mas R, et al. Comparison of the efficacy, safety and tolerability of original policosanol versus other mixtures of higher aliphatic primary alcohols in patients with type II hypercholesterolemia. Int.J.Clin.Pharmacol.Res. 2002;22:5
  8. Arruzazabala, M. L., Carbajal, D., Mas, R., Valdes, S., and Molina, V. Pharmacological Interaction Between Policosanol and Nitroprusside in Rats. J Med Food 2001;4(2):67-70. PubMed
  9. Castano G, Mas R, Gamez R, et al. Concomitant use of policosanol and beta-blockers in older patients. Int J Clin Pharmacol.Res 2004;24:65-77.
  10. Francini-Pesenti F, Brocadello F, Beltramolli D, et al. Sugar cane policosanol failed to lower plasma cholesterol in primitive, diet-resistant hypercholesterolaemia: A double blind, controlled study. Complement Ther Med 2008;16:61-65. PubMed
  11. Castaño G, Fernández L, Mas R, Illnait J, Mesa M, Fernández JC. Comparison of the effects of policosanol and atorvastatin on lipid profile and platelet aggregation in patients with dyslipidaemia and type 2 diabetes mellitus. Clin Drug Investig. 2003;23(10 PubMed
  12. Fernandez L, Mas R, Illnait J, Fernandez JC. Policosanol: results of a postmarketing surveillance study of 27,879 patients. Curr Ther Res 1998;59(10):717-22. DOI
  13. Wang HY, Jiao QP, Chen SY, et al. Efficacy and safety of policosanol plus fenofibrate combination therapy in elderly patients with mixed dyslipidemia: A randomized, controlled clinical study. Am J Med Sci. 2018;356(3):254-261. PubMed
  14. Xu K, Liu X, Li Y, Wang Y, Zang H, Guo L, et al. Safety and efficacy of policosanol in patients with high on-treatment platelet reactivity after drug-eluting stent implantation: two-year follow-up results. Cardiovasc Ther. 2016 Oct;34(5):337-42. doi: 10.1 PubMed
  15. Li C, Ding Y, Si Q, Li K, Xu K. Multiple functions of policosanol in elderly patients with dyslipidemia. J Int Med Res. 2020;48(7):300060520936082. PubMed

See these in context on the Policosanol monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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