Pomegranate Ingredients & Drug Interactions
by GNC Herbal Plus Standardized
What is this page for?
First and foremost: checking Pomegranate against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pomegranate is a dietary supplement by GNC Herbal Plus Standardized with 1 active ingredient. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, high blood pressure.Based on those ingredients, 922 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pomegranate Fruit Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pomegranate by GNC Herbal Plus Standardized
Ask about any prescription or over-the-counter medication and we check it for interactions with Pomegranate by GNC Herbal Plus Standardized — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pomegranate by GNC Herbal Plus Standardized
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: pomegranate fruit extract — a concentrated form of the pomegranate fruit. The capsules also contain two inactive ingredients: dicalcium phosphate and vegetable cellulose (the capsule material itself).
Pomegranate extract pulls the active compounds from the fruit into a more concentrated dose than you'd get from eating the fruit or drinking juice. The extract is what we've checked for interactions and safety — it's different from the whole fruit.
Does it work?
Moderate evidence
According to the evidence we hold, pomegranate is possibly effective for high blood pressure (hypertension) — the research suggests it may help lower it modestly. For high cholesterol (hyperlipidemia) and diabetes, the data shows it's possibly ineffective.
For nonalcoholic fatty liver disease, there isn't enough reliable evidence to rate whether it works or doesn't.
How safe is it?
Well-documented data
Pomegranate fruit and juice are generally well tolerated when eaten in normal food amounts. The fruit extract in this product also seems to be well tolerated.
The most common side effects are mild stomach issues — diarrhea and gas happen in a small number of people, and in one study, diarrhea occurred in about 10% of those taking a high-dose extract. A small number of trial participants also reported nausea, belly pain, constipation, stomach upset, or vomiting at high doses.
There isn't enough information on concentrated supplements to know if they're completely safe long-term, so use caution. Pomegranate root, stem, and peel shouldn't be used in large amounts — this product is the fruit extract, which is safer.
In pregnancy and breastfeeding, pomegranate is rated possibly safe, but talk with your doctor or pharmacist for personalized advice.
Meds to double-check
Moderate interaction found
Before taking this, check if you use warfarin (Coumadin) or other blood thinners, blood pressure medications (especially ACE inhibitors), drugs broken down by the liver enzyme CYP2D6, or rosuvastatin (Crestor). The warfarin interaction is the most serious — pomegranate can affect how your blood thinner works and your bleeding risk.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
If you have high blood pressure and don't take blood pressure medication or warfarin, pomegranate extract might be worth discussing with your pharmacist. But if you take any blood pressure drugs, warfarin, or medications metabolized by the liver, check this supplement against your list first — the interactions are real and worth reviewing.
A pharmacist can help you time doses or suggest alternatives if there's a conflict.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pomegranate, straight from the product label.
| Brand | GNC Herbal Plus Standardized |
|---|---|
| Barcode (UPC) | 048107066987 |
| Net contents | 50 Vegetarian Capsules |
| Market status | On market |
| Date entered into DSLD | Oct 26, 2011 |
| DSLD ID | 847 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pomegranate by GNC Herbal Plus Standardized, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pomegranate Fruit Extract | 250 mg | -- |
Other ingredients: Dicalcium Phosphate, Vegetable Cellulose Capsule
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement
*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formula
Standardized Extract ?250 mg
Formulation
No Sugar, No Artficial Colors, No Artifical Flavors, Sodium Free, No Wheat, No Gluten, No Soy, No Dairy, Yeast Free.
Precautions
KEEP OUT OF REACH OF CHILDREN.
WARNING: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition. Discontinue use two weeks prior to surgery.
Storage
Store in a cool, dry place.
General Statements
Antioxidant Support*
Conforms to USP <2091> for weight. Meets USP <2040> disintegration.
Lot No./Best By:
Potency verified by GNC procedure #5298.
General
CODE 198411 EKG
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one to two capsules daily.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pomegranate by GNC Herbal Plus Standardized label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pomegranate by GNC Herbal Plus Standardized
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Pomegranate Fruit Extract
Interacts with922 drugs
Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...
Pomegranate Fruit Extract monograph & interactionsOther (inactive) ingredients: Dicalcium Phosphate, Vegetable Cellulose Capsule. These complete the product’s ingredient list but are not active constituents.
Pomegranate by GNC Herbal Plus Standardized Drug Interactions
HelloPharmacist Interaction Report
GNC Herbal Plus Standardized Pomegranate has documented interactions with several medication types.
The most serious concern is warfarin (a blood thinner): pomegranate may raise warfarin levels and increase bleeding risk, and stopping pomegranate after regular use might lower warfarin levels. This is a Moderate severity interaction that needs attention if you take it.
Read the full breakdown — every affected drug type, severity by severity
Pomegranate also has Moderate interactions with blood pressure medications (antihypertensives and ACE inhibitors), since pomegranate itself can lower blood pressure — combining them might drop your pressure too far. It may also affect how your body metabolizes certain drugs processed by the liver enzyme CYP2D6 (a Moderate concern), and there's a case report of muscle breakdown (rhabdomyolysis) in someone taking rosuvastatin with pomegranate juice, though that patient had other risk factors.
Minor interactions are documented with drugs broken down by CYP2C9 and CYP3A4 liver enzymes, and with carbamazepine — though research suggests these are less likely to cause problems in real life. Altogether, these interactions span 911 individual medications.
Before you start this supplement, check your exact medications with the tool on this page. If you take warfarin, blood pressure drugs, or any medication metabolized by the liver, run them through first.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pomegranate?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pomegranate interact with 922 drugs. Click any drug to see the details.
1 of the 1 ingredient in Pomegranate interact with drugs. Each result below shows which ingredient is responsible. Pomegranate Fruit Extract
Codeine, PapaverineCopavin
How Codeine, Papaverine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Codeine, Papaverine interactionCodeine, ParacetamolCo-codamol
How Codeine, Paracetamol interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Codeine, Paracetamol interactionCryptenamine, MethyclothiazideDiutensen
How Cryptenamine, Methyclothiazide interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Fruit Extract + Cryptenamine, Methyclothiazide interactionCyclobenzaprineCyclobenzaprine, Cycloprine, Flexeril
How Cyclobenzaprine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Cyclobenzaprine interactionCyclothiazideAnhydron, Fluidil
How Cyclothiazide interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Fruit Extract + Cyclothiazide interactionDeserpidineHarmonyl
How Deserpidine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Fruit Extract + Deserpidine interactionDeserpidine, HydrochlorothiazideOreticyl, Oreticyl Forte
How Deserpidine, Hydrochlorothiazide interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Fruit Extract + Deserpidine, Hydrochlorothiazide interactionDeserpidine, MethyclothiazideEnduronyl, Enduronyl Forte
How Deserpidine, Methyclothiazide interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Fruit Extract + Deserpidine, Methyclothiazide interactionDesipramineDesipramine, Norpramin, Pertofrane
How Desipramine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Desipramine interactionDesvenlafaxineKhedezla, Pristiq
How Desvenlafaxine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Desvenlafaxine interactionDeutetrabenazineAustedo
How Deutetrabenazine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Deutetrabenazine interactionDexfenfluramineRedux
How Dexfenfluramine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Dexfenfluramine interactionDextroamphetamineDexedrine
How Dextroamphetamine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Dextroamphetamine interactionDextroamphetamine (patch)Xelstrym
How Dextroamphetamine (patch) interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Dextroamphetamine (patch) interactionDextroamphetamine SulphateDexedrine Spansule
How Dextroamphetamine Sulphate interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Dextroamphetamine Sulphate interactionDextromethorphanBenylin Adult, Benylin Pediatric, Hold, Neo Citran Thin Strips Cough, Theraflu Thin Strips Long Acting Cough
How Dextromethorphan interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Dextromethorphan interactionDextromethorphan HbrVicks Formula 44 Cough Relief
How Dextromethorphan Hbr interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Fruit Extract + Dextromethorphan Hbr interactionDextromethorphan Hbr, GuaifenesinPediatric Vicks Formula 44e Cough & Chest Congesti, Vicks Formula 44E Cough & Chest Congestion Relief
How Dextromethorphan Hbr, Guaifenesin interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Dextromethorphan Hbr, Guaifenesin interactionDextromethorphan Hbr, Phenylephrine HclVicks Formula 44D Cough & Head Congestion Relief
How Dextromethorphan Hbr, Phenylephrine Hcl interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Fruit Extract + Dextromethorphan Hbr, Phenylephrine Hcl interactionDextromethorphan, GuaifenesinAmibid DM, Aquatab DM, Benylin Expectorant, Bidex DM, Fenesin DM, GFN 500 DTMH 30 +17 more
How Dextromethorphan, Guaifenesin interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Fruit Extract + Dextromethorphan, Guaifenesin interactionDextromethorphan, Guaifenesin, PhenylephrineAlbatussin Sr, Giltuss
How Dextromethorphan, Guaifenesin, Phenylephrine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Fruit Extract + Dextromethorphan, Guaifenesin, Phenylephrine interactionDextromethorphan, Guaifenesin, PhenylpropanolamineProfen LA
How Dextromethorphan, Guaifenesin, Phenylpropanolamine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Dextromethorphan, Guaifenesin, Phenylpropanolamine interactionDextromethorphan, Guaifenesin, PseudoephedrineMaxifed DM, Med Rx DM, Medent DM, Panmist DM, Profen Forte DM, Profen II DM +4 more
How Dextromethorphan, Guaifenesin, Pseudoephedrine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Fruit Extract + Dextromethorphan, Guaifenesin, Pseudoephedrine interactionDextromethorphan, Guaifenesin, PseudophedrineAnatuss DM, Organidin NR
How Dextromethorphan, Guaifenesin, Pseudophedrine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Fruit Extract + Dextromethorphan, Guaifenesin, Pseudophedrine interactionDextromethorphan, Guaifenesin, PsuedoephedrineAquatab C
How Dextromethorphan, Guaifenesin, Psuedoephedrine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Dextromethorphan, Guaifenesin, Psuedoephedrine interactionDextromethorphan, Methscopolamine, PhenylephrineDA Chewable
How Dextromethorphan, Methscopolamine, Phenylephrine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Fruit Extract + Dextromethorphan, Methscopolamine, Phenylephrine interactionDextromethorphan, PseudoephedrineSudafed Cold/Flu
How Dextromethorphan, Pseudoephedrine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Dextromethorphan, Pseudoephedrine interactionDextromethorphan, Pseudoephedrine, TriprolidineActifed DM
How Dextromethorphan, Pseudoephedrine, Triprolidine interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
Read the full Pomegranate Fruit Extract + Dextromethorphan, Pseudoephedrine, Triprolidine interactionDiltiazemAdizem-SR, Adizem-XL, Angitil SR, Angitil XL, Calcicard CR, Cardizem +23 more
How Diltiazem interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractAntihypertensive Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Read the full Pomegranate Fruit Extract + Diltiazem interactionDiltiazem, EnalaprilTeczem
How Diltiazem, Enalapril interacts with Pomegranate — through 1 ingredient. Tap an ingredient for the detail:
Pomegranate Fruit ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Ace Inhibitors (aceis) +1 Moderate
Interaction Summary
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Read the full Pomegranate Fruit Extract + Diltiazem, Enalapril interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pomegranate with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Pomegranate Fruit Extract
Ace Inhibitors (Aceis)
Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.
Antihypertensive Drugs
Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.
Rosuvastatin (Crestor)
Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.
Warfarin (Coumadin)
Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.
Carbamazepine (Tegretol)
Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.
Tolbutamide (Orinase)
Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.
Brand information
Manufacturer and brand details for Pomegranate, from the product label.
GNC Herbal Plus Standardized
See all GNC Herbal Plus Standardized products- Phone Number
- 1-888-462-2548
Pomegranate by GNC Herbal Plus Standardized: Common Questions
Does Pomegranate by GNC Herbal Plus Standardized interact with any medications?
How can one product interact with so many drugs?
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Will pomegranate extract lower my blood pressure?
What are the side effects I should expect?
Is this safe to take while pregnant or breastfeeding?
What's the difference between pomegranate juice and this extract?
Will it help my cholesterol or diabetes?
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The Full Monographs Behind Pomegranate’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pomegranate's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Pomegranate 27 references
- Igea JM, Cuesta J, Cuevas M, et al. Adverse reaction to pomegranate ingestion. Allergy 1991;46:472-4. DOI
- Gaig P, Bartolome B, Lleonart R, et al. Allergy to pomegranate (Punica granatum). Allergy 1999;54:287-8.
- Aviram M, Dornfeld L. Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 2001;158:195-8. PubMed
- Valsecchi R, Reseghetti A, Leghissa P, et al. Immediate contact hypersensitivity to pomegranate. Contact Dermatitis 1998;38:44-5. PubMed
- Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food 2004;7:305-8. PubMed
- Aviram M, Rosenblat M, Gaitini D, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 2004;23:423-33. DOI
- Hidaka M, Okumura M, Fujita K, et al. Effects of pomegranate juice on human cytochrome p450 3A (CYP3A) and carbamazepine pharmacokinetics in rats. Drug Metab Dispos 2005;33:644-8. PubMed
- Loren DJ, Seeram NP, Schulman RN, Holtzman DM. Maternal dietary supplementation with pomegranate juice is neuroprotective in an animal model of neonatal hypoxic-ischemic brain injury. Pediatr Res 2005;57:858-64. PubMed
- Kim ND, Mehta R, Yu W, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 2002;71:203-17. PubMed
- Sorokin AV, Duncan B, Panetta R, Thompson PD. Rhabdomyolysis associated with pomegranate juice consumption. Am J Cardiol 2006;98:705-6. PubMed
- Farkas D, Oleson LE, Zhao Y, et al. Pomegranate juice does not impair clearance of oral or intravenous midazolam, a probe for cytochrome P450-3A activity: comparison with grapefruit juice. J Clin Pharmacol 2007;47:286-94. PubMed
- Yeo C, Shon J, Liu K, et al. The effects of pomegranate juice on the pharmacokinetics of simvastatin in healthy Korean subjects (PI-63). Clin Pharmacol Ther 2006;79:23.
- Farkas D, Greenblatt DJ. Influence of fruit juices on drug disposition: discrepancies between in vitro and clinical studies. Expert Opin Drug Metab Toxicol 2008;4:381-93.
- Nagata M, Hidaka M, Sekiya H, et al. Effects of pomegranate juice on human cytochrome P450 2C9 and tolbutamide pharmacokinetics in rats. Drug Metab Dispos 2007;35:302-5. PubMed
- Komperda KE. Potential interaction between pomegranate juice and warfarin. Pharmacotherapy 2009;29:1002-6. PubMed
- Gangemi S, Mistrello G, Roncarolo D, et al. Pomegranate-dependent exercise-induced anaphylaxis. J Investig Allergol Clin Immunol 2008;18:491-2.
- Misaka S, Nakamura R, Uchida S, et al. Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers. Clin Ther PubMed
- Jarvis S, Li C, Bogle RG. Possible interaction between pomegranate juice and warfarin. Emerg Med J 2010;27:74-5. PubMed
- Esmaillzadeh, A., Tahbaz, F., Gaieni, I., Alavi-Majd, H., and Azadbakht, L. Cholesterol-lowering effect of concentrated pomegranate juice consumption in type II diabetic patients with hyperlipidemia. Int J Vitam.Nutr Res 2006;76(3):147-151. PubMed
- Forest, C. P., Padma-Nathan, H., and Liker, H. R. Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study PubMed
- Wright, H. and Pipkin F. B. Pomegranates (Punica granatum), kiwifruit (Actinidia deliciosa) and blood pressure: a pilot study. Proceedings of the Nutrition Society 2008;67(8):1.
- Sohrab G, Sotoodeh G, Siasi F, et al. Effect of pomegranate juice consumption on blood pressure in type 2 diabetic patients. Iranian Journal of Endocrinology and Metabolism 2008;9:399-405, 470.
- Enrique E, Utz M, De Mateo JA, et al. Allergy to lipid transfer proteins: cross-reactivity among pomegranate, hazelnut, and peanut. Ann Allergy Asthma Immunol 2006;96(1):122-3. PubMed
- Hanley MJ, Masse G, Harmatz JS, et al. Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: divergence from in vitro results. Clin Pharmacol Ther 2012;92(5):651-7. PubMed
- Paller CJ, Ye X, Wozniak PJ, et al. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis 2013;16(1):50-5. PubMed
- Park SJ, Yeo CW, Shim EJ, et al. Pomegranate juice does not affect the disposition of simvastatin in healthy subjects. Eur J Drug Metab Pharmacokinet 2016;41(4):339-44. PubMed
- Ross MM, Cherkerzian S, Mikulis ND, et al. A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR. Sci Rep. 2021;11(1):3569. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC