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Dietary supplement

Pomegranate Extract Ellagic Acid 40% Ingredients & Drug Interactions

by PureBulk.com

Pomegranate Extract Ellagic Acid 40% label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pomegranate Extract Ellagic Acid 40% against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pomegranate Extract Ellagic Acid 40% is a dietary supplement by PureBulk.com with 1 active ingredient. Its ingredients are commonly taken for antioxidant support, general anti-aging or 'cleanse' products, cancer prevention interest.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Ellagic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pomegranate Extract Ellagic Acid 40% by PureBulk.com

Ask about any prescription or over-the-counter medication and we check it for interactions with Pomegranate Extract Ellagic Acid 40% by PureBulk.com — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pomegranate Extract Ellagic Acid 40% by PureBulk.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: ellagic acid, a naturally occurring compound found in pomegranates. The powder is formulated to deliver 40% ellagic acid by weight.

The product also contains maltodextrin as an inactive ingredient (a filler that helps with texture and stability).

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Ellagic Acid product and its label doesn't state a use — see Ellagic Acid's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for ellagic acid is not yet established for the conditions studied. Our data shows insufficient reliable evidence to rate it for bladder cancer, cognitive function, diabetes, melasma, and polycystic ovary syndrome (PCOS).

That doesn't mean it doesn't work—it means larger or more rigorous human trials are needed before we can say either way.

The evidence, ingredient by ingredient Ellagic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Ellagic acid is generally considered safe when consumed in food amounts, but concentrated supplements like this one haven't been well studied in humans, so the safety data on supplement doses is limited. The safety notes we have advise caution or avoidance of concentrated supplements until more human research is available.

In one clinical trial, a combination product containing ellagic acid and graviola was linked to nausea and diarrhea in a small number of participants, though it's unclear whether ellagic acid alone was responsible. There isn't enough safety information on file regarding pregnancy and lactation, so talk with your doctor or pharmacist before using this if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Ellagic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Ellagic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take diabetes medication—metformin, sulfonylureas, insulin, or any other class—you should check your specific drugs before adding this supplement. The risk is a Moderate one of low blood sugar if ellagic acid and your diabetes medication combine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This single-ingredient supplement may appeal to someone interested in pomegranate's natural compounds, but the evidence for its effectiveness isn't established yet. If you take diabetes medication, definitely check with your pharmacist first—the blood-sugar-lowering effect is real enough to matter.

Because concentrated supplements haven't been well studied in humans, you'll want to discuss this one with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pomegranate Extract Ellagic Acid 40%, straight from the product label.

Brand PureBulk.com
Net contents 100 Gram(s); 3.53 oz.
Market status On market
Date entered into DSLD Sep 25, 2013
DSLD ID 23204
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pomegranate Extract Ellagic Acid 40% by PureBulk.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
750 mg
Maximum serving Sizes:
750 mg
Servings per container
133
IngredientAmount% DV
Ellagic Acid300 mg--

Other ingredients: Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Derived from Punica granatum hulls

US Standard Measuring Spoons Spoon Size (level) milligrams 1/8 teaspoon 391 1/4 teaspoon 782 1/2 teaspoon 1565

Storage

Storage: Keep dry, cool & dark

Formulation

Free of: soy, dairy, yeast, and gluten.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take 750 mg (scant 1/4 tsp) twice a day, or as directed by physician.

Precautions

Warning: This product is not intended for use by those with a serious medical condition or pregnant or lactating women.

Consult your physician before use.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pomegranate Extract Ellagic Acid 40% by PureBulk.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pomegranate Extract Ellagic Acid 40% label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pomegranate Extract Ellagic Acid 40% by PureBulk.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size750 mg Dosage formPowder Servings per container133 Amounts shown are per serving.

Ellagic Acid

Interacts with
86 drugs
300 mg per serving

Ellagic acid is a natural plant compound (a polyphenol) found in foods like pomegranates, raspberries, strawberries, and walnuts. It is studied mostly...

Ellagic Acid monograph & interactions

Other (inactive) ingredients: Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pomegranate Extract Ellagic Acid 40% by PureBulk.com Drug Interactions

Want to check YOUR meds against Pomegranate Extract Ellagic Acid 40%?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Ellagic Acid 86

Individual Drug Interactions

The ingredients in Pomegranate Extract Ellagic Acid 40% interact with 86 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pomegranate Extract Ellagic Acid 40% interact with drugs. Each result below shows which ingredient is responsible. Ellagic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Pomegranate Extract Ellagic Acid 40% with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Ellagic Acid1 drug type · 86 drugs

Antidiabetes Drugs

Some clinical research shows that ellagic acid reduces fasting and postprandial glucose levels in patients with type 2 diabetes who are on stable doses of hypoglycemic agents such as metformin. Theoretically, taking ellagic acid with antidiabetes drugs might increase the risk of hypoglycemia.

Likelihood Possible Evidence B
Ellagic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pomegranate Extract Ellagic Acid 40%, from the product label.

PureBulk.com

See all PureBulk.com products
Name
PureBulk.com
City
Roseburg
State
OR
ZipCode
97471
Phone Number
(541) 679-1500
Web Address
PureBulk.com
Pharmacist Counseling Corner

Pomegranate Extract Ellagic Acid 40% by PureBulk.com: Common Questions

Does Pomegranate Extract Ellagic Acid 40% by PureBulk.com interact with any medications?
Yes. Based on its ingredients, Pomegranate Extract Ellagic Acid 40% has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pomegranate Extract Ellagic Acid 40% contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this actually lower blood sugar?
Some clinical research shows ellagic acid does lower fasting and postprandial (after-meal) blood sugar in people with type 2 diabetes. That's why people taking diabetes drugs need to be careful—it could add up to too much of a blood-sugar drop. But we don't have enough evidence yet to say whether it works well enough on its own for diabetes.
What are the main side effects?
The most specific data we have comes from one trial of a combination product (ellagic acid plus graviola), where a few people reported nausea and diarrhea. We can't say for certain those came from the ellagic acid itself, and we don't have broad safety data on this supplement at typical doses in humans.
Is it safe to take if I'm pregnant or breastfeeding?
There isn't enough safety information on file for us to know either way. Talk with your doctor or pharmacist before using this while pregnant or nursing—they can weigh your personal situation against what little we know and help you decide.
What's the difference between this powder and eating pomegranate?
Pomegranate in food is considered safe, but this is a concentrated supplement—much more potent than what you'd get from eating the fruit. Because concentrated supplements haven't been well studied in humans, the safety profile is less clear.
Can I take this with my other vitamins and supplements?
The only documented interaction we have for this product is with diabetes drugs. If you take other supplements or medications, use the search tool on this page to check your specific drugs, or ask your pharmacist to run them through.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pomegranate Extract Ellagic Acid 40% is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pomegranate Extract Ellagic Acid 40% label
Go deeper

The Full Monographs Behind Pomegranate Extract Ellagic Acid 40%’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Ellagic Acid

Interacts with 86 drugs

Ellagic acid is a natural plant compound (a polyphenol) found in foods like pomegranates, raspberries, strawberries, and walnuts. It is studied mostly in laboratory and animal research for a...

Read the full Ellagic Acid monograph →
Sources

Sources & How We Checked

Pomegranate Extract Ellagic Acid 40%'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Ellagic Acid 9 references
  1. Ertam I, Mutlu B, Unal I, Alper S, Kivçak B, Ozer O. Efficiency of ellagic acid and arbutin in melasma: a randomized, prospective, open-label study. J Dermatol. 2008;35(9):570-4. PubMed
  2. Dahl A, Yatskayer M, Raab S, Oresajo C. Tolerance and efficacy of a product containing ellagic and salicylic acids in reducing hyperpigmentation and dark spots in comparison with 4% hydroquinone. J Drugs Dermatol. 2013;12(1):52-8.
  3. Falsaperla M, Morgia G, Tartarone A, Ardito R, Romano G. Support ellagic acid therapy in patients with hormone refractory prostate cancer (HRPC) on standard chemotherapy using vinorelbine and estramustine phosphate. Eur Urol. 2005;47(4):449-54 PubMed
  4. Le Donne M, Lentini M, Alibrandi A, et al. Antiviral activity of Ellagic acid and Annona Muricata in cervical HPV related pre-neoplastic lesions: A randomized trial. J Funct Food 2017;35:549-54. DOI
  5. Liu Y, Yu S, Wang F, et al. Chronic administration of ellagic acid improved the cognition in middle-aged overweight men. Appl Physiol Nutr Metab. 2018;43(3):266-73. PubMed
  6. Serretta V, Berardinis E, Simonato A, et al. A prospective observational study on oral administration of Ellagic Acid and Annona Muricata in patients affected by non-muscle invasive bladder cancer not undergoing maintenance after 6-week intravesical proph
  7. Ghadimi M, Foroughi F, Hashemipour S, et al. Randomized double-blind clinical trial examining the Ellagic acid effects on glycemic status, insulin resistance, antioxidant, and inflammatory factors in patients with type 2 diabetes. Phytother Res 2021;35(2) PubMed
  8. Kazemi M, Lalooha F, Nooshabadi MR, Dashti F, Kavianpour M, Haghighian HK. Randomized double blind clinical trial evaluating the Ellagic acid effects on insulin resistance, oxidative stress and sex hormones levels in women with polycystic ovarian syndrome PubMed
  9. Ghadimi M, Foroughi F, Hashemipour S, et al. Decreased insulin resistance in diabetic patients by influencing Sirtuin1 and Fetuin-A following supplementation with ellagic acid: a randomized controlled trial. Diabetol Metab Syndr 2021;13(1):16. PubMed

See these in context on the Ellagic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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