Pre & Pro Biotic Huckleberry Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Pre & Pro Biotic Huckleberry against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pre & Pro Biotic Huckleberry is a dietary supplement by Wink Naturals with 4 active ingredients. Its ingredients are commonly taken for digestive health and regularity, infant colic and gut support, diarrhea (including antibiotic-related).Based on those ingredients, 308 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium breve, Larch Arabinogalactans, Apple Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pre & Pro Biotic Huckleberry by Wink Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Pre & Pro Biotic Huckleberry by Wink Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pre & Pro Biotic Huckleberry by Wink Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Partial disclosure
This product contains 4 active ingredients: two probiotics (Lactobacillus plantarum and Bifidobacterium breve), a proprietary probiotic blend, Apple Pectin, and Larch Arabinogalactans. The probiotics are live beneficial bacteria meant to support your digestive tract.
Apple Pectin is a soluble fiber from apples, and Larch Arabinogalactans is a fiber from larch trees. The inactive ingredients are mannitol starch complex, natural huckleberry flavor, microcrystalline cellulose, citric acid, ascorbyl palmitate, croscarmellose sodium, silica, and stevia leaf extract.
Does it work?
Not established
The evidence for this product's ingredients is mixed and often limited. Bifidobacterium breve has been rated possibly ineffective for age-related cognitive decline and sepsis, but there isn't enough reliable evidence to rate it for antibiotic-related diarrhea, hay fever, or atopic disease.
Apple Pectin is rated possibly effective for high cholesterol, but there isn't enough evidence to rate it for prediabetes or radiation exposure. Larch Arabinogalactans shows insufficient evidence for the common cold or high cholesterol.
Overall, the data we hold doesn't establish strong effectiveness for this combination.
How safe is it?
Well-documented data
Bifidobacterium breve is generally well tolerated in healthy people, but caution is advised if you're very ill or immunocompromised — there have been rare cases of the bacteria entering the bloodstream in critically ill patients and preterm infants. Apple Pectin is generally well tolerated in food and typical supplement amounts; common side effects include diarrhea, gas, loose stools, and mild cramps.
Rarely, pectin can cause allergic reactions including anaphylaxis in sensitive people. Larch Arabinogalactans is generally well tolerated but can cause bloating and flatulence, and long-term safety data are limited.
All three ingredients advise checking with your doctor before use, especially during pregnancy or breastfeeding.
Meds to double-check
Moderate interaction found
Before you take this product, double-check if you're on digoxin (a heart medication) — Apple Pectin may significantly reduce how much your body absorbs it (Moderate). Also check for lovastatin or other cholesterol drugs, tetracycline antibiotics, any antibiotic you're currently taking, and immunosuppressant medications used after transplants or for autoimmune disease — all Moderate interactions that could make those drugs less effective.
The bottom line
Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
This product combines probiotics and fibers, but the evidence for their benefits in this form is not well established. If you take heart medications (like digoxin), cholesterol drugs (like lovastatin), tetracycline antibiotics, or immunosuppressants, you need to talk to your pharmacist before starting it — several of these interactions could reduce how well your medications work.
Always check your exact medications with the tool on this page.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pre & Pro Biotic Huckleberry, straight from the product label.
| Brand | Wink Naturals |
|---|---|
| Net contents | 30 Melt(s) |
| Market status | On market |
| Date entered into DSLD | Dec 13, 2022 |
| DSLD ID | 278508 |
| Product type | Other Combinations |
| Supplement form | Other (e.g. Tea Bag) |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Children 4 or More Years of Age, Adult (18 - 50 Years), Infants/Baby (0 - 1 Year), Children more than 1 but less than 4 |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pre & Pro Biotic Huckleberry by Wink Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Lactobacillus plantarum | 0 NP | -- |
| Bifidobacterium breve | 0 NP | -- |
| Proprietary Probiotic Blend | 0 NP | -- |
| Apple Pectin | 10 mg | -- |
| Larch Arabinogalactans | 10 mg | -- |
Other ingredients: Mannitol Starch Complex, Huckleberry Flavor, Natural, Microcrystalline Cellulose, Citric Acid, Ascorbyl Palmitate, Croscarmellose Sodium, Silica, Stevia leaf extract
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: Infants 0-11 months: dissolve 1/2 melt in mouth, daily Ages 1-3 years: dissolve 1/2 melt in mouth, daily Ages 4-12 years: dissolve 1 melt in mouth daily Adults: dissolve 1-2 melts in mouth, daily
Formulation
Healthy gut, happy life: Regular bowel habits Alleviates constipation/bloating Reduces inflammation in GI tract
Immune & digestive system support
Made in USA
Precautions
Warning: Consult your physician before using or for a worsening condition.
Do not use if pregnant or lactating without the advice of your physician.
Storage
Store at room temperature.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
General Statements
Doctor developed Doctor recommended
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pre & Pro Biotic Huckleberry by Wink Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pre & Pro Biotic Huckleberry by Wink Naturals
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size0.5 Melt(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Probiotic Blend
- › Lactobacillus plantarum
- › Bifidobacterium breve
Apple Pectin
Interacts with23 drugs
Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...
Apple Pectin monograph & interactionsLarch Arabinogalactans
Interacts with121 drugs
Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but...
Larch Arabinogalactans monograph & interactionsOther (inactive) ingredients: Mannitol Starch Complex, Huckleberry Flavor, Natural, Microcrystalline Cellulose, Citric Acid, Ascorbyl Palmitate, Croscarmellose Sodium, Silica, Stevia leaf extract. These complete the product’s ingredient list but are not active constituents.
Pre & Pro Biotic Huckleberry by Wink Naturals Drug Interactions
HelloPharmacist Interaction Report
Wink Naturals Pre & Pro Biotic Huckleberry contains several ingredients with documented interactions.
The most serious concern is Apple Pectin, which can reduce how your body absorbs digoxin (a heart medication) — a Moderate interaction that could decrease the drug's effectiveness by a significant amount. You'd need to separate when you take them by several hours.
Read the full breakdown — every affected drug type, severity by severity
Apple Pectin also interacts with lovastatin (a cholesterol drug) and tetracycline antibiotics (Moderate severity for both), potentially lowering their effectiveness. Larch Arabinogalactans may interfere with immunosuppressant medications used after transplants or for autoimmune conditions, also Moderate severity.
Bifidobacterium breve, one of the probiotic ingredients, can theoretically be killed by antibiotics if taken at the same time, reducing the probiotic's benefit — another Moderate interaction.
Altogether, these interactions span 304 individual medications. We couldn't check Lactobacillus plantarum, the other probiotic in the blend, because we don't hold interaction data for it.
Before you start this product, run your exact medications through the checker below.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pre & Pro Biotic Huckleberry?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pre & Pro Biotic Huckleberry interact with 308 drugs. Click any drug to see the details.
3 of the 4 ingredients in Pre & Pro Biotic Huckleberry interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium breve Larch Arabinogalactans Apple Pectin
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Abrocitinib interactionAdalimumabHumira
How Adalimumab interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Adalimumab interactionAdalimumab-adazHyrimoz
How Adalimumab-adaz interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Adalimumab-adaz interactionAdalimumab-adbmCyltezo
How Adalimumab-adbm interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Adalimumab-adbm interactionAdalimumab-afzbAbrilada
How Adalimumab-afzb interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Adalimumab-afzb interactionAdalimumab-attoAmjevita
How Adalimumab-atto interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Adalimumab-atto interactionAdalimumab-bwwdHadlima
How Adalimumab-bwwd interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Adalimumab-bwwd interactionAdalimumab-fkjpHulio
How Adalimumab-fkjp interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Adalimumab-fkjp interactionAlefaceptAmevive
How Alefacept interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Alefacept interactionAlemtuzumabCampath
How Alemtuzumab interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Alemtuzumab interactionAmikacinAmikin, Arikayce
How Amikacin interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Amikacin interactionAmoxicillinAmix, Amoram, Amoxident, Amoxil Capsules, Amoxil Injection, Galenamox +3 more
How Amoxicillin interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Amoxicillin interactionAmoxicillin VeterinaryBiomox
How Amoxicillin Veterinary interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Amoxicillin Veterinary interactionAmoxicillin, Clavulanate PotassiumAugmentin, Augmentin '125/31 SF', Augmentin '250/62 SF', Augmentin XR, Augmentin-Duo 400/57, Clavulin
How Amoxicillin, Clavulanate Potassium interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Amoxicillin, Clavulanate Potassium interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAmphotericin, TetracyclineMysteclin-F
How Amphotericin, Tetracycline interacts with Pre & Pro Biotic Huckleberry — through 2 ingredients. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Amphotericin, Tetracycline interactionApple PectinTetracycline Antibiotics Moderate
Interaction Summary
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
Read the full Apple Pectin + Amphotericin, Tetracycline interactionAmpicillinOmnipen, Omnipen-N, Penbritin, Principen, Rimacillin
How Ampicillin interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Ampicillin interactionAmpicillin, SulbactamUnasyn
How Ampicillin, Sulbactam interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Ampicillin, Sulbactam interactionAnifrolumab-fniaSaphnelo
How Anifrolumab-fnia interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Anifrolumab-fnia interactionAntithymocyte GlobulinThymoglobulin
How Antithymocyte Globulin interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Antithymocyte Globulin interactionAtezolizumabTecentriq
How Atezolizumab interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Atezolizumab interactionAvibactam Sodium, CeftazidimeAvycaz
How Avibactam Sodium, Ceftazidime interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Avibactam Sodium, Ceftazidime interactionAzamuneImmunoprin
How Azamune interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Azamune interactionAzathioprineAzamune, Imuran
How Azathioprine interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Azathioprine interactionAzithromycinAzasite, Zithromax, Zmax
How Azithromycin interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Azithromycin interactionAztreonamAzactam
How Aztreonam interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Aztreonam interactionBacampicillinPenglobe
How Bacampicillin interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Bacampicillin interactionBacitracinBaci-IM, Baciguent, Bacitracin Ointment
How Bacitracin interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Bifidobacterium BreveAntibiotic Drugs Moderate
Interaction Summary
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B.
Read the full Bifidobacterium Breve + Bacitracin interactionBasiliximabSimulect
How Basiliximab interacts with Pre & Pro Biotic Huckleberry — through 1 ingredient. Tap an ingredient for the detail:
Larch ArabinogalactansImmunosuppressants Moderate
Interaction Summary
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects.
Read the full Larch Arabinogalactans + Basiliximab interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pre & Pro Biotic Huckleberry with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Bifidobacterium breve
Antibiotic Drugs
Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.
Larch Arabinogalactans
Immunosuppressants
Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.
Apple Pectin
Digoxin (Lanoxin)
Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.
Lovastatin (Mevacor)
Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.
Tetracycline Antibiotics
Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.
Brand information
Manufacturer and brand details for Pre & Pro Biotic Huckleberry, from the product label.
Wink Naturals
See all Wink Naturals products- Name
- Wink Naturals, LLC
- City
- Pleasant Grove
- State
- UT
- ZipCode
- 84062
- Phone Number
- 888-799-5656
- Web Address
- WinkNaturals.com
Pre & Pro Biotic Huckleberry by Wink Naturals: Common Questions
Does Pre & Pro Biotic Huckleberry by Wink Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe if I'm pregnant or breastfeeding?
Can I take this with my antibiotics?
What side effects might I notice?
Does this actually help with digestion or colds?
Should I separate this from my other medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pre & Pro Biotic Huckleberry is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pre & Pro Biotic Huckleberry’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Bifidobacterium Breve
Interacts with 182 drugsBifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...
Read the full Bifidobacterium Breve monograph → Herb & supplement monographPectin
Interacts with 23 drugsPectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly help with cholesterol, blood sugar, and di...
Read the full Pectin monograph → Herb & supplement monographLarch Arabinogalactan
Interacts with 121 drugsLarch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but limited, and most claims are not yet fi...
Read the full Larch Arabinogalactan monograph →Sources & How We Checked
Pre & Pro Biotic Huckleberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 28 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Bifidobacterium Breve 9 references
- Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
- Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
- Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
- Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
- Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
- Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
- Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
- Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
- Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed
See these in context on the Bifidobacterium Breve monograph →
Pectin 11 references
- Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
- Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
- Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
- Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
- Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
- Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
- Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
- Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
- Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed
Larch Arabinogalactan 8 references
- D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-7.
- Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103.
- Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9.
- Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr 2001;20:279-85. PubMed
- Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32. PubMed
- Grube B, Stier H, Riede L, Gruenwald J. Tolerability of a proprietary larch arabinogalactan extract: a randomized, double-blind, placebo-controlled clinical trial in healthy subjects. Food Nutr Sci 2012;3:1533-8. DOI
- Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond) 2016;13:28. PubMed
- Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory tract infections. Curr Med Res Opin 2013;29(3):251-8.
See these in context on the Larch Arabinogalactan monograph →
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