Interactions on record — worth a quick check against your medications. Based on 3 of 4 ingredients. Check your meds →
Dietary supplement

Pre & Pro Biotic Huckleberry Ingredients & Drug Interactions

by Wink Naturals

Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Pre & Pro Biotic Huckleberry is a dietary supplement by Wink Naturals with 4 active ingredients. Its ingredients are commonly taken for digestive health and regularity, infant colic and gut support, diarrhea (including antibiotic-related).Based on those ingredients, 308 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium breve, Larch Arabinogalactans, Apple Pectin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Pre & Pro Biotic Huckleberry by Wink Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 4 active ingredients: two probiotics (Lactobacillus plantarum and Bifidobacterium breve), a proprietary probiotic blend, Apple Pectin, and Larch Arabinogalactans. The probiotics are live beneficial bacteria meant to support your digestive tract.

Apple Pectin is a soluble fiber from apples, and Larch Arabinogalactans is a fiber from larch trees. The inactive ingredients are mannitol starch complex, natural huckleberry flavor, microcrystalline cellulose, citric acid, ascorbyl palmitate, croscarmellose sodium, silica, and stevia leaf extract.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Digestive and immune system support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Colic, Constipation, Diarrhea, Gastroesophageal reflux disease (GERD), Helicobacter pylori — and 4 related terms.
  • The closest evidence on file: Pectin is rated "Insufficient Reliable Evidence To Rate" for Diarrhea (Natural Medicines).
  • Also on file: Pectin is rated "Insufficient Reliable Evidence To Rate" for Gastroesophageal reflux disease (GERD), Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Breve is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea, Respiratory tract infections, Constipation, Rotaviral diarrhea.

The evidence for this product's ingredients is mixed and often limited. Bifidobacterium breve has been rated possibly ineffective for age-related cognitive decline and sepsis, but there isn't enough reliable evidence to rate it for antibiotic-related diarrhea, hay fever, or atopic disease.

Apple Pectin is rated possibly effective for high cholesterol, but there isn't enough evidence to rate it for prediabetes or radiation exposure. Larch Arabinogalactans shows insufficient evidence for the common cold or high cholesterol.

Overall, the data we hold doesn't establish strong effectiveness for this combination.

The evidence, ingredient by ingredient Bifidobacterium Breve Pectin Larch Arabinogalactan

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bifidobacterium breve is generally well tolerated in healthy people, but caution is advised if you're very ill or immunocompromised — there have been rare cases of the bacteria entering the bloodstream in critically ill patients and preterm infants. Apple Pectin is generally well tolerated in food and typical supplement amounts; common side effects include diarrhea, gas, loose stools, and mild cramps.

Rarely, pectin can cause allergic reactions including anaphylaxis in sensitive people. Larch Arabinogalactans is generally well tolerated but can cause bloating and flatulence, and long-term safety data are limited.

All three ingredients advise checking with your doctor before use, especially during pregnancy or breastfeeding.

Side effects, ingredient by ingredient Bifidobacterium Breve Pectin Larch Arabinogalactan

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Pectin, Larch Arabinogalactan, Bifidobacterium Breve.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; heart-rhythm medications.
  • For scale: 308 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check if you're on digoxin (a heart medication) — Apple Pectin may significantly reduce how much your body absorbs it (Moderate). Also check for lovastatin or other cholesterol drugs, tetracycline antibiotics, any antibiotic you're currently taking, and immunosuppressant medications used after transplants or for autoimmune disease — all Moderate interactions that could make those drugs less effective.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines probiotics and fibers, but the evidence for their benefits in this form is not well established. If you take heart medications (like digoxin), cholesterol drugs (like lovastatin), tetracycline antibiotics, or immunosuppressants, you need to talk to your pharmacist before starting it — several of these interactions could reduce how well your medications work.

Always check your exact medications with the tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pre & Pro Biotic Huckleberry, straight from the product label.

Brand Wink Naturals
Net contents 30 Melt(s)
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 278508
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Infants/Baby (0 - 1 Year), Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pre & Pro Biotic Huckleberry by Wink Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 Melt(s), 1 Melt(s), 1 Melt(s)
Maximum serving Sizes:
0.5 Melt(s), 1 Melt(s), 2 Melt(s)
Servings per container
30
IngredientAmount% DV
Lactobacillus plantarum0 NP--
Bifidobacterium breve0 NP--
Proprietary Probiotic Blend0 NP--
Apple Pectin10 mg--
Larch Arabinogalactans10 mg--

Other ingredients: Mannitol Starch Complex, Huckleberry Flavor, Natural, Microcrystalline Cellulose, Citric Acid, Ascorbyl Palmitate, Croscarmellose Sodium, Silica, Stevia leaf extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Infants 0-11 months: dissolve 1/2 melt in mouth, daily Ages 1-3 years: dissolve 1/2 melt in mouth, daily Ages 4-12 years: dissolve 1 melt in mouth daily Adults: dissolve 1-2 melts in mouth, daily

Formulation

Healthy gut, happy life: Regular bowel habits Alleviates constipation/bloating Reduces inflammation in GI tract

Immune & digestive system support

Made in USA

Precautions

Warning: Consult your physician before using or for a worsening condition.

Do not use if pregnant or lactating without the advice of your physician.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Doctor developed Doctor recommended

See for yourself

Pre & Pro Biotic Huckleberry by Wink Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Pre & Pro Biotic Huckleberry by Wink Naturals

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size0.5 Melt(s) Dosage formOther (e.g. Tea Bag) Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

0 NP per serving

Apple Pectin

Interacts with
23 drugs
10 mg per serving

Pectin is a natural soluble fiber found in fruits like apples and citrus, and it is widely used in foods and as a fiber supplement. It may modestly he...

Apple Pectin monograph & interactions

Larch Arabinogalactans

Interacts with
121 drugs
10 mg per serving

Larch arabinogalactan is a soluble fiber from larch trees that is mainly used as a prebiotic and for immune support. Early research is interesting but...

Larch Arabinogalactans monograph & interactions

Other (inactive) ingredients: Mannitol Starch Complex, Huckleberry Flavor, Natural, Microcrystalline Cellulose, Citric Acid, Ascorbyl Palmitate, Croscarmellose Sodium, Silica, Stevia leaf extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pre & Pro Biotic Huckleberry by Wink Naturals Drug Interactions

Want to check YOUR meds against Pre & Pro Biotic Huckleberry?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
308Drugs
308 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Pre & Pro Biotic Huckleberry with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium breve1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D

Larch Arabinogalactans1 drug type · 121 drugs

Immunosuppressants

Theoretically, larch arabinogalactan might interfere with immunosuppression therapy due to immunostimulant effects. Immunosuppressant drugs include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and other drugs.

Likelihood Possible Evidence D

Apple Pectin3 drug types · 23 drugs

Digoxin (Lanoxin)

Theoretically, pectin might reduce the absorption of digoxin, potentially decreasing its effectiveness.
A small clinical study shows that taking digoxin with a kaolin-pectin suspension reduces the absorption of digoxin by about 62%. It is unclear if these effects are due to pectin, kaolin, or the combination.

Likelihood Possible Evidence B
Lovastatin (Mevacor)

Theoretically, pectin might reduce the absorption of lovastatin, potentially decreasing its effectiveness.
Case reports suggest that concomitant use of pectin and lovastatin might reduce the cholesterol-lowering effect of lovastatin, possibly due to reduced intestinal absorption of lovastatin.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, pectin might reduce the absorption of tetracycline antibiotics, potentially decreasing their effectiveness.
A small clinical study shows that taking tetracycline with bismuth subsalicylate in a kaolin-pectin suspension reduces the absorption of tetracycline by about 34%. It is unclear if these effects are due to pectin, kaolin, bismuth subsalicylate, or the combination.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Pre & Pro Biotic Huckleberry, from the product label.

Wink Naturals

See all Wink Naturals products
Name
Wink Naturals, LLC
City
Pleasant Grove
State
UT
ZipCode
84062
Phone Number
888-799-5656
Web Address
WinkNaturals.com
Pharmacist Counseling Corner

Pre & Pro Biotic Huckleberry by Wink Naturals: Common Questions

Does Pre & Pro Biotic Huckleberry by Wink Naturals interact with any medications?
Yes. Based on its ingredients, Pre & Pro Biotic Huckleberry has a known interaction with 308 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pre & Pro Biotic Huckleberry contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant or breastfeeding?
The data we have is limited. Bifidobacterium breve and Larch Arabinogalactans don't have enough safety information during pregnancy or breastfeeding, so your doctor should weigh the decision. Apple Pectin is likely safe at food amounts but hasn't been well studied in concentrated supplement form during pregnancy and lactation. Talk with your doctor or midwife before starting.
Can I take this with my antibiotics?
Not at the same time. The probiotics and possibly the pectin can be affected by antibiotics. Separate them by at least two to three hours — take your antibiotic at one time of day and this product at another. Your pharmacist can help you time them.
What side effects might I notice?
The most common are bloating, gas, flatulence, loose stools, and mild cramps from the probiotics and fibers. These are usually mild. Rarely, pectin can cause allergic reactions, including anaphylaxis, in sensitive people — stop and seek help right away if you have trouble breathing or swelling.
Does this actually help with digestion or colds?
The evidence we hold shows either limited or unclear benefit. Bifidobacterium breve doesn't have reliable evidence for antibiotic-related diarrhea or cold prevention. Larch Arabinogalactans also lacks strong evidence for colds. The product isn't rated clearly effective for these uses based on the data available.
Should I separate this from my other medications?
Yes, if you take digoxin, lovastatin, tetracycline antibiotics, or immunosuppressants — Apple Pectin and Bifidobacterium breve can interfere with how your body absorbs or benefits from them. Use the medication checker on this page with your full list, and ask your pharmacist for a dosing schedule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pre & Pro Biotic Huckleberry is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pre & Pro Biotic Huckleberry label
Sources

Sources & How We Checked

Pre & Pro Biotic Huckleberry's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Pectin 11 references
  1. Jaakkola MS, et al. Asthma caused by occupational exposure to pectin. J Allergy Clin Immunol 1997;100:575-6. PubMed
  2. Westphal W, et al. [Exogenous allergic asthma following pectin exposure-a new occupational allergen]. Pneumologie 1990;44(Suppl 1):337-8.
  3. Baldwin JL, et al. Pectin-induced occupational asthma. Chest 1993;104:1936-7. PubMed
  4. Cohen AJ, Forse MS, Tarlo SM. Occupational asthma caused by pectin inhalation during the manufacture of jam. Chest 1993;103:309-11.
  5. Kraut A, et al. Christmas candy maker's asthma. IgG4-mediated pectin allergy. Chest 1992;102:1605-7. PubMed
  6. Richter WO, Jacob BG, Schwandt P. Interaction between fibre and lovastatin. Lancet 1991;338:706.
  7. Albert KS, Ayres JW, DiSanto AR, et al. Influence of kaolin-pectin suspension on digoxin bioavailability. J Pharm Sci 1978;67:1582-6. PubMed
  8. Albert KS, Welch RD, DeSante KA, et al. Decreased tetracycline bioavailability caused by a bismuth subsalicylate antidiarrheal mixture. J Pharm Sci 1979;68:586-8. PubMed
  9. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  10. Federal Register April 17,2003. Anti-Diarrheal Products for over-the-counter human use; final monograph. Available at: http://www.fda.gov/OHRMS/DOCKETS/98fr/03-9380.pdf (Accessed 27 December 2004).
  11. Washio K, Nakamura M, Sato N, et al. Anaphylaxis in a pectin- and cashew nut-allergic child caused by a citrus bath. Allergol Int 2022;71(1):155-157. PubMed

See these in context on the Pectin monograph →

Larch Arabinogalactan 8 references
  1. D'Adamo P. Larch arabinogalactan. J Naturopath Med 1996;6:33-7.
  2. Kelly GS. Larch arabinogalactan: Clinical relevance of a novel immune-enhancing polysaccharide. Alt Med Rev 1999;4:96-103.
  3. Marett R, Slavin JL. No long-term benefits of supplementation with arabinogalactan on serum lipids and glucose. J Am Diet Assoc 2004;104:636-9.
  4. Robinson RR, Feirtag J, Slavin JL. Effects of dietary arabinogalactan on gastrointestinal and blood parameters in healthy human subjects. J Am Coll Nutr 2001;20:279-85. PubMed
  5. Udani JK, Singh BB, Barrett ML, Singh VJ. Proprietary arabinogalactan extract increases antibody response to the pneumonia vaccine: a randomized, double-blind, placebo-controlled, pilot study in healthy volunteers. Nutr J 2010;9:32. PubMed
  6. Grube B, Stier H, Riede L, Gruenwald J. Tolerability of a proprietary larch arabinogalactan extract: a randomized, double-blind, placebo-controlled clinical trial in healthy subjects. Food Nutr Sci 2012;3:1533-8. DOI
  7. Dion C, Chappuis E, Ripoll C. Does larch arabinogalactan enhance immune function? A review of mechanistic and clinical trials. Nutr Metab (Lond) 2016;13:28. PubMed
  8. Riede L, Grube B, Gruenwald J. Larch arabinogalactan effects on reducing incidence of upper respiratory tract infections. Curr Med Res Opin 2013;29(3):251-8.

See these in context on the Larch Arabinogalactan monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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