Interactions on record — worth a quick check against your medications. Based on 1 of 6 ingredients. Check your meds →
Dietary supplement

Premium CLA 3-6-9 Ingredients & Drug Interactions

by GNC Total Lean Advanced

Premium CLA 3-6-9 label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Premium CLA 3-6-9 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Premium CLA 3-6-9 is a dietary supplement by GNC Total Lean Advanced with 6 active ingredients. Its ingredients are commonly taken for heart health, healthy cooking fat, skin moisturizing.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Oleic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Premium CLA 3-6-9 by GNC Total Lean Advanced

Ask about any prescription or over-the-counter medication and we check it for interactions with Premium CLA 3-6-9 by GNC Total Lean Advanced — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Premium CLA 3-6-9 by GNC Total Lean Advanced

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains six active ingredients: Docosahexaenoic Acid and Eicosapentaenoic Acid (both omega-3 fatty acids), Medium Chain Triglycerides (a type of fat), Gamma-Linolenic Acid (an omega-6 fatty acid), Clarinol CLA (conjugated linoleic acid), and Oleic Acid (a monounsaturated fat found in olive oil). It also contains four inactive ingredients—Gelatin, Glycerin, Rosemary extract, and Mixed Tocopherols—that serve as the capsule shell, preservatives, and stabilizers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Oleic Acid's overall clinical evidence instead.

Moderate

Some clinical evidence supports Oleic Acid for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Coronary heart disease (CHD) — rated "Possibly Effective" (Natural Medicines).
  • On file: Hypercholesterolemia — rated "Possibly Effective" (Natural Medicines).

The only ingredient we have effectiveness data for is Oleic Acid, which is rated Possibly Effective for high cholesterol (hypercholesterolemia) and for supporting heart health in coronary heart disease (CHD). The evidence base for the other five active ingredients—the omega-3s, medium chain triglycerides, gamma-linolenic acid, and CLA—is not established in the data we hold.

The evidence, ingredient by ingredient Oleic Acid

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 0 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Oleic Acid is generally recognized as safe when you consume it in normal amounts from foods like olive oil. However, concentrated supplements at higher doses haven't been well studied, especially in pregnancy and breastfeeding.

Adverse effects are not documented in our data for any ingredient. If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before taking this product, since the safety data for supplement-level doses isn't complete.

Side effects, ingredient by ingredient Oleic Acid

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Oleic Acid.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking GNC Total Lean Advanced Premium CLA 3-6-9, double-check your antidiabetes medications with your doctor or pharmacist—Oleic Acid may increase their blood-sugar-lowering effect. For the five ingredients we could not check (Docosahexaenoic Acid, Medium Chain Triglycerides, Eicosapentaenoic Acid, Gamma-Linolenic Acid, and Clarinol CLA), use the medication interaction tool on this page with your full medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and some safety-information gaps remain.

If you take antidiabetes drugs, check with your doctor or pharmacist first—oleic acid in this product might boost the blood-sugar-lowering effect. For the other five ingredients, we couldn't find interaction data, so run your exact medications through the checker on this page.

Oleic Acid may help with cholesterol and heart health, but the evidence for the other active ingredients isn't established yet.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Premium CLA 3-6-9, straight from the product label.

Brand GNC Total Lean Advanced
Net contents 120 Softgel Capsule(s)
Market status On market
Date entered into DSLD Jul 24, 2015
DSLD ID 47835
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Premium CLA 3-6-9 by GNC Total Lean Advanced, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
60
IngredientAmount% DV
Calories300 {Calories}--
Calories from Fat30 {Calories}--
Total Fat3 Gram(s)5%
Docosahexaenoic Acid58 mg--
Medium Chain Triglycerides50 mg--
Eicosapentaenoic Acid92 mg--
Gamma-Linolenic Acid150 mg--
Clarinol CLA1.7 Gram(s)--
Oleic Acid100 mg--

Other ingredients: Gelatin, Glycerin, Rosemary extract, Mixed Tocopherols

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

GNC Total Lean(TM) Challenge

Clarinol(R)

Gf

General Statements

Are you up for the challenge? Visit GNC.com/TLC to join and for more information.

Actual size

GNC Quality Commitment For more than 79 years, GNC has been the leader in the development of superior nutritional supplements. Our products are produced using only fresh, high-quality ingredients and are manufactured under the strictest quality controls.

GNC Guarantee If you are not 100% completely satisfied, return the unused portion of the product with your receipt to a GNC store within 30 days. Our trained sales staff will either refund your purchase price or, if you prefer, assist you in finding a replacement product to help you LIVE WELL.

Please recycle this box.

Start a new phase in your weight management journey with this next-level, weight-loss innovation designed specifically for those who strive for body tone and definition. With fat metabolism and body sculpting at the core, this comprehensive approach includes targeted solutions to help you transform common weight loss challenges into results that you can see and feel. These research-based solutions are designed by our weight management experts to provide you with personalized supplement and meal plans, plus body-defining exercise regimens. Get started now with the enclosed overview and visit GNC.com/TotalLeanAdvanced today!

Premium CLA 3-6-9 Fuels lean muscle tone Promotes cardio & joint health Improves body composition Targeted fat metabolism Features Clinically proven ingredients Delivers Omegas 3-6-9

CLA & Omega driven metabolism support

Non Stimulant Diet Support

Fuels lean muscle tone Promotes cardio & joint health Improves body composition

Clinically studied

Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

Precautions

Keep out of reach of children.

Warning: For adult use only.

Do not use this product if you are pregnant or lactating. If you are taking medication or have a medical condition, consult a physician before using this product.

Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

The Total Lean(TM) Advanced Body Toning System For Personalized stacking suggestions, meal and exercise plans, and to learn more about the complete line of Total Lean(TM) Advanced Products, visit www.GNC.com/TotalLeanAdvanced.

When used in conjunction with the Total Lean(TM) Advanced Body Toning System

Clarinol(R) is a registered trademark of Stepan Lipid Nutrition.

Total Lean(TM) Advanced Body Toning system

Formula

Advanced metabolism support formula with Omegas 3-6 & 9 featuring CLA & GLA designed to deliver these key benefits:

Gluten Free

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General

CODE 488213 HPG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take two softgels twice daily with meals. To ensure optimal results, take four softgels daily. To supercharge your metabolism, use in combination with Total Lean(TM) Advanced Lean Shake(TM) Burn.

Formulation

No sugar, no artificial colors, no artificial flavors, no preservatives, sodium free, no wheat, gluten free, no dairy, no starch, no corn, no soy, yeast free.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Premium CLA 3-6-9 by GNC Total Lean Advanced label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Premium CLA 3-6-9 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Premium CLA 3-6-9 by GNC Total Lean Advanced

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Docosahexaenoic Acid

58 mg per serving Form: Fish Oil

Medium Chain Triglycerides

50 mg per serving Form: Coconut Oil

Eicosapentaenoic Acid

92 mg per serving Form: Fish Oil

Gamma-Linolenic Acid

150 mg per serving Form: Safflower Oil

Clarinol CLA

1.7 Gram(s) per serving Form: Safflower Oil

Oleic Acid

Interacts with
86 drugs
100 mg per serving Form: Safflower Oil

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it...

Oleic Acid monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Rosemary extract, Mixed Tocopherols. These complete the product’s ingredient list but are not active constituents.

Interaction report

Premium CLA 3-6-9 by GNC Total Lean Advanced Drug Interactions

Want to check YOUR meds against Premium CLA 3-6-9?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Oleic Acid 86

Individual Drug Interactions

The ingredients in Premium CLA 3-6-9 interact with 86 drugs. Click any drug to see the details.

1 of the 6 ingredients in Premium CLA 3-6-9 interact with drugs. Each result below shows which ingredient is responsible. Oleic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Premium CLA 3-6-9 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Oleic Acid1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, oleic acid might increase the effects of antidiabetes drugs. Preliminary clinical research in patients with type 2 diabetes taking oral hypoglycemic drugs shows that eating a diet rich in oleic acid from olive oil decreases fasting blood glucose levels when compared to eating a diet rich in linoleic acid from sunflower oil. It is unknown if taking oleic acid supplements would have this effect or if this change is clinically significant. Until more is known, use caution. Dose adjustment may be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), rosiglitazone (Avandia), and others.

Likelihood Possible Evidence B
Oleic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Premium CLA 3-6-9, from the product label.

GNC Total Lean Advanced

See all GNC Total Lean Advanced products
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Premium CLA 3-6-9 by GNC Total Lean Advanced: Common Questions

Does Premium CLA 3-6-9 by GNC Total Lean Advanced interact with any medications?
Yes. Based on its ingredients, Premium CLA 3-6-9 has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Premium CLA 3-6-9 contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help lower my cholesterol?
The Oleic Acid in this product is rated Possibly Effective for high cholesterol based on preliminary research. We don't have established effectiveness data for the other five active ingredients in our records, so the overall benefit depends on the full formula working together—something we can't confirm from the data we hold.
Is this safe to take while pregnant or breastfeeding?
The safety data for this product at supplement-level doses during pregnancy and breastfeeding isn't complete. Food amounts of oleic acid are considered fine, but concentrated supplements haven't been well studied in these situations. Talk with your doctor or pharmacist about whether it's right for you.
What are the side effects?
Adverse effects are not documented in our data for any ingredient in this product. That doesn't mean none can occur—it means we don't have a documented record of them yet. If you notice anything unusual after taking it, let your doctor or pharmacist know.
Do I need to worry about this product interfering with my diabetes medication?
Yes—oleic acid in this product may increase the blood-sugar-lowering effect of diabetes drugs, raising the risk of low blood sugar. Check with your doctor or pharmacist before taking it; they can advise you on whether it's safe for you and whether your blood sugar needs monitoring.
What is CLA, and why is it in this product?
CLA stands for conjugated linoleic acid, a type of fat found in the product as Clarinol CLA. We don't have effectiveness data on file for CLA in our records, so we can't tell you what role it plays in this formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Premium CLA 3-6-9 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Premium CLA 3-6-9 label
Go deeper

The Full Monographs Behind Premium CLA 3-6-9’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Oleic Acid

Interacts with 86 drugs

Oleic acid is a heart-healthy monounsaturated fat found mainly in olive oil, canola oil, avocados, and nuts. As part of a Mediterranean-style diet, it is widely viewed as a healthier replace...

Read the full Oleic Acid monograph →
Sources

Sources & How We Checked

Premium CLA 3-6-9's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Oleic Acid 19 references
  1. Madigan C, Ryan M, Owens D, et al. Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet. Diabetes Care 2000;23:1472-7. PubMed
  2. Gillingham, L. G., Gustafson, J. A., Han, S. Y., Jassal, D. S., and Jones, P. J. High-oleic rapeseed (canola) and flaxseed oils modulate serum lipids and inflammatory biomarkers in hypercholesterolaemic subjects. Br J Nutr 2011;105(3):417-427. PubMed
  3. Jones PJ, Senanayake VK, Pu S, Jenkins DJ, Connelly PW, Lamarche B, Couture P, Charest A, Baril-Gravel L, West SG, Liu X, Fleming JA, McCrea CE, Kris-Etherton PM. DHA-enriched high-oleic acid canola oil improves lipid profile and lowers predicted cardiova
  4. Cater, N. B., Heller, H. J., and Denke, M. A. Comparison of the effects of medium-chain triacylglycerols, palm oil, and high oleic acid sunflower oil on plasma triacylglycerol fatty acids and lipid and lipoprotein concentrations in humans. Am.J Clin.Nutr PubMed
  5. Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63(Suppl 2):S22-33. PubMed
  6. Cao Y, Hou L, Wang W. Dietary total fat and fatty acids intake, serum fatty acids and risk of breast cancer: A meta-analysis of prospective cohort studies. Int J Cancer. 2016;138(8):1894-904. doi: 10.1002/ijc.29938. PubMed
  7. FDA completes review of qualified health claim petition for oleic acid and the risk of coronary heart disease. November 2018. Available at: www.fda.gov/Food/NewsEvents/ConstituentUpdates/ucm624758.htm. Accessed January 25, 2019.
  8. Liu X, Kris-Etherton PM, West SG, et al. Effects of canola and high-oleic-acid canola oils on abdominal fat mass in individuals with central obesity. Obesity. 2016;24(11):2261-2268. PubMed
  9. Bowen KJ, Kris-Etherton PM, West SG, et al. Diets enriched with conventional or high-oleic acid canola oils lower atherogenic lipids and lipoproteins compared to a diet with a western fatty acid profile in adults with central adiposity. J Nutr. 2019;149(3 PubMed
  10. Steffen BT, Duprez D, Szklo M, Guan W, Tsai MY. Circulating oleic acid levels are related to greater risks of cardiovascular events and all-cause mortality: The Multi-Ethnic Study of Atherosclerosis. J Clin Lipidol. 2018;12(6):1404-1412. PubMed
  11. Banim PJ, Luben R, Khaw KT, Hart AR. Dietary oleic acid is inversely associated with pancreatic cancer - Data from food diaries in a cohort study. Pancreatology. 2018;18(6):655-660. PubMed
  12. Morin SJ, Gaziano JM, Djoussé L. Relation between plasma phospholipid oleic acid and risk of heart failure. Eur J Nutr. 2018;57(8):2937-2942. PubMed
  13. Samieri C, Féart C, Proust-Lima C, et al. Olive oil consumption, plasma oleic acid, and stroke incidence: the Three-City Study. Neurology. 2011;77(5):418-25. PubMed
  14. Compher CW, Kinosian BP, Rubesin SE, Ratcliffe SJ, Metz DC. Energy absorption is reduced with oleic acid supplements in human short bowel syndrome. JPEN J Parenter Enteral Nutr. 2009;33(1):102-8. PubMed
  15. Ben Fradj MK, Ouanes Y, Hadj-Taieb S, et al. Decreased oleic acid and marine n?-?3 polyunsaturated fatty acids in Tunisian patients with urothelial bladder cancer. Nutr Cancer. 2018;70(7):1043-1050.
  16. de Silva PS, Luben R, Shrestha SS, Khaw KT, Hart AR. Dietary arachidonic and oleic acid intake in ulcerative colitis etiology: a prospective cohort study using 7-day food diaries. Eur J Gastroenterol Hepatol. 2014;26(1):11-8. PubMed
  17. Higashi K, Shige H, Ito T, et al. Effect of a low-fat diet enriched with oleic acid on postprandial lipemia in patients with type 2 diabetes mellitus. Lipids. 2001;36(1):1-6. PubMed
  18. Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci. 2001;46(2):223-9. PubMed
  19. Li D, Tong Y, Li Y. Associations between dietary oleic acid and linoleic acid and depressive symptoms in perimenopausal women: The Study of Women's Health Across the Nation. Nutrition. 2020 Mar;71:110602. PubMed

See these in context on the Oleic Acid monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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