Major interaction on record — check this product against your medications before combining. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Tone & Define Ingredients & Drug Interactions

by GNC Total Lean Advanced

Tone & Define label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Tone & Define against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Tone & Define is a dietary supplement by GNC Total Lean Advanced with 4 active ingredients. Its ingredients are commonly taken for weight loss, appetite suppression, curbing sugar and carb cravings.Based on those ingredients, 1,440 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Garcinia Cambogia fruit extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Tone & Define by GNC Total Lean Advanced

Ask about any prescription or over-the-counter medication and we check it for interactions with Tone & Define by GNC Total Lean Advanced — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Tone & Define by GNC Total Lean Advanced

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 17, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 8 active ingredients.
  • “Meratrim Proprietary Blend” is a proprietary blend — the label gives one combined amount (400 mg) without saying how much of each component you get.
  • “Body Composition Matrix” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Citri-Sculpt(TM) Blend Proprietary Blend” is a proprietary blend — the label gives one combined amount (450 mg) without saying how much of each component you get.

Tone & Define contains 8 active ingredients, several of them in proprietary blends whose exact component doses are not disclosed separately. The named active ingredients are garcinia cambogia fruit extract (which contains hydroxycitric acid, a compound that may affect blood sugar and fat metabolism), sweet orange extract and blood orange extract (citrus sources of plant compounds), grapefruit extract (another citrus), guarana extract (a caffeine-rich plant), garcinia mangostana extract (mangosteen, a tropical fruit), and two ingredients we could not fully assess: Sphaeranthus indicus extract and EGCG.

The product also contains inactive ingredients — cellulose, crospovidone, stearic acid, magnesium stearate, food glaze, medium chain triglycerides, titanium dioxide, mica, artificial colors, vanilla mint flavoring, and sucralose — that serve as binders, fillers, and flavorings.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Body toning and weight management support.
  • We looked for evidence on: Obesity, Athletic performance, Muscle strength, Body composition, Lean mass, Metabolic support.
  • The closest evidence on file: Garcinia is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Garcinia is rated "Insufficient Reliable Evidence To Rate" for Obesity.
  • Also on file: Sweet Orange is rated "Insufficient Reliable Evidence To Rate" for Obesity.

The evidence for Tone & Define's ingredients is limited. Garcinia cambogia has not been rated with sufficient reliable evidence for athletic performance, liver health, cholesterol, or weight loss.

Sweet orange extract, blood orange extract, and grapefruit extract are all rated insufficient evidence for the conditions they're sometimes marketed to address — anxiety, asthma, colds, and others. Guarana is similarly unrated for cancer-related fatigue, anxiety, or athletic performance in the data we hold.

Mangosteen shows possibly effective evidence only for gum disease (periodontitis); its use for hair loss, Alzheimer's, or eczema lacks reliable evidence. We have no effectiveness information on file for Sphaeranthus indicus or EGCG.

The evidence, ingredient by ingredient Garcinia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Garcinia cambogia is generally well tolerated short-term, though the most common side effects are diarrhea, nausea, headache, and stomach upset. Rare but serious concerns include liver injury (acute hepatitis has been reported), cases of mania or unusual mood changes, and one case of severe heart inflammation; avoid garcinia during pregnancy and breastfeeding due to insufficient safety data.

Sweet orange extract and blood orange extract are likely safe during pregnancy and lactation when eaten as whole fruit, but concentrated extracts have not been well studied — use caution with supplements. Grapefruit extract is generally well tolerated as a whole fruit, though concentrated extracts lack safety data and should be avoided unless your doctor approves; avoid grapefruit during pregnancy and breastfeeding.

Guarana is high in caffeine and should be avoided during pregnancy and limited or avoided while breastfeeding because caffeine passes into breast milk. Mangosteen extract has not been studied enough to be safe during pregnancy or lactation — avoid supplement amounts.

EGCG and Sphaeranthus indicus safety information is not on file.

Side effects, ingredient by ingredient Garcinia

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Garcinia, Sweet Orange, Guarana, Grapefruit, Mangosteen.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,441 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any of the following, check with your pharmacist or doctor before using this product: blood thinners or antiplatelet drugs (due to garcinia and mangosteen), heart medications including amiodarone or beta-blockers like celiprolol (grapefruit and orange extracts can dangerously increase or decrease their levels), antidepressants and serotonergic drugs (garcinia), statin cholesterol medications especially pravastatin (sweet and blood orange can raise levels significantly), diabetes medications (garcinia may lower blood sugar further), seizure medications (guarana's caffeine may reduce their effectiveness), antipsychotics and certain psychiatric medications (guarana), and any drug metabolized by the liver (garcinia carries a rare liver injury risk). No interactions are documented for EGCG or Sphaeranthus indicus in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient weight-management supplement with significant medication interaction potential, especially if you take heart medications, blood thinners, seizure drugs, antidepressants, or diabetes medications. Before you start, check your exact medications using the tool on this page and discuss the results with your doctor or pharmacist — they know your health history and can tell you whether it's safe for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 6 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Tone & Define, straight from the product label.

Brand GNC Total Lean Advanced
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jul 24, 2015
DSLD ID 47848
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Tone & Define by GNC Total Lean Advanced, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
IngredientAmount% DV
Meratrim Proprietary Blend400 mg--
Sphaeranthus indicus extract0 NP--
Garcinia Cambogia fruit extract250 mg--
Sweet Orange extract0 NP--
Blood Orange extract0 NP--
Body Composition Matrix0 NP--
Citri-Sculpt(TM) Blend Proprietary Blend450 mg--
Grapefruit extract0 NP--
Guarana extract0 NP--
Garcinia mangostana extract0 NP--
Metabolic Activation Blend0 NP--
EGCG22.2 mg--

Other ingredients: Cellulose, Crospovidone, Stearic Acid, Magnesium Stearate, Food Glaze, Medium Chain Triglycerides, Titanium Dioxide, Mica, Artificial colors, natural Vanilla Mint flavor, Sucralose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

GNC Total Lean Challenge Are you up for the challenge? Visit GNC.com/TLC to join and for more information.

GNC Quality Commitment For more than 79 years, GNC has been the leader in the development of superior nutritional supplements. Our products are produced using only fresh, high quality ingredients and are manufactured under the strictest quality controls.

GNC Guarantee If you are not 100% satisfied, return the unused portion of the product with your receipt to a GNC store within 30 days. Our trained sales staff will either refund your purchase price or, if you prefer, assist you in finding a replacement product to help you LIVE WELL.

Please recycle this box.

Total Lean(TM) Advanced Body Toning System Start a new phase in your weight management journey with this next-level, weight-loss innovation designed specifically for those who strive for body tone and definition. With fat metabolism and body sculpting at the core, this comprehensive approach includes targeted solutions to help you transform common weight loss challenges into results that you can see and feel. These research-based solutions are designed by our weight management experts to provide you with personalized supplement and meal plans, plus body-defining exercise regimens. Get started now with the enclosed overview and visit GNC.com/TotalLeanAdvanced today!

Clinically studied body toning breakthrough Tone & Define features a breakthrough blend of clinically studied, low-stimulant ingredients designed to fuel fat metabolism, improve body composition, and support the lean, toned, and defined body you want!

Enhances fitness & definition Improves body shape Fuels fat metabolism Reduces oxidative stress Delivers targeted results Features breakthrough ingredients Tone & define

NEW

Body Toning Breakthrough

Low stim diet support

Enhances fitness and definition Improves body shape Fuels fat metabolism

Clinically studied

Precautions

Keep out of reach of children.

With less than 20 mg of caffeine per serving, this no-jitters tablet can be taken individually or stacked with a high-energy thermogenic for supercharged metabolism support!

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery.

Each serving provides 18 mg of caffeine.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

The Total Lean(TM) Advanced Body Toning System For personalized stacking suggestions, meal and exercise plans, and to learn more about the complete line of Total Lean(TM) Advanced products, visit www.GNC.com/TotalLeanAdvanced.

When used in conjunction with the Total Lean(TM) Advanced Body Toning System

Meratrim(R) brand proprietary blend of two plant extracts is a registered trademark of Laila Nutraceuticals and is exclusively licensed by InterHealth Nutraceuticals, Benicia, CA 94510.

Formula

Fueled by the unique Citri-Sculpt(TM) Blend, a combination of clinically studied Mediterranean citrus extracts, plus clinically researched Meratrim(R), Garcinia Cambogia and green tea extracts, Tone & Define delivers ultra-premium, scientifically formulated diet support.

With less than 20 mg of caffeine per serving, this no-jitters tablet can be taken individually or stacked with a high-energy thermogenic for supercharged metabolism support!

Each serving provides 18 mg of caffeine.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General

CODE 479800 IPG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one tablet twice daily. For maximum results, use for at least 12 weeks in conjunction with a healthy diet and exercise program. To supercharge your metabolism, use in combination with Total Lean(TM) Advanced metabolic Elite(TM). For personalized stacking suggestions and to learn more, visit www.GNC.com/TotalLeanAdvanced.

Seals/Symbols

Gf Gluten Free

Meratrim(R)

Formulation

Gluten Free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Tone & Define by GNC Total Lean Advanced label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Tone & Define label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Tone & Define by GNC Total Lean Advanced

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Body Composition Matrix

0 NP per serving
  • › Meratrim Proprietary Blend
  • › Citri-Sculpt(TM) Blend Proprietary Blend

Metabolic Activation Blend

0 NP per serving

Other (inactive) ingredients: Cellulose, Crospovidone, Stearic Acid, Magnesium Stearate, Food Glaze, Medium Chain Triglycerides, Titanium Dioxide, Mica, Artificial colors, Natural Vanilla Mint flavor, Sucralose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Tone & Define by GNC Total Lean Advanced Drug Interactions

Want to check YOUR meds against Tone & Define?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,440Drugs
784 Major 632 Moderate 24 Minor

Ingredients driving the most interactions

Garcinia Cambogia fruit extract 704

Individual Drug Interactions

The ingredients in Tone & Define interact with 1,440 drugs. Click any drug to see the details.

1 of the 4 ingredients in Tone & Define interact with drugs. Each result below shows which ingredient is responsible. Garcinia Cambogia fruit extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Tone & Define with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Garcinia Cambogia fruit extract4 drug types · 704 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
HCA inhibits platelet aggregation in vitro. The inhibitory effect seems to be greater in platelets extracted from diabetic subjects than non-diabetic subjects.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, hydroxycitric acid (HCA), the main active ingredient in garcinia, might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia.
HCA reduces fasting and postprandial blood glucose levels in animal models, theoretically by delaying glucose absorption. This effect has not been reported in humans.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use with other potentially hepatotoxic drugs might increase the risk of developing liver damage.
There have been reports of acute hepatitis with elevated liver enzymes associated with garcinia, when taken alone or in combination with other ingredients. Case reports collected from the Drug Induced Liver Injury Network suggest this risk may be greater in people who carry the HLA B*35:01 allele.

Likelihood Possible Evidence D
Serotonergic Drugs

Theoretically, combining garcinia with other serotonergic drugs might increase the risk of serotonergic side effects, including serotonin syndrome.
In one report, a patient experienced serotonin syndrome after taking garcinia extract (60% hydroxycitric acid) 1000 mg daily in combination with escitalopram 20 mg, which had been taken for a year. The patient was switched to sertraline 50 mg daily and again experienced serotonin syndrome.

Likelihood Possible Evidence D
Garcinia Cambogia fruit extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Tone & Define, from the product label.

GNC Total Lean Advanced

See all GNC Total Lean Advanced products
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Tone & Define by GNC Total Lean Advanced: Common Questions

Does Tone & Define by GNC Total Lean Advanced interact with any medications?
Yes. Based on its ingredients, Tone & Define has a known interaction with 1,440 medications, including 784 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Tone & Define contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take if I'm pregnant or breastfeeding?
No — avoid it. Garcinia, guarana, mangosteen, and grapefruit extract all lack enough safety information for pregnancy, and some are rated unsafe. Guarana's high caffeine content is best avoided while breastfeeding. Talk to your doctor or pharmacist before considering any weight-loss supplement during pregnancy or while nursing.
What's garcinia cambogia supposed to do?
Garcinia contains hydroxycitric acid (HCA), which is thought to reduce blood sugar and may help with weight loss. However, we have insufficient reliable evidence that it actually works for weight loss, athletic performance, cholesterol, or liver health in people. Most of the evidence is limited to animal or test-tube studies.
Why is guarana a concern if I take seizure medication?
Guarana is high in caffeine, and animal research shows that caffeine can lower how well seizure medications like valproate and carbamazepine work — this could increase the risk of breakthrough seizures. Your doctor or pharmacist should clear it for you if you're on these drugs.
What if I take a statin like atorvastatin — will this product interact?
Possibly. If you take pravastatin specifically, sweet orange and blood orange extracts in this product can increase its blood levels by about 149%, which could raise your risk of statin side effects. Other statins are affected differently. Always ask your pharmacist to check your specific medication.
What side effects might I get from taking this?
The most common are diarrhea, nausea, headache, and stomach upset — mainly from garcinia. Guarana's caffeine can cause jitteriness, insomnia, or nervousness. Rare but serious concerns with garcinia include liver damage and mood changes (mania). Stop and talk to your doctor if you notice unusual mood shifts, fatigue, dark urine, or abdominal pain.
Can I take this with my other supplements?
That depends on what they are. This product contains six ingredients with interactions to medications — if you're also taking plant supplements or over-the-counter drugs, there's potential for overlap. Use the medication checker on this page or ask your pharmacist to review your full supplement and medicine list.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Tone & Define is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Tone & Define label
Go deeper

The Full Monographs Behind Tone & Define’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Garcinia

Interacts with 704 drugs

Garcinia is a tropical fruit whose rind contains hydroxycitric acid (HCA), widely marketed for weight loss and appetite control. The scientific evidence is weak and mixed, with most studies...

Read the full Garcinia monograph →
Sources

Sources & How We Checked

Tone & Define's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 338 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Garcinia 44 references
  1. Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 1998;280:1596-600. PubMed
  2. Soni MG, Burdock GA, Preuss HG, et al. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol 2004;42:1513-29. PubMed
  3. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
  4. Willis SL, Moawad FJ, Hartzell JD, et al. Hypertensive retinopathy associated with use of the ephedra-free weight-loss herbal supplement Hydroxycut. MedGenMed 2006;8:82.
  5. Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab 2004;6:171-180.
  6. Mansi IA, Huang J. Rhabdomyolysis in response to weight-loss herbal medicine. Am J Med Sci 2004;327:356-357. PubMed
  7. Lopez AM, Kornegay J, Hendrickson RG. Serotonin Toxicity Associated with Garcinia cambogia Over-the-counter Supplement. J Med Toxicol. 2014 Apr 4. [Epub ahead of print]. PubMed
  8. Michno A, Skibowska A, Raszeja-Specht A, Cwikowska J, Szutowicz A. The role of adenosine triphosphate citrate lyase in the metabolism of acetyl coenzyme a and function of blood platelets in diabetes mellitus. Metabolism 2004;53(1):66-72. PubMed
  9. Asghar M, Monjok E, Kouamou G, et al. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem 2007;304(1-2):93-99. PubMed
  10. Wielinga PY, Wachters-Hagedoorn RE, Bouter B, et al. Hydroxycitric acid delays intestinal glucose absorption in rats. Am J Physiol Gastrointest Liver Physiol 2005;288(6):G1144-G1149. PubMed
  11. Leonhardt M, Balkan B, Langhans W. Effect of hydroxycitrate on respiratory quotient, energy expenditure, and glucose tolerance in male rats after a period of restrictive feeding. Nutrition 2004;20(10):911-915. PubMed
  12. Bunchorntavakul, C. and Reddy, K. R. Review article: herbal and dietary supplement hepatotoxicity. Aliment.Pharmacol.Ther 2013;37(1):3-17. PubMed
  13. Vasques CA, Schneider R, Klein-Júnior LC, et al. Hypolipemic effect of Garcinia Cambogia in obese women. Phytother Res 2014;28(6):887-91.
  14. Marquez F, Babio N, Bullo M, Salas-Salvado J. Evaluation of the safety and efficacy of hydroxycitric acid or Garcinia cambogia extracts in humans. Crit Rev Food Sci Nutr 2012;52:585-94.
  15. Allen SF, Godley RW, Evron JM, et al. Acute necrotizing eosinophilic myocarditis in a patient taking Garcinia cambogia extract successfully treated with high-dose corticosteroids. Can J Cardiol 2014;30(12):1732 e13-1732 e15. PubMed
  16. Dara L, Hewett J, Lim JK. Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements. World J Gastroenterol. 2008 Dec 7;14(45):6999-7004. PubMed
  17. Sharma T, Wong L, Tsai N, Wong RD. Hydroxycut(®) (herbal weight loss supplement) induced hepatotoxicity: a case report and review of literature. Hawaii Med J. 2010 Aug;69(8):188-90.
  18. Rashid NN, Grant J. Hydroxycut hepatotoxicity. Med J Aust. 2010 Feb 1;192(3):173-4. PubMed
  19. Actis GC, Bugianesi E, Ottobrelli A, Rizzetto M. Fatal liver failure following food supplements during chronic treatment with montelukast. Dig Liver Dis. 2007 Oct;39(10):953-5. PubMed
  20. Corey R, Werner KT, Singer A, Moss A, Smith M, Noelting J, Rakela J. Acute liver failure associated with Garcinia cambogia use. Ann Hepatol. 2016 Jan-Feb;15(1):123-6. PubMed
  21. Melendez-Rosado J, Snipelisky D, Matcha G, Stancampiano F. Acute hepatitis induced by pure Garcinia cambogia. J Clin Gastroenterol. 2015 May-Jun;49(5):449-50. PubMed
  22. García-Cortés M, Robles-Díaz M, Ortega-Alonso A, Medina-Caliz I, Andrade RJ. Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics. Int J Mol Sci. 2016 Apr 9;17(4):537. PubMed
  23. Dehoney S, Wellein M. Rhabdomyolysis associated with the nutritional supplement Hydroxycut. Am J Health Syst Pharm. 2009;66(2):142-8. PubMed
  24. Fong TL, Klontz KC, Canas-Coto A, et al. Hepatotoxicity due to hydroxycut: a case series. Am J Gastroenterol. 2010;105(7):1561-6. PubMed
  25. Hendrickson BP, Shaikh N, Occhiogrosso M, Penzner JB. Mania Induced by Garcinia cambogia: A Case Series. Prim Care Companion CNS Disord. 2016;18(2).
  26. Kaswala D, Shah S, Patel N, Raisoni S, Swaminathan S. Hydroxycut-induced Liver Toxicity. Ann Med Health Sci Res. 2014; 4(1):143-5. PubMed
  27. Lobb A. Hepatoxicity associated with weight-loss supplements: a case for better post-marketing surveillance. World J Gastroenterol. 2009;15(14):1786-7. PubMed
  28. Lunsford KE, Bodzin AS, Reino DC, Wang HL, Busuttil RW. Dangerous dietary supplements: Garcinia cambogia -associated hepatic failure requiring transplantation. World J Gastroenterol. 2016;22(45):10071-10076.
  29. Narasimha A, Shetty PH, Nanjundaswamy MH, Viswanath B, Bada Math S. Hydroxycut - Dietary supplements for weight loss: Can they induce mania? Aust N Z J Psychiatry. 2013;47(12):1205-6. PubMed
  30. Shim M, Saab S. Severe hepatotoxicity due to Hydroxycut: a case report. Dig Dis Sci. 2009;54(2):406-8. PubMed
  31. Stohs SJ, Preuss HG, Ohia SE, et al. No evidence demonstrating hepatotoxicity associated with hydroxycitric acid. World J Gastroenterol. 2009;15(32):4087-9. PubMed
  32. Gavril A, Ribnikar M, Smid L, Luzar B, Stabuc B. Fat burner-induced acute liver injury: case series of four patients. Nutrition. 2018;47:110-114. doi: 10.1016/j.nut.2017.10.002. PubMed
  33. Bystrak T, Cervera-Hernandez ME, Reddy N, King Z, Bratberg J. Garcinia cambogia, diabetic ketoacidosis, and pancreatitis. R I Med J (2013). 2017 Oct 2;100(10):48-50. NO DOI
  34. Smith RJ, Bertilone C, Robertson AG. Fulminant liver failure and transplantation after use of dietary supplements. Med J Aust. 2016;204(1):30-2. PubMed
  35. Nguyen DC, Timmer TK, Davison BC, McGrane IR. Possible Garcinia cambogia-induced mania with psychosis: a case report. J Pharm Pract 2019;32(1):99-102. doi: 10.1177/0897190017734728.
  36. Yousaf MN, Chaudhary FS, Hodanazari SM, Sittambalam CD. Hepatotoxicity associated with Garcinia cambogia: a case report. World J Hepatol 2019;11(11):735-42.
  37. Mas Ordeig A, Bordón García N. Hepatotoxicity caused by Garcinia cambogia. Gastroenterol Hepatol 2020;43(3):134-5. DOI
  38. Cho HK, Han YS, Park JM. Ocular complications of Garcinia cambogia extract diet pills: case report. Eur J Ophthalmol 2019:1120672119872364. PubMed
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  155. Piscitelli J, Nikanjam M, Capparelli EV, et al. Fexofenadine Plasma Concentrations to Estimate Systemic Exposure in Healthy Adults Using a Limited Sampling Strategy with a Population Pharmacokinetic Approach. Ther Drug Monit 2023;45(4):539-545. PubMed
  156. Abu Dayyih W, Zakaraya Z, Hailat M, et al. The Validation and Determination of Empagliflozin Concentration in the Presence of Grapefruit Juice Using HPLC for Pharmacokinetic Applications. Molecules 2024;29(6):1236. PubMed
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See these in context on the Grapefruit monograph →

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See these in context on the Guarana monograph →

Mangosteen 6 references
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See these in context on the Mangosteen monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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