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Dietary supplement

Stress Hormone Balancing Blend Ingredients & Drug Interactions

by GNC Total Lean Advanced

Stress Hormone Balancing Blend label
See full label image
Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Stress Hormone Balancing Blend against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Stress Hormone Balancing Blend is a dietary supplement by GNC Total Lean Advanced with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine & Phosphatidic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Stress Hormone Balancing Blend by GNC Total Lean Advanced

Ask about any prescription or over-the-counter medication and we check it for interactions with Stress Hormone Balancing Blend by GNC Total Lean Advanced — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Stress Hormone Balancing Blend by GNC Total Lean Advanced

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Phosphatidylserine & Phosphatidic Acid” is listed as a grouped ingredient — the label gives one combined amount (400 mg) without saying how much of each component you get.

This product contains 2 active ingredients: phosphatidylserine and phosphatidic acid. Phosphatidylserine is a naturally occurring compound found in cell membranes; it's used in supplements to support brain health and stress response.

The blend is housed in a vegetarian capsule with inactive ingredients including silicon dioxide and magnesium stearate.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Phosphatidylserine's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: stress defense and hormone balance support.
  • We looked for evidence on: Depression, Stress management, Cortisol regulation, Anxiety.
  • The closest evidence on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Depression (Natural Medicines).

Phosphatidylserine has been rated possibly effective for age-related cognitive decline and Alzheimer disease. However, the evidence isn't established for athletic performance, ADHD, general cognitive function, or dementia.

We hold no effectiveness data for phosphatidic acid.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea — with insomnia more likely at higher doses around 600 mg, and stomach upset possible at 200–300 mg daily.

The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to confirm it's safe.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any anticholinergic drugs or cholinergic medications you're on. Both carry Moderate interactions with phosphatidylserine.

Use the medication checker on this page to verify your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This blend may help if you're looking to support brain health or manage stress-related cognitive changes. If you take anticholinergic or cholinergic medications, check with us first — the interactions are theoretical but worth verifying with your exact drugs.

Anyone pregnant, breastfeeding, or on prescription medication should talk with their pharmacist before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Stress Hormone Balancing Blend, straight from the product label.

Brand GNC Total Lean Advanced
Net contents 10 Purifying Complex Packet(s); 5 Daily Pill Strip(s)
Market status On market
Date entered into DSLD Jan 25, 2018
DSLD ID 82935
Product type Fat/fatty Acid
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Stress Hormone Balancing Blend by GNC Total Lean Advanced, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
5
IngredientAmount% DV
Phosphatidylserine0 NP--
Phosphatidic Acid0 NP--
Phosphatidylserine & Phosphatidic Acid400 mg--

Other ingredients: Vegetarian Capsule Shell, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Each Daily Pill Strip contains: 2 Stress hormone balancing blend capsules 1 Probiotic & Digestive Support blend capsule 1 System Detox & Metabolic Support Blend tablet

Our Quality Commitment To You Since 1935, our mission as the industry leader has been to provide you with the highest-quality nutritional supplements. We continue to stand behind this mission. If you're not 100% satisfied with your purchase, return the unused portion of the product with your receipt within 30 days and we'll either refund your money or find you a replacement product that is right for you.

This comprehensive detox system targets support for 6 key areas in the body and helps you gently eliminate unwanted chemicals and toxins that can sabotage your dieting efforts. Made with probiotics, real fruits and veggies and clinically studied ingredients, these high-quality formulas provide you with essential nutrients as you strive to become a totally new you.

Diet Cleanse ~ Stress defense ~ Fluid balance ~ Metabolism ~ Digestive system ~ Immune system ~ Hormone balance

New

Kick-start your weigh loss program Cleansing and detox Reset & purify 5-day detox system 50 billion CFU Probiotics Reduces bloating Stress defense

Contains: ~ 10 - Purifying Complex Packets ~ 5- Daily Pill Strips ~ Meal & Exercise Plan

Clinically studied

Are you up for the challenge? Visit GNC.com/TLC to join and for more information.

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one daily pill strip each day with food for 5 consecutive days.

For best results, simply take as directed for 5 consecutive days and follow the enclosed meal and exercise plan.

Formula

Contains: Soybeans.

Precautions

Contains: Soybeans.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medications, or have a medical condition.

Discontinue use two weeks prior to surgery.

Keep out of reach of children.

Brand IP Statement(s)

Become a totally new you Rejuvenate and replenish your weight loss program with the Total Lean Advanced Diet Cleanse.

The Total Lean Advanced Diet Cleanse targets support for 6 key areas in the body unique to dieters.

GNC Total Lean Challenge

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administrations. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formulation

Gluten free

General

CODE 732239 KPG

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Stress Hormone Balancing Blend by GNC Total Lean Advanced label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Stress Hormone Balancing Blend label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Stress Hormone Balancing Blend by GNC Total Lean Advanced

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container5 Amounts shown are per serving.

Phosphatidylserine & Phosphatidic Acid

Interacts with
219 drugs
400 mg per serving

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine & Phosphatidic Acid monograph & interactions

Other (inactive) ingredients: Vegetarian Capsule Shell, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Stress Hormone Balancing Blend by GNC Total Lean Advanced Drug Interactions

Want to check YOUR meds against Stress Hormone Balancing Blend?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine & Phosphatidic Acid 219

Individual Drug Interactions

The ingredients in Stress Hormone Balancing Blend interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in Stress Hormone Balancing Blend interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine & Phosphatidic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Stress Hormone Balancing Blend with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine & Phosphatidic Acid2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine & Phosphatidic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Stress Hormone Balancing Blend, from the product label.

GNC Total Lean Advanced

See all GNC Total Lean Advanced products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Stress Hormone Balancing Blend by GNC Total Lean Advanced: Common Questions

Does Stress Hormone Balancing Blend by GNC Total Lean Advanced interact with any medications?
Yes. Based on its ingredients, Stress Hormone Balancing Blend has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Stress Hormone Balancing Blend contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my memory or brain fog?
Phosphatidylserine in this blend is rated possibly effective for age-related cognitive decline and Alzheimer disease. For general brain fog or other cognitive concerns, the evidence we have isn't strong enough to say it will help. Your pharmacist can discuss whether it might be right for your situation.
What side effects should I watch for?
Most people tolerate it well, but common side effects include stomach upset, flatulence, nausea, headache, and insomnia. Insomnia is more likely with higher doses around 600 mg, and gastrointestinal upset can happen at 200–300 mg daily. If you experience any of these, let your pharmacist know.
Is it safe to take while pregnant or breastfeeding?
No — the safety data advises against use in both pregnancy and breastfeeding because there isn't enough information to confirm it's safe. Talk with your doctor or pharmacist about alternatives if you're pregnant or nursing.
Can I take this with my medications?
It depends on what you're taking. This product interacts with anticholinergic and cholinergic medications. Use the medication checker on this page to look up your exact prescriptions, and then check with your pharmacist before starting.
What's the difference between the two ingredients?
Both phosphatidylserine and phosphatidic acid are phospholipids — compounds related to how cells function. We have interaction and safety data for phosphatidylserine, but we don't hold data for phosphatidic acid on its own, so we can't tell you much about it individually.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Stress Hormone Balancing Blend is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Stress Hormone Balancing Blend label
Go deeper

The Full Monographs Behind Stress Hormone Balancing Blend’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

Stress Hormone Balancing Blend's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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