Premium Vitamin D3 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Premium Vitamin D3 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Premium Vitamin D3 is a dietary supplement by Tropical Oasis with 1 active ingredient. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D3. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Premium Vitamin D3 by Tropical Oasis
Ask about any prescription or over-the-counter medication and we check it for interactions with Premium Vitamin D3 by Tropical Oasis — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Premium Vitamin D3 by Tropical Oasis
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Tropical Oasis Premium Vitamin D3 contains one active ingredient: vitamin D3 (cholecalciferol), the same form your body makes from sunlight. It comes as a liquid, which makes it easy to adjust your dose.
The product also includes inactive ingredients — water, xylitol, natural flavors, potassium sorbate, and citric acid — to preserve and flavor it.
Does it work?
Strong evidence
Vitamin D3 is effective for treating several serious deficiency conditions: familial hypophosphatemia, osteomalacia (soft bones), renal osteodystrophy (bone disease from kidney failure), rickets, and hypoparathyroidism. If you're taking this to correct a diagnosed vitamin D deficiency or one of these conditions, the evidence supports its use.
If you're using it for other reasons — like general bone health or immune support — check the product label or speak with your doctor about whether it's the right choice for your situation.
How safe is it?
Well-documented data
Vitamin D3 is generally well tolerated at recommended doses. Very high doses over time can cause vitamin D toxicity, with symptoms including high calcium levels (hypercalcemia), bone loss in adults, slowed growth in children, and eye problems like light sensitivity.
During pregnancy, recommended amounts are likely safe, but higher doses may carry risk — use it only under your doctor's guidance. While breastfeeding, recommended doses are considered likely safe.
If you're thinking about taking more than the standard amount, talk it over with your doctor or pharmacist first.
Meds to double-check
Moderate interaction found
Before taking this product, double-check if you're on any heart rhythm drugs (digoxin, verapamil, diltiazem) or thiazide diuretics — these carry Moderate-severity risks from raised calcium. Also mention any cholesterol medications (like atorvastatin), psoriasis treatments (calcipotriene), or aluminum supplements, and let your doctor or pharmacist know if you have kidney disease or take medications processed by the CYP3A4 liver enzyme pathway.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This product is well suited for people with a confirmed vitamin D deficiency or specific conditions like rickets or osteomalacia. If you take any heart rhythm medications, blood pressure pills, cholesterol drugs, or have kidney disease, check your specific medications against the interaction tool before starting.
Talk with your doctor or pharmacist before you begin, especially if you're pregnant, breastfeeding, or considering higher doses.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Premium Vitamin D3, straight from the product label.
| Brand | Tropical Oasis |
|---|---|
| Barcode (UPC) | 617279340036 |
| Net contents | 16 Fluid Ounce(s); 480 Milliliter(s) |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2022 |
| DSLD ID | 258887 |
| Product type | Vitamin |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Premium Vitamin D3 by Tropical Oasis, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Vitamin D3 | 5000 IU | 1250% |
| Sugar Alcohols | 1.5 Gram(s) | -- |
| Calories | 5 Calorie(s) | -- |
| Total Carbohydrates | 1.5 Gram(s) | 1% |
Other ingredients: Water, Purified, Xylitol, Natural Flavors, Potassium Sorbate, Citric Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
Official Certification Double Checked Highest Quality Standard
Made In The USA
GMP Certified Certified By An Independent Laboratory GMP Certified All of our products are manufactured in our state of the art GMP certified facility.
Formulation
Take your liquid daily vitamins for better absorption.
Gluten free
No artificial flavors or colors. Unconditionally guaranteed.
Better ingredients + better absorption Supports optimum health Boosts calcium absorption Immune system essential
Precautions
Caution: Keep out of reach of children.
Do not use if safety seal is damaged or missing.
If pregnant, nursing or on medication, consult with your healthcare practitioner prior to use.
Suggested/Recommended/Usage/Directions
Best if consumed within 60 days of opening.
Suggested Use: As a dietary supplement take 3 teaspoons daily with a meal.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Your vitamins for life Sunshine in a bottle
30-day supply
96% liquids Absorption 18% pills Research has shown that particles suspended in liquid form are much more readily absorbed by the body, thus offering more positive health benefits.
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Premium Vitamin D3 by Tropical Oasis label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Premium Vitamin D3 by Tropical Oasis
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size3 Teaspoon(s) Dosage formLiquid Servings per container32 Amounts shown are per serving.
Vitamin D3
Interacts with715 drugs
Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...
Vitamin D3 monograph & interactionsOther (inactive) ingredients: Water, Purified, Xylitol, Natural Flavors, Potassium Sorbate, Citric Acid. These complete the product’s ingredient list but are not active constituents.
Premium Vitamin D3 by Tropical Oasis Drug Interactions
HelloPharmacist Interaction Report
Tropical Oasis Premium Vitamin D3 does interact with medications, primarily through its vitamin D3 content.
The most serious concern is with heart rhythm drugs: high-dose vitamin D can raise calcium levels (hypercalcemia), which increases the risk of dangerous heart arrhythmias if you're taking digoxin, verapamil, or diltiazem. This is a Moderate severity risk.
Read the full breakdown — every affected drug type, severity by severity
Other Moderate-severity interactions to watch for include thiazide diuretics (water pills that lower blood pressure), which can trap calcium in your body and raise levels further when combined with vitamin D. Vitamin D may also reduce how well atorvastatin (a cholesterol drug) works, and it theoretically increases the risk of high calcium if you're using calcipotriene for psoriasis.
If you have kidney problems and take aluminum-containing products, vitamin D might increase aluminum absorption to harmful levels.
One more thing: vitamin D may induce liver enzymes (CYP3A4) that break down a wide range of other drugs, potentially lowering their effectiveness — this is Minor severity, but it affects many medications. Altogether, these interactions span 716 individual medications.
Before you start this supplement, search your exact medications on this page to see if any are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Premium Vitamin D3?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Premium Vitamin D3 interact with 715 drugs. Click any drug to see the details.
1 of the 1 ingredient in Premium Vitamin D3 interact with drugs. Each result below shows which ingredient is responsible. Vitamin D3
Alginic Acid, Aluminum HydroxideRafton
How Alginic Acid, Aluminum Hydroxide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Alginic Acid, Aluminum Hydroxide interactionAluminum Acetate, Benzethonium ChlorideBuro-Sol Otic Solution
How Aluminum Acetate, Benzethonium Chloride interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Acetate, Benzethonium Chloride interactionAluminum ChlorideAluminum Chloride, Anhydrol Forte, Driclor, Drysol
How Aluminum Chloride interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Chloride interactionAluminum HydroxideAlu-Cap, Amphojel, Gaviscon
How Aluminum Hydroxide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAluminum Hydroxide, Magnesium Hydroxide (otc Drug)Maalox, Mucogel
How Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Magnesium Hydroxide (otc Drug) interactionAluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug)Mylanta
How Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum Hydroxide, Magnesium Hydroxide, Simethicone (otc Drug) interactionAluminum, CalciumDomeboro
How Aluminum, Calcium interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum, Calcium interactionAluminum, Magnesium (otc Drug)Almagel
How Aluminum, Magnesium (otc Drug) interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum, Magnesium (otc Drug) interactionAluminum, Magnesium Hydroxide (otc Drug)Wingel
How Aluminum, Magnesium Hydroxide (otc Drug) interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aluminum, Magnesium Hydroxide (otc Drug) interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Amiloride, Hydrochlorothiazide interactionAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
How Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Aluminum Moderate
Interaction Summary
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
Read the full Vitamin D3 + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAtenolol, ChlortalidoneAtenixCo, Tenoret 50, Totaretic
How Atenolol, Chlortalidone interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Atenolol, Chlortalidone interactionAtenolol, ChlorthalidoneTenoretic
How Atenolol, Chlorthalidone interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Atenolol, Chlorthalidone interactionAtorvastatinAtorvaliq
How Atorvastatin interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Cytochrome P450 3a4 (cyp3a4) Substrates, Atorvastatin (lipitor) Moderate
Interaction Summary
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
Read the full Vitamin D3 + Atorvastatin interactionAtorvastatin CalciumLipitor
How Atorvastatin Calcium interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Atorvastatin (lipitor), Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Vitamin D might reduce absorption of atorvastatin.
Read the full Vitamin D3 + Atorvastatin Calcium interactionAzilsartan, ChlorthalidoneEdarbyclor
How Azilsartan, Chlorthalidone interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Azilsartan, Chlorthalidone interactionBenazepril, HydrochlorothiazideLotensin HCT
How Benazepril, Hydrochlorothiazide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Benazepril, Hydrochlorothiazide interactionBendroflumethiazideAprinox, Naturetin, Neo-NaClex
How Bendroflumethiazide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide interactionBendroflumethiazide, NadololCorzide
How Bendroflumethiazide, Nadolol interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Nadolol interactionBendroflumethiazide, PotassiumCentyl K, Neo-NaClex-K
How Bendroflumethiazide, Potassium interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Potassium interactionBendroflumethiazide, Rauwolfia SerpentinaRauzide
How Bendroflumethiazide, Rauwolfia Serpentina interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bendroflumethiazide, Rauwolfia Serpentina interactionBenzthiazideExna
How Benzthiazide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Benzthiazide interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Calcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D3 + Betamethasone Dipropionate, Calcipotriene interactionBisoprolol, HydrochlorothiazideZiac
How Bisoprolol, Hydrochlorothiazide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Bisoprolol, Hydrochlorothiazide interactionCalcipotrieneDovonex
How Calcipotriene interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Calcipotriene (dovonex) Moderate
Interaction Summary
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Read the full Vitamin D3 + Calcipotriene interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Captopril, Hydrochlorothiazide interactionChlorothiazideDiuril
How Chlorothiazide interacts with Premium Vitamin D3 — through 1 ingredient. Tap an ingredient for the detail:
Vitamin D3Thiazide Diuretics Moderate
Interaction Summary
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Read the full Vitamin D3 + Chlorothiazide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Premium Vitamin D3 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Vitamin D3
Aluminum
Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.
Atorvastatin (Lipitor)
Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.
Calcipotriene (Dovonex)
Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.
Digoxin (Lanoxin)
Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.
Diltiazem (Cardizem, Others)
Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.
Thiazide Diuretics
Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.
Verapamil (Calan, Others)
Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.
Brand information
Manufacturer and brand details for Premium Vitamin D3, from the product label.
Tropical Oasis
See all Tropical Oasis products- Name
- Tropical Oasis
- Street Address
- 1300 Hutton Drive, Plant #110
- City
- Carrollton
- State
- TX
- ZipCode
- 75006
- Web Address
- www.TropicalOasis.com
Premium Vitamin D3 by Tropical Oasis: Common Questions
Does Premium Vitamin D3 by Tropical Oasis interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is it safe to take vitamin D3 while pregnant?
Can I take this if I'm breastfeeding?
What are the side effects of taking too much vitamin D?
Does this product work for general bone health, or just vitamin D deficiency?
Why is this a liquid instead of a pill?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Premium Vitamin D3 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Premium Vitamin D3’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Premium Vitamin D3's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 26 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Vitamin D 26 references
- McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
- Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
- Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
- Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
- Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
- Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
- Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
- Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
- Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
- Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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