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Dietary supplement

Prevagen Professional Formula Ingredients & Drug Interactions

by Quincy Bioscience

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Prevagen Professional Formula is a dietary supplement by Quincy Bioscience with 2 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis, correcting vitamin d deficiency, immune system support.Based on those ingredients, 715 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin D. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Prevagen Professional Formula by Quincy Bioscience

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Prevagen Professional Formula contains two active ingredients: vitamin D and apoaequorin. Vitamin D is a fat-soluble vitamin that your body needs for calcium absorption and bone health; it's used medically to treat conditions like rickets, osteomalacia, and problems with parathyroid function.

Apoaequorin is a calcium-binding protein originally isolated from jellyfish; it's included in this formula for its claimed effects on memory and cognitive function, though the evidence supporting those claims is not well established. The capsule also contains several inactive ingredients—microcrystalline cellulose, cellulose, maltodextrin, casein peptones, lactose, magnesium stearate, modified corn starch, salt, soy peptones, and sugar—which serve as fillers, binders, and flow agents to hold the capsule together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Improves memory and supports healthy brain function.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Cognitive impairment, Dementia, Memory — and 3 related terms.
  • The closest evidence on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Vitamin D is rated "Insufficient Reliable Evidence To Rate" for Alzheimer disease, Cognitive function, Cognitive impairment, Dementia.
  • Also on file: Apoaequorin is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Cognitive function.

Vitamin D is well established for treating vitamin D deficiency diseases. It's effective for rickets, osteomalacia (soft bones), renal bone disease, and hypoparathyroidism (low parathyroid hormone).

Apoaequorin, however, is a different story. The evidence doesn't support its use for age-related cognitive decline, memory problems, thinking function, insomnia, or Lou Gehrig's disease—the data we hold shows insufficient reliable evidence to rate it for any of these.

The evidence, ingredient by ingredient Vitamin D Apoaequorin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin D is generally well tolerated at recommended doses, though very high doses over time can cause toxicity with symptoms of high blood calcium (hypercalcemia), which can also trigger anemia and kidney problems. The data notes it's often used in pregnancy under doctor guidance and is generally acceptable while breastfeeding, but pregnancy use should be at recommended amounts only.

Apoaequorin appears well tolerated in short-term studies, but long-term safety isn't established. The most common side effects reported with this product include dizziness, headache, and nausea; one study reported mild anxiety.

The safety data advises against apoaequorin in pregnancy and while breastfeeding because there isn't enough safety information.

Side effects, ingredient by ingredient Vitamin D Apoaequorin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Vitamin D.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: heart-rhythm medications.
  • For scale: 716 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Prevagen Professional Formula, double-check with your doctor or pharmacist if you're on any heart rhythm medications (verapamil, diltiazem, digoxin), thiazide water pills, cholesterol drugs like atorvastatin, the psoriasis medication calcipotriene, or aluminum-containing antacids. Altogether, these interactions span 716 individual medications.

No interactions are documented for apoaequorin.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Prevagen Professional Formula is built on vitamin D, which has real medical uses for bone and calcium disorders, paired with apoaequorin, which lacks solid evidence for memory or cognition. If you take heart medications, cholesterol drugs, or aluminum-containing antacids, you'll need to check with your doctor or pharmacist before starting this—vitamin D can interfere with how several of those work.

Talk it over with your own healthcare provider to see if it makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Prevagen Professional Formula, straight from the product label.

Brand Quincy Bioscience
Barcode (UPC) 894047001010
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 293712
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Prevagen Professional Formula by Quincy Bioscience, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
894047001010
IngredientAmount% DV
Vitamin D50 mcg250%
Apoaequorin40 mg--

Other ingredients: Microcrystalline Cellulose, Cellulose, Water, Maltodextrin, Casein Peptones, Lactose, Magnesium Stearate, Modified Corn Starch, Salt, Soy Peptones, Sugar

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Prevagen Improves Memory

Healthier brain. Better life.

Formulation

Supports healthy brain function Supports a sharper mind

Prevagen is clinically shown to help with mild memory loss associated with aging.

Safe and clinically tested ingredient

Originally discovered in jellyfish, Prevagen Professional is now produced in a controlled scientific process. Prevagen is safe and easy to take.

Suggested/Recommended/Usage/Directions

One capsule daily

Suggested use: Take one capsule daily in the morning, with or without food.

Only one capsule per day

FDA Statement of Identity

Dietary Supplement

Precautions

Contains: Milk and soy

Contains a bioengineered food ingredient.

General Statements

Full 30 day supply

Each bottle contains a 30 day supply. Based on a clinical study of subgroups of individuals who were cognitively normal or mildly impaired.

Formula

Prevagen is formulated with apoaequorin, which uniquely supports brain function. In a computer-assessed, double-blinded, placebo-controlled clinical study, Prevagen improved certain aspects of cognitive function over a 90 day period.

The most advanced formula. Prevagen Professional, now with Vitamin D, is designed to have four times the apoaequorin as Prevagen Regular Strength.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

See for yourself

Prevagen Professional Formula by Quincy Bioscience label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Prevagen Professional Formula by Quincy Bioscience

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin D

Interacts with
715 drugs
50 mcg per serving Form: Cholecalciferol, Vitamin D3

Vitamin D is a fat-soluble vitamin that helps your body absorb calcium and is important for healthy bones, muscles, and immune function. Many people,...

Vitamin D monograph & interactions

Apoaequorin

No known
interactions
40 mg per serving

Apoaequorin is a jellyfish-derived protein marketed (as Prevagen) to support memory and brain health. The scientific evidence that it improves memory...

Apoaequorin monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Cellulose, Water, Maltodextrin, Casein Peptones, Lactose, Magnesium Stearate, Modified Corn Starch, Salt, Soy Peptones, Sugar. These complete the product’s ingredient list but are not active constituents.

Interaction report

Prevagen Professional Formula by Quincy Bioscience Drug Interactions

Want to check YOUR meds against Prevagen Professional Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
715Drugs
80 Moderate 635 Minor

Ingredients driving the most interactions

Vitamin D 715

Each ingredient & the kinds of drugs it affects

For each ingredient in Prevagen Professional Formula with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin D8 drug types · 715 drugs

Aluminum

Vitamin D might increase aluminum absorption and toxicity, but this has only been reported in people with renal failure.
The protein that transports calcium across the intestinal wall can also bind and transport aluminum. This protein is stimulated by vitamin D, which may therefore increase aluminum absorption. This mechanism may contribute to increased aluminum levels and toxicity in people with renal failure, when they take vitamin D and aluminum-containing phosphate binders chronically.

Likelihood Probable Evidence B
Atorvastatin (Lipitor)

Vitamin D might reduce absorption of atorvastatin.
A small, low-quality clinical study shows that taking vitamin D reduces levels of atorvastatin and its active metabolites by up to 55%. However, while atorvastatin levels decreased, total cholesterol, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels did not substantially change. Atorvastatin is metabolized in the gut by CYP3A4 enzymes, and researchers theorized that vitamin D might induce CYP3A4, causing reduced levels of atorvastatin. However, this proposed mechanism was not specifically studied.

Likelihood Probable Evidence B
Calcipotriene (Dovonex)

Taking calcipotriene with vitamin D increases the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with vitamin D supplements might increase the risk of hypercalcemia.

Likelihood Probable Evidence D
Digoxin (Lanoxin)

Theoretically, hypercalcemia induced by high-dose vitamin D can increase the risk of arrhythmia from digoxin.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and digoxin concurrently.

Likelihood Possible Evidence D
Diltiazem (Cardizem, Others)

Theoretically, hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of diltiazem for arrhythmia.
High doses of vitamin D can cause hypercalcemia. Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically this could also occur with diltiazem. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and diltiazem concurrently.

Likelihood Probable Evidence B
Thiazide Diuretics

Theoretically, taking thiazide diuretics and high-dose vitamin D can increase the risk of hypercalcemia.
Thiazide diuretics decrease urinary calcium excretion, which could lead to hypercalcemia if vitamin D supplements are taken concurrently. This has been reported in people being treated with vitamin D for hypoparathyroidism, and also in elderly people with normal parathyroid function who were taking a thiazide, vitamin D, and calcium-containing antacids daily.

Likelihood Probable Evidence D
Verapamil (Calan, Others)

Hypercalcemia induced by high-dose vitamin D can reduce the therapeutic effects of verapamil for arrhythmia.
Hypercalcemia due to high doses of vitamin D can reduce the effectiveness of verapamil in atrial fibrillation. Avoid vitamin D doses above the tolerable upper intake level (4000 IU daily for adults) and monitor serum calcium levels in people taking vitamin D and verapamil concurrently.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Vitamin D might induce CYP3A4 enzymes and reduce the bioavailability of CYP3A4 substrates.
There is some concern that vitamin D might induce CYP3A4. In vitro research suggests that vitamin D induces CYP3A4 transcription. Additionally, observational research has found that increased UV light exposure and serum vitamin D levels are associated with decreased serum levels of CYP3A4 substrates such as tacrolimus and sirolimus, while no association between UV light exposure or vitamin D levels and levels of mycophenolic acid, a non-CYP3A4 substrate, was found. A small, low-quality clinical study shows that taking vitamin D reduces levels of the CYP3A4 substrate atorvastatin and its active metabolites by up to 55%; however, the clinical effects of atorvastatin were not reduced. While researchers theorized that vitamin D might induce CYP3A4, this proposed mechanism was not specifically studied.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Prevagen Professional Formula, from the product label.

Quincy Bioscience

See all Quincy Bioscience products
Name
Quincy Bioscience Holding Company, Inc.
City
Madison
State
WI
ZipCode
53717
Phone Number
888.565.5385
Web Address
www.prevagen.com
Pharmacist Counseling Corner

Prevagen Professional Formula by Quincy Bioscience: Common Questions

Does Prevagen Professional Formula by Quincy Bioscience interact with any medications?
Yes. Based on its ingredients, Prevagen Professional Formula has a known interaction with 715 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Prevagen Professional Formula contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take during pregnancy?
The safety data for this product is mixed. Vitamin D at recommended doses is often used in pregnancy under a doctor's guidance, but apoaequorin has not been studied enough in pregnancy—the data advises against it. Talk with your doctor before taking this if you're pregnant or planning to become pregnant.
What's apoaequorin, and does it actually work for memory?
Apoaequorin is a calcium-binding protein from jellyfish included for its claimed effects on memory and thinking. However, we don't have reliable evidence that it works for age-related memory loss, cognitive decline, or insomnia. The evidence rating for all these uses is insufficient.
Can this cause side effects?
Dizziness, headache, and nausea are the most commonly reported side effects with this product. One study also reported mild anxiety. At very high doses, vitamin D can cause toxicity with symptoms like high blood calcium, anemia, and kidney problems.
Is this safe to take while breastfeeding?
Vitamin D is generally considered acceptable while breastfeeding at recommended doses, but apoaequorin should be avoided—there isn't enough safety information. Check with your doctor or pharmacist for personalized advice.
Why is there vitamin D in a memory supplement?
Vitamin D is included because it's essential for calcium absorption and bone health, and some research has explored links between vitamin D status and brain function. However, the primary claim of this product—that apoaequorin helps memory—isn't backed by reliable evidence.
If I take this with my heart medication, will it interfere?
Yes—vitamin D at high doses can raise blood calcium and interfere with how heart rhythm medications work or increase their side effects. Before you start this product, check your exact medications with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Prevagen Professional Formula label
Sources

Sources & How We Checked

Prevagen Professional Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 27 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin D 26 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Tatro DS, ed. Drug Interactions Facts. Facts and Comparisons Inc., St. Louis, MO. 1999.
  3. Koutkia P, Chen TC, Holick MF. Vitamin D intoxication associated with an over-the-counter supplement. N Engl J Med 2001;345:66-7. PubMed
  4. Bar-Or D, Yoel G. Calcium and calciferol antagonize effect of verapamil in atrial fibrillation. Br Med J 1981;282:1585-6.
  5. Demontis R, Leflon A, Fournier A, et al. 1 alpha(OH) vitamin D3 increases plasma aluminum in hemodialyzed patients taking AI(OH)3. Clin Nephrol 1986;26:146-9.
  6. Crowe M, Wollner L, Griffiths RA. Hypercalcemia following vitamin D and thiazide therapy in the elderly. Practitioner 1984;228:312-3.
  7. Parfitt AM. Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism. Ann Intern Med 1972;77:557-63. PubMed
  8. Thiazide diuretics and the risk of osteoporosis. Pharmacist's Letter/Prescriber's Letter 2003;19(11):191105.
  9. Moon J. The role of vitamin D in toxic metal absorption. J Am Coll Nutr 1994;13:559-64.
  10. Demontis R, Reissi D, Noel C, et al. Indirect clinical evidence that 1alphaOH vitamin D<SUB>3</SUB> increases the intestinal absorption of aluminum. Clin Nephrol 1989;31:123-7.
  11. Adler AJ, Berlyne GM. Duodenal aluminum absorption in the rat: effect of vitamin D. Am J Physiol 1985;249:G209-13. PubMed
  12. Schwartz JB. Effects of vitamin D supplementation in atorvastatin-treated patients: A new drug interaction with an unexpected consequence. Clin Pharmacol Ther 2009;85:198-203. PubMed
  13. Dietary reference intakes for calcium and vitamin D. Institute of Medicine, November 30, 2010. Available at: http://www.iom.edu/~/media/Files/Report%20Files/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D/Vitamin%20D%20and%20Calcium%202010%20Repo
  14. Cox KA, Dunn MA. Aluminum toxicity alters the regulation of calbindin-D28k protein and mRNA expression in chick intestine. J Nutr 2001;131:2007-13. PubMed
  15. Escribano, J., Balaguer, A., Pagone, F., Feliu, A., and Roque, I. Figuls. Pharmacological interventions for preventing complications in idiopathic hypercalciuria. Cochrane.Database.Syst.Rev. 2009;(1):CD004754. PubMed
  16. Carlton, S., Clopton, D., and Cappuzzo, K. A. Vitamin D deficiency: appropriate replenishment therapies and the effects of vitamin D toxicity. Consult Pharm 2010;25(3):171-177. PubMed
  17. Wang, H., Xia, N., Yang, Y., and Peng, D. Q. Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials. Lipids Health Dis. 2012;11:42. PubMed
  18. Turner AN, Carr Reese P, Fields KS, Anderson J, Ervin M, Davis JA, Fichorova RN, Roberts MW, Klebanoff MA, Jackson RD. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. Am J Obstet G PubMed
  19. Weiner M, Epstein FH. Signs and symptoms of electrolyte disorders. Yale J Biol Med. 1970;43(2):76-109.
  20. Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. PubMed
  21. Roth DE, Leung M, Mesfin E, Qamar H, Watterworth J, Papp E. Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials. BMJ. 2017;359:j5237. PubMed
  22. Murai IH, Fernandes AL, Sales LP, et al. Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: A randomized clinical trial. JAMA. 2021.
  23. Wang Z, Schuetz EG, Xu Y, Thummel KE. Interplay between vitamin D and the drug metabolizing enzyme CYP3A4. J Steroid Biochem Mol Biol 2013;136:54-8. PubMed
  24. Doyle D, Browne U, Brickley A, Murphy D. Vitamin D-induced hypercalcaemia and acute kidney injury in sarcoidosis. BMJ Case Rep 2023;16(1):e250580. PubMed
  25. Williamson A, Martineau AR, Sheikh A, Jolliffe D, Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev 2023;2(2):CD011511. PubMed
  26. Kinesya E, Santoso D, Gde Arya N, et al. Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN 2023;54:137-143. PubMed

See these in context on the Vitamin D monograph →

Apoaequorin 1 reference
  1. GRAS Notice (GRN) No. 568. U.S. Food and Drug Administration Web site. Available at: http://www.fda.gov/downloads/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/UCM457034.pdf. Accessed September 28, 2015.

See these in context on the Apoaequorin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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