Major interaction on record — check this product against your medications before combining. Based on 1 of 4 ingredients. Check your meds →
Dietary supplement

Pro Clinical Hydroxycut Gummies Mixed Fruit Ingredients & Drug Interactions

by Hydroxycut

Pro Clinical Hydroxycut Gummies Mixed Fruit label
See full label image
Gummy Or Jelly Category: Botanical With Nutrients
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pro Clinical Hydroxycut Gummies Mixed Fruit against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Pro Clinical Hydroxycut Gummies Mixed Fruit is a dietary supplement by Hydroxycut with 4 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 1,331 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pro Clinical Hydroxycut Gummies Mixed Fruit by Hydroxycut

Ask about any prescription or over-the-counter medication and we check it for interactions with Pro Clinical Hydroxycut Gummies Mixed Fruit by Hydroxycut — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pro Clinical Hydroxycut Gummies Mixed Fruit by Hydroxycut

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 10 active ingredients.
  • “Hydroxyprovia (Herb/Botanical)” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Hydroxagen (Herb/Botanical)” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Pro Clinical Hydroxycut(R) Gummies Blend” is a proprietary blend — the label gives one combined amount (160 mg) without saying how much of each component you get.

Pro Clinical Hydroxycut Gummies Mixed Fruit contains 10 active ingredients, the principal ones being calcium (for bone and metabolic support), acerola concentrate (a source of vitamin C), and extracts from goji, bilberry, blueberry, pomegranate, cumin, lady's mantle, wild mint, and olive. The product also includes three proprietary blends—Hydroxyprovia, Hydroxagen, and Pro Clinical Hydroxycut Gummies Blend—whose individual component ingredients are not separately listed here.

The gummies are rounded out with inactive ingredients such as gelatin, corn syrup, and natural flavors.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: weight loss and BMI reduction.
  • We looked for evidence on: Dyslipidemia, Hypertension, Impaired glucose tolerance (prediabetes), Metabolic syndrome, obesity, overweight — and 1 related terms.
  • The strongest evidence on file: Pomegranate is rated "Possibly Effective" for Hypertension (Natural Medicines).
  • Also on file: Calcium is rated "Possibly Effective" for Pregnancy-induced hypertension.
  • Also on file: Pomegranate is rated "Possibly Ineffective" for Diabetes.

The evidence for this product's effectiveness is mixed. Calcium is Likely Effective for preventing osteoporosis and Effective for several other bone and metabolic conditions, though this supplement form is meant to support calcium intake rather than treat deficiency.

Acerola is Possibly Effective for vitamin C deficiency but has Insufficient Reliable Evidence for colds, diarrhea, or atherosclerosis. Blueberry, goji, bilberry, pomegranate, cumin, and olive extracts all carry Insufficient Reliable Evidence or Possibly Ineffective ratings for their commonly claimed uses—things like blood pressure, cholesterol, blood sugar, and cognitive health.

Lady's mantle extract has no established effectiveness in our data. Because the product blends multiple ingredients with limited or unproven benefits, the overall effectiveness for weight management or any other specific health claim is not established in the data we hold.

The evidence, ingredient by ingredient Calcium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended doses, though high intakes can cause problems; common side effects include constipation, diarrhea, and stomach upset. Acerola is generally safe in food amounts, though concentrated supplements are less studied; rare allergic reactions and large-dose gastrointestinal upset have been reported.

Blueberry is generally safe as food, with mild adverse effects like constipation or nausea possible with freeze-dried forms (one trial saw 26% dropout in the first week due to stomach complaints). Goji, bilberry, pomegranate, and cumin are generally well tolerated as foods but have limited long-term safety data in concentrated supplement form.

Lady's mantle is considered low-risk in small amounts, though human data are sparse. A small number of trial participants reported dark-colored stools or tongue discoloration with bilberry.

Concerns have been raised about very high calcium intake potentially increasing prostate cancer risk and cardiovascular risk, though evidence is mixed and these relate to long-term, high dietary intakes rather than typical supplemental amounts.

Side effects, ingredient by ingredient Calcium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 8 of the 10 matched ingredients can interact with medications — Bilberry, Pomegranate, Acerola, Cumin, Alchemilla, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; cancer treatments; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,332 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take HIV integrase inhibitors (dolutegravir, elvitegravir), blood thinners (warfarin), thyroid medication (levothyroxine), chemotherapy drugs, blood pressure medications, diabetes medications, heart rhythm drugs, or statins—these carry the most serious documented risks. The product also interacts with many enzyme-metabolizing drugs; your own pharmacist can help you search your specific medications against the full interaction list on this page.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

If you take HIV medications, warfarin, thyroid medication, blood pressure drugs, or chemotherapy, this product poses real risks and needs review by your own doctor or pharmacist before you start. Even if you don't take those, the sheer number of potential drug interactions here means checking your full medication list against the tool on this page first is a smart move.

Calcium and the herbal extracts offer some nutritional support, but most of the other ingredients lack strong evidence for the benefits they're claimed to deliver. Talk it over with your own healthcare provider to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pro Clinical Hydroxycut Gummies Mixed Fruit, straight from the product label.

Brand Hydroxycut
Barcode (UPC) 631656630022
Net contents 60 Gummie(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 41771
Product type Botanical With Nutrients
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pro Clinical Hydroxycut Gummies Mixed Fruit by Hydroxycut, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummie(s)
Maximum serving Sizes:
2 Gummie(s)
Servings per container
30
UPC/BARCODE
631656630022
IngredientAmount% DV
Calories30 {Calories}--
Total Carbohydrates7 Gram(s)2%
Sugar3 Gram(s)--
Calcium90 mg9%
Acerola concentrate0 NP--
Wild Mint extract0 NP--
Hydroxyprovia (Herb/Botanical)0 NP--
Hydroxagen (Herb/Botanical)0 NP--
Pro Clinical Hydroxycut(R) Gummies Blend160 mg--
Lady's Mantle extract0 NP--
Blueberry0 NP--
Goji extract0 NP--
Bilberry extract0 NP--
Olive extract0 NP--
Cumin extract0 NP--
Pomegranate0 NP--

Other ingredients: Corn Syrup, Maltodextrin, Gelatin, Water, Tricalcium Phosphate, Citric Acid, Lactic Acid, Natural Flavors, Colors, fractionated Coconut Oil, Lo Han fruit concentrate, Ascorbic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Losing Weight Can Taste GREAT!

Lose Weight and Reduce BMI with Clinically Proven Key Ingredients! 1 Average weight loss with key ingredients (lady's mantle, olive extract, cumin extract, wild mint) was 20.94 lbs. in the 12-week study and 16.50 lbs. in the 8-week study. All groups followed a calorie-reduced diet.

NEW AMERICA'S #1 SELLING WEIGHT LOSS SUPPLEMENT BRAND

Lose Weight1

Great Tasting!

Natural Flavors

Patent pending.

Made in the U.S.A. from international ingredients.

For lot no. and expiry date: see bottle.

NEW FLAVOR

Brand IP Statement(s)

ALL-NEW! The 1st Weight Loss Gummies from HYDROXYCUT(R)!

Based on IRI F/D/MX sales data for Hydroxycut(R) caplets.

(C) 2014.

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take 1 serving (2 gummies) approximately 30 minutes before your three main meals. Do not snack after dinner or between meals. Do not exceed 2 gummies in a 4-hour period and/or 6 gummies in a 24-hour period. For best results, use for 8 to 12 weeks in conjunction with a calorie-reduced diet and exercise program. Consume 8 to 10 glasses of water per day. Read the entire label before use and follow directions.

Precautions

WARNING: Not intended for use by persons under 18.

Do not use if pregnant or nursing.

Discontinue use and consult a medical doctor immediately if you experience unusual symptoms.

Consult a medical doctor before use if you have been treated for, or diagnosed with or have a family history of any medical condition, or if you are using any prescription or over-the-counter drug(s), including blood thinners.

Consult a medical doctor before starting any diet or exercise program. Do not exceed recommended serving. Improper use of this product will not improve results and is not advised. Use only as directed. Do not use if packaging has been tampered with.

KEEP OUT OF REACH OF CHILDREN.

Contains Coconut Ingredient.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formulation

Stimulant-Free

FDA Statement of Identity

Dietary Supplement

General

10380US 0714

Seals/Symbols

WEIGHT LOSS KEY INGREDIENTS CLINICALLY PROVEN

Formula

Contains Coconut Ingredient.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pro Clinical Hydroxycut Gummies Mixed Fruit by Hydroxycut label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pro Clinical Hydroxycut Gummies Mixed Fruit label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pro Clinical Hydroxycut Gummies Mixed Fruit by Hydroxycut

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummie(s) Dosage formGummy Or Jelly Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

3 Gram(s) per serving

Calcium

Interacts with
168 drugs
90 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Pro Clinical Hydroxycut(R) Gummies Blend

160 mg per serving
  • › Hydroxyprovia (Herb/Botanical)
  • › Hydroxagen (Herb/Botanical)

Other (inactive) ingredients: Corn Syrup, Maltodextrin, Gelatin, Water, Tricalcium Phosphate, Citric Acid, Lactic Acid, Natural Flavors, Colors, Fractionated Coconut Oil, Lo Han fruit concentrate, Ascorbic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pro Clinical Hydroxycut Gummies Mixed Fruit by Hydroxycut Drug Interactions

Want to check YOUR meds against Pro Clinical Hydroxycut Gummies Mixed Fruit?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,331Drugs
9 Major 1,181 Moderate 141 Minor

Ingredients driving the most interactions

Calcium 168

Individual Drug Interactions

The ingredients in Pro Clinical Hydroxycut Gummies Mixed Fruit interact with 1,331 drugs. Click any drug to see the details.

1 of the 4 ingredients in Pro Clinical Hydroxycut Gummies Mixed Fruit interact with drugs. Each result below shows which ingredient is responsible. Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Pro Clinical Hydroxycut Gummies Mixed Fruit with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pro Clinical Hydroxycut Gummies Mixed Fruit, from the product label.

Hydroxycut

See all Hydroxycut products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
1105 North Market Street, Suite 1330
City
Wilmington
State
DE
ZipCode
19801
Pharmacist Counseling Corner

Pro Clinical Hydroxycut Gummies Mixed Fruit by Hydroxycut: Common Questions

Does Pro Clinical Hydroxycut Gummies Mixed Fruit by Hydroxycut interact with any medications?
Yes. Based on its ingredients, Pro Clinical Hydroxycut Gummies Mixed Fruit has a known interaction with 1,331 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pro Clinical Hydroxycut Gummies Mixed Fruit contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is calcium in this product safe if I take levothyroxine for my thyroid?
No—calcium significantly reduces how your body absorbs levothyroxine, which could make your thyroid medication less effective. The safety data advises taking levothyroxine and calcium at least 4 hours apart. Because this is a gummy you may take with food, timing control is tricky. Talk with your doctor or pharmacist about whether to take this product and how to space it from your thyroid medication.
Can I take these gummies if I'm on warfarin?
You need to check with your doctor or pharmacist first. Both the goji and pomegranate in this product can increase warfarin levels and bleeding risk, and there are documented case reports of this happening. Your provider may need to monitor your bleeding time more closely or adjust your warfarin dose if you take this product.
What's acerola concentrate, and why is it in here?
Acerola is a tropical fruit rich in vitamin C. It's Possibly Effective for vitamin C deficiency, but the evidence for colds, diarrhea, or other common uses is Insufficient. It's included here likely for its antioxidant content, though high-dose vitamin C can theoretically interfere with some chemotherapy drugs and blood thinners.
Are there any common side effects I should know about?
Calcium commonly causes constipation, diarrhea, and stomach upset. Blueberry, bilberry, and pomegranate can cause mild gastrointestinal effects like gas, diarrhea, or nausea, especially at higher doses. One clinical trial of freeze-dried blueberries saw 26% of people drop out in the first week due to stomach complaints. Start with one gummy and see how you tolerate it.
Is this safe to use during pregnancy?
Calcium is Likely Safe in pregnancy if you stay within recommended amounts, and blueberry is Likely Safe as food. However, goji should be avoided in pregnancy due to limited safety data and traditional reports of uterine effects. Lady's mantle is advised against in pregnancy because there isn't enough safety information. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
Can I take this if I'm taking diabetes medication?
Possibly, but you'll need to check with your doctor first. Both blueberry and cumin theoretically increase the risk of low blood sugar (hypoglycemia) when combined with diabetes drugs, and goji may do the same. Your doctor may need to monitor your blood sugar more closely or adjust your medication if you add this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pro Clinical Hydroxycut Gummies Mixed Fruit label
Go deeper

The Full Monographs Behind Pro Clinical Hydroxycut Gummies Mixed Fruit’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph →
Sources

Sources & How We Checked

Pro Clinical Hydroxycut Gummies Mixed Fruit's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 159 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
  14. Moser LR, Smythe MA, Tisdale JE. The use of calcium salts in the prevention and management of verapamil-induced hypotension. Ann Pharmacother 2000;34:622-9. PubMed
  15. Singh N, Singh PN, Hershman JM. Effect of calcium carbonate on the absorption of levothyroxine. JAMA 2000;283:2822-5. PubMed
  16. Kahela P, Anttila M, Tikkanen R, Sundquist H. Effect of food, food constituents and fluid volume on the bioavailability of sotalol. Acta Pharmacol Toxicol (Copenh) 1979;44:7-12.. PubMed
  17. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
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Acerola 20 references
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Wild Mint 2 references
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Alchemilla 1 reference
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Blueberry 7 references
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Goji 14 references
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Bilberry 14 references
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Olive 2 references
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Cumin 10 references
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Pomegranate 27 references
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  24. Hanley MJ, Masse G, Harmatz JS, et al. Pomegranate juice and pomegranate extract do not impair oral clearance of flurbiprofen in human volunteers: divergence from in vitro results. Clin Pharmacol Ther 2012;92(5):651-7. PubMed
  25. Paller CJ, Ye X, Wozniak PJ, et al. A randomized phase II study of pomegranate extract for men with rising PSA following initial therapy for localized prostate cancer. Prostate Cancer Prostatic Dis 2013;16(1):50-5. PubMed
  26. Park SJ, Yeo CW, Shim EJ, et al. Pomegranate juice does not affect the disposition of simvastatin in healthy subjects. Eur J Drug Metab Pharmacokinet 2016;41(4):339-44. PubMed
  27. Ross MM, Cherkerzian S, Mikulis ND, et al. A randomized controlled trial investigating the impact of maternal dietary supplementation with pomegranate juice on brain injury in infants with IUGR. Sci Rep. 2021;11(1):3569. PubMed

See these in context on the Pomegranate monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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