Major interaction on record — check this product against your medications before combining. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Pro Clinical Hydroxycut Rapid Release Caplets Ingredients & Drug Interactions

by Hydroxycut

Pro Clinical Hydroxycut Rapid Release Caplets label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pro Clinical Hydroxycut Rapid Release Caplets against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Pro Clinical Hydroxycut Rapid Release Caplets is a dietary supplement by Hydroxycut with 3 active ingredients. Its ingredients are commonly taken for bone health and osteoporosis prevention, dietary calcium deficiency, heartburn relief (calcium carbonate antacids).Based on those ingredients, 971 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pro Clinical Hydroxycut Rapid Release Caplets by Hydroxycut

Ask about any prescription or over-the-counter medication and we check it for interactions with Pro Clinical Hydroxycut Rapid Release Caplets by Hydroxycut — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Pro Clinical Hydroxycut Rapid Release Caplets by Hydroxycut

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 8 active ingredients.
  • “Weight-Loss Plus Matrix” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Hydroxycut Blend” is a proprietary blend — the label gives one combined amount (441 mg) without saying how much of each component you get.
  • “HydroxyBoost” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Pro Clinical Hydroxycut Rapid Release Caplets contains 8 ingredients. The active ones are calcium (for bone and metabolic health), maqui berry extract (a fruit antioxidant), caffeine (a stimulant for energy and alertness), papaya (fruit enzymes and nutrients), amla extract, also called Indian gooseberry (an antioxidant fruit), and saffron extract (a spice used traditionally for various conditions).

The product also includes three proprietary blends—Hydroxycut Blend, HydroxyBoost, and Caffeine Anhydrous—whose individual components we cannot list here but are detailed in the full label. Inactive ingredients (binders, fillers, and capsule material) include microcrystalline cellulose, dicalcium phosphate, starch, stearic acid, croscarmellose sodium, magnesium stearate, and silicon dioxide.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: weight loss and metabolism boost.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, body composition, metabolic rate.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.
  • Also on file: Saffron is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Exercise-induced muscle soreness.

The evidence for this product's ingredients is mixed. Calcium is effective for bone health (osteoporosis), low blood calcium (hypocalcemia), high potassium (hyperkalemia), and kidney disease, and likely effective for osteoporosis prevention.

Caffeine is effective for newborn breathing problems and possibly effective for mental alertness and athletic performance. For the other active ingredients—maqui, papaya, amla extract, and saffron—the evidence we hold is either insufficient to rate or only possibly effective.

Maqui shows insufficient evidence for blood sugar control or dry eye; papaya shows insufficient evidence for skin aging, hair loss, colorectal cancer, or diabetes; amla shows possibly effective evidence for GERD and cholesterol but insufficient evidence for hair loss; and saffron shows possibly effective evidence for nerve pain from chemotherapy and Alzheimer's disease. The effectiveness of the proprietary blends is not detailed in our data.

The evidence, ingredient by ingredient Calcium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended doses, though high amounts can cause constipation, diarrhea, belching, or stomach upset. Very high doses raise theoretical concerns about kidney stones and a small risk of increased prostate cancer or heart disease, though results are mixed.

Caffeine in moderate doses is generally well tolerated but can cause anxiety, insomnia, jitteriness, tremor, nausea, headaches, and rarely stroke; high doses carry risk in pregnancy. Papaya fruit is safe as food, but unripe papaya and papaya latex should be avoided; supplements are less well studied.

Maqui, amla extract, and saffron are not well studied as supplements—maqui and amla should be avoided in supplement amounts, while saffron can cause nausea, vomiting, sedation, and rare anaphylaxis. Blackberry fruit is safe; medicinal supplements lack data.

During pregnancy, calcium and papaya are likely safe (though large papaya amounts are best avoided), caffeine is possibly safe but should be limited, and saffron should be avoided. During breastfeeding, calcium and papaya are likely safe, caffeine in small amounts is usually acceptable, while amla and saffron lack sufficient safety information.

Side effects, ingredient by ingredient Calcium

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Papaya, Calcium, Indian Gooseberry, Saffron, Caffeine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 971 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your doctor or pharmacist if you take any of the following: HIV integrase inhibitors (dolutegravir, elvitegravir), ephedrine or similar stimulants, intravenous ceftriaxone, blood thinners or antiplatelet drugs (warfarin, clopidogrel, aspirin), diabetes medications, levothyroxine (thyroid hormone), heart or blood pressure drugs (sotalol, diltiazem, amiodarone, antihypertensives), calcipotriene (psoriasis treatment), sedatives or central nervous system depressants, cimetidine, quinolone antibiotics, phenobarbital, or carbamazepine. These are the most serious risks; caffeine and saffron in particular may amplify each other's effects on the nervous system.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is built around caffeine and calcium with several fruit extracts added. It may appeal to people seeking energy support and bone health, but the interaction profile is substantial—especially if you take HIV drugs, blood thinners, diabetes medications, heart or blood pressure drugs, or stimulant-containing products.

Before starting, review all your current medications with your own doctor or pharmacist, because timing and dosing changes may be necessary. Do not use this product without that conversation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pro Clinical Hydroxycut Rapid Release Caplets, straight from the product label.

Brand Hydroxycut
Barcode (UPC) 631656601930
Net contents 72 Rapid Release Caplet(s)
Market status On market
Date entered into DSLD Aug 23, 2019
DSLD ID 206107
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pro Clinical Hydroxycut Rapid Release Caplets by Hydroxycut, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Rapid Release Caplet(s)
Maximum serving Sizes:
2 Rapid Release Caplet(s)
Servings per container
36
UPC/BARCODE
631656601930
IngredientAmount% DV
Calcium145 mg15%
Maqui0 NP--
Caffeine200 mg--
Papaya0 NP--
Robusta Coffee extract0 NP--
Blackberry0 NP--
Weight-Loss Plus Matrix0 NP--
Amla extract0 NP--
Saffron extract0 NP--
Hydroxycut Blend441 mg--
HydroxyBoost0 NP--
Caffeine Anhydrous0 NP--

Other ingredients: Microcrystalline Cellulose, Dicalcium Phosphate Dihydrate, pregelatinized Starch, Stearic Acid, Coating, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

America's #1 selling weight loss supplement brand

Over 100 million bottles sold

Advanced weight loss Boost metabolism Increase energy

Based on sales of Hydroxycut branded products 1995 to present. Based on AC Nielsen FDMx sales data for Hydroxycut caplets.

Made in the U.S.A. from international ingredients.

Lose weight fast. In study #1, subjects taking the key ingredient in Hydroxycut (C. canephora robusta) for 60 days lost on average 10.95 lbs. versus the placebo group, which lost and average of 5.40 lbs. Both groups followed a low-calorie diet. In a separate 8-week study, subjects taking C. canephora robusta lost an average of 3.7 lbs. versus the placebo, who lost 1.25 lbs. Both groups followed a calorie-reduced diet and performed moderate exercise.

#1 in America - It really works! Thank you, America, for making Hydroxycut America's #1 selling weight loss supplement brand! Millions from coast to coast have chosen Hydroxcyut to help them reach their weight loss goals. Quality and purity have been the focus for Hydroxycut for the past 20 years. The result is over 95 million bottles sold. Hydroxycut really works!

Mix & Match your Hydroxycut Whether you prefer to take Hydroxycut as a caplet, gummy, or as a delicious drink, there is a mix and match option to help you lose weight your way.

Seals/Symbols

Scientifically researched weight loss key ingredient

Triple check 100% quality commitment science Quality Purity

FDA Statement of Identity

Dietary Supplement

Precautions

Warning: Not intended for use by persons under 18.

Do not use if pregnant or nursing.

Discontinue use and consult a medical doctor if you experience unusual symptoms.

Consult a medical doctor before use if you have been treated for or diagnosed with, or have a family history of any medical condition, or if you are using any prescription or over-the-counter drug(s).

One serving (2 caplets) of this product contains up to as much caffeine as 2.5 cups of coffee. Caffeine sensitive individuals may experience symptoms including (but not limited to) restlessness, nervousness, tremors, headaches, anxiety, palpitations, increased heart rate or difficulty sleeping.

Do not combine with other sources of caffeine. Consult a medical doctor before starting any diet or exercise program. Do not exceed recommended serving.

Improper use of this product will not improve results and is not advised.

Use only as directed.

Keep out of reach of children.

Do not use if packaging has been tampered with.

Formula

One serving (2 caplets) of this product contains up to as much caffeine as 2.5 cups of coffee.

Increase energy for your busy lifestyle Scientifically researched ingredient caffeine anhydrous (1,3,7-trimethylxanthine) is shown to boost your metabolism and provide fast-acting energy so yo can keep up with your busy lifestyle.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

New advanced formula- More convenient! Hydroxycut provides powerful weight lose in a convenient, twice-a-day advanced formula. Now you need only two servings per day versus three servings of the previous formula.

To assess individual tolerance, for the first three days, start with one (1) caplet, taken with a glass of water two (2) times daily, approximately 30 to 60 minutes before your two main meals. For days 4 and beyond, follow the chart below. Do not exceed two (2) caplets in a 4-hour period and/or four (4) caplets in a 24-hour period. DO not take within 5 hours of bedtime. For best results use Hydroxycut for 60 days in conjunction with a calorie-reduced diet and regular exercise program. Consume 8 to 10 glasses of water per day. Read the entire label before use and follow directions. Day 1 to 3 1 caplet, 2x daily day 4 & beyond 2 caplets, 2x daily

Brand IP Statement(s)

2015

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pro Clinical Hydroxycut Rapid Release Caplets by Hydroxycut label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pro Clinical Hydroxycut Rapid Release Caplets label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pro Clinical Hydroxycut Rapid Release Caplets by Hydroxycut

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Rapid Release Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container36 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Calcium

Interacts with
168 drugs
145 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Hydroxycut Blend

441 mg per serving
  • › Weight-Loss Plus Matrix
  • › HydroxyBoost

Other (inactive) ingredients: Microcrystalline Cellulose, Dicalcium Phosphate Dihydrate, Pregelatinized Starch, Stearic Acid, Coating, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pro Clinical Hydroxycut Rapid Release Caplets by Hydroxycut Drug Interactions

Want to check YOUR meds against Pro Clinical Hydroxycut Rapid Release Caplets?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
971Drugs
15 Major 883 Moderate 73 Minor

Ingredients driving the most interactions

Calcium 168

Individual Drug Interactions

The ingredients in Pro Clinical Hydroxycut Rapid Release Caplets interact with 971 drugs. Click any drug to see the details.

1 of the 3 ingredients in Pro Clinical Hydroxycut Rapid Release Caplets interact with drugs. Each result below shows which ingredient is responsible. Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Pro Clinical Hydroxycut Rapid Release Caplets with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pro Clinical Hydroxycut Rapid Release Caplets, from the product label.

Hydroxycut

See all Hydroxycut products
Name
Iovate Health Science U.S.A, Inc.
Street Address
1105 North Market Street Suite 1330
City
Wilmington
State
DE
ZipCode
19801
Pharmacist Counseling Corner

Pro Clinical Hydroxycut Rapid Release Caplets by Hydroxycut: Common Questions

Does Pro Clinical Hydroxycut Rapid Release Caplets by Hydroxycut interact with any medications?
Yes. Based on its ingredients, Pro Clinical Hydroxycut Rapid Release Caplets has a known interaction with 971 medications, including 15 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pro Clinical Hydroxycut Rapid Release Caplets contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Calcium and papaya in this product are likely safe in pregnancy in normal amounts, and caffeine is possibly safe if limited. However, saffron should be avoided in supplement doses during pregnancy. Talk with your doctor or pharmacist about whether this product is right for you and your pregnancy.
Can I take this while breastfeeding?
Calcium and papaya are likely safe, and a small amount of caffeine typically passes into breast milk in amounts usually considered acceptable. However, amla extract and saffron lack enough safety information for breastfeeding. Speak with your pharmacist or doctor before using this product while nursing.
What does calcium do in this product?
Calcium supports bone health and is effective for preventing and treating weak bones (osteoporosis), low blood calcium, and high potassium levels. It's also used in kidney disease support.
Will this help me lose weight?
The product name suggests weight loss, but the effectiveness of the active ingredients for weight loss is not established in our data. The proprietary blends' individual ingredients and claimed effects are not detailed here.
What's the most common side effect I might notice?
From caffeine, you might experience jitteriness, anxiety, insomnia, or headache. From calcium, constipation or stomach upset is common. From saffron or papaya, nausea is possible. Start with a lower dose if you're new to high-caffeine products.
Is saffron extract safe at the dose in this product?
Saffron is likely safe in food amounts but less well studied at supplement doses. The exact amount of saffron extract in this product isn't clear from the label, so ask your pharmacist about the dose and whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pro Clinical Hydroxycut Rapid Release Caplets is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pro Clinical Hydroxycut Rapid Release Caplets label
Go deeper

The Full Monographs Behind Pro Clinical Hydroxycut Rapid Release Caplets’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph →
Sources

Sources & How We Checked

Pro Clinical Hydroxycut Rapid Release Caplets's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 344 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Calcium 62 references
  1. Shils M, Olson A, Shike M. Modern Nutrition in Health and Disease. 8th ed. Philadelphia, PA: Lea and Febiger, 1994.
  2. Hernandez-Avila M, Gonzalez-Cossio T, Hernandez-Avila JE, et al. Dietary calcium supplements to lower blood lead levels in lactating women: a randomized placebo-controlled trial. Epidemiology 2003;14:206-12.. PubMed
  3. Thys-Jacobs S, Ceccarelli S, Bierman A, et al. Calcium supplementation in premenstrual syndrome: a randomized crossover trial. J Gen Intern Med 1989;4:183-9. PubMed
  4. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  5. Clemens JD, Feinstein AR. Calcium carbonate and constipation: a historical review of medical mythopoeia. Gastroenterology 1977;72:957-61. DOI
  6. Saunders D, Sillery J, Chapman R. Effect of calcium carbonate and aluminum hydroxide on human intestinal function. Dig Dis Sci 1988;33:409-13. PubMed
  7. Friedman PA, Bushinsky DA. Diuretic effects on calcium metabolism. Semin Nephrol 1999;19:551-6.
  8. Koo WK, Walters JC, Esterlitz J, et al. Maternal calcium supplementation and fetal bone mineralization. Obstet Gynecol 1999;94:577-82. DOI
  9. Raman L, Rajalakshmi K, Krishnamachari KAVR, et al. Effect of calcium supplementation to undernourished mothers during pregnancy on the bone density of the neonates. Am J Clin Nutr 1978; 31:466-9. DOI
  10. Murry JJ, Healy MD. Drug-mineral interactions: a new responsibility for the hospital dietician. J Am Diet Assoc 1991;91:66-73.
  11. Chan JM, Giovannucci E, Andersson SO, et al. Dairy products, calcium, phosphorous, vitamin D, and risk of prostate cancer. Cancer Causes Control 1998;9:559-66.
  12. Butner LE, Fulco PP, Feldman G, et al. Calcium carbonate-induced hypothyroidism. Ann Intern Med 2000:132:595. PubMed
  13. Schneyer CR. Calcium carbonate and reduction of levothyroxine efficacy. JAMA 1998;279:750. PubMed
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Maqui 3 references
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See these in context on the Maqui monograph →

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Papaya 14 references
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Blackberry 1 reference
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Indian Gooseberry 6 references
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Saffron 22 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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