Major interaction on record — check this product against your medications before combining. Based on 6 of 9 ingredients. Check your meds →
Dietary supplement

Hydroxycut +Women Ingredients & Drug Interactions

by Hydroxycut

Hydroxycut +Women label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Hydroxycut +Women against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Hydroxycut +Women is a dietary supplement by Hydroxycut with 9 active ingredients. Its ingredients are commonly taken for hair growth and thinning hair, brittle nails, skin health.Based on those ingredients, 826 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are L-Cysteine, Iron, Folic Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Hydroxycut +Women by Hydroxycut

Ask about any prescription or over-the-counter medication and we check it for interactions with Hydroxycut +Women by Hydroxycut — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Hydroxycut +Women by Hydroxycut

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 13 active ingredients.
  • “Folate” is listed as a grouped ingredient — the label gives one combined amount (340 mcg DFE) without saying how much of each component you get.
  • “Caffeine Anhydrous” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “Robusta Coffee bean extract” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Hydroxycut +Women contains 13 ingredients total. The active ones are folic acid (a B vitamin), silicon dioxide (a mineral form), biotin (a B vitamin), kiwi, caffeine, prickly pear leaf extract, iron, L-methionine (an amino acid), L-cysteine (an amino acid), and avocado oil.

The product also contains several proprietary blends (Hydroxycut + Women Complex, HydroxyBoost Blend, ProDefine Blend, and Radiance Support Blend) whose individual components are listed separately. No inactive fillers or binders are listed.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: weight loss and metabolism support.
  • We looked for evidence on: Athletic performance, Cognitive function, Body weight management, Energy and fatigue, Metabolic rate.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Iron is rated "Possibly Effective" for Cognitive function.
  • Also on file: Iron is rated "Possibly Ineffective" for Athletic performance.

The evidence for this product is mixed and varies by ingredient. Folic acid is effective for treating folate deficiency and likely effective for preventing neural tube birth defects and reducing methotrexate toxicity; it's possibly effective for depression and cognitive impairment.

Silicon dioxide is possibly effective for bone health. Biotin is likely effective for biotin deficiency.

Iron is effective for iron-deficiency anemia and pregnancy-related iron deficiency. L-methionine is possibly effective for neural tube birth defects.

Caffeine is effective for neonatal apnea and postoperative headache, and likely effective for mental alertness and athletic performance. For kiwi, prickly pear leaf extract, L-cysteine, and avocado oil, the evidence we hold either shows insufficient data or ratings that don't support their use for specific conditions.

We have no effectiveness data on file for collagen, chlorogenic acid, mango, or the proprietary blends.

The evidence, ingredient by ingredient Biotin Folic Acid Iron Silicon Methionine L-cysteine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 10 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 10 of 10.
  • General safety write-ups exist for 10 of 10.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated at recommended doses. Folic acid is recommended during pregnancy at standard prenatal doses to help prevent birth defects and is considered safe while breastfeeding.

Biotin, L-methionine, and L-cysteine are likely safe in pregnancy. Silicon dioxide should be avoided in pregnancy and breastfeeding due to insufficient safety data.

Prickly pear leaf extract should also be avoided at supplement doses in pregnancy and breastfeeding. Avocado oil lacks pregnancy/lactation safety data.

Caffeine carries caution in pregnancy and breastfeeding — high amounts may pose risks and smaller amounts pass into breast milk. At higher doses, folic acid (15 mg daily or more) can cause nausea, confusion, sleep problems, and impaired judgment.

Iron commonly causes constipation, diarrhea, nausea, and abdominal pain. Caffeine frequently causes anxiety, insomnia, restlessness, and tremor.

Kiwi can trigger allergic reactions including mouth and throat swelling, and rarely anaphylaxis in sensitive individuals. Prickly pear leaf extract can cause mild diarrhea, nausea, and abdominal fullness.

Side effects, ingredient by ingredient Biotin Folic Acid Iron Silicon Methionine L-cysteine

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 10 matched ingredients can interact with medications — Prickly Pear Cactus, Avocado, Iron, Kiwi, Caffeine, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium; Parkinson's medications.
  • For scale: 813 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking Hydroxycut +Women if you're on any of these: seizure medications (phenobarbital, phenytoin, carbamazepine, primidone), cancer drugs (methotrexate, capecitabine, 5-fluorouracil), blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), diabetes medications, blood pressure drugs, thyroid hormone (levothyroxine), Parkinson's medication (levodopa), bone medications (bisphosphonates), antipsychotics (clozapine), tetracycline or quinolone antibiotics, the antiparasitic pyrimethamine, or any drug that slow caffeine clearance. The Major-severity caffeine–ephedrine interaction is the most serious concern.

Additionally, inform your provider of folic acid use if you're being treated with methotrexate or any seizure medication.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is intended as a multi-ingredient supplement and should not be started without checking your medications first — especially if you take seizure drugs, cancer treatments, blood thinners, diabetes drugs, blood pressure medications, or certain antibiotics. The caffeine content is notable and carries its own risks with some common medications.

If you're on any prescription, run it through our interaction checker below. Talk to your pharmacist before starting, particularly if you're pregnant, breastfeeding, or managing any chronic condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 10 of 13 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Hydroxycut +Women, straight from the product label.

Brand Hydroxycut
Net contents 60 Rapid-Release Liquid Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 325594
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Hydroxycut +Women by Hydroxycut, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Rapid-Release Liquid Capsule(s)
Maximum serving Sizes:
2 Rapid-Release Liquid Capsule(s)
Servings per container
30
IngredientAmount% DV
Calories10 Calorie(s)--
Folic Acid200 mg--
Silicon Dioxide0 NP--
Biotin300 mcg1000%
Total Fat1 Gram(s)1%
Folate340 mcg DFE85%
Caffeine Anhydrous0 NP--
Kiwi0 NP--
Caffeine150 mg--
Collagen, Hydrolyzed0 NP--
Prickly Pear leaf extract0 NP--
Iron2 mg11%
Chlorogenic Acid0 NP--
Robusta Coffee bean extract0 NP--
Mango0 NP--
L-Methionine0 NP--
Hydroxycut + Women Complex430.8 mg--
HydroxyBoost Blend0 NP--
Avocado Oil0 NP--
ProDefine Blend0 NP--
Radiance Support Blend0 NP--
L-Cysteine0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

America's #1 selling weight loss supplement brand

Simulant scale

Formula

Designed with Biotin, Collagen, Folate & Iron

150mg caffeine

Formulation

Burns calories Boost metabolism

Scientifically researched weight loss key ingredient

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Hydroxycut +Women by Hydroxycut label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Hydroxycut +Women label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Hydroxycut +Women by Hydroxycut

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Rapid-Release Liquid Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Biotin

No known
interactions
300 mcg per serving

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get...

Biotin monograph & interactions

Folate

340 mcg DFE per serving

Iron

Interacts with
80 drugs
2 mg per serving Form: Ferrous Gluconate

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventin...

Iron monograph & interactions

Hydroxycut + Women Complex

430.8 mg per serving
  • › HydroxyBoost Blend
  • › ProDefine Blend

Radiance Support Blend

0 NP per serving
Interaction report

Hydroxycut +Women by Hydroxycut Drug Interactions

Want to check YOUR meds against Hydroxycut +Women?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
826Drugs
8 Major 737 Moderate 81 Minor

Ingredients driving the most interactions

L-Cysteine 86
Iron 80
Folic Acid 40

Individual Drug Interactions

The ingredients in Hydroxycut +Women interact with 826 drugs. Click any drug to see the details.

3 of the 9 ingredients in Hydroxycut +Women interact with drugs. Each result below shows which ingredient is responsible. L-Cysteine Iron Folic Acid

Each ingredient & the kinds of drugs it affects

For each ingredient in Hydroxycut +Women with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Cysteine1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking L-cysteine supplements with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that L-cysteine can have hypoglycemic effects.

Likelihood Possible Evidence D
L-Cysteine full monograph & interactions

Iron13 drug types · 80 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Iron might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and iron can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, iron containing products.

Likelihood Probable Evidence D
Bisphosphonates

Iron reduces the absorption of bisphosphonates.
Advise patients that doses of bisphosphonates should be separated by at least two hours from doses of all other medications, including supplements such as iron. Divalent cations, including iron, can decrease absorption of bisphosphonates by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Denosumab (Prolia, Others)

Administration of intravenous iron within one month of denosumab administration might increase the risk of severe hypophosphatemia and hypocalcemia.
A case of severe hypocalcemia (albumin corrected calcium 6.88 mg/dL, ionized calcium 3.68 mg/dL) and hypophosphatemia (<0.5 mg/dL) with respiratory acidosis, QT interval prolongation, and nonsustained ventricular tachycardia was reported in a 76-year-old male who had received an iron polymaltose infusion within 2 weeks of a subcutaneous injection of denosumab. Serum parathyroid hormone was also elevated (348 pg/mL). Subsequent iron infusions with iron polymaltose and ferric carboxymaltose were followed by transient hypophosphatemia, but without hypocalcemia. Additionally, a literature review describes 6 additional cases of hypophosphatemia and hypocalcemia in patients 52-92 years of age who had been administered intravenous iron as either ferric carboxymaltose or iron polymaltose and subcutaneous denosumab within 1-4 weeks of each other.

Likelihood Possible Evidence D
Dolutegravir (Tivicay)

Iron might decrease dolutegravir levels by reducing its absorption.
Advise patients to take dolutegravir at least 2 hours before or 6 hours after taking iron. Pharmacokinetic research shows that iron can decrease the absorption of dolutegravir from the gastrointestinal tract through chelation. When taken under fasting conditions, a single dose of ferrous fumarate 324 mg orally along with dolutegravir 50 mg reduces overall exposure to dolutegravir by 54%.

Likelihood Probable Evidence B
Integrase Inhibitors

Theoretically, taking iron along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Iron is a divalent cation. There is concern that iron may decrease the absorption of integrase inhibitors from the gastrointestinal tract through chelation. One pharmacokinetic study shows that iron can decrease blood levels of the specific integrase inhibitor dolutegravir through chelation. Also, other pharmacokinetic research shows that other divalent cations such as calcium can decrease the absorption and levels of some integrase inhibitors through chelation.

Likelihood Possible Evidence D
Levodopa

Iron might decrease levodopa levels by reducing its absorption.
Advise patients to separate doses of levodopa and iron as much as possible. There is some evidence in healthy people that iron forms chelates with levodopa, reducing the amount of levodopa absorbed by around 50%. The clinical significance of this hasn't been determined.

Likelihood Probable Evidence B
Levothyroxine (Synthroid, Others)

Iron might decrease levothyroxine levels by reducing its absorption.
Advise patients to separate levothyroxine and iron doses by at least 2 hours. Iron can decrease the absorption and efficacy of levothyroxine by forming insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence B
Methyldopa (Aldomet)

Iron might decrease methyldopa levels by reducing its absorption.
Advise patients to separate methyldopa and iron doses by at least 2 hours. Iron can decrease the absorption of methyldopa from the gastrointestinal tract through chelation, resulting in increases in blood pressure.

Likelihood Probable Evidence B
Mycophenolate Mofetil (Cellcept)

Theoretically, iron might decrease mycophenolate mofetil levels by reducing its absorption.
Advise patients to take iron 4-6 hours before, or 2 hours after, mycophenolate mofetil. It has been suggested that a decrease of absorption is possible, probably by forming nonabsorbable chelates. However, mycophenolate pharmacokinetics are not affected by iron supplementation in available clinical research.

Likelihood Unlikely Evidence D
Penicillamine (Cuprimine, Depen)

Iron might decrease penicillamine levels by reducing its absorption.
Advise patients to separate penicillamine and iron doses by at least 2 hours. Oral iron supplements can reduce absorption of penicillamine by 30% to 70%, probably due to chelate formation. In people with Wilson's disease, this interaction has led to reduced efficacy of penicillamine.

Likelihood Probable Evidence D
Quinolone Antibiotics

Iron might decrease levels of quinolone antibiotics by reducing their absorption.
Advise patients to separate quinolone antibiotics and iron doses by at least 2 hours. Iron decreases the absorption of quinolones due to formation of insoluble complexes in the gastrointestinal tract.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Iron might decrease levels of tetracycline antibiotics by reducing their absorption.
Advise patients to take iron at least 2 hours before or 4 hours after tetracycline antibiotics. Concomitant use can decrease absorption of tetracycline antibiotics from the gastrointestinal tract by 50% to 90%.

Likelihood Probable Evidence D
Chloramphenicol

Theoretically, taking chloramphenicol with iron might reduce the response to iron therapy in iron deficiency anemia.
Chloramphenicol interferes with erythrocyte maturation. However, since chloramphenicol isn't usually taken for prolonged periods, this isn't likely to be clinically significant.

Likelihood Unlikely Evidence D
Iron full monograph & interactions

Folic Acid7 drug types · 40 drugs

5-Fluorouracil

Theoretically, high doses of folic acid might increase the toxicity of 5-fluorouracil.
Increases in gastrointestinal side effects of 5-fluorouracil, such as stomatitis and diarrhea, have been described in two clinical studies when leucovorin, a form of folic acid, was administered with 5-fluorouracil.

Likelihood Possible Evidence D
Capecitabine (Xeloda)

Use of high-dose folic acid might contribute to capecitabine toxicity.
Clinical research suggests that higher serum folate levels are associated with an increased risk for moderate or severe toxicity during capecitabine-based treatment for colorectal cancer. Additionally, in one case report, taking folic acid 15 mg daily might have contributed to increased toxicity, including severe diarrhea, vomiting, edema, hand-foot syndrome, and eventually death, in a patient prescribed capecitabine.

Likelihood Possible Evidence D
Methotrexate (Trexall, Others)

Folic acid might reduce the efficacy of methotrexate as a cancer treatment when given concurrently.
Methotrexate exerts its cytotoxic effects by preventing conversion of folic acid to the active form needed by cells. There is some evidence that folic acid supplements reduce the efficacy of methotrexate in the treatment of acute lymphoblastic leukemia, and theoretically they could reduce its efficacy in the treatment of other cancers. Advise cancer patients to consult their oncologist before using folic acid supplements. In patients treated with long-term, low-dose methotrexate for rheumatoid arthritis (RA) or psoriasis, folic acid supplements can reduce the incidence of side effects, without reducing efficacy.

Likelihood Probable Evidence B
Phenobarbital (Luminal)

Folic acid might have antagonistic effects on phenobarbital and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of phenobarbital and worsening seizure control. Monitor closely for increased seizure activity.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Folic acid might reduce serum levels of phenytoin in some patients.
Folic acid may be a cofactor in phenytoin metabolism. Folic acid, in doses of 1 mg daily or more, can reduce serum levels of phenytoin in some patients. Increases in seizure frequency have been reported. If folic acid supplements are added to established phenytoin therapy, monitor serum phenytoin levels closely. If phenytoin and folic acid are started at the same time and continued together, adverse changes in phenytoin pharmacokinetics are avoided. Note that phenytoin also reduces serum folate levels.

Likelihood Probable Evidence B
Primidone (Mysoline)

Folic acid might have antagonistic effects on primidone and increase the risk for seizures.
Folic acid can have direct convulsant activity in some people, reversing the effects of primidone and worsening seizure control. Monitor closely for increased seizure activity. Note that primidone also reduces serum folate levels.

Likelihood Probable Evidence B
Pyrimethamine (Daraprim)

Folic acid might antagonize the effects of pyrimethamine.
Folic acid can antagonize the antiparasitic effects of pyrimethamine against toxoplasmosis and Pneumocystis carinii pneumonia. Folic acid doesn't antagonize the effects of pyrimethamine in the treatment of malaria, because malarial parasites cannot use exogenous folic acid. Use folinic acid as an alternative to folic acid when indicated.

Likelihood Probable Evidence D
Folic Acid full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Hydroxycut +Women, from the product label.

Hydroxycut

See all Hydroxycut products
Name
Hydroxycut
Pharmacist Counseling Corner

Hydroxycut +Women by Hydroxycut: Common Questions

Does Hydroxycut +Women by Hydroxycut interact with any medications?
Yes. Based on its ingredients, Hydroxycut +Women has a known interaction with 826 medications, including 8 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Hydroxycut +Women contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me lose weight?
The product facts don't provide effectiveness data for weight loss. We'd need to see clinical evidence specific to this formula to answer that. Talk with your pharmacist or doctor about whether it's right for your goals.
Is the caffeine in this going to keep me awake?
Caffeine commonly causes insomnia, restlessness, anxiety, and sleep disturbances in some people, especially at higher doses. If you're sensitive to caffeine or take it late in the day, sleep problems are a real risk. Check the label for the exact caffeine amount.
Can I take this while pregnant?
Some ingredients are recommended or likely safe in pregnancy (folic acid, biotin, L-methionine), but others should be avoided or need caution (silicon dioxide, prickly pear leaf extract, and caffeine in high amounts). Because this is a multi-ingredient product and pregnancy requires personalized guidance, please talk to your obstetrician or midwife before starting it.
Can I take this if I'm breastfeeding?
Caffeine passes into breast milk and can affect your baby. Silicon dioxide and prickly pear leaf extract also lack good safety data while breastfeeding. Several ingredients are considered safe or likely safe at normal doses (folic acid, biotin, iron, L-methionine). Check with your doctor or pharmacist before starting, and discuss safe amounts of caffeine.
Are there any side effects I should watch for?
Common ones include caffeine-related effects (jitteriness, anxiety, insomnia), iron's digestive effects (constipation, diarrhea, nausea), and nausea or abdominal discomfort from other ingredients. At higher folic acid doses, confusion and sleep problems can occur. If you're allergic to kiwi or latex, be cautious — kiwi can trigger allergic reactions including mouth swelling and rarely anaphylaxis.
Is it safe to use this long-term?
Most individual ingredients are generally well tolerated, but the product facts note that long-term safety isn't well studied for some of them, especially silicon dioxide and the proprietary blends. For any supplement used regularly over months or years, discuss it with your pharmacist or doctor to make sure it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Hydroxycut +Women label
Go deeper

The Full Monographs Behind Hydroxycut +Women’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Biotin

Biotin (vitamin B7) is a water-soluble vitamin your body needs to turn food into energy and to support healthy hair, skin, and nails. Most people get plenty from a normal diet, and true defi...

Read the full Biotin monograph → Herb & supplement monograph

Folic Acid

Interacts with 40 drugs

Folic acid is the man-made form of vitamin B9 and is one of the most well-studied supplements, especially for preventing serious birth defects when taken before and during early pregnancy. I...

Read the full Folic Acid monograph → Herb & supplement monograph

Iron

Interacts with 80 drugs

Iron is an essential mineral your body needs to make hemoglobin and carry oxygen in the blood. Supplements are mainly useful for treating or preventing iron deficiency and iron-deficiency an...

Read the full Iron monograph → Herb & supplement monograph

Silicon

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for hair, skin, nail, and bone health. Some s...

Read the full Silicon monograph → Herb & supplement monograph

Methionine

Methionine is an essential amino acid that your body needs for protein building and many basic chemical reactions. Most people get enough from a normal diet, and supplements are generally no...

Read the full Methionine monograph → Herb & supplement monograph

L-cysteine

Interacts with 86 drugs

L-cysteine is a sulfur-containing amino acid your body uses to make proteins and the antioxidant glutathione. Most people get enough from food, and supplements are usually well tolerated, bu...

Read the full L-cysteine monograph →
Sources

Sources & How We Checked

Hydroxycut +Women's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 627 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Folic Acid 56 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Duhra P. Treatment of gastrointestinal symptoms associated with methotrexate therapy for psoriasis. J Am Acad Dermatol 1993;28:466-9. PubMed
  3. Morgan SL, Baggott JE, Vaughn WH, et al. Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Ann Intern Med 1994;121:833-41. PubMed
  4. Froscher W, Maier V, Laage M, et al. Folate deficiency, anticonvulsant drugs, and psychiatric morbidity. Clin Neuropharmacol 1995;18:165-82. PubMed
  5. Lewis DP, Van Dyke DC, Willhite LA, et al. Phenytoin-folic acid interaction. Ann Pharmacother 1995;29:726-35. PubMed
  6. Berg MJ, Stumbo PJ, Chenard CA, et al. Folic acid improves phenytoin pharmacokinetics. J Am Diet Assoc 1995;95:352-6. PubMed
  7. Berg MJ, Fincham RW, Ebert BE, et al. Phenytoin pharmacokinetics: Before and after folic acid administration. Epilepsia 1992;33:712-20. PubMed
  8. Shafer RB, Nuttall FQ. Calcium and folic acid absorption in patients taking anticonvulsant drugs. J Clin Endocrinol Metab 1975;41:1125-9. PubMed
  9. Leeb BF, Witzmann G, Ogris E, et al. Folic acid and cyanocobalamin levels in serum and erythrocytes during low-dose methotrexate therapy of rheumatoid arthritis and psoriatic arthritis patients. Clin Exp Rheumatol 1995;13:459-63.
  10. Morgan SL, Baggott JE, Lee JY, Alarcón GS. Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease preventi
  11. Dijkmans BA. Folate supplementation and methotrexate. Br J Rheumatol 1995;34:1172-4. PubMed
  12. Segal S, Kaminski S. Drug-nutrient interactions. American Druggist 1996 Jul;42-8.
  13. Lambie DG, Johnson RH. Drugs and folate metabolism. Drugs 1985;30:145-55. PubMed
  14. Amer College of Rheumatology ad hoc committee on clinical guidelines. Guidelines for monitoring drug therapy in rheumatoid arthritis. Arthritis Rheum 1996;39:723-31. DOI
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See these in context on the Coffee monograph →

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See these in context on the Methionine monograph →

Avocado 10 references
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See these in context on the Avocado monograph →

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See these in context on the L-cysteine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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