Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

Probiotic 40 Billion CFU Ingredients & Drug Interactions

by NutriRise

Probiotic 40 Billion CFU label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotic 40 Billion CFU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotic 40 Billion CFU is a dietary supplement by NutriRise with 6 active ingredients. Its ingredients are commonly taken for digestive and gut health, prebiotic to support good bacteria, constipation relief.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus La-14. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotic 40 Billion CFU by NutriRise

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotic 40 Billion CFU by NutriRise — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotic 40 Billion CFU by NutriRise

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 6 active ingredients.
  • “Proprietary Blend of Probiotic Bacteria” is a proprietary blend — the label doesn't break down how much of each component you get.

NutriRise Probiotic 40 Billion CFU provides 6 active ingredients, with the bulk coming from a blend of three bacterial strains: Lactobacillus paracasei, Bifidobacterium lactis, and Lactobacillus plantarum. It also contains Lactobacillus acidophilus, fructooligosaccharides (a type of prebiotic fiber that feeds beneficial bacteria), and a marine polysaccharide complex.

The capsule itself is made from inactive ingredients like cellulose, rice maltodextrin, and L-leucine, which are standard fillers and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: healthy digestion and intestinal health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Constipation, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Fructo-oligosaccharides (fos) is rated "Insufficient Reliable Evidence To Rate" for Constipation, Travelers' diarrhea.

The evidence for this product's active ingredients is mixed. Lactobacillus acidophilus appears possibly effective for irritable bowel syndrome, certain bacterial infections, and antibiotic-associated diarrhea — though the data are still limited.

It's rated possibly ineffective for atopic disease (conditions like eczema and allergies), and we don't have enough evidence yet to rate it for acute respiratory distress syndrome. Fructooligosaccharides — the prebiotic fiber included here — hasn't shown reliable evidence for osteoporosis, constipation, diabetes, traveler's diarrhea, or high cholesterol in the studies we hold.

The three other bacterial strains don't have effectiveness ratings in our data.

The evidence, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Uncommon side effects from the probiotic blend may include stomach discomfort, pain, bloating, gas, diarrhea, or burping — usually mild and temporary.

Fructooligosaccharides often causes gas and bloating, especially at higher doses, though studies show that doses under 10 grams daily don't consistently produce more symptoms than placebo. Because this is a live-organism supplement and long-term safety data for these bacterial strains are limited, check with your doctor before use, particularly if you have a weakened immune system or serious underlying illness.

Side effects, ingredient by ingredient Fructo-oligosaccharides (fos) Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, the most important thing to know is that taking them at the same time as this probiotic may lower the supplement's effectiveness — antibiotics can kill the beneficial bacteria before they colonize your gut. Space out your doses if possible, and talk with your doctor or pharmacist about the best timing for your specific antibiotic.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may be worth trying if you have irritable bowel syndrome or antibiotic-associated diarrhea and want to see if Lactobacillus acidophilus helps. If you take antibiotics, talk with your pharmacist about spacing out the timing so the medication doesn't reduce the supplement's live bacteria.

Anyone with a compromised immune system should clear it with their doctor first. Start with the full dose to see how your stomach handles the prebiotic fiber — gas and bloating are common at the start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic 40 Billion CFU, straight from the product label.

Brand NutriRise
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Dec 18, 2021
DSLD ID 257163
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic 40 Billion CFU by NutriRise, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Lactobacillus paracasei Lpc-370 NP--
Bifidobacterium lactis Bl-040 NP--
Lactobacillus plantarum Lp-1150 NP--
Fructooligosaccharides0 NP--
Lactobacillus acidophilus La-140 NP--
Marine Polysaccharide Complex0 NP--
Proprietary Blend of Probiotic Bacteria0 NP--

Other ingredients: Cellulose, Rice Maltodextrin, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Get your free bottle at FREE.NUTRIRISE.COM

Please recycle

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take two (2) capsules once daily. For best results, take one (1) capsule during the day and one (1) capsule in the evening. Repeat the process daily. Do not exceed two capsules per day.

Formulation

This Probiotic offers a balanced spectrum of live organisms. Probiotic bacteria are critical for healthy digestion, help maintain the integrity of the intestinal lining, support proper intestinal mobility and participate in the detoxification process.

This product is formulated with 40 billion CFU per 2 caps and to deliver a minimum potency of 20 billion CFU per 2 caps through the best by date.

With Maktrek for targeted delivery Helps enhance & restore gut flora Powerful immune system support Professional grade

Non-GMO, gluten & dairy free ingredients

Precautions

Caution: Do not exceed recommended dose.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Pregnant or nursing mothers, children under the age of 18, and individuals with a known medical condition should consult a physician before using this or any dietary supplement.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Diverse strains for gut & microbiome support

Made with natural ingredients

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Manufactured in USA

FDA Registered Facility

Lab tested

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotic 40 Billion CFU by NutriRise label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotic 40 Billion CFU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotic 40 Billion CFU by NutriRise

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend of Probiotic Bacteria

0 NP per serving

Other (inactive) ingredients: Cellulose, Rice Maltodextrin, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic 40 Billion CFU by NutriRise Drug Interactions

Want to check YOUR meds against Probiotic 40 Billion CFU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus La-14 182

Individual Drug Interactions

The ingredients in Probiotic 40 Billion CFU interact with 182 drugs. Click any drug to see the details.

1 of the 6 ingredients in Probiotic 40 Billion CFU interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus La-14

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic 40 Billion CFU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus La-141 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus La-14 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotic 40 Billion CFU, from the product label.

NutriRise

See all NutriRise products
Name
NutriRise
City
Houston
State
TX
ZipCode
78701
Phone Number
1 (855) 302-3867
Web Address
http://nutririse.com
Pharmacist Counseling Corner

Probiotic 40 Billion CFU by NutriRise: Common Questions

Does Probiotic 40 Billion CFU by NutriRise interact with any medications?
Yes. Based on its ingredients, Probiotic 40 Billion CFU has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic 40 Billion CFU contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my irritable bowel syndrome?
Lactobacillus acidophilus, one of the strains in here, is rated possibly effective for IBS based on the evidence we have — meaning some studies show promise, but more research is needed. Results aren't guaranteed, so you may want to try it for a few weeks and see if your symptoms improve. Talk with your doctor if you don't notice a change or if your gut symptoms get worse.
What's the prebiotic (fructooligosaccharides) for?
Fructooligosaccharides are a type of fiber that feeds the beneficial bacteria already in your gut, helping them grow. That's why probiotics often pair them together — the idea is to give the good bacteria fuel to thrive. However, this fiber frequently causes gas and bloating, especially when you first start taking it.
Can I take this while I'm on an antibiotic?
Antibiotics kill bacteria — including the live ones in this supplement — so taking them together at the same time can reduce how well the probiotic works. Ask your pharmacist about separating the doses by at least 2-3 hours so the antibiotic has time to do its job before you take your probiotic.
Are there any side effects I should expect?
Gas, bloating, and abdominal discomfort are the most common, though these are usually mild and temporary. Some people also report loose stools or burping. Most side effects settle down as your gut adjusts, but if they're severe or don't improve within a few weeks, stop and talk with your doctor.
Is it safe to take during pregnancy?
Lactobacillus acidophilus is rated possibly safe in pregnancy, but we don't have enough safety data for the other bacterial strains or the marine polysaccharide complex to say either way. Talk with your obstetrician or midwife about whether this product is right for you during pregnancy — they can weigh your specific situation.
Does this product have fillers?
Yes — the capsule contains cellulose, rice maltodextrin, and L-leucine as inactive ingredients. These are standard binders and flow agents used to hold the capsule together and keep the powder from clumping.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic 40 Billion CFU is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic 40 Billion CFU label
Go deeper

The Full Monographs Behind Probiotic 40 Billion CFU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Probiotic 40 Billion CFU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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