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Dietary supplement

Women's Probiotic Pearls 1 Billion Ingredients & Drug Interactions

by Nature's Way

Women's Probiotic Pearls 1 Billion label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Women's Probiotic Pearls 1 Billion against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Women's Probiotic Pearls 1 Billion is a dietary supplement by Nature's Way with 3 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Howaru. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Women's Probiotic Pearls 1 Billion by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Women's Probiotic Pearls 1 Billion by Nature's Way — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Women's Probiotic Pearls 1 Billion by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (17 mg) without saying how much of each component you get.

This product contains three active probiotic ingredients: L. plantarum LP-115, L. rhamnosus Lr-32, and Lactobacillus acidophilus (Howaru strain). These are beneficial live bacteria meant to support your gut flora.

The inactive ingredients are palm oil, gelatin, glycerin, sunflower lecithin, and pectin — these serve as the capsule material and preservatives, not active components.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Supports vaginal and digestive health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Constipation, Irritable bowel syndrome (IBS), Lactose intolerance, Rotaviral diarrhea — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Lactose intolerance, Rotaviral diarrhea, Travelers' diarrhea.

Lactobacillus acidophilus, one of the three strains in this product, shows possibly effective evidence for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis. The evidence for atopic disease (allergic conditions) is possibly ineffective, and there isn't enough reliable evidence to rate it for acute respiratory distress syndrome.

We have no effectiveness data on file for the other two probiotic strains in this formula.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Orally, taking it with other probiotics — as you do in this multi-strain product — may occasionally cause mild gastrointestinal side effects like gas, bloating, abdominal discomfort, or diarrhea, but these are uncommon.

In very rare cases, Lactobacillus acidophilus has been found in serious infections like bacteremia or sepsis, but this typically happens in patients with compromised immune systems or those where the bacteria have moved from their normal location in the body. We have no pregnancy or breastfeeding safety data on file for any of the ingredients in this product — talk with your doctor or pharmacist for personalized guidance if you're pregnant or nursing.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this product if you use antibiotic drugs — the live bacteria in it may be killed off if you take them together. Space them apart by a few hours for best results.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This probiotic may help with IBS, antibiotic-related diarrhea, or bacterial vaginosis. The main thing to watch: don't take it at the same time as antibiotics — space them a few hours apart so the antibiotics don't kill off the live cultures.

If you're generally healthy, it's well tolerated, but always check your specific medications before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Women's Probiotic Pearls 1 Billion, straight from the product label.

Brand Nature's Way
Barcode (UPC) 763948102280
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Sep 25, 2025
DSLD ID 334441
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Female (18 - 50 Years), Seniors/Mature (>50 Years) - Women ONLY, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Women's Probiotic Pearls 1 Billion by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
763948102280
IngredientAmount% DV
Proprietary Probiotic Blend17 mg--
L. plantarum LP-1150 NP--
L. rhamnosus Lr-320 NP--
Howaru0 NP--

Other ingredients: Palm Oil, Gelatin, Glycerin, Sunflower Lecithin, Pectin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

1 Billion cultures Pearls easy to swallow

Active Lactobacilli cultures to benefit intestinal and vaginal flora

Howaru Probiotic quality you can feel

Formulation

Supports vaginal & digestive health Designed to survive stomach acid

Survives stomach acid to release in the intestine Easy to swallow Survives stomach acid

Fortifies women's digestive tract and vaginal flora Supports immune and urinary tract health Protects against occasional bloating, constipation and digestive discomfort Advanced triple-layer softgel survives stomach acid

Gluten free. No salt, wheat, soy, dairy, or artificial colors.

Product of Japan

FDA Statement of Identity

Probiotic Supplement

This statement has not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Brand IP Statement(s)

Nature's Way The Smarter Probiotic

HOWARU is a registered trademark of IFF and is used under license. Copyright 2024 Nature's Way Brands, LLC

Suggested/Recommended/Usage/Directions

Once Daily

Recommendation: : Adults swallow 1 softgel daily. May be taken with or without food. Do not chew or crush.

Storage

No refrigeration required

Store at room temperature. Avoid excessive heat and direct sunlight.

General Statements

Explore more products at NATURESWAY.COM Questions? 1-800-962-8873/pearlsprobiotics.com

Precautions

Contains fish (Tilapia).

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

This product has a tamper-evident foil pouch. Do not use if foil or plastic is punctured.

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Women's Probiotic Pearls 1 Billion by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Women's Probiotic Pearls 1 Billion label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Women's Probiotic Pearls 1 Billion by Nature's Way

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

17 mg per serving
  • › L. plantarum LP-115
  • › L. rhamnosus Lr-32
  • › Howaru

Other (inactive) ingredients: Palm Oil, Gelatin, Glycerin, Sunflower Lecithin, Pectin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Women's Probiotic Pearls 1 Billion by Nature's Way Drug Interactions

Want to check YOUR meds against Women's Probiotic Pearls 1 Billion?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Howaru 182

Individual Drug Interactions

The ingredients in Women's Probiotic Pearls 1 Billion interact with 182 drugs. Click any drug to see the details.

1 of the 3 ingredients in Women's Probiotic Pearls 1 Billion interact with drugs. Each result below shows which ingredient is responsible. Howaru

Each ingredient & the kinds of drugs it affects

For each ingredient in Women's Probiotic Pearls 1 Billion with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Howaru1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Howaru full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Women's Probiotic Pearls 1 Billion, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
pearlsprobiotics.com
Pharmacist Counseling Corner

Women's Probiotic Pearls 1 Billion by Nature's Way: Common Questions

Does Women's Probiotic Pearls 1 Billion by Nature's Way interact with any medications?
Yes. Based on its ingredients, Women's Probiotic Pearls 1 Billion has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Women's Probiotic Pearls 1 Billion contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this probiotic actually work?
The Lactobacillus acidophilus in this product has possibly effective evidence for IBS, antibiotic-related diarrhea, bacterial vaginosis, and H. pylori infection. We don't have effectiveness data for the other two strains. Results vary person to person.
Can I take this with antibiotics?
Yes, but not at the same time. Antibiotics kill the live bacteria in the probiotic, so separate them by a few hours. Your pharmacist can tell you the best timing for your specific antibiotic.
What are the side effects?
Mild stomach symptoms like gas, bloating, or diarrhea can happen when you first take probiotics, but they're uncommon. In very rare cases, serious infections have occurred, mainly in people with weak immune systems.
Is this safe if I'm pregnant or breastfeeding?
We don't have safety data on file for these specific ingredients during pregnancy or breastfeeding. Talk with your doctor or pharmacist — they can give you personalized advice based on your situation.
What are these three bacterial strains for?
All three are beneficial bacteria meant to support your gut flora. We have effectiveness evidence for Lactobacillus acidophilus for IBS and diarrhea; the other two strains don't have effectiveness data we can reference.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Women's Probiotic Pearls 1 Billion is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Women's Probiotic Pearls 1 Billion label
Go deeper

The Full Monographs Behind Women's Probiotic Pearls 1 Billion’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Women's Probiotic Pearls 1 Billion's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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