Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

ProDHA Eye 360 EPA/845 DHA Ingredients & Drug Interactions

by Nordic Naturals

ProDHA Eye 360 EPA/845 DHA label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking ProDHA Eye 360 EPA/845 DHA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

ProDHA Eye 360 EPA/845 DHA is a dietary supplement by Nordic Naturals with 5 active ingredients. Its ingredients are commonly taken for eye and macular health, age-related macular degeneration (amd), protection from blue light.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against ProDHA Eye 360 EPA/845 DHA by Nordic Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with ProDHA Eye 360 EPA/845 DHA by Nordic Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of ProDHA Eye 360 EPA/845 DHA by Nordic Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “Total Omega-3 Fatty Acids” is listed as a grouped ingredient — the label gives one combined amount (1,460 mg) without saying how much of each component you get.

ProDHA Eye 360 contains five active ingredients: eicosapentaenoic acid and docosahexaenoic acid (two types of omega-3 fatty acids from fish oil), zeaxanthin and FloraGlo Lutein (plant pigments concentrated in the eye), and a blend of other omega-3s. The product also contains inactive ingredients including purified deep sea fish oil, soft gel capsule material, beeswax, vitamin E (D-alpha tocopherol), and rosemary extract.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye health and macular vision support.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Diabetic retinopathy, Dry eye, Myopia — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Zeaxanthin is rated possibly effective for age-related macular degeneration (AMD); evidence for cognitive decline, Alzheimer's disease, asthma, breast cancer, and bronchopulmonary dysplasia is insufficient to rate. Lutein is rated possibly effective for AMD and cataracts, but possibly ineffective for retinitis pigmentosa, necrotizing enterocolitis, retinopathy of prematurity, and bronchopulmonary dysplasia.

The effectiveness of the omega-3 fatty acids in this product is not established in the data we hold.

The evidence, ingredient by ingredient Zeaxanthin Lutein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Zeaxanthin and lutein are both rated likely safe in pregnancy and lactation. However, while dietary amounts from food are fine, supplement safety in pregnancy and breastfeeding is not well studied — use caution and talk with your doctor or pharmacist about whether concentrated supplements are right for you.

Lutein at doses up to 20 mg daily has not resulted in adverse effects, and both ingredients are generally well tolerated at typical supplement amounts.

Side effects, ingredient by ingredient Zeaxanthin Lutein

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your antidiabetes medications before taking this product — zeaxanthin may theoretically increase your risk of low blood sugar (hypoglycemia). For all other medications, no interactions are documented in our data for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is formulated for eye health, particularly age-related macular degeneration. If you take diabetes medication, check with your doctor or pharmacist before starting it.

Pregnant or breastfeeding? Talk it over with your healthcare provider about the safety of concentrated supplements, even though the individual ingredients are rated likely safe.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about ProDHA Eye 360 EPA/845 DHA, straight from the product label.

Brand Nordic Naturals
Barcode (UPC) 768990500978
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 277309
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for ProDHA Eye 360 EPA/845 DHA by Nordic Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
60
UPC/BARCODE
768990500978
IngredientAmount% DV
Calories20 Calorie(s)--
Eicosapentaenoic Acid360 mg--
Docosahexaenoic Acid845 mg--
Zeaxanthin4 mg--
Total Omega-3 Fatty Acids1460 mg--
Total Fat2 Gram(s)3%
Saturated Fat0 Gram(s)--
Trans Fat0 Gram(s)--
Other Omega-3s255 mg--
FloraGlo Lutein20 mg--

Other ingredients: purified deep sea Fish Oil, Soft Gel Capsule, FloraGLO Lutein, Beeswax, D-Alpha Tocopherol, Zeaxanthin, Rosemary Extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Pharmaceutical grade Molecularly distilled Every batch of Nordic Naturals fish oils is tested by a third-party certified lab for environmental toxins, including heavy metals. All fish oils are in the triglyceride form and surpass the strictest international standards for purity and freshness. Certificates of Analysis available upon request. Friend of the Sea certified.

Better Absorption True Triglyceride Supports brain and visual function Promotes long-term eye health

Condition-Specific Support

Non GMO Verified No gluten, milk derivatives, or artificially derived colors or flavors.

Suggested/Recommended/Usage/Directions

Suggested Use: Two soft gels daily, with food, or as directed by your health care professional or pharmacist.

Storage

Store in a cool, dry place, away from sunlight

Precautions

Do not take if tamper-evident seal is broken or missing

Keep out of the reach of children.

Warning: Consult with your physician before using this product if you are allergic to iodine, or use blood thinners.

Brand IP Statement(s)

Product protected by U.S. patent #s 6346231 & 6641837

FloraGLO is a registered trademark of Kemin Industries, Inc.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Fish Oil Processed in Norway Better Absorption True Triglyceride High levels of FloraGLO Lutein and Zeaxanthin

ProHDA Eye 1000 mg

Seals/Symbols

Non GMO Verified

FDA Statement of Identity

Dietary Supplement

General Statements

Please Recycle this container

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

ProDHA Eye 360 EPA/845 DHA by Nordic Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

ProDHA Eye 360 EPA/845 DHA label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in ProDHA Eye 360 EPA/845 DHA by Nordic Naturals

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Zeaxanthin

Interacts with
86 drugs
4 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Total Omega-3 Fatty Acids

1460 mg per serving
  • › Eicosapentaenoic Acid
  • › Docosahexaenoic Acid
  • › Other Omega-3s

FloraGlo Lutein

No known
interactions
20 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

FloraGlo Lutein monograph & interactions

Other (inactive) ingredients: Purified deep sea Fish Oil, Soft Gel Capsule, FloraGLO Lutein, Beeswax, D-Alpha Tocopherol, Zeaxanthin, Rosemary Extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

ProDHA Eye 360 EPA/845 DHA by Nordic Naturals Drug Interactions

Want to check YOUR meds against ProDHA Eye 360 EPA/845 DHA?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in ProDHA Eye 360 EPA/845 DHA interact with 86 drugs. Click any drug to see the details.

1 of the 5 ingredients in ProDHA Eye 360 EPA/845 DHA interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in ProDHA Eye 360 EPA/845 DHA with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for ProDHA Eye 360 EPA/845 DHA, from the product label.

Nordic Naturals

See all Nordic Naturals products
Name
Nordic Naturals, Mfg.
Street Address
111 Jennings Drive
City
Watsonville
State
CA
ZipCode
95076
Phone Number
800-662-2544
Web Address
nordicnaturals.com
Pharmacist Counseling Corner

ProDHA Eye 360 EPA/845 DHA by Nordic Naturals: Common Questions

Does ProDHA Eye 360 EPA/845 DHA by Nordic Naturals interact with any medications?
Yes. Based on its ingredients, ProDHA Eye 360 EPA/845 DHA has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
ProDHA Eye 360 EPA/845 DHA contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is this product for?
ProDHA Eye 360 is designed to support eye health with omega-3 fatty acids, zeaxanthin, and lutein — nutrients that concentrate in the eye. Zeaxanthin and lutein are both rated possibly effective for age-related macular degeneration (AMD) and age-related eye changes.
Is it safe if I'm pregnant?
Both zeaxanthin and lutein are rated likely safe in pregnancy, but supplement safety (as opposed to food sources) is not well studied. Talk with your doctor or pharmacist about whether concentrated supplements are appropriate for you during pregnancy.
Can I take it while breastfeeding?
Both ingredients are rated likely safe while breastfeeding. That said, lutein occurs naturally in breast milk, and safety of higher supplement doses is not well studied — check with your doctor or pharmacist to confirm it's the right choice for you.
Are there any side effects?
Lutein at typical doses up to 20 mg daily has not resulted in reported adverse effects. Both zeaxanthin and lutein are generally well tolerated at supplement amounts. Neither ingredient had adverse effects listed in our data.
I take diabetes medication — is this safe?
Zeaxanthin in this product may theoretically increase your risk of low blood sugar when combined with antidiabetes drugs. Check your exact medications with your doctor or pharmacist before taking this product.
Does it contain any allergens?
This product contains fish (from deep sea fish oil) and beeswax. If you have allergies to fish or bee products, check the label carefully or talk with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if ProDHA Eye 360 EPA/845 DHA is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

ProDHA Eye 360 EPA/845 DHA label
Go deeper

The Full Monographs Behind ProDHA Eye 360 EPA/845 DHA’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph →
Sources

Sources & How We Checked

ProDHA Eye 360 EPA/845 DHA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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