Propolis Astragalus Throat Spray Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Propolis Astragalus Throat Spray against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Propolis Astragalus Throat Spray is a dietary supplement by Eclectic Herb with 4 active ingredients. Its ingredients are commonly taken for immune support, colds and flu, upper respiratory infections.Based on those ingredients, 2,206 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Slippery Elm, Dry, Propolis, Fresh, Echinacea purpurea, Fresh. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Propolis Astragalus Throat Spray by Eclectic Herb
Ask about any prescription or over-the-counter medication and we check it for interactions with Propolis Astragalus Throat Spray by Eclectic Herb — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Propolis Astragalus Throat Spray by Eclectic Herb
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This throat spray contains four active herbal ingredients. Astragalus (a traditional immune-supporting root), propolis (a resinous compound made by bees), echinacea purpurea (also called purple coneflower), and slippery elm (inner bark known for its mucilage, a soothing compound).
The product also includes inactive ingredients — glycerin, filtered water, and alcohol — which serve as a base and preservative for the liquid formula.
Does it work?
Moderate evidence
The evidence on what this spray actually does is limited. Propolis has possibly effective evidence for oral mucositis (mouth sores from cancer treatment) and cold sores, and possibly effective evidence for diabetes support.
For the other ingredients — astragalus, echinacea, and slippery elm — the conditions listed in our data are rated as having insufficient reliable evidence, meaning we don't have enough solid research to say whether they work for those uses. The product is marketed as a throat spray, but the effectiveness evidence we hold doesn't specifically address sore throat or general throat health.
How safe is it?
Well-documented data
Propolis is generally well tolerated short-term, though allergic reactions are possible — especially if you're sensitive to bee products. Astragalus is generally well tolerated in the short term, but human safety data is limited.
Echinacea is well tolerated short-term but may cause allergic reactions, particularly in people sensitive to ragweed and related plants; rare cases of echinacea-linked hepatitis (liver inflammation) have been reported. Slippery elm is generally well tolerated short-term.
Common side effects across these ingredients are mild — headache (propolis), abdominal discomfort or digestive upset (echinacea), and rarely rash or allergic reactions. If you have a bee allergy or are sensitive to ragweed or related plants, mention that to your pharmacist before using this product.
During pregnancy, the safety data advises against astragalus and propolis — there isn't enough reliable information. For echinacea and slippery elm, there isn't enough data to know either way; talk with your doctor or pharmacist for personalized advice.
The same caution applies during breastfeeding across all four ingredients.
Meds to double-check
Moderate interaction found
Before using this product, double-check if you take immunosuppressants, blood thinners (including warfarin), diabetes medications, lithium, chemotherapy drugs like etoposide or cyclophosphamide, or any medication broken down by the liver — especially those metabolized by enzymes labeled CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, or CYP2E1. Additionally, if you take medications by mouth generally, slippery elm may slow their absorption.
Use the medication checker on this page to verify your specific drugs.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This spray is a blend of four herbs with limited safety concerns for most people in the short term, but it interacts with many medication types — particularly blood thinners, immunosuppressants, diabetes drugs, lithium, and drugs metabolized by the liver. If you take any prescription medication, check it against our interaction tool before starting.
Pregnant or breastfeeding people should talk with their pharmacist first. Anyone with a bee allergy or ragweed sensitivity should be cautious.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Propolis Astragalus Throat Spray, straight from the product label.
| Brand | Eclectic Herb |
|---|---|
| Barcode (UPC) | 023363200733 |
| Net contents | 1 Fluid Ounce(s); 30 Milliliter(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2023 |
| DSLD ID | 294846 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Children (All), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Propolis Astragalus Throat Spray by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Astragalus, Dry | 0 NP | -- |
| Propolis, Fresh | 0 NP | -- |
| Echinacea purpurea, Fresh | 0 NP | -- |
| Slippery Elm, Dry | 0 NP | -- |
Other ingredients: Glycerin, Water, Filtered, Alcohol
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Herbal throat spray
Non gmo Soy free Gluten free
FDA Statement of Identity
Dietary Supplement
General Statements
Sustainable
@eclecticherb
Formula
Kid friendly
Suggested/Recommended/Usage/Directions
Shake well; spray into open mouth 3 times daily.
Storage
Store upright.
Precautions
Keep out of reach of children. Consult your health care advisor about herbs with pregnancy, infants or prescription drugs.
Discontinue use if unusual symptoms occur.
Consult your health care advisor about herbs with pregnancy, infants or prescription drugs.
FDA Disclaimer Statement
This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Propolis Astragalus Throat Spray by Eclectic Herb label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Propolis Astragalus Throat Spray by Eclectic Herb
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Spray(s) Dosage formLiquid Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Astragalus, Dry
Interacts with208 drugs
Astragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While...
Astragalus, Dry monograph & interactionsPropolis, Fresh
Interacts with921 drugs
Propolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research sugges...
Propolis, Fresh monograph & interactionsEchinacea purpurea, Fresh
Interacts with816 drugs
Echinacea is a popular herb taken to help prevent or shorten the common cold, but study results are mixed and the overall benefit appears small at bes...
Echinacea purpurea, Fresh monograph & interactionsSlippery Elm, Dry
Interacts with2,022 drugs
Slippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated di...
Slippery Elm, Dry monograph & interactionsOther (inactive) ingredients: Glycerin, Water, Filtered, Alcohol. These complete the product’s ingredient list but are not active constituents.
Propolis Astragalus Throat Spray by Eclectic Herb Drug Interactions
HelloPharmacist Interaction Report
Propolis Astragalus Throat Spray by Eclectic Herb has documented interactions with a number of medications across its four active ingredients.
The most serious concern comes from astragalus, which may theoretically interfere with immunosuppressive drugs (like those taken after transplant or for autoimmune conditions) by stimulating immune function and reducing their effectiveness — a Moderate-severity interaction.
Read the full breakdown — every affected drug type, severity by severity
Astragalus also carries Moderate interactions with lithium (a mood-stabilizer), where its diuretic properties may increase lithium levels and side effects; with cyclophosphamide (a chemotherapy drug), where it may interfere with treatment; and with diabetes medications, where it may increase the risk of low blood sugar (hypoglycemia).
Propolis contributes Moderate interactions with several drug-metabolism pathways — specifically drugs broken down by liver enzymes CYP2C19, CYP2D6, CYP1A2, CYP2C9, CYP3A4, and CYP2E1 — where high doses might theoretically raise blood levels. It also has Moderate interactions with blood thinners and antiplatelet drugs (raising bleeding risk) and with warfarin (potentially decreasing its effectiveness).
Echinacea purpurea adds Moderate interactions with CYP1A2 and CYP3A4 substrates, immunosuppressants, the chemotherapy drug etoposide, caffeine, and warfarin — though its warfarin interaction is Minor in severity. Finally, slippery elm may theoretically slow absorption and lower blood levels of any oral medication taken around the same time.
Additionally, you should check your exact medications using the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Propolis Astragalus Throat Spray?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Propolis Astragalus Throat Spray interact with 2,206 drugs. Click any drug to see the details.
4 of the 4 ingredients in Propolis Astragalus Throat Spray interact with drugs. Each result below shows which ingredient is responsible. Slippery Elm, Dry Propolis, Fresh Echinacea purpurea, Fresh Astragalus, Dry
"phentolamineOraVerse, Rogitine, Ryzumvi
How "phentolamine interacts with Propolis Astragalus Throat Spray — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + "phentolamine interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + 6-mercaptopurine interactionAstragalus, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus, Dry + 6-mercaptopurine interactionEchinacea Purpurea, FreshImmunosuppressants Moderate
Interaction Summary
Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.
Read the full Echinacea Purpurea, Fresh + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Propolis Astragalus Throat Spray — through 2 ingredients. Tap an ingredient for the detail:
Echinacea Purpurea, FreshCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea, Fresh + Ado-trastuzumab Emtansine interactionPropolis, FreshCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis, Fresh + Ado-trastuzumab Emtansine interactionAbacavirZiagen
How Abacavir interacts with Propolis Astragalus Throat Spray — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Abacavir interactionAbacavir Sulfate, Dolutegravir, LamivudineTriumeq
How Abacavir Sulfate, Dolutegravir, Lamivudine interacts with Propolis Astragalus Throat Spray — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Abacavir Sulfate, Dolutegravir, Lamivudine interactionAbacavir, LamivudineEpzicom
How Abacavir, Lamivudine interacts with Propolis Astragalus Throat Spray — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Abacavir, Lamivudine interactionAbciximabReoPro
How Abciximab interacts with Propolis Astragalus Throat Spray — through 2 ingredients. Tap an ingredient for the detail:
Propolis, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Propolis, Fresh + Abciximab interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Propolis, FreshCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis, Fresh + Abemaciclib interactionEchinacea Purpurea, FreshCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea, Fresh + Abemaciclib interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Echinacea Purpurea, FreshCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea, Fresh + Abiraterone interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Abiraterone interactionPropolis, FreshCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis, Fresh + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Propolis, FreshCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis, Fresh + Abiraterone Acetate interactionEchinacea Purpurea, FreshCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea, Fresh + Abiraterone Acetate interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Propolis Astragalus Throat Spray — through 4 ingredients. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Abrocitinib interactionEchinacea Purpurea, FreshImmunosuppressants Moderate
Interaction Summary
Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.
Read the full Echinacea Purpurea, Fresh + Abrocitinib interactionPropolis, FreshCytochrome P450 2c9 (cyp2c9) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
Read the full Propolis, Fresh + Abrocitinib interactionAstragalus, DryImmunosuppressants Moderate
Interaction Summary
Theoretically, astragalus might interfere with immunosuppressive therapy.
Read the full Astragalus, Dry + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Propolis, FreshCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis, Fresh + Acalabrutinib interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acalabrutinib interactionEchinacea Purpurea, FreshCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea, Fresh + Acalabrutinib interactionAcamprosateCampral
How Acamprosate interacts with Propolis Astragalus Throat Spray — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acamprosate interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Propolis Astragalus Throat Spray — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acarbose interactionAstragalus, DryAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Astragalus, Dry + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Propolis Astragalus Throat Spray — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Propolis Astragalus Throat Spray — through 2 ingredients. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acenocoumarol interactionPropolis, FreshAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
Read the full Propolis, Fresh + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Propolis Astragalus Throat Spray — through 1 ingredient. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen interactionPropolis, FreshCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Propolis, Fresh + Acetaminophen interactionEchinacea Purpurea, FreshCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Purpurea, Fresh + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Echinacea Purpurea, FreshCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Aspirin interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Aspirin interactionPropolis, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis, Fresh + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Propolis, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis, Fresh + Acetaminophen, Aspirin, Caffeine interactionEchinacea Purpurea, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Aspirin, Caffeine interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionPropolis, FreshCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Propolis, Fresh + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionEchinacea Purpurea, FreshCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Echinacea Purpurea, FreshCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Butalbital interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Butalbital interactionPropolis, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis, Fresh + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Propolis, FreshCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Read the full Propolis, Fresh + Acetaminophen, Butalbital, Caffeine interactionEchinacea Purpurea, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Caffeine +1 Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Butalbital, Caffeine interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Butalbital, Caffeine, Codeine interactionPropolis, FreshCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
Read the full Propolis, Fresh + Acetaminophen, Butalbital, Caffeine, Codeine interactionEchinacea Purpurea, FreshCytochrome P450 3a4 (cyp3a4) Substrates, Caffeine +1 Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Echinacea Purpurea, FreshCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Butalbital, Codeine interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Butalbital, Codeine interactionPropolis, FreshCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Propolis, Fresh + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Propolis, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +1 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis, Fresh + Acetaminophen, Butalbital, Codeine Phosphate interactionEchinacea Purpurea, FreshCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Butalbital, Codeine Phosphate interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionPropolis, FreshCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Propolis, Fresh + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionEchinacea Purpurea, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Echinacea Purpurea, FreshCaffeine, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Caffeine, Codeine interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Caffeine, Codeine interactionPropolis, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis, Fresh + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Propolis, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
Read the full Propolis, Fresh + Acetaminophen, Caffeine, Codeine, Salicylamide interactionEchinacea Purpurea, FreshCytochrome P450 1a2 (cyp1a2) Substrates, Caffeine +1 Moderate
Interaction Summary
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Caffeine, Codeine, Salicylamide interactionSlippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Propolis Astragalus Throat Spray — through 3 ingredients. Tap an ingredient for the detail:
Slippery Elm, DryOral Drugs Moderate
Interaction Summary
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Read the full Slippery Elm, Dry + Acetaminophen, Caffeine, Dihydrocodeine interactionPropolis, FreshCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +2 Moderate
Interaction Summary
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
Read the full Propolis, Fresh + Acetaminophen, Caffeine, Dihydrocodeine interactionEchinacea Purpurea, FreshCytochrome P450 3a4 (cyp3a4) Substrates, Caffeine +1 Moderate
Interaction Summary
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4.
Read the full Echinacea Purpurea, Fresh + Acetaminophen, Caffeine, Dihydrocodeine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Propolis Astragalus Throat Spray with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Slippery Elm, Dry
Oral Drugs
Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.
Slippery elm inner bark contains mucilage, which may interfere with the absorption of orally administered drugs.
Propolis, Fresh
Anticoagulant/Antiplatelet Drugs
Theoretically, propolis might increase the risk of bleeding when taken with antiplatelet or anticoagulant drugs.
In vitro research shows that propolis water extract and the propolis constituent, caffeic acid phenethyl ester, can inhibit platelet aggregation. Additionally, evidence from an animal model shows that taking propolis in addition to warfarin decreases INR, suggesting that propolis can decrease the effectiveness of warfarin.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP1A2.
In vitro research shows that propolis extract can inhibit CYP1A2. However, animal research shows that propolis extract does not significantly affect CYP1A2 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP1A2 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C19.
In vitro research shows that propolis extract can inhibit CYP2C19. However, animal research shows that propolis extract does not significantly affect CYP2C19 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C19 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2C9.
In vitro research shows that propolis extract can inhibit CYP2C9. However, animal research shows that propolis extract does not significantly affect CYP2C9 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2C9 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP2D6.
In vitro research shows that propolis extract can inhibit CYP2D6. However, animal research shows that propolis extract does not significantly affect CYP2D6 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that inhibit CYP2D6 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, propolis might increase levels of drugs metabolized by CYP2E1.
In vitro research shows that propolis can inhibit CYP2E1. This effect has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, high doses of propolis might increase blood levels of drugs metabolized by CYP3A4.
Some in vitro research shows that propolis extract can inhibit CYP3A4; however, other in vitro research shows that propolis has no effect on CYP3A4 activity. Furthermore, animal research shows that propolis extract does not significantly affect CYP3A4 activity when administered to rats at doses up to 250 mg/kg. It is postulated that the constituents of propolis that might in inhibit CYP3A4 in vitro do not have significant effects in vivo due to low bioavailability and hepatic first-pass effect. This effect has not been reported in humans.
Warfarin (Coumadin)
Theoretically, propolis might decrease the effectiveness of warfarin.
Animal research shows that taking propolis in addition to warfarin decreases the international normalized ratio (INR). This effect has not been reported in humans.
Echinacea purpurea, Fresh
Caffeine
Echinacea can increase plasma levels of caffeine by inhibiting its metabolism.
Echinacea seems to increase plasma concentrations of caffeine by around 30%. This is likely due to inhibition of cytochrome P450 1A2 (CYP1A2) by echinacea.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Echinacea might inhibit the metabolism of CYP1A2 and increase plasma levels of some drugs.
Echinacea appears to inhibit CYP1A2 enzymes in humans. Additionally, echinacea seems to increase plasma concentrations of caffeine, a CYP1A2 substrate, by around 30%. Theoretically, echinacea might increase levels of other drugs metabolized by CYP1A2.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Echinacea may induce hepatic CYP3A4 and inhibit intestinal CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Several clinical trials have shown that taking echinacea for up to one month does not significantly affect the metabolism of various CYP3A4 substrates, including midazolam, docetaxel, etravirine, lopinavir-ritonavir, and darunavir-ritonavir. However, other clinical research shows that echinacea may increase the clearance of midazolam, suggesting that echinacea might induce CYP3A4. The discrepancy is thought to be due to differing effects of echinacea on intestinal versus hepatic CYP3A4 enzymes. Echinacea appears to induce hepatic CYP3A4 but inhibit intestinal CYP3A4. In some cases, these effects might cancel each other out, but in others, drug levels may be increased or decreased depending on the level of effect at hepatic and intestinal sites. The effect of echinacea on CYP3A4 activity may differ depending on the CYP3A4 substrate.
Etoposide (Vepesid)
Echinacea may increase levels of etoposide.
In one report, concomitant use of etoposide and echinacea was associated with more severe thrombocytopenia than the use of etoposide alone, suggesting inhibition of etoposide metabolism. Etoposide is a cytochrome P450 3A4 (CYP3A4) substrate. Echinacea has variable effects on CYP3A4, but some studies have reported inhibition of the enzyme.
Immunosuppressants
Echinacea has immunostimulant activity which may interfere with immunosuppressant therapy.
Theoretically, echinacea may interfere with immunosuppressant therapy because of its immunostimulant activity.
Darunavir (Prezista)
Theoretically, echinacea may interfere with the metabolism of darunavir; however, a small clinical study found no effect.
Darunavir is metabolized by cytochrome P450 3A4 (CYP3A4) and is administered with the CYP3A4 inhibitor ritonavir to increase its plasma concentrations. Echinacea has variable effects on CYP3A4, but administration of an E. purpurea root extract (Arkocapsulas Echinacea, Arkopharma) 500 mg four times daily for 14 days did not affect darunavir/ritonavir pharmacokinetics in 15 HIV-infected patients.
Dayquil Severe
Echinacea is reported to have varying effects on a number of Cytochrome P450 metabolizing enzymes in the liver, including CYP1A2 and CYP3A4, which play a role in acetaminophen and dextromethorphan metabolism (both contained in DayQuil Severe), respectively. Studies have reported both enzyme inhibition and induction, making it difficult to predict clinically significant drug interactions with reliability. Specific drug interaction studies reporting definitive results are rare, and potential drug interactions involving echinacea should likely be taken on a case-by-case basis. Based on what we know about how acetaminophen and dextromethorphan are metabolized, the risk of a clinically significant interaction between echinacea and DayQuil Severe is low.
Docetaxel (Taxotere)
Theoretically, echinacea may interfere with the metabolism of docetaxel; however, a small clinical study found no effect.
Docetaxel is metabolized by cytochrome P450 3A4 (CYP3A4). Echinacea has variable effects on CYP3A4, but taking E. purpurea whole plant extract (Echinaforce, A. Vogel Biopharma AG) 20 drops three times daily for 2 weeks did not alter the pharmacokinetics of docetaxel in one clinical study.
Etravirine (Intelence)
Theoretically, echinacea may interfere with the metabolism of etravirine; however, a small clinical study found no effect.
Etravirine is metabolized by cytochrome P450 3A4 (CYP3A4). Echinacea has variable effects on CYP3A4, but taking E. purpurea root extract (Arkocapsulas Echinacea, Arkopharma) 500 mg three times daily for 14 days did not alter the pharmacokinetics of etravirine in HIV-infected patients.
Lopinavir/Ritonavir (Kaletra)
Theoretically, echinacea may interfere with the metabolism of lopinavir; however, a small clinical study found no effect.
Lopinavir is metabolized by cytochrome P450 3A4 (CYP3A4) and is administered with the CYP3A4 inhibitor ritonavir to increase its plasma concentrations. Echinacea has variable effects on CYP3A4, but taking E. purpurea (Echinamide, Natural Factors Nutritional Products, Inc.) 500 mg three times daily for 14 days did not alter the pharmacokinetics of lopinavir/ritonavir in healthy volunteers.
Midazolam (Versed)
Theoretically, echinacea may increase the metabolism of intravenous midazolam.
Echinacea induces hepatic CYP3A4 and might decrease plasma levels of midazolam by about 20%, reducing the effectiveness of intravenous midazolam. Echinacea also appears to inhibit intestinal CYP3A4, which could theoretically increase the bioavailability of oral midazolam. This may cancel out the decrease in availability caused by induction of hepatic CYP3A4, such that overall plasma levels after oral administration of midazolam are not affected by echinacea.
Warfarin (Coumadin)
Echinacea seems to increase the clearance of warfarin, although the effect may not be clinically significant.
Preliminary clinical research in healthy male volunteers suggests that taking echinacea increases the clearance of the active S-isomer of warfarin after a single dose of warfarin, but there was not a clinically significant effect on the INR.
Astragalus, Dry
Antidiabetes Drugs
Theoretically, taking astragalus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research in humans shows that astragalus might have hypoglycemic effects. Theoretically, taking astragalus, especially in combination with other hypoglycemic agents, might increase the risk of hypoglycemia.
Cyclophosphamide
Theoretically, astragalus might interfere with cyclophosphamide therapy.
Evidence regarding the effect of astragalus on immunosuppression caused by cyclophosphamide is conflicting. Some animal research suggests that astragalus reverses cyclophosphamide-induced immunosuppression. However, other animal research shows no effect.
Immunosuppressants
Theoretically, astragalus might interfere with immunosuppressive therapy.
Astragalus seems to stimulate immune function. Theoretically, taking astragalus might decrease the effects of immunosuppressive therapy.
Lithium
Theoretically, astragalus might increase levels and adverse effects of lithium.
Animal research suggests that astragalus has diuretic properties. Theoretically, due to this diuretic effect, astragalus might reduce excretion and increase levels of lithium.
Brand information
Manufacturer and brand details for Propolis Astragalus Throat Spray, from the product label.
Eclectic Herb
See all Eclectic Herb products- Name
- Eclectic Herb
- Street Address
- 755 NE 6th St.
- City
- Gresham
- State
- Oregon
- ZipCode
- 97030
- Phone Number
- 503.668.4120
- Web Address
- www.eclecticherb.com
Propolis Astragalus Throat Spray by Eclectic Herb: Common Questions
Does Propolis Astragalus Throat Spray by Eclectic Herb interact with any medications?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Propolis Astragalus Throat Spray’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Astragalus
Interacts with 208 drugsAstragalus is a root used for centuries in traditional Chinese medicine, mainly to support the immune system and help the body cope with stress. While early studies are interesting, strong h...
Read the full Astragalus monograph → Herb & supplement monographPropolis
Interacts with 921 drugsPropolis is a natural, resin-like substance made by bees that has antimicrobial and anti-inflammatory properties in lab studies. Early research suggests it may help with cold sores, mouth so...
Read the full Propolis monograph → Herb & supplement monographEchinacea
Interacts with 816 drugsEchinacea is a popular herb taken to help prevent or shorten the common cold, but study results are mixed and the overall benefit appears small at best. It is generally well tolerated for sh...
Read the full Echinacea monograph → Herb & supplement monographSlippery Elm
Interacts with 2,022 drugsSlippery elm is a traditional herbal remedy made from the inner bark of a North American elm tree, used mainly to soothe sore throats and irritated digestive tracts. Its mucilage can coat an...
Read the full Slippery Elm monograph →Sources & How We Checked
Propolis Astragalus Throat Spray's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 88 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Astragalus 13 references
- Upton R, ed. Astragalus Root: Analytical, quality control, and therapeutic monograph. Santa Cruz, CA: American Herbal Pharmacopoeia. 1999:1-25.
- Khoo KS, Ang PT. Extract of astragalus membranaceus and ligustrum lucidum does not prevent cyclophosphamide-induced myelosuppression. Singapore Med J 1995;36:387-90.
- Chu DT, Wong WL, Mavligit GM. Immunotherapy with Chinese medicinal herbs. II. Reversal of cyclophosphamide-induced immune suppression by administration of fractionated Astragalus membranaceus in vivo. J Clin Lab Immunol 1988;25:125-9.
- Sun Y, Hersh EM, Lee SL, et al. Preliminary observations on the effects of the Chinese medicinal herbs Astragalus membranaceus and Ligustrum lucidum on lymphocyte blastogenic responses. J Biol Response Mod 1983;2:227-37..
- Ma J, Peng A, Lin S. Mechanisms of the therapeutic effect of astragalus membranaceus on sodium and water retention in experimental heart failure. Chin Med J (Engl) 1998;111:17-23.
- Matkovic Z, Zivkovic V, Korica M, et al. Efficacy and safety of Astragalus membranaceus in the treatment of patients with seasonal allergic rhinitis. Phytother Res 2010;24:175-81.
- Zhang, J. G., Yang, N., He, H., Wei, G. H., Gao, D. S., Wang, X. L., Wang, X. Z., and Song, G. Y. [Effect of Astragalus injection on plasma levels of apoptosis-related factors in aged patients with chronic heart failure.]. Chin J Integr.Med 2005;11(3):18 PubMed
- Chen, H. W., Lin, I. H., Chen, Y. J., Chang, K. H., Wu, M. H., Su, W. H., Huang, G. C., and Lai, Y. L. A novel infusible botanically-derived drug, PG2, for cancer-related fatigue: a phase II double-blind, randomized placebo-controlled study. Clin Invest PubMed
- Tian H, Lu J, He H, et al.The effect of Astragalus as an adjuvant treatment in type 2 diabetes mellitus: A (preliminary) meta-analysis. J Ethnopharmacol. 2016;191:206-215. doi: 10.1016/j.jep.2016.05.062. PubMed
- Hong KF, Liu PY, Zhang W, Gui DK, Xu YH. The Efficacy and Safety of Astragalus as an Adjuvant Treatment for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. J Integr Complement Med 2023. PubMed
- Chan KW, Kwong ASK, Tsui PN, et al. Add-on astragalus in type 2 diabetes and chronic kidney disease: A multi-center, assessor-blind, randomized controlled trial. Phytomedicine 2024;130:155457. PubMed
- Han X, Yu T, Chen X, Du Z, Yu M, Xiong J. Effect of Astragalus membranaceus on left ventricular remodeling in HFrEF: a systematic review and meta-analysis. Front Pharmacol 2024;15:1345797. PubMed
- Jing P, Hongzheng H, Zhenqi WU, Meijuan Z, Zuojing LI, Gang C. Long-term efficacy and safety of Huangqi ()-based Traditional Chinese Medicine in diabetic peripheral neuropathy: a Meta-analysis of randomized controlled trials. J Tradit Chin Med 2024;44(2):
Propolis 21 references
- Hay KD, Greig DE. Propolis allergy: a cause of oral mucositis with ulceration. Oral Surg Oral Med Oral Pathol 1990;70:584-6. PubMed
- Li YJ, Lin JL, Yang CW, Yu CC. Acute renal failure induced by a Brazilian variety of propolis. Am J Kidney Dis 2005;46:e125-9. PubMed
- Jensen CD, Andersen KE. Allergic contact dermatitis from cera alba (purified propolis) in a lip balm and candy. Contact Dermatitis 2006;55:312-3. PubMed
- Chen, T. G., Lee, J. J., Lin, K. H., Shen, C. H., Chou, D. S., and Sheu, J. R. Antiplatelet activity of caffeic acid phenethyl ester is mediated through a cyclic GMP-dependent pathway in human platelets. Chin J Physiol 6-30-2007;50(3):121-126.
- Hsu, C. Y., Chiang, W. C., Weng, T. I., Chen, W. J., and Yuan, A. Laryngeal edema and anaphalactic shock after topical propolis use for acute pharyngitis. Am J Emerg.Med 2004;22(5):432-433. PubMed
- Black, R. J. Vulval eczema associated with propolis sensitization from topical therapies treated successfully with pimecrolimus cream. Clin Exp.Dermatol. 2005;30(1):91-92. PubMed
- Matos D, Serrano P, Brandao FM. A case of allergic contact dermatitis caused by propolis-enriched honey. Contact Dermatitis 2015;72(1):59-60. PubMed
- Naramoto K, Kato M, Ichihara K. Effects of an ethanol extract of Brazilian green propolis on human cytochrome P450 enzyme activities in vitro. J Agric Food Chem 2014;62(46):11296-302. PubMed
- Nyman G, Hagvall L. A case of allergic contact cheilitis caused by propolis and honey. Contact Dermatitis 2016;74(3):186-7. PubMed
- Ryu CS, Oh SJ, Oh JM, et al. Inhibition of cytochrome P450 by propolis in human liver microsomes. Toxicol Res 2016;32(3):207-13. PubMed
- Akbay E, Özenirler Ç, Çelemli ÖG, Durukan AB, Onur MA, Sorkun K. Effects of propolis on warfarin efficacy. Kardiochir Torakochirurgia Pol. 2017;14(1):43-46. PubMed
- Lamoureux A, Meharon M, Durand AL, Darrigade AS, Doutre MS, Milpied B. A first case of erythema multiforme-like contact dermatitis caused by propolis. Contact Dermatitis. 2017;77(4):263-264. PubMed
- Piredda M, Facchinetti G, Biagioli V, et al. Propolis in the prevention of oral mucositis in breast cancer patients receiving adjuvant chemotherapy: A pilot randomised controlled trial. Eur J Cancer Care (Engl). 2017;26(6). PubMed
- Zhang YX, Yang TT, Xia L, Zhang WF, Wang JF, Wu YP. Inhibitory Effect of Propolis on Platelet Aggregation In Vitro. J Healthc Eng. 2017;2017:3050895. PubMed
- Nyman GSA, Tang M, Inerot A, Osmancevic A, Malmberg P, Hagvall L. Contact allergy to beeswax and propolis among patients with cheilitis or facial dermatitis. Contact Dermatitis 2019;81(2):110-6. PubMed
- Igarashi G, Segawa T, Akiyama N, et al. Efficacy of Brazilian propolis supplementation for japanese lactating women for atopic sensitization and nonspecific symptoms in their offspring: a randomized, double-blind, placebo-controlled trial. Evid Based Comp PubMed
- Soleimani D, Rezaie M, Rajabzadeh F, et al. Protective effects of propolis on hepatic steatosis and fibrosis among patients with nonalcoholic fatty liver disease (NAFLD) evaluated by real-time two-dimensional shear wave elastography: a randomized clinical
- D'Ercole MC. Prolonged use of propolis can increase liver enzymes. J Gastrointestin Liver Dis 2020;29(3):468-9. PubMed
- Cho E, Lee JD, Cho SH. Systemic contact dermatitis from propolis ingestion. Ann Dermatol. 2011;23(1):85-88. PubMed
- Hallajzadeh J, Milajerdi A, Amirani E, Attari VE, Maghsoudi H, Mirhashemi SM. Effects of propolis supplementation on glycemic status, lipid profiles, inflammation and oxidative stress, liver enzymes, and body weight: a systematic review and meta-analysis
- Gheflati A, Dehnavi Z, Ghannadzadeh Yazdi A, Khorasanchi Z, Raeisi-Dehkordi H, Ranjbar G. The effects of propolis supplementation on metabolic parameters: a systematic review and meta-analysis of randomized controlled clinical trials. Avicenna J Phytomed
Echinacea 51 references
- Mullins RJ. Echinacea-associated anaphylaxis. Med J Aust 1998;168:170-1. PubMed
- Mullins RJ. Allergic reactions to Echinacea. J Allergy Clin Immunol 2000;104:S340-341 (Abstract 1003).
- Chavez ML, Chavez PI. Echinacea. Hosp Pharm 1998;33:180-8.
- Grimm W, Muller HH. A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections. Am J Med 1999;106:138-43. PubMed
- Taylor JA, Weber W, Standish L, et al. Efficacy and safety of echinacea in treating upper respiratory tract infections in children: a randomized controlled trial. JAMA 2003;290:2824-30.. PubMed
- Luettig B, Steinmuller C, Gifford GE, et al. Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. J Natl Cancer Inst 1989;81:669-75. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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