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Dietary supplement

PS-100 100 mg Ingredients & Drug Interactions

by Metabolic Maintenance

Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

PS-100 100 mg is a dietary supplement by Metabolic Maintenance with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sharp-PS Green. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of PS-100 100 mg by Metabolic Maintenance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

PS-100 contains one active ingredient: phosphatidylserine (marketed as Sharp-PS Green), a naturally occurring compound found in cell membranes. The softgel also contains inactive ingredients — medium chain triglyceride oil, gelatin, glycerin, polyglycitol syrup, and purified water — which serve as the capsule shell and delivery vehicle.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: memory and cognitive support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Attention deficit-hyperactivity disorder (ADHD), mental performance, focus — and 1 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

The evidence for phosphatidylserine is mixed. It's rated possibly effective for age-related cognitive decline and Alzheimer disease, meaning there's some supportive research but it's not conclusive.

For athletic performance, ADHD, general cognitive function, and dementia, the evidence isn't established enough to rate — we simply don't have reliable data to say whether it works for those uses.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated, though long-term safety hasn't been fully studied. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea.

Gastrointestinal upset can occur at doses of 200–300 mg per day, and insomnia is more likely at higher doses around 600 mg. During pregnancy, the safety data advises against use.

Safety while breastfeeding is unknown, so avoidance is recommended.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take anticholinergic drugs (like antihistamines for allergies or certain bladder medications) or cholinergic drugs before starting this product — both interactions are Moderate severity. Use our medication checker on this page to look up your specific prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

PS-100 may be worth considering if you're dealing with age-related cognitive decline or early Alzheimer disease and want to explore the research. However, if you take anticholinergic or cholinergic medications, you'll need to check your exact drugs with our tool first.

Watch for gastrointestinal upset and insomnia, especially at higher doses. Talk with your pharmacist before starting, especially if you're pregnant, breastfeeding, or on any prescription medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PS-100 100 mg, straight from the product label.

Brand Metabolic Maintenance
Barcode (UPC) 838287006404
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 321274
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PS-100 100 mg by Metabolic Maintenance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
3 Softgel(s)
Servings per container
60
UPC/BARCODE
838287006404
IngredientAmount% DV
Calories5 Calorie(s)--
Total Fat0.5 Gram(s)1%
Sharp-PS Green100 mg--

Other ingredients: Medium Chain Triglyceride Oil, Gelatin, Glycerin, Polyglycitol Syrup, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Caution: pregnant or lactating women, or individuals taking prescription medication, consult your healthcare professional before taking this product.

Keep tightly closed in a cool, dry place, out of the reach of children.

Storage

Keep tightly closed in a cool, dry place, out of the reach of children.

Formulation

Egg free Gluten free Free of nuts Dairy free

Manufactured in a GMP Compliant Facility

FDA Statement of Identity

Dietary Supplement

Formula

Phosphatidylserine

Suggested/Recommended/Usage/Directions

Directions: One to three (1-3) softgels daily, or as directed by a healthcare professional. Best taken with meals.

Brand IP Statement(s)

Smart PS, is a trademark of Soft Gel Technologies, Inc. Sharp-PS is a registered trademark of Frutarom Ltd.

See for yourself

PS-100 100 mg by Metabolic Maintenance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in PS-100 100 mg by Metabolic Maintenance

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.

Sharp-PS Green

Interacts with
219 drugs
100 mg per serving Form: Phosphatidylserine

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Sharp-PS Green monograph & interactions

Other (inactive) ingredients: Medium Chain Triglyceride Oil, Gelatin, Glycerin, Polyglycitol Syrup, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

PS-100 100 mg by Metabolic Maintenance Drug Interactions

Want to check YOUR meds against PS-100 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in PS-100 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Sharp-PS Green2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for PS-100 100 mg, from the product label.

Metabolic Maintenance

See all Metabolic Maintenance products
Name
Metabolic Maintenance
Street Address
601 N Larch Street
City
Sisters
State
Oregon
ZipCode
97759
Phone Number
800-772-7873
Web Address
MetabolicMaintenance.com
Pharmacist Counseling Corner

PS-100 100 mg by Metabolic Maintenance: Common Questions

Does PS-100 100 mg by Metabolic Maintenance interact with any medications?
Yes. Based on its ingredients, PS-100 100 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PS-100 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is phosphatidylserine?
It's a naturally occurring compound found in cell membranes. Phosphatidylserine is thought to increase levels of a brain chemical called acetylcholine, which is why it's being studied for cognitive and memory support.
Will this help my memory?
The evidence suggests it's possibly effective for age-related cognitive decline and Alzheimer disease, but that's not a guarantee — the research isn't conclusive. For other memory or cognitive issues, we don't have enough reliable evidence to say.
Can I take this while pregnant or breastfeeding?
No — there isn't enough safety information during pregnancy, so avoidance is recommended. Safety while breastfeeding is also unknown, so it's best to avoid then too. Talk with your doctor or pharmacist if you have questions about your specific situation.
What side effects should I expect?
Most people tolerate it well, but common side effects include flatulence, gastrointestinal upset, headache, insomnia, and nausea. Gastrointestinal upset can happen at doses around 200–300 mg per day, and insomnia is more likely if you take higher doses.
Is this safe to use long-term?
Phosphatidylserine is generally well tolerated in studies, but long-term safety hasn't been fully established, so we don't have complete data on years of continuous use.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PS-100 100 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PS-100 100 mg label
Sources

Sources & How We Checked

PS-100 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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