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Dietary supplement

PS Phosphatidylserine 100 mg Ingredients & Drug Interactions

by Natural Factors

PS Phosphatidylserine 100 mg label
See full label image
Softgel Capsule Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PS Phosphatidylserine 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

PS Phosphatidylserine 100 mg is a dietary supplement by Natural Factors with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, age-related cognitive decline, attention and focus (adhd).Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against PS Phosphatidylserine 100 mg by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with PS Phosphatidylserine 100 mg by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of PS Phosphatidylserine 100 mg by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel contains a single active ingredient: phosphatidylserine, a natural fat-like compound found in cell membranes. The capsule itself is made from gelatin, glycerin, purified water, and non-GMO sunflower lecithin—all inactive ingredients that help deliver the phosphatidylserine.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy brain function.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Cognitive function, Dementia, Attention deficit-hyperactivity disorder (ADHD), memory — and 2 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylserine is rated "Possibly Effective" for Alzheimer disease.
  • Also on file: Phosphatidylserine is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia.

Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer's disease, based on the evidence we have on file. For athletic performance, ADHD, general cognitive function, and dementia, the evidence isn't strong enough yet to say whether it works.

Talk with your doctor about whether it might make sense for your specific situation.

The evidence, ingredient by ingredient Phosphatidylserine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine is generally well tolerated in studies, though long-term safety isn't fully established. The most common side effects are flatulence, gastrointestinal upset, headache, insomnia, and nausea—and insomnia is more likely at higher doses (around 600 mg).

Gastrointestinal upset can show up at doses of 200–300 mg per day. The safety data advises against use during pregnancy and while breastfeeding because there isn't enough information to know it's safe.

If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Phosphatidylserine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any anticholinergic drugs (used for overactive bladder, Parkinson's disease, or urinary symptoms) or cholinergic drugs (used for myasthenia gravis or Alzheimer's disease) with your doctor or pharmacist. Phosphatidylserine may reduce the effectiveness of anticholinergic medications or add to the effects of cholinergic ones.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may help with age-related memory changes or early Alzheimer's disease if you and your doctor think it's a fit for you. If you take anticholinergic or cholinergic medications, you'll need to check with your doctor or pharmacist first—this product could interfere with how those drugs work.

Most people tolerate it well, though some experience mild stomach upset or headache. Run it by your own healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PS Phosphatidylserine 100 mg, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958026152
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Jan 23, 2023
DSLD ID 282618
Product type Fat/fatty Acid
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PS Phosphatidylserine 100 mg by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
068958026152
IngredientAmount% DV
Phosphatidylserine100 mg--

Other ingredients: Gelatin, Glycerin, Water, Purified, non-GMO Sunflower Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

ISURA Non-GMO Mass Spec Documentation Lab Tested

Suggested/Recommended/Usage/Directions

Suggested usage:1 softgel 1–3 times per day or as directed by a health professional.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formula

Phosphatidylserine (PS) is a natural component of the brain and is integral to all brain cell activity. Supplementing the diet daily with PS supports healthy brain function. Natural Factors uses Sharp-PS GREEN phosphatidylserine, which is derived from non-GMO sunflower lecithin and is 100% soy-free.

Sharp-PS GREEN

Formulation

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, salt, tree nuts, or GMOs.

Product of Canada

Non-GMO Soy free

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Recyclable container and label.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

PS Factor The key to brain health

Sharp-PS is a registered trademark of Enzymotec Ltd. Manufactured and protected under U.S. Patent #8,324,187. Isura is a trademark of ISURA.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PS Phosphatidylserine 100 mg by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PS Phosphatidylserine 100 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PS Phosphatidylserine 100 mg by Natural Factors

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: Sunflower Lecithin

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Water, Purified, Non-GMO Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

PS Phosphatidylserine 100 mg by Natural Factors Drug Interactions

Want to check YOUR meds against PS Phosphatidylserine 100 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Phosphatidylserine 219

Individual Drug Interactions

The ingredients in PS Phosphatidylserine 100 mg interact with 219 drugs. Click any drug to see the details.

1 of the 1 ingredient in PS Phosphatidylserine 100 mg interact with drugs. Each result below shows which ingredient is responsible. Phosphatidylserine

Each ingredient & the kinds of drugs it affects

For each ingredient in PS Phosphatidylserine 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for PS Phosphatidylserine 100 mg, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors, Canada
Pharmacist Counseling Corner

PS Phosphatidylserine 100 mg by Natural Factors: Common Questions

Does PS Phosphatidylserine 100 mg by Natural Factors interact with any medications?
Yes. Based on its ingredients, PS Phosphatidylserine 100 mg has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PS Phosphatidylserine 100 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is phosphatidylserine, and what is it supposed to do?
Phosphatidylserine is a natural fat-like compound that's part of cell membranes throughout your body. It's possibly effective for age-related cognitive decline and Alzheimer's disease, though the evidence for other uses like ADHD or general brain function isn't strong enough yet to say it works.
What are the most common side effects?
The most common ones are flatulence, stomach upset, headache, insomnia, and nausea. Insomnia is more likely if you take a higher dose (around 600 mg), and stomach upset can happen at doses of 200–300 mg per day. Most people tolerate it well overall.
Can I take this while pregnant or breastfeeding?
The safety data advises against it. There isn't enough information to know it's safe during pregnancy or while breastfeeding, so talk with your doctor or pharmacist for personalized advice if you're in either situation.
Is this product safe long-term?
It's generally well tolerated in studies, but long-term safety hasn't been fully established. If you're considering taking it regularly, it's worth discussing with your doctor or pharmacist.
What are the inactive ingredients?
The softgel capsule is made with gelatin, glycerin, purified water, and non-GMO sunflower lecithin. These help deliver the phosphatidylserine but are not active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PS Phosphatidylserine 100 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PS Phosphatidylserine 100 mg label
Go deeper

The Full Monographs Behind PS Phosphatidylserine 100 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph →
Sources

Sources & How We Checked

PS Phosphatidylserine 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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