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Dietary supplement

Pure Liquid Orange NuStevia Ingredients & Drug Interactions

by NuNaturals

Pure Liquid Orange NuStevia label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pure Liquid Orange NuStevia against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pure Liquid Orange NuStevia is a dietary supplement by NuNaturals with 1 active ingredient. Its ingredients are commonly taken for sugar substitute / sweetener, blood sugar support in diabetes, weight management.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Stevia extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pure Liquid Orange NuStevia by NuNaturals

Ask about any prescription or over-the-counter medication and we check it for interactions with Pure Liquid Orange NuStevia by NuNaturals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pure Liquid Orange NuStevia by NuNaturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: stevia extract, a natural sweetener derived from the stevia plant. It's mixed with water, vegetable glycerine, and natural flavors as inactive ingredients to create a liquid sweetener you can use in place of sugar or other sweeteners.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Stevia product and its label doesn't state a use — see Stevia's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The data we hold doesn't establish reliable evidence that stevia works for diabetes, high blood pressure, or weight loss. Some small studies hint it might help lower blood sugar levels after meals in people with type 2 diabetes, but other research hasn't confirmed a significant blood pressure effect.

We'd need stronger clinical evidence to say whether it's truly effective for these uses.

The evidence, ingredient by ingredient Stevia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Purified stevia in typical food amounts is generally well tolerated, though we'd caution that high-dose supplements like this one aren't as well studied as food-level use. Most people who experience side effects — bloating, dizziness, headache, muscle pain, nausea, or numbness — find they go away after the first week.

Allergic reactions are rare. Because stevia in supplement doses lacks robust safety data, use caution, especially if you're taking other medications or have health conditions that might be affected.

Side effects, ingredient by ingredient Stevia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Stevia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take lithium (a Moderate severity interaction), blood pressure medications, or diabetes drugs. Stevia may affect how these work or raise their levels in your body.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're a healthy person using this as an occasional sweetener without lithium, blood pressure meds, or diabetes medications, it's likely fine. But if you take any prescription drugs — especially lithium, heart or blood pressure medications, or diabetes treatments — talk with your doctor or pharmacist before starting this product.

They can confirm it's safe with your specific medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pure Liquid Orange NuStevia, straight from the product label.

Brand NuNaturals
Barcode (UPC) 739223001791
Net contents 2 fl. Oz.; 59 mL
Market status On market
Date entered into DSLD May 22, 2015
DSLD ID 45082
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pure Liquid Orange NuStevia by NuNaturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.35 mL
Maximum serving Sizes:
0.7 mL
Servings per container
169
UPC/BARCODE
739223001791
IngredientAmount% DV
Stevia extract140 mg--

Other ingredients: Water, Vegetable Glycerine, Natural Flavors

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Shake before using. Use 7-14 drops directly in your favorite food or beverage.

Brand IP Statement(s)

NuNaturals uses our highly concentrated NuStevia(TM) extract and should not be confused with less potent powdered herbs or extracts.

NuStevia(TM) brand Stevia is a natural plant extract.

General Statements

NuNaturals uses plant-based natural flavors that help to make our Stevia products the best-tasting ones available.

Concentrated 2 fl. oz. (59 ml) Extract

General

V1

Formulation

Contains no msg, soy, milk, synthetics, artificial colors or flavor, preservatives, saccharin, aspartame, sucralose, or artificial sweeteners.

Alcohol Free

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pure Liquid Orange NuStevia by NuNaturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pure Liquid Orange NuStevia label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pure Liquid Orange NuStevia by NuNaturals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.35 mL Dosage formLiquid Servings per container169 Amounts shown are per serving.

Stevia extract

Interacts with
259 drugs
140 mg per serving

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regu...

Stevia extract monograph & interactions

Other (inactive) ingredients: Water, Vegetable Glycerine, Natural Flavors. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pure Liquid Orange NuStevia by NuNaturals Drug Interactions

Want to check YOUR meds against Pure Liquid Orange NuStevia?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
1 Moderate 258 Minor

Ingredients driving the most interactions

Stevia extract 259

Individual Drug Interactions

The ingredients in Pure Liquid Orange NuStevia interact with 259 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pure Liquid Orange NuStevia interact with drugs. Each result below shows which ingredient is responsible. Stevia extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pure Liquid Orange NuStevia with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Stevia extract3 drug types · 259 drugs

Lithium

Theoretically, stevia might decrease clearance and increase levels of lithium.
Animal research suggests that stevia extracts might have diuretic activity. Theoretically, increased reabsorption of lithium along with sodium might reduce excretion and increase levels of lithium.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, stevia might increase the risk for hypoglycemia when combined with antidiabetes drugs.
Preliminary clinical research in patients with type 2 diabetes suggests that taking a single dose of stevia extract 1000 mg reduces postprandial blood glucose levels when taken with a meal. However, other clinical research in patients with type 1 or type 2 diabetes suggests that taking stevioside 250 mg three times daily does not significantly affect blood glucose levels or glycated hemoglobin (HbA1C) after three months of treatment.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, combining stevia or stevia constituents with antihypertensive agents might increase the risk of hypotension.
Stevia extract and stevioside might lower blood pressure in patients with hypertension. However, other clinical research suggests that stevioside does not significantly lower blood pressure in patients with hypertension.

Likelihood Possible Evidence D
Stevia extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pure Liquid Orange NuStevia, from the product label.

NuNaturals

See all NuNaturals products
Name
NuNaturals, Inc.
Street Address
2220 West 2nd Ave. #1
City
Eugene
State
OR
ZipCode
97402
Phone Number
800-753-4372
Web Address
www.nunaturals.com
Pharmacist Counseling Corner

Pure Liquid Orange NuStevia by NuNaturals: Common Questions

Does Pure Liquid Orange NuStevia by NuNaturals interact with any medications?
Yes. Based on its ingredients, Pure Liquid Orange NuStevia has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pure Liquid Orange NuStevia contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this stevia product lower my blood sugar or blood pressure?
The evidence isn't strong enough to say it will. Some small studies suggest stevia extract might lower blood sugar after meals in people with type 2 diabetes, but other research hasn't found a clear blood pressure effect. We don't have reliable evidence it works for either purpose as a supplement.
What side effects might I notice?
Common ones are abdominal bloating, dizziness, headache, muscle pain, nausea, and numbness. Most people find these side effects go away within the first week. Allergic reactions are rare. If side effects persist or worsen, stop using it and talk to your pharmacist.
Is this safe to use if I'm pregnant or breastfeeding?
We don't hold safety data on stevia during pregnancy or lactation. Talk with your doctor or pharmacist before using this product if you're pregnant, breastfeeding, or planning to become pregnant — they can give you personalized advice based on your situation.
What's the difference between this liquid and other stevia products?
This product is a purified stevia extract in liquid form, mixed with water, vegetable glycerine, and natural flavors. Purified stevia in food amounts is recognized as safe, but supplement-dose products like this aren't as thoroughly studied, so use caution and talk to your pharmacist if you have questions.
Can I use this if I take heart or blood pressure medication?
Stevia might theoretically lower your blood pressure further or interact with how these drugs work. Before starting this product, check with your doctor or pharmacist — they'll know your specific medications and can confirm it's safe for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pure Liquid Orange NuStevia is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pure Liquid Orange NuStevia label
Go deeper

The Full Monographs Behind Pure Liquid Orange NuStevia’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Stevia

Interacts with 259 drugs

Stevia is a plant-based, calorie-free sweetener that is widely used as a sugar alternative and is considered safe in normal food amounts by major regulators. Purified stevia extracts have a...

Read the full Stevia monograph →
Sources

Sources & How We Checked

Pure Liquid Orange NuStevia's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Stevia 10 references
  1. Chan P, Xu DY, Liu JC, et al. The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats. Life Sci 1998;63:1679-84. PubMed
  2. Melis MS. A crude extract of Stevia rebaudiana increases the renal plasma flow of normal and hypertensive rats. Braz J Med Biol Res 1996;29:669-75.
  3. Melis MS. Chronic administration of aqueous extract of Stevia rebaudiana in rats: renal effects. J Ethnopharmacol 1995;47:129-34. PubMed
  4. Melis MS, Sainati AR. Effect of calcium and verapamil on renal function of rats during treatment with stevioside. J Ethnopharmacol 1991;33:257-622. PubMed
  5. Hsieh MH, Chan P, Sue YM, et al. Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study. Clin Ther 2003;25:2797-808. PubMed
  6. Chan P, Tomlinson B, Chen YJ, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral stevioside in human hypertension. Br J Clin Pharmacol 2000;50:215-20. PubMed
  7. Gregersen S, Jeppesen PB, Holst JJ, Hermansen K. Antihyperglycemic effects of stevioside in type 2 diabetic subjects. Metabolism 2004;53:73-6. PubMed
  8. Barriocanal LA, Palacios M, Benitez G, et al. Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabeti
  9. Ferri LA, Alves-Do-Prado W, Yamada SS, et al. Investigation of the antihypertensive effect of oral crude stevioside in patients with mild essential hypertension. Phytother Res 2006;20:732-6. PubMed
  10. Almiron-Roig E, Navas-Carretero S, Castelnuovo G, et al. Impact of acute consumption of beverages containing plant-based or alternative sweetener blends on postprandial appetite, food intake, metabolism, and gastro-intestinal symptoms: Results of the SWEE

See these in context on the Stevia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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