Pycnogenol 100 mg Ingredients & Drug Interactions
by Source Naturals
What is this page for?
First and foremost: checking Pycnogenol 100 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Pycnogenol 100 mg is a dietary supplement by Source Naturals with 1 active ingredient. Its ingredients are commonly taken for circulation and vein health, antioxidant support, skin health and aging.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are French Maritime Pine bark extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Pycnogenol 100 mg by Source Naturals
Ask about any prescription or over-the-counter medication and we check it for interactions with Pycnogenol 100 mg by Source Naturals — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Pycnogenol 100 mg by Source Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Pycnogenol 100 mg is a single-ingredient supplement containing French Maritime Pine bark extract, a plant-derived compound that's been studied for a range of conditions. The tablet also contains inactive ingredients—microcrystalline cellulose, dibasic calcium phosphate, modified cellulose gum, magnesium stearate, silica, and stearic acid—which serve as binders and fillers.
Does it work?
Moderate evidence
The evidence for maritime pine bark extract is mixed. It's rated possibly effective for osteoarthritis and chronic venous insufficiency (poor circulation in the legs and veins)—meaning some clinical research supports it, but more data would strengthen the case.
For asthma, it's also rated possibly effective. However, for lowering cholesterol (hyperlipidemia), the evidence suggests it's probably not effective.
How safe is it?
Well-documented data
Maritime pine bark extract is generally well tolerated in studies, though long-term safety hasn't been fully established. The most common side effects are gastrointestinal complaints, dizziness, and vertigo; headache has been reported in one trial.
Very rarely, cases of chest pain and worsening heart failure have been reported, though it's unclear whether the extract was directly responsible, and those patients had existing heart conditions. Regarding pregnancy, there isn't enough safety data, so the evidence advises against it during pregnancy.
Breastfeeding data is also insufficient; talk with your doctor or pharmacist about whether it's right for you if you're nursing.
Meds to double-check
Moderate interaction found
Before taking Pycnogenol, check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs (like warfarin, aspirin, or clopidogrel)—the extract may raise bleeding risk. Also check if you're on immune-suppressing medications or antidiabetes drugs; the extract could reduce the effectiveness of immunosuppressants and increase the risk of low blood sugar with diabetes medications.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Pycnogenol may be worth considering if you're dealing with osteoarthritis or poor leg circulation and want to explore plant-based options—the evidence is modest but promising. However, if you take blood thinners, immune-suppressing medications, or diabetes drugs, you need to check with your own doctor or pharmacist before starting, because the extract could change how these medications work.
Pregnant or breastfeeding? Discuss it with your healthcare provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Pycnogenol 100 mg, straight from the product label.
| Brand | Source Naturals |
|---|---|
| Barcode (UPC) | 021078003328 |
| Net contents | 30 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | May 24, 2017 |
| DSLD ID | 73835 |
| Product type | Botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Pycnogenol 100 mg by Source Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| French Maritime Pine bark extract | 100 mg | -- |
Other ingredients: Microcrystalline Cellulose, Dibasic Calcium Phosphate, modified Cellulose Gum, Magnesium Stearate, Silica, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
General Statements
Proanthocyanidin complex
Pycnogenol is a natural plant product made from the bark of the European coastal pine, Pinus maritima.
Proanthocyanidins are believed to play an important role in maintaining good health.
Seals/Symbols
Non GMO Validated
Formulation
Non GMO Validated
Formula
Pycnogenol contains 65% procyanidins, a special class of water-soluble antioxidant flavonoids, which are excellent free radical scavengers.
Suggested/Recommended/Usage/Directions
Suggested Use: 1 tablet daily. To build reserves rapidly, start with one tablet per 100 pounds of body weight per day, for 7 to 10 days.
Precautions
Note: If you are pregnant, may become pregnant, or breastfeeding, consult your health care professional before using this product.
Do not use if either tamper-evident seal is broken or missing.
Keep out of the reach of children.
Brand IP Statement(s)
Pycnogenol is a registered trademark of Horphag Research, Ltd. Use of this product may be protected by one or more U.S. Patents and other international patents.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General
SN0332 REV A151
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Pycnogenol 100 mg by Source Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Pycnogenol 100 mg by Source Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.
French Maritime Pine bark extract
Interacts with327 drugs
Maritime pine bark extract (often sold as Pycnogenol) is a plant-based antioxidant most studied for circulation, vein, and skin health. Some research...
French Maritime Pine bark extract monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Dibasic Calcium Phosphate, Modified Cellulose Gum, Magnesium Stearate, Silica, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
Pycnogenol 100 mg by Source Naturals Drug Interactions
HelloPharmacist Interaction Report
Pycnogenol by Source Naturals contains French Maritime Pine bark extract, which has documented interactions with blood thinners (anticoagulants and antiplatelet drugs), immune-suppressing medications, and diabetes drugs.
The most serious concern is with blood thinners: the extract may increase bleeding risk, though we don't yet know how significant this effect is in real patients.
Read the full breakdown — every affected drug type, severity by severity
With immune-suppressing drugs (immunosuppressants), the extract theoretically could reduce how well these medications work — animal and lab research suggests it boosts immune activity, but this hasn't been proven in humans. For diabetes medications, one clinical study found the extract lowered blood sugar in patients already on antidiabetes drugs, raising the risk of low blood sugar (hypoglycemia); if you take diabetes medication, your blood sugar will need close monitoring and your dose may need adjustment.
Altogether, these interactions span 327 individual medications. Before you start this product, check your exact medications with the search tool on this page, especially if you take any blood thinner, immune-suppressing drug, or diabetes medication.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Pycnogenol 100 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Pycnogenol 100 mg interact with 327 drugs. Click any drug to see the details.
1 of the 1 ingredient in Pycnogenol 100 mg interact with drugs. Each result below shows which ingredient is responsible. French Maritime Pine bark extract
Aspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
How Aspirin, Meprobamate interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Aspirin, Meprobamate interactionAspirin, MethocarbamolRobaxisal
How Aspirin, Methocarbamol interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Aspirin, Methocarbamol interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Aspirin, Omeprazole interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Aspirin, Pentazocine interactionAtezolizumabTecentriq
How Atezolizumab interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Atezolizumab interactionAzamuneImmunoprin
How Azamune interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Azamune interactionAzathioprineAzamune, Imuran
How Azathioprine interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Azathioprine interactionBasiliximabSimulect
How Basiliximab interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Basiliximab interactionBeclometasone DipropionateBecotide
How Beclometasone Dipropionate interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Beclometasone Dipropionate interactionBeclomethasoneBeclovent, Vanceril
How Beclomethasone interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Beclomethasone interactionBeclomethasone DipropionateQNASL, Qvar
How Beclomethasone Dipropionate interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Beclomethasone Dipropionate interactionBetamethasoneCelestone, Diprolene AF, Diprosone
How Betamethasone interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Betamethasone interactionBetamethasone DipropionateSernivo
How Betamethasone Dipropionate interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Betamethasone Dipropionate interactionBetamethasone Dipropionate, CalcipotrieneEnstilar, Wynzora
How Betamethasone Dipropionate, Calcipotriene interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Betamethasone Dipropionate, Calcipotriene interactionBetamethasone ValerateLuxiq
How Betamethasone Valerate interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Betamethasone Valerate interactionBetrixabanBevyxxa
How Betrixaban interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Betrixaban interactionBimekizumab-bkzxBimzelx
How Bimekizumab-bkzx interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Bimekizumab-bkzx interactionBivalirudinAngiomax, Angiomax Rtu, Angiox
How Bivalirudin interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Bivalirudin interactionBromfenac SodiumBromsite, Prolensa
How Bromfenac Sodium interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Bromfenac Sodium interactionCabliviCablivi
How Cablivi interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Cablivi interactionCanagliflozinInvokana
How Canagliflozin interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Canagliflozin interactionCanagliflozin, MetforminInvokamet
How Canagliflozin, Metformin interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Canagliflozin, Metformin interactionCanagliflozin, Metformin HydrochlorideInvokamet XR
How Canagliflozin, Metformin Hydrochloride interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Canagliflozin, Metformin Hydrochloride interactionCangrelorKengreal
How Cangrelor interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Cangrelor interactionChlorpropamideChlorpropam, Diabinese
How Chlorpropamide interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
Read the full French Maritime Pine Bark Extract + Chlorpropamide interactionCiclesonideAlvesco, Omnaris, Zetonna
How Ciclesonide interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Ciclesonide interactionCilostazolPletal
How Cilostazol interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Read the full French Maritime Pine Bark Extract + Cilostazol interactionCisplatinPlatinol-AQ
How Cisplatin interacts with Pycnogenol 100 mg — through 1 ingredient. Tap an ingredient for the detail:
French Maritime Pine Bark ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
Read the full French Maritime Pine Bark Extract + Cisplatin interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Pycnogenol 100 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
French Maritime Pine bark extract
Anticoagulant/Antiplatelet Drugs
Theoretically, maritime pine bark extract might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs.
Clinical research suggests that maritime pine bark extract inhibits platelet aggregation. However, the clinical significance of this effect is unclear.
Antidiabetes Drugs
Theoretically, maritime pine bark extract might increase the risk of hypoglycemia when used with antidiabetes drugs.
One clinical study shows that maritime pine bark extract decreases blood sugar in patients with diabetes being treated with antidiabetes agents. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Immunosuppressants
Theoretically, maritime pine bark extract might decrease the effectiveness of immunosuppressant therapy.
In vitro and animal research suggests that maritime pine bark extract has immunostimulant activity. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Pycnogenol 100 mg, from the product label.
Source Naturals
- Name
- Source Naturals, Inc.
- Street Address
- P. O. Box 2118
- City
- Santa Cruz
- State
- CA
- ZipCode
- 95062
- Web Address
- www.sourcenaturals.com
Pycnogenol 100 mg by Source Naturals: Common Questions
Does Pycnogenol 100 mg by Source Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Pycnogenol while I'm pregnant?
What side effects might I notice?
Does Pycnogenol really work for joint pain?
What does French Maritime Pine bark extract actually do?
Is Pycnogenol safe to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Pycnogenol 100 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Pycnogenol 100 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Pycnogenol 100 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 14 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Maritime Pine 14 references
- Rice-Evans CA, Packer L, eds. Flavonoids in Health and Disease. Manhattan, NY: Marcel Dekker, Inc., 1998.
- Liu FJ, Zhang YX, Lau BH. Pycnogenol enhances immune and haemopoietic functions in senescence-accelerated mice. Cell Mol Life Sci 1998;54:1168-72. PubMed
- Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. PubMed
- Kohama T, Inoue M. Pycnogenol alleviates pain associated with pregnancy. Phytother Res 2006;20:232-4.
- Liu X, Zhou HJ, Rohdewald P. French maritime pine bark extract pycnogenol dose-dependently lowers glucose in type 2 diabetic patients (letter). Diabetes Care 2004;27:839. PubMed
- Liu X, Wei J, Tan F, et al. Antidiabetic effect of Pycnogenol French maritime pine bark extract in patients with diabetes type II. Life Sci 2004;75:2505-13. PubMed
- Wilson D, Evans M, Guthrie N et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of pycnogenol for improving allergic rhinitis symptoms. Phytother Res 2010;24:1115-9.
- Araghi-Niknam, M., Hosseini, S., Larson, D., Rohdewald, P., and Watson, R. R. Pine bark extract reduces platelet aggregation. Integr.Med. 3-21-2000;2(2):73-77. PubMed
- Trebaticka, J., Kopasova, S., Hradecna, Z., Cinovsky, K., Skodacek, I., Suba, J., Muchova, J., Zitnanova, I., Waczulikova, I., Rohdewald, P., and Durackova, Z. Treatment of ADHD with French maritime pine bark extract, Pycnogenol. Eur.Child Adolesc.Psychi PubMed
- Suzuki, N., Uebaba, K., Kohama, T., Moniwa, N., Kanayama, N., and Koike, K. French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled study
- Cisar, P., Jany, R., Waczulikova, I., Sumegova, K., Muchova, J., Vojtassak, J., Durackova, Z., Lisy, M., and Rohdewald, P. Effect of pine bark extract (Pycnogenol) on symptoms of knee osteoarthritis. Phytother.Res. 2008;22(8):1087-1092.
- Enseleit, F., Sudano, I., Periat, D., Winnik, S., Wolfrum, M., Flammer, A. J., Frohlich, G. M., Kaiser, P., Hirt, A., Haile, S. R., Krasniqi, N., Matter, C. M., Uhlenhut, K., Hogger, P., Neidhart, M., Luscher, T. F., Ruschitzka, F., and Noll, G. Effects
- Schoonees, A., Visser, J., Musekiwa, A., and Volmink, J. Pycnogenol(R) (extract of French maritime pine bark) for the treatment of chronic disorders. Cochrane.Database.Syst.Rev. 2012;4:CD008294.
- Wang S, Tan D Zhao Y et al. The effect of pycnogenol on the microcirculation, platelet function and ischemic myocardium in patients with coronary artery diseases. Eur Bull Drug Res 1999;7:19-25.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC