Interactions on record — worth a quick check against your medications. Based on 9 of 11 ingredients. Check your meds →
Dietary supplement

RejuvenZyme Ingredients & Drug Interactions

by Source Naturals

RejuvenZyme label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking RejuvenZyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

RejuvenZyme is a dietary supplement by Source Naturals with 11 active ingredients. Its ingredients are commonly taken for varicose veins and chronic venous insufficiency, hemorrhoids, easy bruising and fragile capillaries.Based on those ingredients, 227 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Amla, Bromelain, Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against RejuvenZyme by Source Naturals

Ask about any prescription or over-the-counter medication and we check it for interactions with RejuvenZyme by Source Naturals — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of RejuvenZyme by Source Naturals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 11 active ingredients.
  • “Pancreatin” is listed as a grouped ingredient — the label gives one combined amount (320 mg) without saying how much of each component you get.

RejuvenZyme contains 11 active ingredients, most of them digestive enzymes. Lipase, amylase, protease, trypsin, chymotrypsin, and pancreatin are all enzymes that help break down fats, carbohydrates, and proteins in your digestive tract.

Bromelain and serrapeptase are additional proteolytic (protein-breaking) enzymes derived from pineapple and bacteria, respectively. Papain, from papaya, is another enzyme.

Rutin is a plant compound (flavonoid), and amla (Indian gooseberry) is a fruit extract. The product also includes an ionic trace mineral blend for mineral support.

The capsule itself is made from hypromellose, gellan gum, rice bran, and medium-chain triglycerides—these are inactive ingredients that serve as the capsule shell and carriers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Heart, joint and immune support.
  • We looked for evidence on: Cardiovascular disease (CVD), Chronic venous insufficiency, Exercise-induced muscle soreness, Hemorrhoids, Knee pain, Osteoarthritis — and 4 related terms.
  • The strongest evidence on file: Indian Gooseberry is rated "Possibly Effective" for Dyslipidemia (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness.
  • Also on file: Rutin is rated "Insufficient Reliable Evidence To Rate" for Hemorrhoids, Osteoarthritis, Postoperative swelling.

The evidence for most of these ingredients is not established in the data we hold. Chymotrypsin is rated Effective for cataracts; that's the only ingredient with a solid effectiveness rating.

Amla shows Possibly Effective evidence for GERD (acid reflux) and dyslipidemia (abnormal blood fat levels). For the rest—rutin, lipase, protease, trypsin, bromelain, papain, and serrapeptase—the effectiveness ratings we have are Insufficient Reliable Evidence To Rate, meaning the science doesn't yet support claims about their benefits for the conditions listed.

The evidence, ingredient by ingredient Rutin Indian Gooseberry Trypsin Chymotrypsin Papain Bromelain Lipase Proteolytic Enzymes (proteases)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated short-term, but long-term safety data are limited for many of them. Rutin may cause headache, flushing, or rashes in some people.

Trypsin and bromelain can cause mild-to-moderate digestive upset—nausea, heartburn, stomach pain, diarrhea, or gas. Papain and bromelain may trigger allergic reactions in sensitive individuals.

Chymotrypsin rarely causes anaphylaxis (a severe allergic reaction). Serrapeptase may cause epigastric pain, nausea, or gastrointestinal upset, though these side effects appear to occur at the same rate as placebo in clinical trials.

Pregnancy and breastfeeding safety vary by ingredient. Rutin is likely safe in pregnancy but should be avoided as a supplement while breastfeeding.

Papain is possibly unsafe in pregnancy (concentrated forms and unripe papaya products especially) and should be avoided while breastfeeding. Protease, trypsin, chymotrypsin, bromelain, and serrapeptase lack established safety in pregnancy and breastfeeding, so they're best avoided unless your doctor advises otherwise.

Lipase and amla have insufficient safety data for pregnancy and breastfeeding—talk with your doctor or pharmacist about personalized advice.

Side effects, ingredient by ingredient Rutin Indian Gooseberry Trypsin Chymotrypsin Papain Bromelain Lipase Proteolytic Enzymes (proteases)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 9 matched ingredients can interact with medications — Papain, Rutin, Indian Gooseberry, Bromelain, Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 227 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking RejuvenZyme, double-check these medication types with your doctor or pharmacist: anticoagulant or antiplatelet drugs (blood thinners like warfarin, heparin, clopidogrel, or aspirin) due to Moderate risk of increased bleeding from amla, bromelain, and serrapeptase; antidiabetes drugs due to Moderate risk of low blood sugar from rutin and amla; warfarin specifically, due to Moderate risk from papain; and tetracycline antibiotics due to Minor risk from bromelain. No interactions are documented for the ingredients we could check—lipase, protease, trypsin, and chymotrypsin—though we hold no data for amylase and the ionic trace mineral blend.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

RejuvenZyme is an enzyme blend aimed at digestive support, but evidence for most ingredients is not yet established. If you take blood thinners, antidiabetes medications, tetracycline antibiotics, or warfarin, this product requires a careful check beforehand because several ingredients may increase bleeding risk or affect blood sugar or drug levels.

Talk with your doctor or pharmacist before starting it, especially if you're pregnant, breastfeeding, or have any chronic digestive condition.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 11 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about RejuvenZyme, straight from the product label.

Brand Source Naturals
Barcode (UPC) 021078019411
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 275448
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for RejuvenZyme by Source Naturals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
021078019411
IngredientAmount% DV
Rutin105 mg--
Lipase0 NP--
Protease0 NP--
Amla40 mg--
Amylase0 NP--
Trypsin0 NP--
Chymotrypsin0 NP--
Ionic Trace Mineral Blend40 mg--
Papain0 NP--
Bromelain0 NP--
Pancreatin320 mg--
Serrapeptase0 NP--

Other ingredients: Hypromellose, purified Water, Gellan Gum, Rice Bran, Medium Chain Triglycerides

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Delayed release Heart, joint & immune support

Bio Align

Contains no dairy, yeast, egg, gluten, soy or wheat. Contains no preservatives, or artificial color, flavor or fragrance.

Formula

Whole body systemic enzymes

REJUVENZYME, a Bio-Aligned Formula, contains a comprehensive blend of proteolytic systemic enzymes that benefit the entire body. The enzymes support smooth, efficient circulation of blood and nutrients, and reduce minor, occasional pain associated with everyday activities. They provide a balanced approach to cardiovascular, joint and respiratory health, and support the immune system. Additional phytonutrients and mineral provide the body with antioxidant defense.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: 2 capsules twice daily as needed on an empty stomach with at least 8 ounces of water.

Precautions

Caution: Do not take if you are pregnant, may become pregnant, breastfeeding, or if you suffer from any gastrointestinal disorder such as ulcers. Consult your health care professional before using this product if you are taking any drug that affects blood coagulation such as prescription vitamin K, heparin, warfarin (Coumadin), or aspirin.

Do not use if either tamper-evident seal is broken or missing.

Keep out of the reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Copyright SOURCE NATURALS, INC.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

RejuvenZyme by Source Naturals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

RejuvenZyme label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in RejuvenZyme by Source Naturals

These are the 11 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Rutin

Interacts with
86 drugs
105 mg per serving

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins...

Rutin monograph & interactions

Amla

Interacts with
208 drugs
40 mg per serving

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion...

Amla monograph & interactions

Trypsin

No known
interactions
0 NP per serving

Trypsin is a protein-digesting enzyme usually taken from the pancreas of animals and used either by mouth (often combined with other enzymes like chym...

Trypsin monograph & interactions

Chymotrypsin

No known
interactions
0 NP per serving

Chymotrypsin is a protein-digesting (proteolytic) enzyme, usually taken from the pancreas of cattle or pigs, that is mainly used to help reduce swelli...

Chymotrypsin monograph & interactions

Ionic Trace Mineral Blend

40 mg per serving

Papain

Interacts with
2 drugs
0 NP per serving Form: Carica papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Bromelain

Interacts with
141 drugs
0 NP per serving Form: Ananas comosus

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain monograph & interactions

Pancreatin

320 mg per serving Form: Sus scrofa

Serrapeptase

Interacts with
122 drugs
0 NP per serving Form: Serratia marcescens

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Hypromellose, Purified Water, Gellan Gum, Rice Bran, Medium Chain Triglycerides. These complete the product’s ingredient list but are not active constituents.

Interaction report

RejuvenZyme by Source Naturals Drug Interactions

Want to check YOUR meds against RejuvenZyme?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
227Drugs
208 Moderate 19 Minor

Ingredients driving the most interactions

Amla 208
Bromelain 141
Serrapeptase 122
Rutin 86
Papain 2

Individual Drug Interactions

The ingredients in RejuvenZyme interact with 227 drugs. Click any drug to see the details.

5 of the 11 ingredients in RejuvenZyme interact with drugs. Each result below shows which ingredient is responsible. Amla Bromelain Serrapeptase Rutin Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in RejuvenZyme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Amla4 drug types · 208 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, Indian gooseberry may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking Indian gooseberry 500 mg along with clopidogrel 75 mg or ecosprin 75 mg, as a single dose or for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg or ecosprin 75 mg alone. Until more is known, use caution when taking Indian gooseberry in combination with anticoagulant/antiplatelet drugs.

Likelihood Possible Evidence B
Antidiabetes Drugs

Taking Indian gooseberry with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking Indian gooseberry fruit or fruit extract alone or in conjunction with antidiabetes medications can lower blood glucose levels. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Aspirin

Theoretically, Indian gooseberry may increase the risk of bleeding if used with aspirin; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with ecosprin 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus ecosprin 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with ecosprin 75 mg alone.

Likelihood Possible Evidence B
Clopidogrel (Plavix)

Theoretically, Indian gooseberry may increase the risk of bleeding if used with clopidogrel; however, research is conflicting.
Clinical research shows that taking Indian gooseberry 500 mg as a single dose or twice daily for 10 days reduces platelet aggregation by about 24% to 36%, increases bleeding time by about 3.8-5.9 seconds, and increases clotting time by about 9.8-12.7 seconds when compared to baseline. However, taking a single dose of Indian gooseberry 500 mg along with clopidogrel 75 mg, or taking a combination of Indian gooseberry 500 mg twice daily plus clopidogrel 75 mg once daily for 10 days, does not significantly reduce platelet aggregation or increase bleeding time or clotting time when compared with clopidogrel 75 mg alone.

Likelihood Possible Evidence B
Amla full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions

Rutin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking rutin with antidiabetes drugs might increase the risk of hypoglycemia.
Animal research suggests that rutin has hypoglycemic effects.

Likelihood Possible Evidence D
Rutin full monograph & interactions

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for RejuvenZyme, from the product label.

Source Naturals

Name
Source Naturals, Inc.
Street Address
P. O. Box 2118
City
Santa Cruz
State
CA
ZipCode
95062
Web Address
www.sourcenaturals.com
Pharmacist Counseling Corner

RejuvenZyme by Source Naturals: Common Questions

Does RejuvenZyme by Source Naturals interact with any medications?
Yes. Based on its ingredients, RejuvenZyme has a known interaction with 227 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
RejuvenZyme contains 11 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is RejuvenZyme used for?
RejuvenZyme is a blend of digestive enzymes and plant extracts intended to support digestion. The enzymes—lipase, amylase, protease, trypsin, chymotrypsin, papain, bromelain, and serrapeptase—help break down fats, carbohydrates, and proteins. However, the evidence supporting most of these ingredients for their intended effects is not yet established in the data we hold.
Can I take RejuvenZyme if I'm on a blood thinner?
No—not without checking first. Amla, bromelain, and serrapeptase in this product may increase bleeding risk if you're on a blood thinner like warfarin, heparin, clopidogrel, or aspirin. Talk with your doctor or pharmacist before starting it; they can assess whether it's safe for you.
Can I take RejuvenZyme if I have diabetes?
You need to check with your doctor or pharmacist first. Rutin and amla may lower blood sugar, which could increase your risk of low blood sugar (hypoglycemia) if you're on antidiabetes medication. Dose adjustments to your diabetes drugs might be necessary.
Is RejuvenZyme safe to take during pregnancy?
There isn't enough safety data on most of these ingredients during pregnancy. Rutin is likely safe, but papain is possibly unsafe. Several others—protease, trypsin, chymotrypsin, bromelain, and serrapeptase—lack established safety, so they're best avoided unless your doctor advises otherwise. Talk with your doctor or pharmacist about what's safe for you.
What side effects might RejuvenZyme cause?
The most common side effects are digestive—nausea, heartburn, stomach pain, diarrhea, or gas—from the enzyme blend. Rutin may cause headache, flushing, or rashes. Papain and bromelain may trigger allergic reactions in sensitive people. Chymotrypsin very rarely causes anaphylaxis (severe allergic reaction).
Does RejuvenZyme have fillers?
The active ingredients are the enzymes and plant extracts. The capsule itself contains hypromellose, gellan gum, rice bran, medium-chain triglycerides, and purified water as inactive ingredients—these are standard capsule materials and carriers, not fillers in the sense of unnecessary bulk.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if RejuvenZyme is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

RejuvenZyme label
Go deeper

The Full Monographs Behind RejuvenZyme’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rutin

Interacts with 86 drugs

Rutin is a plant flavonoid (often taken from buckwheat or citrus) that people use mainly for blood vessel and circulation problems like varicose veins and hemorrhoids. The evidence is limite...

Read the full Rutin monograph → Herb & supplement monograph

Indian Gooseberry

Interacts with 208 drugs

Indian gooseberry (amla) is a vitamin C-rich fruit used in Ayurvedic medicine for many purposes, from antioxidant support to cholesterol and digestion. Early research is promising for some u...

Read the full Indian Gooseberry monograph → Herb & supplement monograph

Trypsin

Trypsin is a protein-digesting enzyme usually taken from the pancreas of animals and used either by mouth (often combined with other enzymes like chymotrypsin and bromelain) for swelling and...

Read the full Trypsin monograph → Herb & supplement monograph

Chymotrypsin

Chymotrypsin is a protein-digesting (proteolytic) enzyme, usually taken from the pancreas of cattle or pigs, that is mainly used to help reduce swelling and support healing after injury or s...

Read the full Chymotrypsin monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

RejuvenZyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rutin 2 references
  1. Mehta DK (Ex Ed). British National Formulary, Number 37. British Medical Association and Royal Pharmaceutical Society of Great Britain: London, England, March 1999.
  2. Sun C, Wang L, Sun J, Wang Z, Tang Z. Hypoglycemic and hypolipidemic effects of rutin on hyperglycemic rats. J Tradit Chin Med. 2020;40(4):640-645.

See these in context on the Rutin monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Indian Gooseberry 6 references
  1. Sabu, M. C. and Kuttan, R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol. 2002;81(2):155-160. PubMed
  2. Fatima N, Pingali U, Muralidhar N. Study of pharmacodynamic interaction of Phyllanthus emblica extract with clopidogrel and ecosprin in patients with type II diabetes mellitus. Phytomedicine. 2014;21(5):579-85. PubMed
  3. Shanmugarajan D, Girish C, Harivenkatesh N, Chanaveerappa B, Prasanna Lakshmi NC. Antihypertensive and pleiotropic effects of Phyllanthus emblica extract as an add-on therapy in patients with essential hypertension-A randomized double-blind placebo-contro
  4. Akhtar MS, Ramzan A, Ali A, Ahmad M. Effect of amla fruit (Emblica officinalis Gaertn.) on blood glucose and lipid profile of normal subjects and type 2 diabetic patients. Int J Food Sci Nutr. 2011;62(6):609-16.
  5. Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 20 PubMed
  6. Majeed M, Mundkur L, Paulose S, Nagabhushanam K. Novel Emblica officinalis extract containing ß-glucogallin vs. metformin: a randomized, open-label, comparative efficacy study in newly diagnosed type 2 diabetes mellitus patients with dyslipidemia. Food Fu

See these in context on the Indian Gooseberry monograph →

Trypsin 17 references
  1. Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  2. Latha B, Ramakrishnan M, Jayaraman V, Babu M. The efficacy of trypsin: chymotrypsin preparation in the reduction of oxidative damage during burn injury. Burns 1998;24:532-8. PubMed
  3. Latha B, Ramakrishnan M, Jayaraman V, Babu M. Serum enzymatic changes modulated using trypsin: chymotrypsin preparation during burn wounds in humans. Burns 1997;23:560-4. PubMed
  4. Klein, G., Kullich, W., Schnitker, J., and Schwann, H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp
  5. Dale, P. S., Tamhankar, C. P., George, D., and Daftary, G. V. Co-medication with hydrolytic enzymes in radiation therapy of uterine cervix: evidence of the reduction of acute side effects. Cancer Chemother.Pharmacol 2001;47 Suppl:S29-S34. PubMed
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Chymotrypsin 6 references
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See these in context on the Chymotrypsin monograph →

Papain 11 references
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  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
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See these in context on the Papain monograph →

Bromelain 19 references
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  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
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See these in context on the Bromelain monograph →

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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