Interactions on record — worth a quick check against your medications. Based on 2 of 6 ingredients. Check your meds →
Dietary supplement

Rescue Watermelon Ingredients & Drug Interactions

by EBOOST

Rescue Watermelon label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Rescue Watermelon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Rescue Watermelon is a dietary supplement by EBOOST with 6 active ingredients. Its ingredients are commonly taken for heart health, prostate health, antioxidant support.Based on those ingredients, 295 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Citrulline, Lycopene. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Rescue Watermelon by EBOOST

Ask about any prescription or over-the-counter medication and we check it for interactions with Rescue Watermelon by EBOOST — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Rescue Watermelon by EBOOST

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Branched-Chain Amino Acids” is listed as a grouped ingredient — the label gives one combined amount (5 Gram(s)) without saying how much of each component you get.
  • “Watermelon Recovery Matrix” is a proprietary blend — the label gives one combined amount (2.51 Gram(s)) without saying how much of each component you get.

Rescue Watermelon is a powder with 6 active ingredients. It contains lycopene (a red pigment from tomatoes and watermelon with potential antioxidant effects), three branched-chain amino acids — L-leucine, L-isoleucine, and L-valine — that support muscle recovery, plus L-citrulline (an amino acid your body converts to nitric oxide to improve blood flow), watermelon fruit extract, and a proprietary Watermelon Recovery Matrix blend.

The powder also includes inactive ingredients like xylitol (a sweetener), inulin (a fiber), and citric acid for flavor and texture.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle recovery and protein synthesis support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle strength, Sarcopenia, muscle fatigue, nitric oxide production — and 1 related terms.
  • The strongest evidence on file: L-citrulline is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: L-citrulline is rated "Possibly Ineffective" for Sarcopenia.
  • Also on file: Lycopene is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

The evidence for the active ingredients is mixed. Lycopene is possibly effective for prostate cancer but possibly ineffective for bladder cancer and diabetes; the data on its role in high cholesterol (hyperlipidemia), ALS, and exercise-induced asthma is too limited to rate.

L-citrulline is possibly effective for athletic performance but possibly ineffective for sarcopenia; evidence for cardiovascular disease, heart failure, and diabetes is insufficient. We hold no effectiveness data for the branched-chain amino acids or watermelon extracts in this product.

The evidence, ingredient by ingredient Lycopene L-citrulline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lycopene from food is generally well tolerated, though supplements can cause gastrointestinal discomfort including diarrhea, nausea, bloating, and stomach upset in some people. L-citrulline is generally well tolerated in healthy adults but may cause heartburn or stomach discomfort; long-term safety isn't fully established.

For pregnancy, the safety data on lycopene supplements advises against use unless your doctor recommends it — food amounts are fine. L-citrulline should be avoided during pregnancy and breastfeeding due to insufficient safety information.

There is not enough data on L-leucine, L-isoleucine, L-valine, and watermelon extracts in pregnancy and breastfeeding; talk with your doctor or pharmacist if you're pregnant or nursing.

Side effects, ingredient by ingredient Lycopene L-citrulline

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lycopene, L-citrulline.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 295 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood pressure medication, blood thinners (like warfarin or aspirin), or erectile dysfunction drugs (like sildenafil), double-check with your doctor or pharmacist before using this product. L-citrulline can add to blood pressure-lowering effects, and both lycopene and L-citrulline may interact with these drug classes at Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Rescue Watermelon may appeal to athletes or anyone looking to support muscle recovery, since it contains branched-chain amino acids and L-citrulline, which is possibly effective for athletic performance. However, if you take blood pressure medication, blood thinners, or erectile dysfunction drugs, you'll need to check with your doctor or pharmacist first — the interactions are real and documented.

Pregnant and breastfeeding people should avoid it. Talk it over with your own healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Rescue Watermelon, straight from the product label.

Brand EBOOST
Barcode (UPC) 856541002931
Net contents 0.45 Ounce(s); 12.8 Gram(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 247704
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Rescue Watermelon by EBOOST, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
12.8 Gram(s)
Maximum serving Sizes:
12.8 Gram(s)
Servings per container
1
UPC/BARCODE
856541002931
IngredientAmount% DV
Calories0 Calorie(s)--
Lycopene10 mg--
L-Leucine2500 mg--
L-Isoleucine1250 mg--
L-Citrulline2 Gram(s)--
L-Valine1250 mg--
Branched-Chain Amino Acids5 Gram(s)--
Watermelon fruit extract500 mg--
Watermelon Recovery Matrix2.51 Gram(s)--

Other ingredients: Xylitol, Inulin, Citric Acid, Natural Flavors, Silicon Dioxide, Rebaudioside-A, Beet root powder

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Your recovery hero.

Naturally flavored

Helps support muscle recovery & protein synthesis Helps delay muscle fatigue Supports nitric oxide production

Gluten-free, allergen-free, soy-free, and non-GMO No artificial flavors, colors, or sweeteners 0 g of sugar

Rescue delivers optimal recovery with proven, high quality ingredients. Maximize your muscle recovery and crush your next workout.

V Vegan

GF Gluten free Soy free Non GMO

Made in the USA - This product contains ingredients of international and domestic origin.

Formula

2:1:1 BCAA + Watermelon recovery matrix

Keto-friendly

Keto friendly

FDA Statement of Identity

Dietary Supplement

General Statements

Recover like a champion.

Suggested/Recommended/Usage/Directions

Directions: Mix one (1) scoop with 8 to 20 oz of water depending on your taste and hydration level preference. Shake well and consume pre, intra, or post workout for optimal results.

Storage

Protect from heat, light, and moisture.

Precautions

Warning: For healthy adults 18 years of age or older.

Consult a medical doctor before use, especially if you are pregnant, nursing, anticipate surgery, take medication, or are otherwise under medical supervision.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Rescue Watermelon by EBOOST label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Rescue Watermelon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Rescue Watermelon by EBOOST

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size12.8 Gram(s) Dosage formPowder Servings per container1 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Branched-Chain Amino Acids

5 Gram(s) per serving
  • › L-Leucine
  • › L-Isoleucine
  • › L-Valine

Watermelon Recovery Matrix

2.51 Gram(s) per serving

Other (inactive) ingredients: Xylitol, Inulin, Citric Acid, Natural Flavors, Silicon Dioxide, Rebaudioside-A, Beet root powder. These complete the product’s ingredient list but are not active constituents.

Interaction report

Rescue Watermelon by EBOOST Drug Interactions

Want to check YOUR meds against Rescue Watermelon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
295Drugs
295 Moderate

Ingredients driving the most interactions

L-Citrulline 178
Lycopene 122

Individual Drug Interactions

The ingredients in Rescue Watermelon interact with 295 drugs. Click any drug to see the details.

2 of the 6 ingredients in Rescue Watermelon interact with drugs. Each result below shows which ingredient is responsible. L-Citrulline Lycopene

Each ingredient & the kinds of drugs it affects

For each ingredient in Rescue Watermelon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Citrulline2 drug types · 178 drugs

Antihypertensive Drugs

Theoretically, concomitant use of L-citrulline with antihypertensive drugs might have additive effects and increase the chance of hypotension.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. However, a meta-analysis of 5 small clinical studies suggests that taking L-citrulline 3-6 grams daily for 1-8 weeks does not lower blood pressure when compared with control.

Likelihood Possible Evidence B
Phosphodiesterase-5 Inhibitors

Theoretically, concurrent use of phosphodiesterase-5 (PDE-5) inhibitors and L-citrulline might result in additive vasodilation.
L-citrulline is converted to L-arginine, which can increase nitric oxide and cause vasodilation. Theoretically, taking L-arginine with PDE-5 inhibitors might have additive vasodilatory and hypotensive effects. However, in studies evaluating the combined use of L-arginine and sildenafil for erectile dysfunction, hypotension was not reported.

Likelihood Possible Evidence D
L-Citrulline full monograph & interactions

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Rescue Watermelon, from the product label.

EBOOST

See all EBOOST products
Name
VitalizeLabs
City
New York
State
NY
ZipCode
10012
Phone Number
877-432-6678
Web Address
eboost.com
Pharmacist Counseling Corner

Rescue Watermelon by EBOOST: Common Questions

Does Rescue Watermelon by EBOOST interact with any medications?
Yes. Based on its ingredients, Rescue Watermelon has a known interaction with 295 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Rescue Watermelon contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
L-citrulline in this product may add to the blood pressure-lowering effect of your medication, which could cause dizziness or a dangerous drop in pressure. Talk with your doctor or pharmacist before you start — they can tell you whether it's safe for you or if you need any monitoring.
Will this help me recover after a workout?
L-citrulline is possibly effective for athletic performance, and this powder contains branched-chain amino acids that support muscle recovery. However, we hold no direct evidence for the watermelon extracts in this formulation, so the overall effect is unclear.
What are the side effects?
Lycopene and L-citrulline can cause gastrointestinal upset — nausea, diarrhea, bloating, heartburn, or stomach discomfort — in some people. Most people tolerate them well, but these are the main side effects to watch for.
Is it safe during pregnancy?
No — L-citrulline should be avoided during pregnancy due to insufficient safety data. Lycopene supplements are also not well studied in pregnancy and should be avoided unless your doctor says otherwise. Food amounts of both are fine.
Can I take this with blood thinners like warfarin or aspirin?
Lycopene may theoretically increase bleeding risk when combined with blood thinners, based on lab research showing it can affect platelets. Check with your doctor or pharmacist before you start — they can assess the risk for your situation.
What is L-citrulline, and why is it in here?
L-citrulline is an amino acid your body converts to nitric oxide, which widens blood vessels and improves blood flow. It's included because it's possibly effective for athletic performance and may support exercise recovery.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Rescue Watermelon is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Rescue Watermelon label
Go deeper

The Full Monographs Behind Rescue Watermelon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph → Herb & supplement monograph

L-citrulline

Interacts with 178 drugs

L-citrulline is an amino acid that the body turns into L-arginine to help make nitric oxide, which relaxes blood vessels and may improve blood flow. It is popular for exercise performance an...

Read the full L-citrulline monograph →
Sources

Sources & How We Checked

Rescue Watermelon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lycopene 10 references
  1. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
  2. Hsiao, G., Wang, Y., Tzu, N. H., Fong, T. H., Shen, M. Y., Lin, K. H., Chou, D. S., and Sheu, J. R. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med 2005;146(4):216-226. PubMed
  3. Clark, P. E., Hall, M. C., Borden, L. S., Jr., Miller, A. A., Hu, J. J., Lee, W. R., Stindt, D., D'Agostino, R., Jr., Lovato, J., Harmon, M., and Torti, F. M. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse o
  4. O'Kennedy, N., Crosbie, L., Whelan, S., Luther, V., Horgan, G., Broom, J. I., Webb, D. J., and Duttaroy, A. K. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am.J.Clin.Nutr. 2006;84(3):561-569. PubMed
  5. Jatoi, A., Burch, P., Hillman, D., Vanyo, J. M., Dakhil, S., Nikcevich, D., Rowland, K., Morton, R., Flynn, P. J., Young, C., and Tan, W. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II stu
  6. Schwenke, C., Ubrig, B., Thurmann, P., Eggersmann, C., and Roth, S. Lycopene for advanced hormone refractory prostate cancer: a prospective, open phase II pilot study. J.Urol. 2009;181(3):1098-1103. PubMed
  7. Banerjee, S., Jeyaseelan, S., and Guleria, R. Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J.Obstet.Gynaecol.Res. 2009;35(3):477-482. PubMed
  8. Haseen, F., Cantwell, M. M., O'Sullivan, J. M., and Murray, L. J. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic.Dis. 2009;12(4):325-332. PubMed
  9. Ilic, D., Forbes, K. M., and Hassed, C. Lycopene for the prevention of prostate cancer. Cochrane.Database.Syst.Rev. 2011;(11):CD008007. PubMed
  10. Sawardekar SB, Patel TC, Uchil D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: an in vitro study. Indian J Pharmacol 2016;48:26-31. PubMed

See these in context on the Lycopene monograph →

L-citrulline 8 references
  1. Cheng JW, Balwin SN. L-arginine in the management of cardiovascular diseases. Ann Pharmacother 2001;35:755-64. PubMed
  2. Schwedhelm E, Maas R, Freese R, et al. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9. PubMed
  3. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. Therapeutic use of citrulline in cardiovascular disease. Cardiovasc Drug Rev 2006;24:275-90. PubMed
  4. Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, et al. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J 2012;19:612-7. PubMed
  5. Sharif Kashani B, Tahmaseb Pour P, Malekmohammad M, et al. Oral l-citrulline malate in patients with idiopathic pulmonary arterial hypertension and Eisenmenger Syndrome: a clinical trial. J Cardiol 2014;64:231-5. PubMed
  6. Pérez-Guisado J, Jakeman PM. Citrulline malate enhances athletic anaerobic performance and relieves muscle soreness. J Strength Cond Res 2010;24:1215-22. PubMed
  7. Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. PubMed
  8. Xu Z, Liu C, Liu S, Zhou Z. Comparison of efficacy and safety of daily oral L-arginine and PDE5Is alone or combination in treating erectile dysfunction: A systematic review and meta-analysis of randomised controlled trials. Andrologia. 2021:e14007. PubMed

See these in context on the L-citrulline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team