Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Restwelle Ingredients & Drug Interactions

by Quality Of Life

Restwelle label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Restwelle against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Restwelle is a dietary supplement by Quality Of Life with 2 active ingredients. Its ingredients are commonly taken for mild fluid retention (diuretic), urinary tract support, digestive health and fiber.Based on those ingredients, 1,465 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are MicroActive Melatonin-SR, ETAS. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Restwelle by Quality Of Life

Ask about any prescription or over-the-counter medication and we check it for interactions with Restwelle by Quality Of Life — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Restwelle by Quality Of Life

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Restwelle contains 2 active ingredients. The first is ETAS, an extract from asparagus root, which has been studied for several conditions including acne, cancer, constipation, high blood pressure, parasite infection, and kidney stones—though evidence for any of these uses is insufficient.

The second is MicroActive Melatonin-SR, a sustained-release form of the hormone melatonin, which is likely effective for non-24-hour sleep-wake disorder and delayed sleep phase syndrome, and possibly effective for anxiety before procedures, sunburn, and high blood pressure. The capsule also contains inactive ingredients: tapioca dextrin, cellulose, silica, L-leucine, carnauba wax, and sodium alginate.

These are fillers, thickeners, and binders that give the capsule its form and stability.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: improve sleep quality, fall asleep faster, stay asleep longer.
  • We looked for evidence on: Delayed sleep phase syndrome (DSPS), Jet lag, Non-24-hour sleep wake disorder, Shift work disorder, Beta blocker-induced insomnia, Postoperative sleep disturbance — and 4 related terms.
  • The strongest evidence on file: Melatonin is rated "Likely Effective" for Delayed sleep phase syndrome (DSPS) (Natural Medicines).
  • Also on file: Melatonin is rated "Likely Effective" for Non-24-hour sleep wake disorder.
  • Also on file: Melatonin is rated "Possibly Effective" for Jet lag, Beta blocker-induced insomnia.

Melatonin in this product is likely effective for non-24-hour sleep-wake disorder (a rare circadian rhythm condition) and delayed sleep phase syndrome (trouble falling asleep at a normal bedtime). It's possibly effective for easing anxiety before medical procedures, protecting against sunburn, and lowering high blood pressure, though the evidence for these uses is less solid.

For the asparagus root (ETAS), we don't have established evidence in our data for its effectiveness for any of the conditions it's been studied for—acne, cancer, constipation, high blood pressure, parasite infection, and kidney stones all carry insufficient evidence ratings. If you're considering this product for a specific reason, check with your doctor or pharmacist about whether the science backs that use.

The evidence, ingredient by ingredient Asparagus Melatonin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Melatonin is generally well tolerated for short-term use, but long-term safety hasn't been thoroughly studied and product quality varies. The most common side effects are dizziness, drowsiness, headache, and nausea.

Rare serious concerns include a possible increased risk of seizure, and case reports of mood changes (sadness, nervousness, depression), hallucinations, and effects on hormones and sperm quality—though these are uncommon. Asparagus root is safe as a food, but medicinal doses and concentrated extracts are less well studied.

Allergic reactions can occur, especially in people sensitive to onions, garlic, leeks, or chives—symptoms may include itchy eyes, runny nose, coughing, hives, difficulty swallowing, shortness of breath, and in severe cases anaphylaxis. A combination product containing asparagus root caused constipation, abdominal pain, nausea, dry mouth, and gallbladder issues in up to 50% of trial participants; gout developed in about 2%, though it's unclear which ingredient was responsible.

Side effects, ingredient by ingredient Asparagus Melatonin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Asparagus, Melatonin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; immunosuppressants / transplant drugs; diabetes medications; lithium.
  • For scale: 1,466 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Restwelle, have a conversation with your doctor or pharmacist if you take blood thinners or antiplatelet drugs like warfarin—melatonin may increase bleeding risk. Also double-check if you're on heart medications (especially extended-release nifedipine), diabetes drugs, seizure preventers, blood pressure drugs, immunosuppressants, or methamphetamine, as melatonin carries documented interactions with all of these.

Additionally, if you take diuretics (water pills) or lithium, the asparagus root component may affect how these work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Restwelle's melatonin is a solid choice if you have a non-24-hour sleep disorder or delayed sleep phase syndrome, though it's less proven for other sleep or health uses. The asparagus root component lacks established evidence for its intended benefits.

Before starting this product, check your current medications—especially blood thinners, heart drugs, diabetes medications, seizure preventers, and blood pressure drugs—with your doctor or pharmacist to make sure there's no conflict. If you have a history of seizures, are pregnant or breastfeeding, or are allergic to asparagus-family plants, discuss it with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Restwelle, straight from the product label.

Brand Quality Of Life
Barcode (UPC) 812259003547
Net contents 30 Vegicap(s)
Market status On market
Date entered into DSLD Nov 22, 2023
DSLD ID 299347
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Restwelle by Quality Of Life, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Vegicap(s)
Maximum serving Sizes:
1 Vegicap(s)
Servings per container
30
UPC/BARCODE
812259003547
IngredientAmount% DV
ETAS300 mg--
MicroActive Melatonin-SR2 mg--

Other ingredients: Tapioca Dextrin, Cellulose, Silica, L-Leucine, Carnauba wax, Sodium Alginate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

How rested you feel in the morning isn't just about how much you sleep; it's also how well you sleep.

Formulation

Restwelle is uniquely formulated to improve you your quality of sleep while also helping you fall asleep faster and sleep longer.

Sleep Support

Fall asleep faster Stay asleep longer Improve your quality of sleep

V

GF GMO

GMP

This product is suitable for vegetarians and gluten-free.

This product is suitable for vegetarians and gluten-free.

Formula

Restwelle contains: ETAS, a proprietary extract of green asparagus stalk clinically shown to induce "heat shock protein" and replicate the relaxation effect of taking a hot bath, improving your sleep quality without causing grogginess. Melatonin-SR, helping you fall asleep faster and stay asleep longer by delivering gradual release of melatonin over 7 hours.

Restwelle with ETAS and Melatonin-SR

FDA Disclaimer Statement

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

SUGGESTED USE: Take 1 vegicap before bedtime.

Brand IP Statement(s)

ETAS is a trademark of Amino Up Company Ltd. MicroActive is a registered trademark of BioActives LLC.

Precautions

WARNING: DO NOT USE IF SEAL IS BROKEN OR MISSING.

Keep out of reach of children.

Consult your healthcare professional before use if you are pregnant or lactating, have or had a medical condition, or are taking prescription drugs.

Do not drive or operate machinery or consume alcohol while taking this product.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Restwelle by Quality Of Life label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Restwelle label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Restwelle by Quality Of Life

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Vegicap(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

ETAS

Interacts with
76 drugs
300 mg per serving Form: Asparagus Stalk Extract

Asparagus is a nutritious vegetable that is safe and healthy to eat as part of a normal diet. Most of its claimed medicinal benefits, such as use as a...

ETAS monograph & interactions

MicroActive Melatonin-SR

Interacts with
1,461 drugs
2 mg per serving Form: Melatonin

Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timi...

MicroActive Melatonin-SR monograph & interactions

Other (inactive) ingredients: Tapioca Dextrin, Cellulose, Silica, L-Leucine, Carnauba wax, Sodium Alginate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Restwelle by Quality Of Life Drug Interactions

Want to check YOUR meds against Restwelle?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,465Drugs
1,120 Moderate 345 Minor

Ingredients driving the most interactions

MicroActive Melatonin-SR 1,461
ETAS 76

Individual Drug Interactions

The ingredients in Restwelle interact with 1,465 drugs. Click any drug to see the details.

2 of the 2 ingredients in Restwelle interact with drugs. Each result below shows which ingredient is responsible. MicroActive Melatonin-SR ETAS

Each ingredient & the kinds of drugs it affects

For each ingredient in Restwelle with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

MicroActive Melatonin-SR18 drug types · 1,461 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, melatonin may have anticoagulant effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There are isolated case reports of minor bleeding and decreased prothrombin activity in people taking melatonin with warfarin (Coumadin). The mechanism, if any, of this interaction is unknown. Taking melatonin orally seems to decrease coagulation activity within one hour of dosing in healthy men.

Likelihood Possible Evidence B
Anticonvulsants

Theoretically, melatonin may reduce the effects of anticonvulsants. Some clinical research suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological impairment.

Likelihood Possible Evidence B
Antidiabetes Drugs

Theoretically, taking melatonin with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that melatonin reduces levels of fasting blood glucose and improves glycemic control. However, other research suggests that melatonin might impair glucose utilization and increase insulin resistance, while other research has found no effect on glucose levels. Until more is known, use melatonin cautiously in combination with antidiabetes drugs.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking melatonin with antihypertensive drugs might increase the risk of hypotension or hypertension.
Some clinical research suggests that taking melatonin decreases blood pressure in healthy adults. Also, melatonin seems to lower systolic and diastolic blood pressure in individuals with high blood pressure at nighttime or untreated essential hypertension. However, melatonin seems to worsen blood pressure in patients who are taking antihypertensive medications. Immediate-release melatonin 5 mg at night in combination with nifedipine GITS (Procardia XL) increases systolic blood pressure an average of 6.5 mmHg, diastolic blood pressure by an average of 4.9 mmHg, and heart rate by 3.9 bpm. Also, results from animal research suggest that melatonin reduces the effectiveness of certain antihypertensive drugs, including methoxamine and clonidine.

Likelihood Possible Evidence A
Caffeine

Theoretically, taking caffeine with melatonin might increase levels of melatonin.
Some evidence suggests that caffeine consumption can decrease endogenous melatonin levels, while other evidence suggests that caffeine increases endogenous melatonin levels. When administered in combination with melatonin supplements, caffeine seems to increase melatonin effects and levels. The reason for this discrepancy is not completely clear. Part of the discrepancy may result from the fact that caffeine can inhibit melatonin synthesis as well as inhibit melatonin metabolism. By functioning as an adenosine receptor antagonist, caffeine may indirectly inhibit the synthesis of melatonin. Conversely, because melatonin and caffeine are both metabolized by cytochrome P450 1A2 (CYP1A2) enzyme, concomitant use of melatonin and caffeine may reduce the metabolism of melatonin, resulting in higher serum levels.

Likelihood Probable Evidence B
Cns Depressants

Theoretically, taking melatonin might increase the sedative effects of CNS depressants.
Melatonin has sedative effects. Theoretically, concomitant use of melatonin with alcohol, benzodiazepines, or other sedative drugs might cause additive sedation.

Likelihood Possible Evidence D
Contraceptive Drugs

Theoretically, taking contraceptive drugs with melatonin might increase the effects and adverse effects of melatonin.
Contraceptive drugs can increase the levels of endogenous melatonin. Theoretically, these drugs may increase the effects and adverse effects of oral melatonin.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP1A2. Also, other CYP1A2 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with drugs metabolized by the CYP1A2 enzyme might reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP1A2 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Probable Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP2C19. Also, other CYP2C19 substrates might decrease the metabolism of melatonin, increasing melatonin levels.
Melatonin is metabolized in the liver primarily by the CYP2C19 and CYP1A2 enzymes. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2C19 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Conversely, some drugs metabolized by CYP2C19 may inhibit the metabolism of melatonin, resulting in increased serum levels of melatonin. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Probable Evidence D
Fluvoxamine (Luvox)

Theoretically, taking fluvoxamine with melatonin might increase levels of melatonin.
Fluvoxamine can significantly increase melatonin levels. In some cases, fluvoxamine might increase bioavailability of exogenously administered melatonin by up to 20 times. Some researchers think this might be a beneficial interaction and be potentially useful for cases of refractory insomnia. However, this interaction might also cause unwanted excessive drowsiness and possibly other adverse effects. Fluvoxamine is known to increase endogenous melatonin secretion. It seems to increase serum levels of exogenously administered melatonin possibly by decreasing melatonin metabolism by inhibiting cytochrome P450 (CYP450) 1A2 and 2C19 or by inhibiting melatonin elimination. This effect has been found in healthy people taking fluvoxamine 50-75 mg and melatonin 5 mg.

Likelihood Probable Evidence B
Immunosuppressants

Theoretically, melatonin might interfere with immunosuppressive therapy.
Melatonin can stimulate immune function. Theoretically, melatonin might interfere with immunosuppressive therapy.

Likelihood Possible Evidence B
Methamphetamine (Desoxyn)

Theoretically, taking melatonin with methamphetamine may increase the adverse effects of methamphetamine.
Animal research suggests that melatonin exacerbates the adverse effects of methamphetamine, resulting in greater depression of tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) activity, as well as a significant reduction in dopamine levels. This has not been shown in humans.

Likelihood Possible Evidence D
Nifedipine Gits (Procardia Xl)

Theoretically, taking melatonin with extended release nifedipine reduces the effects of nifedipine.
Melatonin can decrease the effectiveness of extended release nifedipine (GITS). Immediate-release melatonin 5 mg at night in combination with nifedipine GITS 30-60 mg daily increases systolic and blood pressure by an average of 6.5 mmHg and 4.9 mmHg, respectively. Concomitant use with melatonin also increases heart rate by 3.9 bpm. The mechanism of this interaction is not known.

Likelihood Probable Evidence B
Seizure Threshold Lowering Drugs

Theoretically, taking melatonin with drugs that lower the seizure threshold might increase the risk of seizure activity.
Some clinical evidence suggests that melatonin may increase the frequency of seizures in certain patients, particularly children with neurological disabilities.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, melatonin may have antiplatelet effects and may increase the risk of bleeding with warfarin.
Three cases of increased prothrombin time have been reported for patients aged 48-72 years who took melatonin orally in combination with warfarin. However, three cases of decreased prothrombin time have also been reported for patients aged 51-84 years who took melatonin orally in combination with warfarin. Until more is known, use melatonin cautiously in patients taking warfarin.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP2D6.
Laboratory research suggests that certain lots of melatonin inhibit CYP2D6. Theoretically, combined administration of melatonin with certain drugs metabolized by the CYP2D6 enzyme may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, melatonin might increase levels of drugs metabolized by CYP3A4.
Laboratory research shows that certain lots of melatonin inhibit CYP3A4. Theoretically, combined administration of melatonin with certain drugs metabolized by CYP3A4 may reduce the metabolism of these drugs, resulting in increased serum levels. Until more is known, use melatonin cautiously in patients taking drugs metabolized by these enzymes.

Likelihood Possible Evidence D
Flumazenil (Romazicon)

Theoretically, taking flumazenil with melatonin might reduce the effects of melatonin.
Animal research shows that flumazenil may inhibit the effect of melatonin.

Likelihood Possible Evidence D
MicroActive Melatonin-SR full monograph & interactions

ETAS2 drug types · 76 drugs

Diuretic Drugs

Theoretically, asparagus root might increase diuresis and electrolyte loss when used with diuretic drugs.
Animal studies show that asparagus root extracts have diuretic effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Lithium

Theoretically, asparagus root might cause diuresis, reducing lithium clearance.
Animal studies show that asparagus root extracts have diuretic effects. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
ETAS full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Restwelle, from the product label.

Quality Of Life

See all Quality Of Life products
Name
QOL Labs, LLC
City
Purchase
State
NY
ZipCode
10577
Phone Number
(914) 251-0981
Web Address
www.QOL.us
Pharmacist Counseling Corner

Restwelle by Quality Of Life: Common Questions

Does Restwelle by Quality Of Life interact with any medications?
Yes. Based on its ingredients, Restwelle has a known interaction with 1,465 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Restwelle contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Restwelle if I'm pregnant or breastfeeding?
The data is mixed. Asparagus root is rated likely safe in pregnancy but possibly unsafe in pregnancy, so there isn't clear guidance—talk with your doctor. Melatonin is rated possibly unsafe in pregnancy and we don't have safety information for breastfeeding, so your doctor or pharmacist should weigh the pros and cons for your situation.
What are the most common side effects of this product?
From melatonin, you might experience dizziness, drowsiness, headache, or nausea. The asparagus root component, in one clinical trial of a similar combination product, caused constipation, belly pain, nausea, dry mouth, and gallbladder complaints in a significant portion of users, though it's not clear which ingredient was to blame.
Is asparagus root extract in this product safe for daily use long-term?
Eating asparagus as food is fine, but medicinal doses and concentrated extracts like ETAS haven't been well studied for safety over the long term. If you're planning to use Restwelle regularly, check with your doctor or pharmacist first.
Will Restwelle help me fall asleep faster if I have regular insomnia?
Melatonin is likely effective for delayed sleep phase syndrome (when your internal clock runs late) and non-24-hour sleep-wake disorder, but the evidence for general insomnia isn't established in our data. Your doctor can advise whether it's right for your specific sleep issue.
Can melatonin in Restwelle interact with my seizure medication?
Yes—melatonin carries a Moderate interaction with anticonvulsants, and some research suggests it may increase seizure frequency, particularly in children with neurological problems. If you take a seizure preventer, absolutely talk with your doctor before starting this product.
Can I be allergic to the asparagus root in this product?
Yes. Allergic reactions can occur, especially if you're sensitive to onions, garlic, leeks, or chives. Symptoms might include itchy eyes, runny nose, coughing, hives, difficulty swallowing, shortness of breath, or in rare cases anaphylaxis. If you have a known sensitivity to any of these foods, avoid this product or check with your allergist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Restwelle label
Go deeper

The Full Monographs Behind Restwelle’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Asparagus

Interacts with 76 drugs

Asparagus is a nutritious vegetable that is safe and healthy to eat as part of a normal diet. Most of its claimed medicinal benefits, such as use as a diuretic or for urinary health, come fr...

Read the full Asparagus monograph → Herb & supplement monograph

Melatonin

Interacts with 1,461 drugs

Melatonin is a hormone your body makes naturally to help control your sleep-wake cycle, and the supplement form is widely used to help with sleep timing problems and jet lag. The evidence is...

Read the full Melatonin monograph →
Sources

Sources & How We Checked

Restwelle's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 132 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Asparagus 14 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  3. Volz T, Berner D, Weigert C, et al. Fixed food eruption caused by asparagus. J Allergy Clin Immunol 2005;116:1390-2. PubMed
  4. Huang X, Kong L. Steroidal saponins from roots of Asparagus officinalis. Steroids 2006;71:171-6. PubMed
  5. Rodriguez R, Jaramillo S, Rodriguez G, et al. Antioxidant activity of ethanolic extracts from several asparagus cultivars. J Agric Food Chem 2005;53:5212-7. PubMed
  6. Rieker J, Ruzicka T, Neumann NJ, Homey B. Protein contact dermatitis to asparagus. J Allergy Clin Immunol 2004;113:354-5. PubMed
  7. Tabar AI, Alvarez-Puebla MJ, Gomez B, et al. Diversity of asparagus allergy: clinical and immunological features. Clin Exp Allergy 2004;34:131-6. PubMed
  8. Rademaker M, Yung A. Contact dermatitis to Asparagus officinalis. Australas J Dermatol 2000;41:262-3.
  9. Misico, R. I., Nicotra, V. E., Oberti, J. C., Barboza, G., Gil, R. R., and Burton, G. Withanolides and related steroids. Prog.Chem.Org.Nat.Prod. 2011;94:127-229.
  10. Hausen BM, Wolf C. 1,2,3-Trithiane-5-carboxylic acid, a first contact allergen from Asparagus officinalis (Liliaceae). Am J Contact Dermat 1996;7(1):41-46. PubMed
  11. Escribano MM, Munoz-Bellido FJ, Serrano P, et al. Acute urticaria after ingestion of asparagus. Allergy 1998;53(6):622-623. PubMed
  12. Chrubasik S, Droste C, Black A. Asparagus P(R) cannot compete with first-line diuretics in lowering the blood pressure in treatment-requiring antihypertensives. Phytother Res 2009;23:1345-6.
  13. Gaus BM, Scheiba N, Schäkel K. Asparagus-induced fixed food eruptions mimicking cutaneous lupus. Acta Derm Venereol 2014;94:731-2. PubMed
  14. Yanagi T, Shimizu H, Shimizu T. Occupational contact dermatitis caused by asparagus. Contact Dermatitis 2010;63:54. PubMed

See these in context on the Asparagus monograph →

Melatonin 118 references
  1. Voordouw BC, Euser R, Verdonk RE, et al. Melatonin and melatonin-progestin combinations alter pituitary-ovarian function in women and can inhibit ovulation. J Clin Endocrinol Metab 1992;74:108-17. DOI
  2. Ellis CM, Lemmens G, Parkes JD. Melatonin and insomnia. J Sleep Res 1996;5:61-5. PubMed
  3. Petrie K, Dawson AG, Thompson L, Brook R. A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Biol Psychiatr 1993;33:526-30. PubMed
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