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Dietary supplement

Royal Jelly 300 mg Ingredients & Drug Interactions

by The Vitamin Shoppe

Royal Jelly 300 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Royal Jelly 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Royal Jelly 300 mg is a dietary supplement by The Vitamin Shoppe with 1 active ingredient. Its ingredients are commonly taken for menopausal symptoms, skin health and wound care, immune support.Based on those ingredients, 174 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Royal Jelly 3X. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Royal Jelly 300 mg by The Vitamin Shoppe

Ask about any prescription or over-the-counter medication and we check it for interactions with Royal Jelly 300 mg by The Vitamin Shoppe — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Royal Jelly 300 mg by The Vitamin Shoppe

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: Royal Jelly 3X, a nutrient-rich secretion from honeybees at 300 mg per softgel capsule. Royal jelly is a traditional supplement used for various purposes, though evidence for most claimed benefits is limited or mixed.

The softgel capsule also contains inactive ingredients (soybean oil, gelatin, glycerin, purified water, yellow beeswax, and lecithin) that help deliver and stabilize the active ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: natural food supplement.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Royal jelly is possibly effective for menopausal symptoms based on available evidence. For other common uses — allergic rhinitis (hay fever), physical performance, and diabetes — the research suggests it's possibly ineffective.

For hair loss (androgenic alopecia), there isn't enough reliable evidence to rate whether it works or doesn't.

The evidence, ingredient by ingredient Royal Jelly

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Royal jelly is generally well tolerated in most people, but it carries a real risk of serious allergic reactions in anyone with a history of asthma or atopy (a tendency toward allergic conditions). Common reactions include itching, hives, eczema, shortness of breath, and oral allergy syndrome.

In rare but severe cases — particularly in people with asthma or atopy — it can trigger anaphylaxis, severe asthma, or even death. There's also one case report of hemorrhagic colitis (inflammation of the colon with bleeding) after taking royal jelly, which resolved within two weeks of stopping it.

Topically, royal jelly can cause contact dermatitis and skin irritation. Pregnancy and breastfeeding: there isn't enough safety information to know whether royal jelly is safe during pregnancy or while breastfeeding.

Talk with your doctor or pharmacist before use if you're pregnant or nursing.

Side effects, ingredient by ingredient Royal Jelly

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Royal Jelly.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 174 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this if you're on warfarin or another blood thinner — royal jelly may increase your bleeding risk. Also double-check if you take blood pressure medications, since royal jelly might lower your blood pressure further.

Altogether, these interactions span 174 individual medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Royal jelly might be worth considering if you're dealing with menopausal symptoms and want to try a natural option — but it's not the right choice if you take warfarin or other blood thinners, or if you have a history of asthma or severe allergies. Check with your doctor or pharmacist before starting, especially if you take blood pressure or blood-thinning medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Royal Jelly 300 mg, straight from the product label.

Brand The Vitamin Shoppe
Barcode (UPC) 766536012404
Net contents 100 Softgel(s)
Market status On market
Date entered into DSLD Jan 25, 2016
DSLD ID 55403
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Royal Jelly 300 mg by The Vitamin Shoppe, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
766536012404
IngredientAmount% DV
Royal Jelly 3X100 mg--

Other ingredients: Soybean Oil, Gelatin, Glycerin, purified Water, yellow Beeswax, Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

superfood

natural food

{softgel} actual size

Visit www.vitaminshoppe.com or call 1-800-223-1216 for more information and to reorder.

FDA Statement of Identity

dietary supplement

Formulation

gluten free dairy free nut free

Does not contain: Yeast, Corn, Wheat, Gluten, Sugar, Salt, Starch, Dairy, Citrus, Fish, Preservatives, Artificial Colors or Flavors.

Formula

Contains: Soy.

This product contains bee products.

Precautions

Contains: Soy.

WARNING: Do not use if you are pregnant or nursing.

This product contains bee products. Bee products can cause allergic reactions in some people.

KEEP OUT OF REACH OF CHILDREN.

TAMPER EVIDENT Do not use if outer seal is broken or missing.

Suggested/Recommended/Usage/Directions

DIRECTIONS: As a dietary supplement, take one (1) softgel daily, preferably with a meal.

Storage

STORE IN A COOL, DRY PLACE.

General

Item No. VS-1240 1042051 CP 6

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Royal Jelly 300 mg by The Vitamin Shoppe label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Royal Jelly 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Royal Jelly 300 mg by The Vitamin Shoppe

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Royal Jelly 3X

Interacts with
174 drugs
100 mg per serving

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune su...

Royal Jelly 3X monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Purified Water, Yellow Beeswax, Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Royal Jelly 300 mg by The Vitamin Shoppe Drug Interactions

Want to check YOUR meds against Royal Jelly 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
174Drugs
174 Moderate

Ingredients driving the most interactions

Royal Jelly 3X 174

Individual Drug Interactions

The ingredients in Royal Jelly 300 mg interact with 174 drugs. Click any drug to see the details.

1 of the 1 ingredient in Royal Jelly 300 mg interact with drugs. Each result below shows which ingredient is responsible. Royal Jelly 3X

Each ingredient & the kinds of drugs it affects

For each ingredient in Royal Jelly 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Royal Jelly 3X2 drug types · 174 drugs

Antihypertensive Drugs

Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that royal jelly might lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Royal jelly might increase the risk of bleeding when taken with warfarin.
In one case, an 87-year-old male who was previously stabilized on warfarin developed hematuria and was found to have an INR of 7.29 after taking a royal jelly supplement for one week.

Likelihood Possible Evidence D
Royal Jelly 3X full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Royal Jelly 300 mg, from the product label.

The Vitamin Shoppe

See all The Vitamin Shoppe products
Name
Vitamin Shoppe, Inc.
City
Secaucus
State
NJ
ZipCode
07094
Phone Number
1-800-223-1216
Web Address
www.vitaminshoppe.com
Pharmacist Counseling Corner

Royal Jelly 300 mg by The Vitamin Shoppe: Common Questions

Does Royal Jelly 300 mg by The Vitamin Shoppe interact with any medications?
Yes. Based on its ingredients, Royal Jelly 300 mg has a known interaction with 174 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Royal Jelly 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take royal jelly if I have asthma or allergies?
Not without checking with your doctor first. Royal jelly can trigger serious allergic reactions — including shortness of breath, hives, and in rare cases anaphylaxis or severe asthma — in people with a history of asthma or atopy. It's a real concern, so talk to your doctor before trying it.
Will royal jelly help with my hot flashes or other menopausal symptoms?
It's possibly effective for menopausal symptoms based on the evidence we have, but results aren't guaranteed and more research is needed. If you want to try it, discuss it with your doctor first — especially if you take other medications.
What are the most common side effects?
Most people tolerate royal jelly well with minimal issues. In people without asthma or allergies, side effects are uncommon. However, those with a history of asthma or allergies may experience itching, hives, eczema, shortness of breath, or oral allergy syndrome.
Is royal jelly safe to take while I'm pregnant or breastfeeding?
The safety information isn't established — there isn't enough data to know either way. Talk with your doctor or pharmacist before using royal jelly if you're pregnant or nursing.
Does royal jelly work for hair loss?
There isn't enough reliable evidence to say whether it helps or doesn't. If you're interested in it for that reason, discuss other options with your doctor.
Can I take this if I'm on blood thinners like warfarin?
You need to talk with your doctor before taking royal jelly with warfarin or other blood thinners. There's a documented case of someone's bleeding risk increasing after taking royal jelly on warfarin, so this combination needs professional oversight.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Royal Jelly 300 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Royal Jelly 300 mg label
Go deeper

The Full Monographs Behind Royal Jelly 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Royal Jelly

Interacts with 174 drugs

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune support, but solid human evidence is limit...

Read the full Royal Jelly monograph →
Sources

Sources & How We Checked

Royal Jelly 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Royal Jelly 14 references
  1. Takahashi M, Matsuo I, Ohkido M. Contact dermatitis due to honeybee royal jelly. Contact Dermatitis 1983;9:452-5.
  2. Bullock RJ, et al. Fatal royal jelly-induced asthma. Med J Aust 1994;160:44. DOI
  3. Thien FC, Leung R, Baldo BA, et al. Asthma and anaphylaxis induced by royal jelly. Clin Exp Allergy 1996;26:216-22. PubMed
  4. Yonei Y, Shibagaki K, Tsukada N, et al. Case report: haemorrhagic colitis associated with royal jelly intake. J Gastroenterol Hepatol 1997;12:495-9.
  5. Harwood M, Harding S, Beasley R, Frankish PD. Asthma following royal jelly. N Z Med J 1996;109:325.
  6. Laporte JR, Ibaanez L, Vendrell L, Ballarin E. Bronchospasm induced by royal jelly. Allergy 1996;51:440. DOI
  7. Leung R, Thien FC, Baldo B, et al. Royal jelly-induced asthma and anaphylaxis: clinical characteristics and immunologic correlations. J Allergy Clin Immunol 1995;96:1004-7. PubMed
  8. Peacock S, Murray V, Turton C. Respiratory distress and royal jelly. BMJ 1995;311:1472. DOI
  9. Winther K, Hedman C. Assessment of the Effects of the Herbal Remedy Femal on the Symptoms of Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study. Curr Ther Res Clin Exp 2002;63:344-53. DOI
  10. Lee NJ, Fermo JD. Warfarin and royal jelly interaction. Pharmacotherapy 2006;26:583-6. PubMed
  11. Tokunaga, K. H., Yoshida, C., Suzuki, K. M., Maruyama, H., Futamura, Y., Araki, Y., and Mishima, S. Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats. Biol.Pharm.Bull. 2004;27(2):189-192. PubMed
  12. Sultana, A., Nabi, A. H., Nasir, U. M., Maruyama, H., Suzuki, K. M., Mishima, S., and Suzuki, F. A dipeptide YY derived from royal jelly proteins inhibits renin activity. Int.J.Mol.Med. 2008;21(6):677-681. DOI
  13. Gómez Torrijos E, Méndez Diaz Y, Borja Segade JM, et al. Occupational allergic respiratory disease due to royal jelly. Ann Allergy Asthma Immunol. 2016;117(1):102-3. PubMed
  14. Li JD, Cui L, Xu YY, Guan K. A case of anaphylaxis caused by major royal jelly protein 3 of royal jelly and its cross-reactivity with honeycomb. J Asthma Allergy 2021;14:1555-7. PubMed

See these in context on the Royal Jelly monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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