Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Royal Jelly 500 mg Ingredients & Drug Interactions

by NewtonEverett

Royal Jelly 500 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Royal Jelly 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Royal Jelly 500 mg is a dietary supplement by NewtonEverett with 1 active ingredient. Its ingredients are commonly taken for menopausal symptoms, skin health and wound care, immune support.Based on those ingredients, 174 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Royal Jelly. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Royal Jelly 500 mg by NewtonEverett

Ask about any prescription or over-the-counter medication and we check it for interactions with Royal Jelly 500 mg by NewtonEverett — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Royal Jelly 500 mg by NewtonEverett

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Royal Jelly” is listed as a grouped ingredient — the label gives one combined amount (500 mg) without saying how much of each component you get.

This product contains one active ingredient: royal jelly concentrate, a nutrient-rich secretion from honeybees. The softgel capsule also holds inactive ingredients — olive oil, gelatin, vegetable glycerin, yellow beeswax, and soy lecithin — to deliver the royal jelly in easy-to-take form.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Royal Jelly's overall clinical evidence instead.

Moderate

Some clinical evidence supports Royal Jelly for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Menopausal symptoms — rated "Possibly Effective" (Natural Medicines).

The data we hold shows royal jelly is possibly effective for menopausal symptoms. For hay fever (allergic rhinitis), diabetes, and physical performance, the evidence suggests it's possibly ineffective.

For hair loss (androgenic alopecia), there isn't enough reliable evidence to rate whether it works.

The evidence, ingredient by ingredient Royal Jelly

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Royal jelly is generally well tolerated in most people. However, it can trigger serious allergic reactions — especially in people with a history of asthma or atopy (a tendency toward allergic conditions).

Common allergic symptoms include itching, hives, eczema, shortness of breath, and oral allergy syndrome. In rare cases, it can cause anaphylaxis or life-threatening breathing problems.

Topically, it may cause contact dermatitis or skin irritation. One case of hemorrhagic colitis (inflammation of the colon with bleeding) was reported after ingestion; symptoms resolved within two weeks of stopping.

There isn't enough safety information to use royal jelly during pregnancy or while breastfeeding. Talk with your doctor or pharmacist about whether it's right for you in those situations.

Side effects, ingredient by ingredient Royal Jelly

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Royal Jelly.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 174 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you take warfarin or any blood pressure medication (antihypertensive drugs). Royal jelly may boost their effects, raising bleeding risk with warfarin and potentially lowering your blood pressure too much.

If you have a history of asthma or allergies, mention that to your healthcare provider as well — royal jelly carries a higher risk of allergic reactions in those groups.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Royal jelly may appeal to you if you're looking for support with menopausal symptoms and don't take blood pressure medications or warfarin. If you're on either of those drug types, or have a history of asthma or severe allergies, check with your doctor or pharmacist before trying it.

Even if your medications don't appear on the interaction list, a conversation with your healthcare provider will help you decide whether it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Royal Jelly 500 mg, straight from the product label.

Brand NewtonEverett
Barcode (UPC) 689076031547
Net contents 120 Softgel(s)
Market status On market
Date entered into DSLD Oct 21, 2017
DSLD ID 79688
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Royal Jelly 500 mg by NewtonEverett, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
120
UPC/BARCODE
689076031547
IngredientAmount% DV
Royal Jelly500 mg--
Royal Jelly concentrate152 mg--

Other ingredients: Olive Oil, Gelatin, Vegetable Glycerin, yellow Beeswax, Soy Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Pure - Potent - Bioavailable We are driven to deliver highly potent, ultra-pure nutritional products with uncompromised quality. Our premium-grade liquid softgels are designed to provide an ideal delivery vehicle for maximum absorption and enhanced bioavailability.

Made in USA

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) softgel one to three times daily, preferably with a meal.

Precautions

Warning: If you are pregnant, nursing, taking any medications or have any medical conditions, consult your doctor before use.

Avoid this product if you are allergic to bees or bee products.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Not suitable for vegetarians.

Storage

Store at room temperature.

Formulation

No artificial color, flavor or sweetener, preservatives, sugar, milk, lactose, gluten, wheat, yeast, fish. Sodium free.

General

L15

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Royal Jelly 500 mg by NewtonEverett label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Royal Jelly 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Royal Jelly 500 mg by NewtonEverett

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.

Royal Jelly

Interacts with
174 drugs
500 mg per serving

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune su...

Royal Jelly monograph & interactions

Other (inactive) ingredients: Olive Oil, Gelatin, Vegetable Glycerin, Yellow Beeswax, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Royal Jelly 500 mg by NewtonEverett Drug Interactions

Want to check YOUR meds against Royal Jelly 500 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
174Drugs
174 Moderate

Ingredients driving the most interactions

Royal Jelly 174

Individual Drug Interactions

The ingredients in Royal Jelly 500 mg interact with 174 drugs. Click any drug to see the details.

1 of the 1 ingredient in Royal Jelly 500 mg interact with drugs. Each result below shows which ingredient is responsible. Royal Jelly

Each ingredient & the kinds of drugs it affects

For each ingredient in Royal Jelly 500 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Royal Jelly2 drug types · 174 drugs

Antihypertensive Drugs

Theoretically, royal jelly might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that royal jelly might lower blood pressure.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Royal jelly might increase the risk of bleeding when taken with warfarin.
In one case, an 87-year-old male who was previously stabilized on warfarin developed hematuria and was found to have an INR of 7.29 after taking a royal jelly supplement for one week.

Likelihood Possible Evidence D
Royal Jelly full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Royal Jelly 500 mg, from the product label.

NewtonEverett

See all NewtonEverett products
Name
Newton-Everett Biotech
Web Address
www.newton-everett.com
Pharmacist Counseling Corner

Royal Jelly 500 mg by NewtonEverett: Common Questions

Does Royal Jelly 500 mg by NewtonEverett interact with any medications?
Yes. Based on its ingredients, Royal Jelly 500 mg has a known interaction with 174 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Royal Jelly 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take royal jelly if I have asthma or allergies?
People with a history of asthma or atopy (allergic tendencies) are at higher risk of allergic reactions to royal jelly — ranging from itching and hives to, rarely, anaphylaxis or severe breathing problems. If that's you, talk with your doctor or pharmacist before taking it.
Does royal jelly work for weight loss or energy?
The data we hold doesn't cover weight loss. For physical performance, the evidence we have suggests it's possibly ineffective. Your doctor or pharmacist can discuss whether it might fit other goals you have.
Is royal jelly safe during pregnancy or breastfeeding?
There isn't enough safety information to know whether royal jelly is safe in pregnancy or while breastfeeding. Talk with your doctor or pharmacist before using it in those situations — they can help you weigh any risks and benefits based on your individual health.
What's in this softgel besides the royal jelly?
The inactive ingredients are olive oil, gelatin, vegetable glycerin, yellow beeswax, and soy lecithin — these help deliver the royal jelly in capsule form. If you're allergic to any of those, check the label carefully or ask your pharmacist.
Can royal jelly cause side effects?
Most people tolerate it well. In those without asthma or allergies, serious side effects are rare. But one case of bleeding in the colon with bloody diarrhea was reported, which improved after stopping the supplement. Allergic reactions are the main concern in susceptible people.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Royal Jelly 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Royal Jelly 500 mg label
Go deeper

The Full Monographs Behind Royal Jelly 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Royal Jelly

Interacts with 174 drugs

Royal jelly is a nutrient-rich substance made by worker bees to feed the queen bee. People take it for menopause symptoms, energy, skin, and immune support, but solid human evidence is limit...

Read the full Royal Jelly monograph →
Sources

Sources & How We Checked

Royal Jelly 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Royal Jelly 14 references
  1. Takahashi M, Matsuo I, Ohkido M. Contact dermatitis due to honeybee royal jelly. Contact Dermatitis 1983;9:452-5.
  2. Bullock RJ, et al. Fatal royal jelly-induced asthma. Med J Aust 1994;160:44. DOI
  3. Thien FC, Leung R, Baldo BA, et al. Asthma and anaphylaxis induced by royal jelly. Clin Exp Allergy 1996;26:216-22. PubMed
  4. Yonei Y, Shibagaki K, Tsukada N, et al. Case report: haemorrhagic colitis associated with royal jelly intake. J Gastroenterol Hepatol 1997;12:495-9.
  5. Harwood M, Harding S, Beasley R, Frankish PD. Asthma following royal jelly. N Z Med J 1996;109:325.
  6. Laporte JR, Ibaanez L, Vendrell L, Ballarin E. Bronchospasm induced by royal jelly. Allergy 1996;51:440. DOI
  7. Leung R, Thien FC, Baldo B, et al. Royal jelly-induced asthma and anaphylaxis: clinical characteristics and immunologic correlations. J Allergy Clin Immunol 1995;96:1004-7. PubMed
  8. Peacock S, Murray V, Turton C. Respiratory distress and royal jelly. BMJ 1995;311:1472. DOI
  9. Winther K, Hedman C. Assessment of the Effects of the Herbal Remedy Femal on the Symptoms of Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study. Curr Ther Res Clin Exp 2002;63:344-53. DOI
  10. Lee NJ, Fermo JD. Warfarin and royal jelly interaction. Pharmacotherapy 2006;26:583-6. PubMed
  11. Tokunaga, K. H., Yoshida, C., Suzuki, K. M., Maruyama, H., Futamura, Y., Araki, Y., and Mishima, S. Antihypertensive effect of peptides from royal jelly in spontaneously hypertensive rats. Biol.Pharm.Bull. 2004;27(2):189-192. PubMed
  12. Sultana, A., Nabi, A. H., Nasir, U. M., Maruyama, H., Suzuki, K. M., Mishima, S., and Suzuki, F. A dipeptide YY derived from royal jelly proteins inhibits renin activity. Int.J.Mol.Med. 2008;21(6):677-681. DOI
  13. Gómez Torrijos E, Méndez Diaz Y, Borja Segade JM, et al. Occupational allergic respiratory disease due to royal jelly. Ann Allergy Asthma Immunol. 2016;117(1):102-3. PubMed
  14. Li JD, Cui L, Xu YY, Guan K. A case of anaphylaxis caused by major royal jelly protein 3 of royal jelly and its cross-reactivity with honeycomb. J Asthma Allergy 2021;14:1555-7. PubMed

See these in context on the Royal Jelly monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team