Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Saffron Gummies Natural Apple Flavored Ingredients & Drug Interactions

by Flamingo Supplements

Saffron Gummies Natural Apple Flavored label
See full label image
Gummy Or Jelly Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Saffron Gummies Natural Apple Flavored against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Saffron Gummies Natural Apple Flavored is a dietary supplement by Flamingo Supplements with 4 active ingredients. Its ingredients are commonly taken for fatigue and low energy, stress and coping (adaptogen), mental performance and focus.Based on those ingredients, 1,284 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Rhodiola rosea Extract, Saffron Extract, Gamma Aminobutyric Acid. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Saffron Gummies Natural Apple Flavored by Flamingo Supplements

Ask about any prescription or over-the-counter medication and we check it for interactions with Saffron Gummies Natural Apple Flavored by Flamingo Supplements — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Saffron Gummies Natural Apple Flavored by Flamingo Supplements

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains four active ingredients. Rhodiola rosea extract is an adaptogenic herb traditionally used for stress and fatigue.

Gamma-aminobutyric acid (GABA) is a naturally occurring chemical messenger in the brain involved in relaxation. Lemon balm extract comes from an herb in the mint family.

Saffron extract is derived from the saffron crocus flower. The remaining ingredients are inactive — glucose syrup, sugar, water, citric acid, pectin, and other excipients that form the gummy and provide flavor and texture.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Stress, mood, and relaxation support.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Depression, Fatigue, Insomnia, Cognitive function — and 4 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Depression (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Anxiety, Cognitive function, Insomnia, and more.
  • Also on file: Gamma-aminobutyric Acid (gaba) is rated "Insufficient Reliable Evidence To Rate" for Anxiety.

The evidence for what these ingredients actually do varies. Lemon balm is possibly effective for cold sores and possibly effective for stress and depression, according to our data.

Saffron is possibly effective for chemotherapy-induced nerve pain and possibly effective for Alzheimer disease. For the other uses these ingredients are marketed for — rhodiola's effects on altitude sickness, anxiety, athletic performance, arrhythmia, and bladder cancer; GABA's effects on anxiety, athletic performance, ADHD, and breathing problems — the evidence we hold is insufficient to rate them.

That doesn't mean they don't work; it means rigorous clinical evidence is lacking.

The evidence, ingredient by ingredient Rhodiola Gamma-aminobutyric Acid (gaba) Lemon Balm Saffron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Rhodiola and GABA are both generally well tolerated for short-term use, but long-term safety hasn't been well studied. Common side effects of rhodiola include dizziness and changes in saliva production.

GABA may cause drowsiness, nausea, stomach upset, mild throat burning, or muscle weakness. Lemon balm is generally well tolerated for short-term use at standard doses; dizziness and sedation have been reported but don't seem more common than with placebo.

Saffron is likely safe in food amounts, but supplement doses warrant caution — common side effects include nausea, stomach problems, and sedation, and rare but serious reactions like anaphylaxis have been reported. One case of an irregular heartbeat and QT prolongation was reported with a multi-ingredient product containing lemon balm, though causality is unclear.

Side effects, ingredient by ingredient Rhodiola Gamma-aminobutyric Acid (gaba) Lemon Balm Saffron

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 4 matched ingredients can interact with medications — Lemon Balm, Gamma-aminobutyric Acid (gaba), Saffron, Rhodiola.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,285 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check your prescriptions against the following medication types: blood pressure medications (antihypertensive drugs) — both rhodiola and saffron may lower blood pressure further; sedatives and sleeping pills (CNS depressants) — all three of GABA, lemon balm, and saffron may add to drowsiness; diabetes medications (antidiabetes drugs) — both rhodiola and saffron may increase low-blood-sugar risk; thyroid hormone replacement — lemon balm may interfere with how well it works; and any drug metabolized by your liver's CYP2C9 system, especially losartan (Cozaar). If you regularly drink caffeine, be aware saffron may slow how quickly your body clears it.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This gummy combines four herbs and a neurotransmitter with documented interactions affecting over 1,200 medications. If you take any prescription drugs — especially blood pressure medications, diabetes medications, thyroid pills, sedatives, or anything metabolized by your liver — check each medication against our tool before starting.

Talk with your pharmacist about whether this product fits your individual situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Saffron Gummies Natural Apple Flavored, straight from the product label.

Brand Flamingo Supplements
Barcode (UPC) X002YBL643
Net contents 60 Natural Apple Flavored Gummy(ies)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 314629
Product type Other Combinations
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Saffron Gummies Natural Apple Flavored by Flamingo Supplements, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummy(ies)
Maximum serving Sizes:
2 Gummy(ies)
Servings per container
30
UPC/BARCODE
X002YBL643
IngredientAmount% DV
Calories12 Calorie(s)--
Total Carbohydrates4 Gram(s)1%
Added Sugars4 Gram(s)12%
Total Sugars4 Gram(s)--
Rhodiola rosea Extract20 mg--
Gamma Aminobutyric Acid20 mg--
Lemon Balm extract40 mg--
Saffron Extract30 mg--

Other ingredients: Glucose Syrup, Beet Sugar, Water, Citric Acid, Pectin, Trisodium Citrate, Coconut Oil, Turmeric, Apple Flavor, Natural, Spirulina, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

No soy, no gluten, no eggs, no dairy, no nuts, no gelatin, no GMOs No artificial colors, flavors, or sweeteners, no preservatives. Gluten free (wheat) Dairy free Egg free Peanut free

Gummy colors vary due to natural colors and flavors. May contain specs from natural herbs.

Precautions

Caution: As with any dietary supplement, consult your healthcare provider before using this product, especially if pregnant, nursing, taking medications, or under medical supervision.

Discontinue use and contact your healthcare professional if you experience a side effect or an allergic reaction.

Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Seals/Symbols

Registered cGMP

General Statements

New Instagram @flamingosupplements Want discounts? Scan QR or go to www.flamingosupplements.com

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

Lemon balm, Rhodiola Rosea Extract, & GABA

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Take 2 gummies daily or as directed by your healthcare provider. Chew thoroughly before swallowing.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Saffron Gummies Natural Apple Flavored by Flamingo Supplements label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Saffron Gummies Natural Apple Flavored label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Saffron Gummies Natural Apple Flavored by Flamingo Supplements

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummy(ies) Dosage formGummy Or Jelly Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Rhodiola rosea Extract

Interacts with
1,271 drugs
20 mg per serving

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue...

Rhodiola rosea Extract monograph & interactions

Gamma Aminobutyric Acid

Interacts with
419 drugs
20 mg per serving

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep...

Gamma Aminobutyric Acid monograph & interactions

Lemon Balm extract

Interacts with
264 drugs
40 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm extract monograph & interactions

Saffron Extract

Interacts with
521 drugs
30 mg per serving

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research us...

Saffron Extract monograph & interactions

Other (inactive) ingredients: Glucose Syrup, Beet Sugar, Water, Citric Acid, Pectin, Trisodium Citrate, Coconut Oil, Turmeric, Apple Flavor, Natural, Spirulina, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Saffron Gummies Natural Apple Flavored by Flamingo Supplements Drug Interactions

Want to check YOUR meds against Saffron Gummies Natural Apple Flavored?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,284Drugs
883 Moderate 401 Minor

Ingredients driving the most interactions

Rhodiola rosea Extract 1,271
Saffron Extract 521
Gamma Aminobutyric Acid 419
Lemon Balm extract 264

Individual Drug Interactions

The ingredients in Saffron Gummies Natural Apple Flavored interact with 1,284 drugs. Click any drug to see the details.

4 of the 4 ingredients in Saffron Gummies Natural Apple Flavored interact with drugs. Each result below shows which ingredient is responsible. Rhodiola rosea Extract Saffron Extract Gamma Aminobutyric Acid Lemon Balm extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Saffron Gummies Natural Apple Flavored with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Rhodiola rosea Extract10 drug types · 1,271 drugs

Antidiabetes Drugs

Theoretically, taking rhodiola with antidiabetes drugs might increase the risk of hypoglycemia.
In vitro and animal research shows that rhodiola extract can decrease blood glucose due to alpha-glucosidase activity.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking rhodiola with antihypertensive drugs might increase the risk of hypotension.
In vitro and animal research shows that rhodiola extract inhibits angiotensin-converting enzyme (ACE) and might lower blood pressure.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP2C9.
In vitro research shows that rhodiola inhibits CYP2C9. This effect is highly variable and appears to be dependent on the rhodiola product studied. Also, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Possible Evidence B
Immunosuppressants

Theoretically, rhodiola use might interfere with immunosuppressive therapy.
In vitro and animal research show that rhodiola has immunostimulatory effects.

Likelihood Possible Evidence D
Losartan (Cozaar)

Rhodiola might increase the levels and adverse effects of losartan.
A clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days reduces the metabolism of losartan, a CYP2C9 substrate, by 21% after 4 hours.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, rhodiola might increase levels of P-glycoprotein substrates.
In vitro research shows that rhodiola inhibits P-glycoprotein. Theoretically, using rhodiola with P-glycoprotein substrates might increase drug levels and potentially increase the risk of adverse effects.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, rhodiola might increase the risk of adverse effects when taken with antidepressants.
A review of adverse event reports in Poland identified cases of tachyarrhythmias, myalgia, arthralgia, gum pain, restless leg syndrome, swallowing disorders, and changes in consciousness when rhodiola was taken in combination with paroxetine, escitalopram, fluoxetine, sertraline, trazodone, and/or duloxetine.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.
A review of adverse event reports in Poland identified cases of excessive sedation, myoclonus, hypotension, and hallucinations when rhodiola was taken with haloperidol, diazepam, or alprazolam.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that rhodiola inhibits CYP1A2. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of caffeine, a CYP1A2 substrate.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, rhodiola might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that rhodiola inhibits CYP3A4. This effect is highly variable and appears to be dependent on the rhodiola product studied. However, a clinical study in healthy young males found that taking rhodiola extract 290 mg daily for 14 days does not inhibit the metabolism of midazolam, a CYP3A4 substrate.

Likelihood Possible Evidence B
Rhodiola rosea Extract full monograph & interactions

Saffron Extract4 drug types · 521 drugs

Antidiabetes Drugs

Theoretically, concomitant use of saffron with antidiabetes drugs might increase the risk of hypoglycemia.
Some clinical research shows that taking saffron extract reduces fasting levels of glucose when used in addition to hypoglycemic agents. However, saffron powder itself has not been shown to reduce fasting glucose levels.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, concomitant use of saffron with antihypertensive drugs might have additive effects.
Animal and human research suggests that saffron extract can decrease blood pressure.

Likelihood Possible Evidence D
Caffeine

Theoretically, saffron might inhibit the metabolism of caffeine.
A small clinical study suggests that taking saffron powder 300 mg in 150 mL water daily for 5 days and then taking caffeine 200 mg seems to reduce caffeine metabolite levels in the saliva and urine in males, but not females. Theoretically, this may be due to the inhibition of cytochrome P450 1A2 by saffron.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, concomitant use of saffron and CNS depressants might have additive sedative effects.
Clinical research shows that taking saffron extract 60 mg orally daily for 26 weeks can cause drowsiness and sedation. Animal research suggests that adding saffron to hexobarbital further increases sleeping and slows motor activity.

Likelihood Possible Evidence D
Saffron Extract full monograph & interactions

Gamma Aminobutyric Acid2 drug types · 419 drugs

Antihypertensive Drugs

Theoretically, taking GABA with antihypertensive drugs might increase the risk of hypotension.
Some clinical research shows that GABA can decrease blood pressure in patients with hypertension.

Likelihood Possible Evidence B
Cns Depressants

Theoretically, GABA might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Endogenous GABA has well-established relaxant effects and GABA(A) receptors have an established physiological role in sleep. However, the effects of GABA supplements are unclear, as it is unknown whether exogenous GABA crosses the blood-brain barrier. Although there have been limited reports of drowsiness or tiredness with GABA supplements, these effects have not been widely reported in clinical studies. Additionally, intravenous GABA 0.1-1 mg/kg has been shown to induce anxiety in a dose-dependent manner.

Likelihood Unlikely Evidence D
Gamma Aminobutyric Acid full monograph & interactions

Lemon Balm extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Saffron Gummies Natural Apple Flavored, from the product label.

Flamingo Supplements

See all Flamingo Supplements products
Name
Flamingo Supplements LLC
City
Beverly Hills
State
CA
ZipCode
90210
Phone Number
1-866-992-8368
Web Address
www.flamingosupplements.com
Pharmacist Counseling Corner

Saffron Gummies Natural Apple Flavored by Flamingo Supplements: Common Questions

Does Saffron Gummies Natural Apple Flavored by Flamingo Supplements interact with any medications?
Yes. Based on its ingredients, Saffron Gummies Natural Apple Flavored has a known interaction with 1,284 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Saffron Gummies Natural Apple Flavored contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this during pregnancy?
No. Rhodiola and GABA have not been studied enough in pregnancy and are best avoided. Saffron in supplement amounts may stimulate the uterus and should be avoided during pregnancy. Lemon balm hasn't been studied enough either, though your doctor might advise otherwise in your specific situation. Talk with your doctor before using this product if you're pregnant.
Is it safe to take this while breastfeeding?
The safety data isn't clear enough. Rhodiola and GABA are best avoided while breastfeeding due to lack of reliable information. Saffron in supplement doses should be avoided as well. Lemon balm has limited safety information, so you'd need to check with your doctor. We'd recommend talking with your pharmacist or doctor before using this product while nursing.
What does lemon balm actually do?
According to our data, lemon balm is possibly effective for cold sores and possibly effective for stress and depression. It does seem to have calming effects — the plant has CNS depressant activity — but evidence for other uses marketed in some products is insufficient.
Does this product work for anxiety?
The evidence we hold is insufficient to rate whether rhodiola works for anxiety or whether GABA works for it. Lemon balm is possibly effective for stress and depression, which are related, but we don't have rated evidence specifically for generalized anxiety disorder.
What are the most common side effects?
Rhodiola commonly causes dizziness and changes in how much saliva you produce. GABA may cause drowsiness, nausea, stomach upset, or muscle weakness. Lemon balm and saffron can both cause drowsiness or sedation. Saffron may also cause nausea or stomach complaints. All are generally well tolerated, but long-term safety isn't well studied.
Can I take this if I'm on blood pressure medication?
You need to check with your pharmacist or doctor first. Both rhodiola and saffron in this product may lower blood pressure, and combining them with your blood pressure medication could cause your pressure to drop too low. Use the search tool on this page to check your specific medication, then talk to your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Saffron Gummies Natural Apple Flavored label
Go deeper

The Full Monographs Behind Saffron Gummies Natural Apple Flavored’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Rhodiola

Interacts with 1,271 drugs

Rhodiola is an herb traditionally used to fight fatigue and help the body cope with stress. Some small studies suggest it may modestly reduce fatigue and improve mood, but the evidence is li...

Read the full Rhodiola monograph → Herb & supplement monograph

Gamma-aminobutyric Acid (gaba)

Interacts with 419 drugs

GABA is a calming chemical messenger (neurotransmitter) that your body makes on its own, and it is sold as a supplement for stress, anxiety, and sleep. The science behind oral GABA supplemen...

Read the full Gamma-aminobutyric Acid (gaba) monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Saffron

Interacts with 521 drugs

Saffron is a costly spice that has shown promise in early studies for mild-to-moderate depression and some mood and PMS symptoms, but most research uses small trials, so results are not defi...

Read the full Saffron monograph →
Sources

Sources & How We Checked

Saffron Gummies Natural Apple Flavored's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 59 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Rhodiola 13 references
  1. Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19.
  2. Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32.
  3. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80.
  4. Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. PubMed
  5. Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 2006;15:433-41.
  6. Hellum BH, Tosse A, Hoybakk K, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med 2010;76:331-8.
  7. Skopriska-Rozewska E, Wojcik R, Siwicki AK, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci 2008;11:105-11.
  8. Mishra KP, Chanda S, Shukla K, Ganju L. Adjuvant effect of aqueous extract of Rhodiola imbricate rhizome on the immune responses to tetanus toxoid and ovalbumin in rats. Immunopharmacol Immunotoxicol 2010;32:141-6.
  9. Li HX, Sze SC, Tong Y, Ng TB. Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol 2009;123:257-66. PubMed
  10. Mishra KP, Ganju L, Chanda S, et al. Aqueous extract of Rhodiola imbricate rhizome stimulates Toll-like receptor 4, granzyme-B and Th1 cytokines in vitro. Immunobiology 2009;214:27-31.
  11. Thu OK, Nilsen OG, Hellum B. In vitro inhibition of cytochrome P-450 activities and quantification of constituents in a selection of commercial Rhodiola rosea products. Pharm Bio. 2016 Dec;54(12):3249-3256.
  12. Thu OK, Spigset O, Nilsen OG, Hellum B. Effect of commercial Rhodiola rosea on CYP enzyme activity in humans. Eur J Clin Pharmacol. 2016 Mar;72(3):295-300. PubMed
  13. Woron J, Siwek M. Unwanted effects of psychotropic drug interactions with medicinal products and diet supplements containing plant extracts. Psychiatr Pol 2018;52(6):983-96. PubMed

See these in context on the Rhodiola monograph →

Gamma-aminobutyric Acid (gaba) 12 references
  1. Cavagnini F, Invitti C, Pinto M, et al. Effect of acute and repeated administration of gamma aminobutyric acid (GABA) on growth hormone and prolactin secretion in man. Acta Endocrinol (Copenh) 1980;93:149-54.
  2. Nurnberger JI Jr, Berrettini WH, Simmons-Alling S, et al. Intravenous GABA administration is anxiogenic in man. Psychiatry Res 1986;19:113-7. PubMed
  3. Gershman RN, Vasilenko MA, Iliushina GG, et al. [Gammalon in the rehabilitation in infantile cerebral palsy]. Pediatr.Akus.Ginekol. 1977;(6):26-7.
  4. Loeb C, Benassi E, Bo, GP, et al. Preliminary evaluation of the effect of GABA and phosphatidylserine in epileptic patients. Epilepsy Res. 1987;1:209-12 . PubMed
  5. Inoue K, Shirai T, Ochiai H, et al. Blood-pressure-lowering effect of a novel fermented milk containing gamma-aminobutyric acid (GABA) in mild hypertensives. Eur J Clin Nutr 2003;57:490-95.
  6. ELLIOTT, K. A. and JASPER, H. H. Gammaaminobutyric acid. Physiol Rev. 1959;39(2):383-406.
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Lemon Balm 12 references
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Saffron 22 references
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  17. Safarinejad MR, Shafiei N, Safarinejad S. An open label, randomized, fixed-dose, crossover study comparing efficacy and safety of sildenafil citrate and saffron (Crocus sativus Linn.) for treating erectile dysfunction in men naïve to treatment. Int J Impo PubMed
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  20. Begas E, Bounitsi M, Kilindris T, et al. Effects of short-term saffron (Crocus sativus L.) intake on the in vivo activities of xenobiotic metabolizing enzymes in healthy volunteers. Food Chem Toxicol. 2019;130:32-43. PubMed
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  22. Abbaszadeh-Mashkani S, Hoque SS, Banafshe HR, Ghaderi A. The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment. Phytother Res. 2021; PubMed

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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