Sage Flower Essence Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Sage Flower Essence against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sage Flower Essence is a dietary supplement by Flower Essence Services with 1 active ingredient. Its ingredients are commonly taken for sore throat and mouth irritation, digestive upset, excessive sweating.Based on those ingredients, 1,296 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are infusion (1:6000) of Salvia officinalis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sage Flower Essence by Flower Essence Services
Ask about any prescription or over-the-counter medication and we check it for interactions with Sage Flower Essence by Flower Essence Services — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sage Flower Essence by Flower Essence Services
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Sage Flower Essence contains one active ingredient: sage (Salvia officinalis) in an infusion form — that's one part sage steeped in a ratio of 1 to 6,000. The base includes water and brandy as inactive ingredients.
Does it work?
Moderate evidence
The evidence we hold shows sage as possibly effective for menopausal symptoms, high cholesterol (hyperlipidemia), and cognitive function — meaning there's some research support but it's not conclusive. For postoperative pain, the data we have rates it as possibly ineffective.
Keep in mind these ratings reflect what's been studied; your own results may vary, and you should talk with your doctor about whether this product fits your health goals.
How safe is it?
Well-documented data
Sage is generally well tolerated as a food or short-term tea, but concentrated extracts and the essential oil need caution. When taken by mouth, the most common side effects are abdominal pain, agitation, diarrhea, dizziness, nausea, and vomiting.
Rare but serious, seizures have been linked to sage's thujone, camphor, and cineol content. Topically, it can cause burning, dermatitis, or pain; spray in the mouth may cause dryness or mild throat burning.
During pregnancy, medicinal or concentrated amounts of sage are not advised because of thujone; food amounts are likely okay. During breastfeeding, medicinal amounts carry risk — sage has traditionally been used to reduce milk supply, so check with your doctor before taking it if you're nursing.
Meds to double-check
Moderate interaction found
Before taking this product, check with your pharmacist or doctor if you take CNS depressants (sedatives, sleep aids, tranquilizers), blood pressure medications, hormone therapy including estrogens, or any drug your liver metabolizes via CYP2D6, CYP2C19, CYP2C9, or CYP3A4 pathways — all rated Moderate severity. These interactions are theoretical based on lab work and not yet confirmed in people, but worth verifying against your exact medications.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Sage Flower Essence may be worth considering if you're exploring options for menopausal symptoms, cholesterol, or brain function, and you're not on medications that interact with it. Anyone taking blood pressure drugs, sedatives, hormone therapy, or medications metabolized by major liver pathways should double-check their specific drugs with their pharmacist or doctor before starting.
Talk it over with your own healthcare provider to make sure it fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 26, 2014.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sage Flower Essence, straight from the product label.
| Brand | Flower Essence Services |
|---|---|
| Barcode (UPC) | 782932121014 |
| Net contents | 0.25 fl. Oz.; 7.5 mL |
| Market status | On market |
| Date entered into DSLD | Feb 26, 2014 |
| DSLD ID | 30472 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | No Claim |
| Intended target group(s) | Adult (18 - 50 Years), Organic |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sage Flower Essence by Flower Essence Services, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| infusion (1:6000) of Salvia officinalis | 0 NP | -- |
Other ingredients: Water, brandy
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: four drops, four times daily
Seals/Symbols
FES Quintessentials(TM)
DEMETER(R)
Formulation
Certified organic by Stellar Certification Services, Inc.
Brand IP Statement(s)
Demeter-certified Biodynamic(R)
General Statements
BEST BY 03/2022 120309
FDA Statement of Identity
herbal supplement
General
120309
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sage Flower Essence by Flower Essence Services label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sage Flower Essence by Flower Essence Services
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size4 Drop(s) Dosage formLiquid Amounts shown are per serving.
Infusion (1:6000) of Salvia officinalis
Interacts with1,296 drugs
Sage is a common kitchen herb that is generally safe in food amounts and is traditionally used for sore throats, digestion, sweating, and memory. Some...
Infusion (1:6000) of Salvia officinalis monograph & interactionsOther (inactive) ingredients: Water, Brandy. These complete the product’s ingredient list but are not active constituents.
Sage Flower Essence by Flower Essence Services Drug Interactions
HelloPharmacist Interaction Report
Sage Flower Essence from Flower Essence Services, made from sage infusion, has documented interactions with a number of medication types.
The most serious concern is with CNS depressants (sedatives, tranquilizers, sleep aids) — sage contains compounds that can have sedative activity, and combined use might increase drowsiness and other unwanted effects at a Moderate severity level.
Read the full breakdown — every affected drug type, severity by severity
Sage may also interact with blood pressure medications (antihypertensives), drugs metabolized by your liver's CYP2D6, CYP2C19, CYP2C9, and CYP3A4 pathways, P-glycoprotein transporters, and hormone therapies including estrogens. All of these are rated Moderate severity — the concern is theoretical based on lab evidence, not yet confirmed in people, but worth checking.
Sage constituents can theoretically increase blood levels of drugs that depend on these pathways, which might boost their effects.
Although these interactions come from lab work rather than human studies so far, they're documented enough to warrant caution. Altogether, these interactions span 1,297 individual medications.
Before you start this product, especially if you take any prescription medication for blood pressure, mood, sleep, hormones, or any drug your doctor says your liver metabolizes, run your exact medications through the checker on this page or talk with your pharmacist.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sage Flower Essence?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sage Flower Essence interact with 1,296 drugs. Click any drug to see the details.
1 of the 1 ingredient in Sage Flower Essence interact with drugs. Each result below shows which ingredient is responsible. infusion (1:6000) of Salvia officinalis
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Infusion (1:6000) Of Salvia Officinalis + Ado-trastuzumab Emtansine interactionAbemaciclibVerzenio
How Abemaciclib interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Infusion (1:6000) Of Salvia Officinalis + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Infusion (1:6000) Of Salvia Officinalis + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Infusion (1:6000) Of Salvia Officinalis + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2c19 (cyp2c19) Substrates, Cytochrome P450 2c9 (cyp2c9) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.
Read the full Infusion (1:6000) Of Salvia Officinalis + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 3a4 (cyp3a4) Substrates, P-glycoprotein Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acebutolol interactionAcepromazineAtravet
How Acepromazine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCns Depressants, Anticholinergic Drugs Moderate
Interaction Summary
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acepromazine interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2d6 (cyp2d6) Substrates, Cns Depressants +1 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCns Depressants, Cytochrome P450 2e1 (cyp2e1) Substrates +3 Moderate
Interaction Summary
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCns Depressants, Cytochrome P450 3a4 (cyp3a4) Substrates +2 Moderate
Interaction Summary
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisAnticholinergic Drugs, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2e1 (cyp2e1) Substrates, Anticholinergic Drugs +3 Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisAnticholinergic Drugs, Cytochrome P450 2e1 (cyp2e1) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2d6 (cyp2d6) Substrates, Anticholinergic Drugs +2 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Sage Flower Essence — through 1 ingredient. Tap an ingredient for the detail:
Infusion (1:6000) Of Salvia OfficinalisCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +2 Moderate
Interaction Summary
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Read the full Infusion (1:6000) Of Salvia Officinalis + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sage Flower Essence with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
infusion (1:6000) of Salvia officinalis
Anticholinergic Drugs
Theoretically, sage might decrease the clinical effects of anticholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.
Anticonvulsants
Theoretically, sage might interfere with the clinical effects of anticonvulsant drugs.
Some species of sage can cause convulsions when consumed in large quantities.
Antidiabetes Drugs
Theoretically, taking sage with antidiabetes drugs might increase the risk of hypoglycemia.
In patients with polycystic ovary syndrome (PCOS) or inadequately controlled type 2 diabetes, common sage (Salvia officinalis) has demonstrated hypoglycemic activity. However, other clinical research in patients with inadequately controlled type 2 diabetes shows that common sage extract does not lower fasting blood glucose levels.
Antihypertensive Drugs
Theoretically, sage might increase or decrease the effects of antihypertensive drugs.
Animal research suggests that common sage (Salvia officinalis) can cause prolonged blood pressure reduction. However, clinical research suggests that Spanish sage (Salvia lavandulaefolia) can increase blood pressure in some people with hypertension. Until more is known, use with caution.
Benzodiazepines
Theoretically, taking sage might increase the sedative and adverse effects of benzodiazepines.
In vitro evidence suggests that certain components of common sage (Salvia officinalis) can bind to benzodiazepine receptors. This effect has not been reported in humans.
Cholinergic Drugs
Theoretically, sage might have additive effects when used with cholinergic drugs.
In vitro evidence suggests that common sage (Salvia officinalis) and Spanish sage (Salvia lavandulaefolia) can inhibit acetylcholinesterase and might increase acetylcholine levels.
Cns Depressants
Theoretically, taking sage might increase the sedative and adverse effects of CNS depressants.
Some constituents of sage have CNS depressant activity.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C19.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C19. So far, this interaction has not been reported in humans.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2C9.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2C9. So far, this interaction has not been reported in humans.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP2D6.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP2D6. So far, this interaction has not been reported in humans.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Theoretically, sage might decrease the levels and clinical effects of drugs metabolized by CYP2E1.
Animal research suggests that drinking common sage (Salvia officinalis) tea increases the expression of CYP2E1. So far, this interaction has not been reported in humans.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, sage might increase the levels and clinical effects of drugs metabolized by CYP3A4.
In vitro evidence suggests that aqueous extracts of sage can inhibit CYP3A4. So far, this interaction has not been reported in humans.
Estrogens
Theoretically, sage might interfere with hormone therapy.
In vitro evidence suggests that geraniol, a constituent of Spanish sage (Salvia lavandulaefolia), exerts estrogenic activity. The clinical significance of this effect is unclear.
P-Glycoprotein Substrates
Theoretically, sage might increase levels of drugs transported by P-glycoprotein.
In vitro research suggests that common sage (Salvia officinalis) can inhibit the multi-drug transporter protein, P-glycoprotein. This effect has not been reported in humans.
Brand information
Manufacturer and brand details for Sage Flower Essence, from the product label.
Sage Flower Essence by Flower Essence Services: Common Questions
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The Full Monographs Behind Sage Flower Essence’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Sage Flower Essence's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 27 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sage 27 references
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Todorov S, Philianos S, Petkov V, et al. Experimental pharmacological study of three species from genus Salvia. Acta Physiol Pharmacol (Bulg) 1984;10:13-20.
- Perry NS, Bollen C, Perry EK, Ballard C. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharmacol Biochem Behav 2003;75:651-9.. PubMed
- Saller R, Buechi S, Meyrat R, Schmidhauser C. Combined herbal preparation for topical treatment of Herpes labialis. Forsch Komplementarmed Klass Naturheilkd 2001;8:373-82. PubMed
- Akhondzadeh S, Noroozian M, Mohammadi M, et al. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther 2003;28:53-9.
- Perry NB, Anderson RE, Brennan NJ, et al. Essential oils from dalmatian sage (Salvia officinalis l.): variations among individuals, plant parts, seasons, and sites. J Agric Food Chem 1999;47:2048-54..
- Foster BC, Vandenhoek S, Hana J, et al. In vitro inhibition of human cytochrome P450-mediated metabolism of marker substrates by natural products. Phytomedicine 2003;10:334-42.. PubMed
- Burkhard PR, Burkhardt K, Haenggeli CA, Landis T. Plant-induced seizures: reappearance of an old problem. J Neurol 1999;246:667-70. PubMed
- Bommer S, Klein P, Suter A. First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Adv Ther 2011;28:490-500. PubMed
- Hellum BH, Nilsen OG. The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol. Basic Clin Pharmacol Toxicol. 2007 Nov;101:350-8.
- Orhan, I., Kartal, M., Kan, Y., and Sener, B. Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. Z.Naturforsch.C. 2008;63(7-8):547-553.
- Perry, N. S., Houghton, P. J., Theobald, A., Jenner, P., and Perry, E. K. In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes. J Pharm Pharmacol 2000;52(7):895-902.
- Perry, N. S., Houghton, P. J., Sampson, J., Theobald, A. E., Hart, S., Lis-Balchin, M., Hoult, J. R., Evans, P., Jenner, P., Milligan, S., and Perry, E. K. In-vitro activity of S. lavandulaefolia (Spanish sage) relevant to treatment of Alzheimer's diseas
- Futrell, J. M. and Rietschel, R. L. Spice allergy evaluated by results of patch tests. Cutis 1993;52(5):288-290.
- Kavvadias, D., Monschein, V., Sand, P., Riederer, P., and Schreier, P. Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med. 2003;69(2):113-117.
- Savelev, S. U., Okello, E. J., and Perry, E. K. Butyryl- and acetyl-cholinesterase inhibitory activities in essential oils of Salvia species and their constituents. Phytother Res 2004;18(4):315-324.
- Kennedy, D. O., Pace, S., Haskell, C., Okello, E. J., Milne, A., and Scholey, A. B. Effects of cholinesterase inhibiting sage (Salvia officinalis) on mood, anxiety and performance on a psychological stressor battery. Neuropsychopharmacology 2006;31(4):84 PubMed
- Hubbert, M., Sievers, H., Lehnfeld, R., and Kehrl, W. Efficacy and tolerability of a spray with Salvia officinalis in the treatment of acute pharyngitis - a randomised, double-blind, placebo-controlled study with adaptive design and interim analysis. Eur
- Lima, C. F., Fernandes-Ferreira, M., and Pereira-Wilson, C. Drinking of Salvia officinalis tea increases CCl(4)-induced hepatotoxicity in mice. Food Chem.Toxicol. 2007;45(3):456-464.
- Hellum, B. H. and Nilsen, O. G. In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products. Basic Clin Pharmacol Toxicol. 2008;102(5):466-475.
- Mayer, E., Gescheidt-Shoshany, H., and Weltfriend, S. Allergic contact dermatitis caused by Salvia officinalis extract. Contact Dermatitis 2011;64(4):237-238. PubMed
- Halicioglu, O., Astarcioglu, G., Yaprak, I., and Aydinlioglu, H. Toxicity of Salvia officinalis in a newborn and a child: an alarming report. Pediatr.Neurol. 2011;45(4):259-260. PubMed
- Sertoli, A., Fabbri, P., Campolmi, P., and Panconesi, E. Allergic contact dermatitis to Salvia Officinalis, Inula Viscosa and Conyza Bonariensis. Contact Dermatitis 1978;4(5):314-315.
- Vandecasteele K, Ost P, Oosterlinck W, et al. Evaluation of the efficacy and safety of Salvia officinalis in controlling hot flashes in prostate cancer patients treated with androgen deprivation. Phytother Res. 2012;26(2):208-13.
- Kianbakht S, Dabaghian FH. Improved glycemic control and lipid profile in hyperlipidemic type 2 diabetic patients consuming Salvia officinalis L. leaf extract: a randomized placebo. Controlled clinical trial. Complement Ther Med. 2013;21(5):441-6. PubMed
- Amini L, Mojab F, Jahanfar S, Sepidarkish M, Raoofi Z, Maleki-Hajiagha A. Efficacy of Salvia officinalis extract on the prevention of insulin resistance in euglycemic patients with polycystic ovary syndrome: A double-blinded placebo-controlled clinical tr
- Behradmanesh S, Derees F, Rafieian-Kopaei M. Effect of Salvia officinalis on diabetic patients. J Renal Inj Prev. 2013;2(2):51-4.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC