SAM-e 400 mg By Jarrow Formulas Overview & Drug Interactions
Check For Interactions With SAM-e 400 mg
Supplement: SAM-e 400 mg by Jarrow Formulas
SAM-e 400 mg Label Images
This product contains
Below is a list of the 'active' ingredients listed on the supplement label for this product.
For a list of 'other ingredients', such as fillers, please see the 'Label Information' section on this page.
S-Adenosyl Methionine
S-adenosyl-l-methionine (SAM-e or SAMe) is a compound that is found naturally in the body and is involved in various processes, including the synthesis of neurotransmitters and the metabolism of hormones. SAM-e has been studied as a potential treatment for a variety of health conditions, including depression, osteoarthritis, and liver disease. As a dietary supplement, it is most often used for improving symptoms of depression and for osteoarthritis. In regard to depression, research suggests that SAM-e may be more effective than placebo in reducing the severity of depression and may be as effective as certain antidepressants for some individuals. However, more research is needed. Similarly, for osteoarthritis, some studies show that it is as effective in reducing symptoms for some individuals as NSAIDs (e.g., ibuprofen). There are a variety of different forms of SAM-e supplements available on the market, typically different salt forms (e.g., sulfate, sulfate-p-toluenesulfonate, and butanedisulfonate), which may affect how well it is absorbed.
See More Information Regarding Same| Ingredient Group | SAMe |
|---|---|
| Category | non-nutrient/non-botanical |
-
SAM-e Tosylate Disulfate
Description:S-adenosyl-l-methionine (SAM-e or SAMe) is a compound that is found naturally in the body and is involved in various processes, including the synthesis of neurotransmitters and the metabolism of hormones. SAM-e has been studied as a potential treatment for a variety of health conditions, including depression, osteoarthritis, and liver disease. As a dietary supplement, it is most often used for improving symptoms of depression and for osteoarthritis. In regard to depression, research suggests that SAM-e may be more effective than placebo in reducing the severity of depression and may be as effective as certain antidepressants for some individuals. However, more research is needed. Similarly, for osteoarthritis, some studies show that it is as effective in reducing symptoms for some individuals as NSAIDs (e.g., ibuprofen). There are a variety of different forms of SAM-e supplements available on the market, typically different salt forms (e.g., sulfate, sulfate-p-toluenesulfonate, and butanedisulfonate), which may affect how well it is absorbed.
See More Information Regarding Same
Ingredient Group SAMe Category non-nutrient/non-botanical
Drugs that interact with SAM-e 400 mg by Jarrow Formulas
Below is a list of drug interactions for each ingredient in this supplement product. Please note that a supplement product may contain more than one ingredient that has interactions.
Label Information
Supplement Facts:
| Daily Value (DV) Target Group(s): | Adults and children 4 or more years of age |
|---|---|
| Minimum serving Sizes: |
1 Tablet(s)
|
| Maximum serving Sizes: |
1 Tablet(s)
|
| Servings per container | 30 |
| UPC/BARCODE | 790011200208 |
| Ingredient | Amount per Serving | Group | % DV, Adults & children 4+ years |
|---|---|---|---|
| S-Adenosyl Methionine |
400 mg
|
SAMe |
--
|
| SAM-e Tosylate Disulfate |
800 mg
|
SAMe |
|
| Other Ingredients: |
Cellulose
Mannitol
Glyceryl Behenate
Magnesium Stearate
Silicon Dioxide
Sodium Starch Glycolate
Enteric Coating
Forms
Magnesium Silicate
Titanium Dioxide
Triethyl Citrate
Riboflavin
Glyceryl Palmitostearate
Medium Chain Triglycerides
|
|---|
Label Statments:
| General Statements |
- S-Adenosyl Methionine
- FULL POTENCY
- Natural
- 400 mg (net yield) SAM-e from 800 mg SAM-e tosylate disulfate
- Highest Concentration of Active S,S Form
- Promotes:
Longevity*
Joint Strength*
Liver Detoxification*
Mood and Brain Function*
- in Foil Blister Pack
- Jarrow FORMULAS® SAM-e 400 provides a full 400 mg SAM-e (net yield) from 800 mg of SAM-e tosylate disulfate.
- SAM-e 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.
- Contains More of the Active S,S Form
Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid). SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow FORMULAS® SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.
- SAM-e has been clinically shown to have the following benefits: Joint Strength SAM-e supports the production of healthy connective tissue through transulfuration. In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.*
Brain Metabolism SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, serotonin, epinephrine and phosphatidylcholine (a component of lecithin).*
Longevity Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process.* Proper methylation through substances such as SAM-e positively influences longevity.*
Liver SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione -dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function.*
- Jarrow FORMULAS® SAM-e 400 is foil blister-packed to maximize stability and safety.
|
|---|---|
| Suggested/Recommended/Usage/Directions |
- USAGE: Take 1 tablet per day on an empty stomach or as directed by your qualified health care consultant.
|
| Precautions |
- WARNING: Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using.
- Individuals with Parkinson’s disease, bi-polar disorder or manic depression should not use SAM-e.
- DO NOT use if outer seal of blister pack is broken.
- Keep out of the reach of children.
|
| Formula |
- Full Potency 400 mg SAM-e is derived from 800 mg of SAM-e tosylate disulfate.
- 400 mg SAM-e
|
| Brand IP Statement(s) |
- For best results, use with Jarrow FORMULAS® JarroSil®, the biologically Activated Silicon®.
- (C) 2011 Jarrow FORMULAS(R)
|
| Storage |
- Store in a cool, dry place.
|
| Seals/Symbols |
- (symbol)vegan
|
| FDA Statement of Identity |
- Dietary Supplement
|
| Formulation |
- Suitable for vegetarians/vegans.
- No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.
|
| General |
- 12111SAM400 PROD # 120020
|
| FDA Disclaimer Statement |
- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
|
Brand Information
See all products by this brand
| Distributed Exclusively by: | |
|---|---|
| Name | Jarrow Formulas Superior Nutrition and Formulation |
| Street Address | P.O. Box 35994 |
| City | Los Angeles |
| State | CA |
| ZipCode | 90035-4317 |
| Web Address | www.Jarrow.com |
Return to the main supplement interaction checker page
Parts of this content are provided by the Therapeutic Research Center, LLC and the Dietary Supplement Label Database.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.