SAMe 400 By Jarrow Formulas Overview & Drug Interactions
Check For Interactions With SAMe 400
Supplement: SAMe 400 by Jarrow Formulas
SAMe 400 Label Images
This product contains
Below is a list of the 'active' ingredients listed on the supplement label for this product.
For a list of 'other ingredients', such as fillers, please see the 'Label Information' section on this page.
S-Adenosyl Methionine
S-adenosyl-l-methionine (SAM-e or SAMe) is a compound that is found naturally in the body and is involved in various processes, including the synthesis of neurotransmitters and the metabolism of hormones. SAM-e has been studied as a potential treatment for a variety of health conditions, including depression, osteoarthritis, and liver disease. As a dietary supplement, it is most often used for improving symptoms of depression and for osteoarthritis. In regard to depression, research suggests that SAM-e may be more effective than placebo in reducing the severity of depression and may be as effective as certain antidepressants for some individuals. However, more research is needed. Similarly, for osteoarthritis, some studies show that it is as effective in reducing symptoms for some individuals as NSAIDs (e.g., ibuprofen). There are a variety of different forms of SAM-e supplements available on the market, typically different salt forms (e.g., sulfate, sulfate-p-toluenesulfonate, and butanedisulfonate), which may affect how well it is absorbed.
See More Information Regarding Same| Ingredient Group | SAMe |
|---|---|
| Category | non-nutrient/non-botanical |
-
SAMe Tosylate Disulfate
Description:S-adenosyl-l-methionine (SAM-e or SAMe) is a compound that is found naturally in the body and is involved in various processes, including the synthesis of neurotransmitters and the metabolism of hormones. SAM-e has been studied as a potential treatment for a variety of health conditions, including depression, osteoarthritis, and liver disease. As a dietary supplement, it is most often used for improving symptoms of depression and for osteoarthritis. In regard to depression, research suggests that SAM-e may be more effective than placebo in reducing the severity of depression and may be as effective as certain antidepressants for some individuals. However, more research is needed. Similarly, for osteoarthritis, some studies show that it is as effective in reducing symptoms for some individuals as NSAIDs (e.g., ibuprofen). There are a variety of different forms of SAM-e supplements available on the market, typically different salt forms (e.g., sulfate, sulfate-p-toluenesulfonate, and butanedisulfonate), which may affect how well it is absorbed.
See More Information Regarding Same
Ingredient Group SAMe Category non-nutrient/non-botanical
Drugs that interact with SAMe 400 by Jarrow Formulas
Below is a list of drug interactions for each ingredient in this supplement product. Please note that a supplement product may contain more than one ingredient that has interactions.
Label Information
Supplement Facts:
| Daily Value (DV) Target Group(s): | Adults and children 4 or more years of age |
|---|---|
| Minimum serving Sizes: |
1 Tablet(s)
|
| Maximum serving Sizes: |
1 Tablet(s)
|
| Servings per container | 30 |
| UPC/BARCODE | 790011200208 |
| Ingredient | Amount per Serving | Group | % DV, Adults & children 4+ years |
|---|---|---|---|
| S-Adenosyl Methionine |
400 mg
|
SAMe |
--
|
| SAMe Tosylate Disulfate |
800 mg
|
SAMe |
|
| Other Ingredients: |
Microcrystalline Cellulose
Hypromellose Acetate Succinate
Stearic Acid
Triethyl Citrate
Riboflavin
Glyceryl Behenate
Magnesium Stearate
Silicon Dioxide
Mannitol
Sodium Starch Glycolate
|
|---|
Label Statments:
| Formula |
- Naturally Derived SAMe 400
Jarrow Formulas SAMe 400 provides a full 400 mg SAMe (net yield) from 800 mg of SAMe tosylate disulfate.
With more of the Biologically Active S,S than R,S Form
Found in all living cells, SAMe is a metabolite of methionine (an essential amino acid). SAMe is a chiral molecule consisting of two forms: (S,S) SAMe and (R,S) SAMe. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive.
- SAMe supports:
Brain Metabolism and Mood
SAMe methylation reactions are involved in the synthesis of phosphatidylcholine, a substantial constituent of grey matter within the brain and cellular membranes. It has also been proposed to be involved in the formation or metabolism of neurotransmitters, which helps to support a balanced mood.
Joint Health
SAMe supports the production of healthy connective tissue through transsulfuration. In this transsulfuration process, critical components of connective tissue known as glycosaminoglycans (GAGs), including glucosamine and chondroitin, are sulfated by SAMe metabolites to yield sulfated GAGs, such as glucosamine sulfate and chondroitin sulfate, the building blocks of cartilage.
Liver Function
SAMe supports the synthesis of glutathione (GSH), which is critical for antioxidant defenses and liver functions including phase II detoxification.
- Jarrow Formulas SAMe 400 is foil blister-packed to maximize stability and provides 400 mg S-Adenosyl Methionine derived from 800 mg of SAMe Tosylate Disulfate.
- S-Adenosyl methionine active S,S form
400 mg (net yield) SAMe from 800 mg SAMe tosylate disulfate
- EnteroGuard Coating
- EnteroGuard is a proprietary cellulose-based, food-grade, pH-sensitive enteric coating that resists stomach acid and disintegrates in the less acidic pH of the upper intestines, where the SAMe is made available for absorption.
|
|---|---|
| Formulation |
- SAMe 400 is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product.
- Jarrow Formulas SAMe is made naturally by microbiological fermentation and processed without chemical solvents to preserve 68-80% (S,S) SAMe.
- Vegan
- Naturally derived
Extra strength
Supports balanced mood, joint health, and liver function
Mood support
In foil blister pack
- No wheat, gluten, soybeans, dairy, egg, fish/shellfish, peanuts/tree nuts or sesame.
|
| FDA Disclaimer Statement |
- These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
|
| Suggested/Recommended/Usage/Directions |
- Suggested use: Adults take 1 tablet once a day on an empty stomach or as directed by your qualified healthcare professional.
|
| Precautions |
- Warning: Do not use if pregnant or nursing. Individuals with Parkinson's disease, bi-polar disorder, or manic depression should not use this product.
Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use.
- Consult a healthcare professional before using this product if you are under the age of 18, are taking medication (antidepressants, selective serotonin re-uptake inhibitors (SSRIs) and MAO inhibitors) or have a medical condition; if adverse reactions occur, discontinue use.
- Keep out of the reach of children.
- May cause gastrointestinal upset in some persons.
- Do not use if safety seal or blister is broken, damaged or missing.
|
| Storage |
- Store in a cool, dry place.
|
| FDA Statement of Identity |
- Dietary Supplement
|
| Brand IP Statement(s) |
- Copyright 2023 Jarrow Formulas
|
| General Statements |
- Mood support
|
Brand Information
See all products by this brand
| Distributed by | |
|---|---|
| Name | Jarrow Formulas, Inc. |
| City | Sherman Oaks |
| State | CA |
| Country | USA |
| ZipCode | 91403 |
| Phone Number | 1-866-459-4154 |
| Web Address | www.Jarrow.com |
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Parts of this content are provided by the Therapeutic Research Center, LLC and the Dietary Supplement Label Database.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Drug descriptions are provided by MedlinePlus.