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Dietary supplement

Sambucus Drops Ultra Strength Ingredients & Drug Interactions

by Nature's Way

Sambucus Drops Ultra Strength label
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Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Sambucus Drops Ultra Strength against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Sambucus Drops Ultra Strength is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for colds, flu (influenza), other respiratory infections.Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Elder (Sambucus nigra L.) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Sambucus Drops Ultra Strength by Nature's Way

Ask about any prescription or over-the-counter medication and we check it for interactions with Sambucus Drops Ultra Strength by Nature's Way — and tell you which ingredient is responsible.

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Computed from our clinical databases

HelloPharmacist Scorecard of Sambucus Drops Ultra Strength by Nature's Way

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

None of the active ingredients could be matched to our evidence database, so intended use can't be graded.

Why this rating?
  • None of the active ingredients could be matched to a HelloPharmacist monograph, so intended use can't be graded against our evidence data.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • “Black Elder (Sambucus nigra L.) extract” is listed as a grouped ingredient — the label gives one combined amount (50 mg) without saying how much of each component you get.
Known Interaction Concern
Not assessable

None of the active ingredients could be matched to our interaction database.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was nothing to check interactions against.
Safety Information
Unable to assess

None of the active ingredients could be matched to our safety data.

Why this rating?
  • We couldn't match any ingredient to a HelloPharmacist monograph, so there was no safety data to measure.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Medication interactions could not be assessed, and safety information could not be assessed.

Assessment coverage: 0 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sambucus Drops Ultra Strength, straight from the product label.

Brand Nature's Way
Barcode (UPC) 033674104934
Net contents 1 fl. Oz.; 30 mL
Market status Off market
Date entered into DSLD Jan 22, 2021
DSLD ID 242448
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sambucus Drops Ultra Strength by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.5 mL, 1 mL
Maximum serving Sizes:
0.5 mL, 1 mL
Servings per container
30
UPC/BARCODE
033674104934
IngredientAmount% DV
Total Carbohydrates0 NP, 1 Gram(s)--
Black Elder (Sambucus nigra L.) extract50 mg, 100 mg--
premium cultivar Elderberries3.2 Gram(s), 0 NP--

Other ingredients: Glycerin, purified Water, Sorbitol, Citric Acid, Natural flavor, Ethyl Alcohol

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommendation: Shake well before each use. Add to water or take directly. For daily maintenance: Adults: take 25 drops (1 mL) daily. Children 7 years of age and older: Take 13 drops (0.5 mL) daily. For intensive use: Adults: take 25 drops (1 mL) four times daily. Children 7 years of age and older: take 13 drops (0.5 mL) three times daily.

Precautions

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with outer shrink seal around cap. Do not use if seal is broken or missing.

Storage

Keep bottle tightly closed. Store at room temperature. Avoid excessive heat and direct sunlight.

General Statements

Compare to Nature's Way Sambucus syrup formulas.

Nature's Way Since 1969

Seals/Symbols

Vegan

Quality global sourcing bottled & tested in the USA

Formulation

Vegan

Our standardized elderberry extract is: Gluten free

Vegan

Contains no: Gluten, dairy, peanuts, or artificial colors

Brand IP Statement(s)

Copyright 2021 Nature's Way Brands, LLC

Formula

Standardized Elderberry

About Black Elderberry For centuries the dark berries of European black elder (Sambucus nigra L.) have been traditionally used as a winter remedy for immune support Ultra strength 10x more elderberry extract per mL than Nature's Way Sambucus syrup formulas. Premium quality elderberries Made with our unique black elderberry extract, ensuring flavonoid bioactives content, which has been tested for identity and potency. Our elderberries are handled & extracted to ensure maximum flavonoid potency.

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

This statement has not been evaluated by the food & Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Sambucus Drops Ultra Strength by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Sambucus Drops Ultra Strength label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Sambucus Drops Ultra Strength by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.5 mL Dosage formLiquid Servings per container30 Amounts shown are per serving.

Black Elder (Sambucus nigra L.) extract

Interacts with
121 drugs
50 mg per serving Form: BioActives

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Black Elder (Sambucus nigra L.) extract monograph & interactions
  • › Premium cultivar Elderberries

Other (inactive) ingredients: Glycerin, Purified Water, Sorbitol, Citric Acid, Natural flavor, Ethyl Alcohol. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sambucus Drops Ultra Strength by Nature's Way Drug Interactions

Sambucus Drops Ultra Strength contains a single active ingredient, and it has known interactions with 121 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Sambucus Drops Ultra Strength?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Black Elder (Sambucus nigra L.) extract 121

Individual Drug Interactions

The ingredients in Sambucus Drops Ultra Strength interact with 121 drugs. Click any drug to see the details.

1 of the 1 ingredient in Sambucus Drops Ultra Strength interact with drugs. Each result below shows which ingredient is responsible. Black Elder (Sambucus nigra L.) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Sambucus Drops Ultra Strength with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Elder (Sambucus nigra L.) extract2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
Black Elder (Sambucus nigra L.) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Sambucus Drops Ultra Strength, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Sambucus Drops Ultra Strength by Nature's Way: Common Questions

Does Sambucus Drops Ultra Strength by Nature's Way interact with any medications?
Yes. Based on its ingredients, Sambucus Drops Ultra Strength has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sambucus Drops Ultra Strength contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sambucus Drops Ultra Strength is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sambucus Drops Ultra Strength label
Go deeper

The Full Monographs Behind Sambucus Drops Ultra Strength’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Elderberry

Interacts with 121 drugs

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu symptoms, but the evidence is limited and n...

Read the full Elderberry monograph →
Sources

Sources & How We Checked

Sambucus Drops Ultra Strength's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Elderberry 6 references
  1. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
  2. Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
  3. European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
  4. Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
  5. Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
  6. Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed

See these in context on the Elderberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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