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Dietary supplement

Sambucus (Nigra) Black Elder Berry Extract Ingredients & Drug Interactions

by Nature's Answer

Liquid Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Sambucus (Nigra) Black Elder Berry Extract is a dietary supplement by Nature's Answer with 1 active ingredient. Its ingredients are commonly taken for colds, flu (influenza), other respiratory infections.Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Elder Berry Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Computed from our clinical databases

HelloPharmacist Scorecard of Sambucus (Nigra) Black Elder Berry Extract by Nature's Answer

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.
Known Interaction Concern
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Elderberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sambucus (Nigra) Black Elder Berry Extract, straight from the product label.

Brand Nature's Answer
Net contents 8 fl. Oz.; 240 mL
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 1683
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sambucus (Nigra) Black Elder Berry Extract by Nature's Answer, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Teaspoon(s)
Maximum serving Sizes:
1 Teaspoon(s)
Servings per container
48
IngredientAmount% DV
Black Elder Berry Extract5000 mg--

Other ingredients: Vegetable Glycerin, USP purified Water, Citric Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BIO-CHELATED(R) COLD EXTRACTION PROCESS

HOLISTICALLY BALANCED

IDEAL WINTER SUPPORT ABOUT NATURE'S ANSWER(R) Nature's Answer(R) - Since 1972, a family-owned and operated company, is a leading manufacturer of the finest quality herbal extracts and bio-available formulas to support vital, healthy living. Well-recognized as an innovator, Nature's Answer(R) has pioneered numerous advancements in the natural health care industry. We were the first company to both develop a line of alcohol-free liquid herbal extracts, and introduce a full family of extracts to the natural health food retailer over 30 years ago! Nature's Answer(R)'s formulas are based on the most current scientific research. By utilizing state-of-the-art R&D and Manufacturing facilities along with a team of Ph.D's and Natural Product Chemists, we can offer you the best natual products for complete nutrititonal support. ©2007 Nature's Answer(R)

NATURE'S ANSWER(R) alcohol-free extracts are produced using alcohol, water and natural extractants. All alcohol and extractants are then removed through our cold Bio-Chelated(R) proprietary extraction process, yielding a Holistically Balanced(R) standardized extract. Holistically Balanced(R) guarantees that the constituents of the extract are in the same synergistic ratios as in the plant. Manufactured in our FDA registered, pharmaceutically licensed, Certified Kosher facility; cGMP Compliant.

FDA Disclaimer Statement

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Formula

K PARVE

Formulation

NO ARTIFICIAL SWEETENERS

Precautions

WARNING: KEEP OUT OF REACH OF CHILDREN. DO NOT USE IF PREGNANT OR NURSING. DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING.

General Statements

All Natural

IDEAL WINTER SUPPORT ABOUT SAMBUCUS (nigro) Sambucus nigra L is the latin name for Black Elder. The dark blue/black berries of this plant have many naturally-occuring nutritional substances such as Rutin, Quercetin (flavonoids) and Anthocyanins. Current research supports the long held beliefs about Elderberry's health benefits on the body. Elderberry syrup has been traditionally used to help support the immune system, especially during the winter season or when experiencing extra stress.* An added advantage to the use of Elderberry is its record of safety for all ages. When deciding on an Elderberry liquid, remember to check the kind of sweetener it contains. Many brands add sugar or sorbitol, while Nature's Answer's(R) Sambucus nigra L. contains only pure extract and vegetable glycerin.

LABORATORY TESTED ALCOHOL-FREE PRESERVATIVE-FREE GREAT-TASTING

Product of the U.S.A

Since 1972

SUPER CONCENTRATED

UNCONDITIONALLY GUARANTEED

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement take one (1) teaspoon 4 times a day in a small amount of water. Shake well before use.

See for yourself

Sambucus (Nigra) Black Elder Berry Extract by Nature's Answer label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Sambucus (Nigra) Black Elder Berry Extract by Nature's Answer

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Teaspoon(s) Dosage formLiquid Servings per container48 Amounts shown are per serving.

Black Elder Berry Extract

Interacts with
121 drugs
5000 mg per serving

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Black Elder Berry Extract monograph & interactions

Other (inactive) ingredients: Vegetable Glycerin, USP purified Water, Citric Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sambucus (Nigra) Black Elder Berry Extract by Nature's Answer Drug Interactions

Sambucus (Nigra) Black Elder Berry Extract contains a single active ingredient, and it has known interactions with 121 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against Sambucus (Nigra) Black Elder Berry Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Sambucus (Nigra) Black Elder Berry Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Elder Berry Extract2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Sambucus (Nigra) Black Elder Berry Extract, from the product label.

Nature's Answer

See all Nature's Answer products
Name
NATURE'S ANSWER(R)
City
Hauppauge
State
NY
ZipCode
11788-3943
Pharmacist Counseling Corner

Sambucus (Nigra) Black Elder Berry Extract by Nature's Answer: Common Questions

Does Sambucus (Nigra) Black Elder Berry Extract by Nature's Answer interact with any medications?
Yes. Based on its ingredients, Sambucus (Nigra) Black Elder Berry Extract has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sambucus (Nigra) Black Elder Berry Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sambucus (Nigra) Black Elder Berry Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sambucus (Nigra) Black Elder Berry Extract label
Go deeper

The Full Monographs Behind Sambucus (Nigra) Black Elder Berry Extract’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Sambucus (Nigra) Black Elder Berry Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Elderberry 6 references
  1. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
  2. Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
  3. European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
  4. Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
  5. Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
  6. Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed

See these in context on the Elderberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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