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Dietary supplement

Sambucus Traditional Elderberry Immune Syrup Zero Sugar Ingredients & Drug Interactions

by Nature's Way

Liquid Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Sambucus Traditional Elderberry Immune Syrup Zero Sugar is a dietary supplement by Nature's Way with 1 active ingredient. Its ingredients are commonly taken for colds, flu (influenza), other respiratory infections.Based on those ingredients, 121 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Black Elderberry Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Sambucus Traditional Elderberry Immune Syrup Zero Sugar by Nature's Way

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product has one active ingredient: black elderberry extract. The extract is made from ripe elderberries and is designed to support immune function.

The remaining ingredients are inactive — sorbitol and glycerin for sweetness and texture, water, natural flavors, citric acid for taste, and potassium sorbate to preserve it.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Immune support and respiratory health.
  • We looked for evidence on: Upper respiratory tract infection (URTI), Lower respiratory tract infections, Respiratory tract infections, Rhinosinusitis, Colds, Flu — and 1 related terms.
  • The closest evidence on file: Elderberry is rated "Insufficient Reliable Evidence To Rate" for Respiratory tract infections (Natural Medicines).
  • Also on file: Elderberry is rated "Insufficient Reliable Evidence To Rate" for Rhinosinusitis, Upper respiratory tract infection (URTI), Lower respiratory tract infections.

The evidence we hold doesn't establish that elderberry works reliably for any condition listed in our data — that includes hay fever, heart health, fatigue, lung disease, brain function, or colds and respiratory infections. Each of these carries a rating of insufficient reliable evidence.

That doesn't mean it doesn't work; it means the studies we have aren't robust enough to say so.

The evidence, ingredient by ingredient Elderberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Properly prepared elderberry extracts from ripe fruit are generally well tolerated, and this product is cooked (which removes any natural toxins). The main risk is from raw or unripe berries, seeds, leaves, or bark — which this product doesn't contain.

We don't have enough safety data to recommend elderberry during pregnancy or while breastfeeding, so talk with your pharmacist or doctor before using it in those situations. A rare case report links elderberry to autoimmune hepatitis (liver inflammation) in someone with an underlying autoimmune disease, so if you have that kind of condition, flag this product with your doctor first.

Side effects, ingredient by ingredient Elderberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Elderberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: immunosuppressants / transplant drugs.
  • For scale: 121 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your exact medications before using this product if you take immunosuppressants (such as those after transplant or for autoimmune disease) or pazopanib (Votrient), a cancer medication — both carry Moderate-severity interaction concerns. Use the medication search tool on this page to verify your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're looking for immune support and don't take immunosuppressants or pazopanib, this product is tolerated well by most people. Anyone on medications that dampen the immune system, or the cancer drug pazopanib, should check with their pharmacist or doctor before starting.

Pregnant or breastfeeding? Talk to your pharmacist for personalized advice on whether to use it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Mar 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Sambucus Traditional Elderberry Immune Syrup Zero Sugar, straight from the product label.

Brand Nature's Way
Net contents 8 Fluid Ounce(s); 240 Milliliter(s)
Market status On market
Date entered into DSLD Mar 25, 2025
DSLD ID 328052
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other
Intended target group(s) Children 4 or More Years of Age, Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Sambucus Traditional Elderberry Immune Syrup Zero Sugar by Nature's Way, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 mL, 10 mL
Maximum serving Sizes:
5 mL, 10 mL
Servings per container
24
IngredientAmount% DV
Calories10 Calorie(s), 25 Calorie(s)--
Total Carbohydrates4 Gram(s), 8 Gram(s)1%, 3%
Added Sugars0 Gram(s), 0 Gram(s)--
Total Sugars0 Gram(s), 0 Gram(s)--
Sugar Alcohol4 Gram(s), 8 Gram(s)--
Black Elderberry Extract50 mg, 100 mg--

Other ingredients: Sorbitol, Water, Purified, Glycerin, Natural Flavors, Citric Acid, Potassium Sorbate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Recommendation: Dosage cup included. Shake well before each use. For daily maintenance: Adults: Take 2 teaspoons (tsp) (10 mL) daily. Children 7 years of age and older: Take 1 teaspoon (5 mL) daily. For intensive use: Adults: Take 2 teaspoons (10 mL) four times daily. Children 7 years of age and older: Take 1 teaspoon (5 mL) three times daily.

Precautions

If you are pregnant, nursing, or taking any medications, consult a healthcare professional before use.

Keep out of reach of children.

Safety sealed with inner seal. Do not use if seal is broken or missing.

Not a low calorie food

Storage

Store at room temperature. Avoid excessive heat and direct sunlight.

Formulation

Gluten free. No peanut, dairy, or artificial colors.

Bottled and tested in the USA

Vegan V Gelatin Free

Vegan V Gelatin Free

Brand IP Statement(s)

Copyright 2024 Nature's Way Brands LLC

General Statements

Questions? 1-800-962-8873 / naturesway.com

Servings per container 48, 24

Seals/Symbols

Vegan V Gelatin Free

Formula

Highly concentrated elderberry extract

FDA Statement of Identity

Dietary Supplement

See for yourself

Sambucus Traditional Elderberry Immune Syrup Zero Sugar by Nature's Way label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Sambucus Traditional Elderberry Immune Syrup Zero Sugar by Nature's Way

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 mL Dosage formLiquid Servings per container24 Amounts shown are per serving.

Black Elderberry Extract

Interacts with
121 drugs
50 mg per serving Form: Sambucus nigra Berry Extract

Elderberry is a popular herbal supplement, mainly taken to help with colds and flu. Some small studies suggest it may modestly shorten cold or flu sym...

Black Elderberry Extract monograph & interactions

Other (inactive) ingredients: Sorbitol, Water, Purified, Glycerin, Natural Flavors, Citric Acid, Potassium Sorbate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Sambucus Traditional Elderberry Immune Syrup Zero Sugar by Nature's Way Drug Interactions

Want to check YOUR meds against Sambucus Traditional Elderberry Immune Syrup Zero Sugar?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
121Drugs
121 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Sambucus Traditional Elderberry Immune Syrup Zero Sugar with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Black Elderberry Extract2 drug types · 121 drugs

Immunosuppressants

Theoretically, elderberry might interfere with immunosuppressant therapy due to its immunostimulant activity.
Elderberry has immunostimulant activity, increasing the production of cytokines, including interleukin and tumor necrosis factor.

Likelihood Possible Evidence B
Pazopanib (Votrient)

Theoretically, elderberry might interact with pazopanib, potentially increasing the risk of adverse effects.
In one case, a 65-year-old patient taking pazopanib for 4 weeks for soft-tissue sarcoma developed severe nausea, loose stools, and elevated alanine transaminase and aspartate transaminase levels and was diagnosed with grade 3 liver injury. The patient reported taking elderberry supplements for 2 years, dose unspecified, and was also taking a multivitamin and a calcium supplement. The patient's symptoms and liver enzyme levels improved upon discontinuation of pazopanib and all supplements. Pazopanib treatment was re-initiated, at a lower dose, with no further evidence of liver injury. It was unclear in this case report if the elderberry supplements were derived from the berry, the flower, or the combination.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Sambucus Traditional Elderberry Immune Syrup Zero Sugar, from the product label.

Nature's Way

See all Nature's Way products
Name
Nature's Way Brands, LLC
City
Green Bay
State
WI
ZipCode
54311
Phone Number
1-800-962-8873
Web Address
naturesway.com
Pharmacist Counseling Corner

Sambucus Traditional Elderberry Immune Syrup Zero Sugar by Nature's Way: Common Questions

Does Sambucus Traditional Elderberry Immune Syrup Zero Sugar by Nature's Way interact with any medications?
Yes. Based on its ingredients, Sambucus Traditional Elderberry Immune Syrup Zero Sugar has a known interaction with 121 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Sambucus Traditional Elderberry Immune Syrup Zero Sugar contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant?
There isn't enough reliable safety information to say either way. Talk with your pharmacist or doctor before using it during pregnancy — they can weigh the pros and cons for your situation.
Can I take it while breastfeeding?
The safety data isn't there to say it's okay while breastfeeding. Check with your pharmacist or doctor first for advice tailored to your circumstances.
Does elderberry actually work for colds?
The evidence we hold isn't strong enough to confirm it. The research isn't conclusive, so we can't say whether it helps prevent or shorten respiratory infections.
What does 'zero sugar' mean here?
The product uses sorbitol and glycerin instead of sugar for sweetness. It's designed for people who need to avoid sugar — though sorbitol can loosen stools in some people if taken in large amounts.
Are there any side effects from properly made elderberry?
Properly cooked elderberry extract is generally well tolerated with minimal side effects. The risks come from raw or unripe berries, seeds, and leaves, which this product doesn't contain.
Does this product have fillers?
Yes — it has inactive ingredients including sorbitol, glycerin, water, natural flavors, citric acid, and potassium sorbate that help with sweetness, taste, and shelf life.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Sambucus Traditional Elderberry Immune Syrup Zero Sugar is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Sambucus Traditional Elderberry Immune Syrup Zero Sugar label
Go deeper

The Full Monographs Behind Sambucus Traditional Elderberry Immune Syrup Zero Sugar’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

Sambucus Traditional Elderberry Immune Syrup Zero Sugar's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Elderberry 6 references
  1. Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw 2001;12:290-6..
  2. Elderberry (Sambucus species). The Poison Plant Patch, Novia Scotia Museum, 2007. Available at: http://museum.gov.ns.ca/poison/?section=species&id=117 (Accessed 16 October 2009).
  3. European elder. Canadian Poisonous Plants Information System. Available at: http://www.cbif.gc.ca/pls/pp/ppack.jump?p_null=all&p_psn=121&p_type=all&p_sci=comm&p_x=px (Accessed 16 October 2009).
  4. Raus K, Pleschka S, Klein P, Schoop R, Fisher P. Effect of an echinacea-based hot drink versus oseltamivir in Influenza treatment: a randomized, double-blind, double-dummy, multicenter, noninferiority clinical trial. . Curr Ther Res Clin Exp. 2015;20;77:6 PubMed
  5. Ramachandran A, Antala D, Pudasainee P, Panginikkod S, Gupta H. A Plausible Association Between the Use of Elderberry and Autoimmune Hepatitis. Cureus 2022;14(4):e24250. PubMed
  6. Agarwal N, Mangla A. Elderberry interaction with pazopanib in a patient with soft-tissue sarcoma: A case report and literature review. Mol Clin Oncol 2024;20(5):36. PubMed

See these in context on the Elderberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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