Sassafras Ingredients & Drug Interactions
by Hawaii Pharm
What is this page for?
First and foremost: checking Sassafras against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sassafras is a dietary supplement by Hawaii Pharm with 1 active ingredient. Its ingredients are commonly taken for digestive complaints, cold and flu symptoms, joint and muscle aches.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sassafras Root Bark Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sassafras by Hawaii Pharm
Ask about any prescription or over-the-counter medication and we check it for interactions with Sassafras by Hawaii Pharm — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sassafras by Hawaii Pharm
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: Sassafras Root Bark Extract in a dried, concentrated form. The liquid base contains alcohol, water, and glycerin as inactive ingredients.
Does it work?
Couldn't assess
We have no effectiveness data on file for sassafras. The supplement's role or proven benefits are not established in our records.
How safe is it?
Well-documented data
Sassafras is not considered safe for medicinal use. It contains safrole, a compound the FDA has banned from food because it is linked to cancer and liver toxicity.
Oral use can cause sweating, hot flashes, hallucinations (especially at high doses), tremors, vomiting, rapid heartbeat, and liver damage. At high doses, safrole has caused death.
Topical application can trigger contact dermatitis. The safety data advises against use during pregnancy and breastfeeding because safrole is toxic and may harm a developing baby or nursing infant.
Meds to double-check
Moderate interaction found
Before taking this product, check your medications for two classes: CNS depressants (sedating drugs) — which may add to drowsiness — and CYP1A2 inducers like omeprazole, which may theoretically increase toxicity in ways not yet seen in humans. Talk with your doctor or pharmacist to be sure.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product carries serious toxicity concerns unrelated to any benefit we have data for. The FDA has banned its active compound from food specifically because of cancer and liver-damage risk.
If you're considering it, talk with your doctor or pharmacist first — especially if you take any medications, particularly sedating drugs or heartburn treatments like omeprazole.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sassafras, straight from the product label.
| Brand | Hawaii Pharm |
|---|---|
| Barcode (UPC) | 840253646453 |
| Net contents | 4 Fluid Ounce(s); 120 mL |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2023 |
| DSLD ID | 301849 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Organic, Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sassafras by Hawaii Pharm, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Sassafras Root Bark Extract, Dry | 983 mg | -- |
Other ingredients: Alcohol, Water, Glycerin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)
Hawaii Pharm Herbal Extract Highest quality since 2008
Suggested/Recommended/Usage/Directions
Suggested use: Shake well before using. For adults add about 20-30 drops (0.7-1 mL, one full squeeze of the dropper bulb) to some juice or water, up to 4 times a day.
Precautions
Warning: We recommend to seek expert medical advice before taking.
Do not use if you are allergic to any ingredients.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
Consult your physician before giving to children under 18, during pregnancy, if nursing or taking medications.
May affect the ability to drive and operate machinery. May have contraindications, can cause side effects and adverse reactions. Do not use if seal is broken or missing.
Keep out of the reach of children!
Storage
Store in a cool dry place.
Seals/Symbols
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Organic Alcohol Based USA Made in United States of America
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Scan this QR-code to get 15% discount on your next purchase. Limited time deal.
Formula
Sassafras albidum
Organic Alcohol Based
Formulation
Only natural ingredients Purity is laboratory tested and verified
All the raw materials are gluten-free by their nature No artificial colors, flavors, or preservatives
Not tested on animals
Organic Alcohol Based
Made in USA, Hawaii
FDA Statement of Identity
Herbal Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sassafras by Hawaii Pharm label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sassafras by Hawaii Pharm
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.7 mL Dosage formLiquid Servings per container120 Amounts shown are per serving.
Sassafras Root Bark Extract, Dry
Interacts with275 drugs
Sassafras is an aromatic North American tree whose root bark and oil were once popular in teas and as a flavoring, but it contains safrole, a compound...
Sassafras Root Bark Extract, Dry monograph & interactionsOther (inactive) ingredients: Alcohol, Water, Glycerin. These complete the product’s ingredient list but are not active constituents.
Sassafras by Hawaii Pharm Drug Interactions
HelloPharmacist Interaction Report
Hawaii Pharm's Sassafras Root Bark Extract has documented interactions with sedating medications and a class of drugs that may affect how your body processes the supplement's active compound.
The most serious concern is a theoretical one: sassafras may add to the sedative effects of CNS depressants (drugs that slow your brain and nervous system), which could cause excessive drowsiness or impaired alertness.
Read the full breakdown — every affected drug type, severity by severity
Additionally, sassafras contains safrole, a compound your liver processes through a specific enzyme pathway. Research in the lab suggests that CYP1A2 inducers — drugs that speed up this pathway, like omeprazole (Prilosec) for heartburn — might theoretically increase how toxic safrole becomes in your body, though this has not yet been reported in humans.
It's also unclear whether this enzyme effect actually raises sassafras toxicity in real life.
Alongside these drug interactions, this product carries serious safety red flags unrelated to medications: sassafras is banned in food by the FDA because safrole is linked to cancer and liver damage. Before you take this product with any prescription or over-the-counter medication, run your exact medications through the search tool on this page.
If you take any drugs, talk it over with your doctor or pharmacist first.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sassafras?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sassafras interact with 275 drugs. Click any drug to see the details.
1 of the 1 ingredient in Sassafras interact with drugs. Each result below shows which ingredient is responsible. Sassafras Root Bark Extract, Dry
Aminophylline, Amobarbital, EphedrineAmesec
How Aminophylline, Amobarbital, Ephedrine interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aminophylline, Amobarbital, Ephedrine interactionAmitriptylineElavil
How Amitriptyline interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Amitriptyline interactionAmitriptyline, ChlordiazepoxideLimbitrol DS
How Amitriptyline, Chlordiazepoxide interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Amitriptyline, Chlordiazepoxide interactionAmitriptyline, PerphenazineEtrafon, Etrafon-A, Etrafon-Forte, Triavil
How Amitriptyline, Perphenazine interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Amitriptyline, Perphenazine interactionAmobarbitalAmytal
How Amobarbital interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Amobarbital interactionAmobarbital, Ephedrine SulfateEphedrine & Amytal
How Amobarbital, Ephedrine Sulfate interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Amobarbital, Ephedrine Sulfate interactionAmobarbital, SecobarbitalTuinal
How Amobarbital, Secobarbital interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Amobarbital, Secobarbital interactionAmoxicillin, Omeprazole Magnesium, RifabutinTalicia
How Amoxicillin, Omeprazole Magnesium, Rifabutin interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCytochrome P450 1a2 (cyp1a2) Inducers Moderate
Interaction Summary
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.
Read the full Sassafras Root Bark Extract, Dry + Amoxicillin, Omeprazole Magnesium, Rifabutin interactionAprobarbital, Butabarbital, PhenobarbitalTriple Barbital
How Aprobarbital, Butabarbital, Phenobarbital interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCytochrome P450 1a2 (cyp1a2) Inducers, Cns Depressants Moderate
Interaction Summary
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.
Read the full Sassafras Root Bark Extract, Dry + Aprobarbital, Butabarbital, Phenobarbital interactionAripiprazoleAbilify, Abilify Maintena, Abilify Mycite
How Aripiprazole interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aripiprazole interactionAripiprazole LauroxilAristada, Aristada Initio Kit
How Aripiprazole Lauroxil interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aripiprazole Lauroxil interactionAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
How Aspirin, Butalbital, Caffeine, Codeine Phosphate interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
How Aspirin, Caffeine, Codeine Phosphate interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
How Aspirin, Caffeine, Dihydrocodeine Bitartrate interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, HydrocodoneDamason-P
How Aspirin, Caffeine, Hydrocodone interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
How Aspirin, Caffeine, Phenacetin, Propoxyphene interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
How Aspirin, Carisoprodol, Codeine Phosphate interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
How Aspirin, Codeine Phosphate interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
How Aspirin, Codeine Phosphate, Methocarbamol interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
How Aspirin, Codeine Phosphate, Phenobarbital interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCytochrome P450 1a2 (cyp1a2) Inducers, Cns Depressants Moderate
Interaction Summary
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
How Aspirin, Diphenhydramine, Phenylpropanolamine interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, Ethoheptazine, MeprobamateEquagesic
How Aspirin, Ethoheptazine, Meprobamate interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
How Aspirin, Hydrocodone interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Hydrocodone interactionAspirin, OmeprazoleYosprala
How Aspirin, Omeprazole interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCytochrome P450 1a2 (cyp1a2) Inducers Moderate
Interaction Summary
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Omeprazole interactionAspirin, OxycodonePercodan
How Aspirin, Oxycodone interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
How Aspirin, Pentazocine interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Aspirin, Pentazocine interactionAtropine, Hyoscyamine, PhenobarbitalHypnaldyne
How Atropine, Hyoscyamine, Phenobarbital interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants, Cytochrome P450 1a2 (cyp1a2) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Atropine, Hyoscyamine, Phenobarbital interactionAtropine, Hyoscyamine, Phenobarbital, ScopolamineBarbidonna No. 2, Belladonna Phenobarbital
How Atropine, Hyoscyamine, Phenobarbital, Scopolamine interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCytochrome P450 1a2 (cyp1a2) Inducers, Cns Depressants Moderate
Interaction Summary
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.
Read the full Sassafras Root Bark Extract, Dry + Atropine, Hyoscyamine, Phenobarbital, Scopolamine interactionAtropine, Hyoscyamine, Scopolamine, PhenobarbitalBarbeloid, Donnatal #2, Donphen
How Atropine, Hyoscyamine, Scopolamine, Phenobarbital interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants, Cytochrome P450 1a2 (cyp1a2) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Atropine, Hyoscyamine, Scopolamine, Phenobarbital interactionAtropine, PhenobarbitalAnthrocol
How Atropine, Phenobarbital interacts with Sassafras — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Root Bark Extract, DryCns Depressants, Cytochrome P450 1a2 (cyp1a2) Inducers Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Root Bark Extract, Dry + Atropine, Phenobarbital interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sassafras with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Sassafras Root Bark Extract, Dry
Cns Depressants
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Cytochrome P450 1A2 (Cyp1A2) Inducers
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole. So far, this interaction has not been reported in humans. Also, it is not known if CYP1A2 inducers increase the toxicity of sassafras. Inducers of CYP1A2 include omeprazole (Prilosec).
Brand information
Manufacturer and brand details for Sassafras, from the product label.
Hawaii Pharm
See all Hawaii Pharm products- Name
- Hawaii Pharm LLC
- Street Address
- 510 Sumner St. Ste. 613
- City
- Honolulu
- State
- HI
- ZipCode
- 96817
- Phone Number
- 888-854-2924
- Web Address
- www.hawaiipharm.com
Sassafras by Hawaii Pharm: Common Questions
Does Sassafras by Hawaii Pharm interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the most common side effects?
Why did the FDA ban sassafras?
What does sassafras do?
Will this interact with my heartburn medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Sassafras is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sassafras’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Sassafras's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 9 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sassafras 9 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Ueng, Y. F., Hsieh, C. H., Don, M. J., Chi, C. W., and Ho, L. K. Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation. Chem Res Toxicol 2004;17(8):1151-1156. PubMed
- Kapadia, G. J., Chung, E. B., Ghosh, B., Shukla, Y. N., Basak, S. P., Morton, J. F., and Pradhan, S. N. Carcinogenicity of some folk medicinal herbs in rats. J Natl.Cancer Inst. 1978;60(3):683-686.
- Segelman, A. B., Segelman, F. P., Karliner, J., and Sofia, R. D. Sassafras and herb tea. Potential health hazards. JAMA 8-2-1976;236(5):477. DOI
- Hu L, Wu F, He J, Zhong L, Song Y, Shao H. Cytotoxicity of safrole in HepaRG cells: studies on the role of CYP1A2-mediated ortho-quinone metabolic activation. Xenobiotica. 2019;49(12):1504-1515. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC