Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Secretagogue-One Lemon Ice Ingredients & Drug Interactions

by MHP Maximum Human Performance

Secretagogue-One Lemon Ice label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Secretagogue-One Lemon Ice against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Secretagogue-One Lemon Ice is a dietary supplement by MHP Maximum Human Performance with 6 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 2,100 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Sodium, Potassium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Secretagogue-One Lemon Ice by MHP Maximum Human Performance

Ask about any prescription or over-the-counter medication and we check it for interactions with Secretagogue-One Lemon Ice by MHP Maximum Human Performance — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Secretagogue-One Lemon Ice by MHP Maximum Human Performance

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 14 active ingredients.
  • “Secretagogue-One:” is listed as a grouped ingredient — the label gives one combined amount (10,935 mg) without saying how much of each component you get.
  • “Proprietary Amino Acid Blend and Secretagogue Factors” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Polymer Carrier Matrix” is a proprietary blend — the label doesn't break down how much of each component you get.

Secretagogue-One Lemon Ice is a powder blend of 13 ingredients, of which several are amino acids and other compounds that work on growth hormone release and metabolic support. The active amino acids include L-glutamine (involved in muscle and immune health), L-arginine (supports blood flow and nitric oxide), L-tyrosine (a precursor to thyroid and stress hormones), glycine (a neurotransmitter and structural amino acid), L-lysine (known for immune and collagen roles), and GABA (a calming brain chemical).

The product also contains sodium and potassium for electrolyte balance, and proprietary blends labeled as Secretagogue-One factors (designed to stimulate growth hormone), anterior pituitary substrates, and a broad bean component. Inactive ingredients include citric acid, potassium bicarbonate, natural flavor, sodium bicarbonate, acesulfame potassium, silica, and beta-carotene.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: improve physical performance and speed recovery.
  • We looked for evidence on: Physical performance, Athletic performance, Exercise-induced muscle damage, Muscle strength, Critical illness (trauma), endurance — and 3 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma) (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.

The evidence for most ingredients in this product is limited or mixed. L-glutamine is rated Effective for sickle cell disease and Possibly Effective for recovery after surgery, HIV-related wasting, and critical illness — but the dose and form matter.

L-tyrosine is Effective for phenylketonuria (PKU) and Possibly Effective for cognitive function and memory, though it is rated Possibly Ineffective for athletic performance. L-lysine is Possibly Effective for cold sores.

Glycine is Possibly Effective for schizophrenia, but most other uses carry Insufficient Reliable Evidence. GABA, sodium, potassium, and L-arginine all lack established effectiveness ratings in our data for the claimed uses in a growth-hormone-releasing supplement.

The product's proprietary blends and specialized ingredients (anterior pituitary substrates, Secretagogue-One factors, broad bean, and the glycoamino-acid-glucose complex) have no effectiveness data on file.

The evidence, ingredient by ingredient Sodium Potassium Black Psyllium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 9 of the 9 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 9 of 9.
  • General safety write-ups exist for 9 of 9.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-Glutamine is Likely Safe in pregnancy and lactation and generally well tolerated orally, though common side effects include belching, bloating, constipation, nausea, vomiting, and diarrhea — especially at high doses (10–30 grams daily). People with kidney or liver disease should take it only under medical supervision.

Sodium is Likely Safe at normal dietary levels but Possibly Unsafe in pregnancy at high supplemental doses; excess sodium is linked to high blood pressure and heart strain. Potassium is Likely Safe in pregnancy and lactation at dietary levels, but supplements can dangerously raise blood potassium, especially in people with kidney disease; common side effects include abdominal pain, nausea, diarrhea, and vomiting.

L-Arginine has Possibly Safe pregnancy data but insufficient lactation data; common side effects are abdominal pain, bloating, nausea, diarrhea, headache, and flushing. L-Tyrosine and L-Lysine lack specific pregnancy and lactation safety data; both are generally well tolerated at typical doses but may cause nausea, heartburn, and gastrointestinal upset.

Glycine and GABA also have insufficient pregnancy/lactation data; glycine can cause rare sedation and GABA may cause drowsiness, gastric upset, or muscle weakness. Long-term safety for most ingredients is not well studied.

Side effects, ingredient by ingredient Sodium Potassium Black Psyllium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 9 of the 9 matched ingredients can interact with medications — Black Psyllium, Lysine, Gamma-aminobutyric Acid (gaba), Potassium, L-arginine, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 2,101 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take any of these: blood thinners or antiplatelet drugs (Moderate), blood pressure medications including ACE inhibitors, ARBs, or antihypertensive drugs (Moderate), seizure medications (Moderate), blood sugar drugs (Moderate), potassium-sparing water pills (Moderate), lithium (Moderate), thyroid hormone (Moderate), levodopa (Moderate), sildenafil (Moderate), GABA-boosting sedative or sleep drugs (Minor), or gut-motility drugs used for constipation (Minor). No interactions are documented for the ingredients we could not check — Pyroglutamic Acid, Novel Polylose, anterior pituitary substrates, broad bean, and the glycoamino-acid-glucose complex — but the absence of documented interactions is not a guarantee none exist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient amino acid and mineral product designed to support growth hormone release and recovery. It may appeal to athletes or people interested in muscle support, but the evidence for growth hormone effects is not established in our data.

Because it contains L-arginine, sodium, and potassium — all of which interact with common blood pressure, heart, blood-sugar, and kidney medications — anyone on prescription drugs needs to check their exact medications with your own doctor or pharmacist before starting. Pregnant or breastfeeding individuals should also talk with their healthcare provider first, since safety data are incomplete for several ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 9 of 14 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 23, 2014.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Secretagogue-One Lemon Ice, straight from the product label.

Brand MHP Maximum Human Performance
Barcode (UPC) 666222031002
Net contents 30 Packet(s); 14.4 oz.; 408 Gram(s)
Market status On market
Date entered into DSLD May 23, 2014
DSLD ID 33143
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Secretagogue-One Lemon Ice by MHP Maximum Human Performance, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
13.6 Gram(s)
Maximum serving Sizes:
13.6 Gram(s)
UPC/BARCODE
666222031002
IngredientAmount% DV
Calories45 {Calories}--
Total Carbohydrates6 Gram(s)2%
L-Glutamine0 NP--
Sugar4 Gram(s)--
Sodium55 mg2%
Potassium200 mg6%
Glycine0 NP--
L-Tyrosine0 NP--
GABA0 NP--
Dietary Fiber0 Gram(s)--
Pyroglutamic Acid0 NP--
L-Arginine0 NP--
L-Lysine0 NP--
Secretagogue-One:10935 mg--
Novel Polylose0 NP--
Proprietary Amino Acid Blend and Secretagogue Factors0 NP--
Anterior pituitary substrates0 NP--
Broad bean0 NP--
Polymer Carrier Matrix0 NP--
Glycoamino-acid-glucose complex0 NP--

Other ingredients: Citric Acid, Potassium Bicarbonate, Natural flavor, Sodium Bicarbonate, Acesulfame Potassium, Silica, Beta-Carotene

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

C6150012

General Statements

0006A1 Exp 02/14

HUMAN GROWTH FACTORS AND IGF-1 PRECURSORS*

IMPROVES PHYSICAL PERFORMANCE SPEEDS RECOVERY ENHANCES CARDIAC OUTPUT

naturally flavored

Increased Human Growth Factors and IGF-1 levels have been shown to improve physical performance, speed recovery from training, increase cardiac output and strengthen the immune functions.

This product is extremely sensitive to heat due to the nature and complexity of compounds it contains.

Individual results vary.

Dr. Vincent C. Giampapa - Founder, Longevity Institute International - Hormonal Replacement Specialist

This nutraceutical formula is designed to naturally optimize the body's production of key precursor hormones for maximum performance and well-being."

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Developed by leading research scientists and biochemists, Secretagogue-One(TM) addresses issues of vital importance for health, wellness and physical performance. Secretagogue-One(TM) is a proprietary blend of amino acids and precursor nutrients which enhance the body's natural production of Human Growth Factors and Insulin-like Growth Factor-1 (IGF-1).

"As a specialist in Hormonal Replacement Therapy (HRT) and Anti-Aging Medicine, I understand the importance of hormone regulation. MHP has taken the latest breakthroughs in scientific research for the development of Secretagogue-One(TM).

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take one packet mixed with 4 to 6 fl. oz. of water at bedtime on an empty stomach.

Precautions

- Keep out of reach of children.

- Do not use if seal is broken.

Storage

- Store at 15-30(0)C (59-86(0)F). - Protect from heat, light and moisture.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Secretagogue-One Lemon Ice by MHP Maximum Human Performance label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Secretagogue-One Lemon Ice label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Secretagogue-One Lemon Ice by MHP Maximum Human Performance

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size13.6 Gram(s) Dosage formPowder Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

4 Gram(s) per serving

Sodium

Interacts with
205 drugs
55 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
200 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Dietary Fiber

Interacts with
2,025 drugs
0 Gram(s) per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Secretagogue-One:

10935 mg per serving
  • › Proprietary Amino Acid Blend and Secretagogue Factors
  • › Polymer Carrier Matrix

Other (inactive) ingredients: Citric Acid, Potassium Bicarbonate, Natural flavor, Sodium Bicarbonate, Acesulfame Potassium, Silica, Beta-Carotene. These complete the product’s ingredient list but are not active constituents.

Interaction report

Secretagogue-One Lemon Ice by MHP Maximum Human Performance Drug Interactions

Want to check YOUR meds against Secretagogue-One Lemon Ice?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,100Drugs
498 Moderate 1,602 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Sodium 205
Potassium 62

Individual Drug Interactions

The ingredients in Secretagogue-One Lemon Ice interact with 2,100 drugs. Click any drug to see the details.

3 of the 6 ingredients in Secretagogue-One Lemon Ice interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Sodium Potassium

Each ingredient & the kinds of drugs it affects

For each ingredient in Secretagogue-One Lemon Ice with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Secretagogue-One Lemon Ice, from the product label.

MHP Maximum Human Performance

See all MHP Maximum Human Performance products
Name
MHP, Inc.
Street Address
21 Dwight Place
City
Fairfield
State
NJ
ZipCode
07004
Phone Number
1.888.783.8844
Web Address
www.MHPSTRONG.com
Pharmacist Counseling Corner

Secretagogue-One Lemon Ice by MHP Maximum Human Performance: Common Questions

Does Secretagogue-One Lemon Ice by MHP Maximum Human Performance interact with any medications?
Yes. Based on its ingredients, Secretagogue-One Lemon Ice has a known interaction with 2,100 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Secretagogue-One Lemon Ice contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on blood pressure medication?
Not without checking first. L-Arginine in this product can lower blood pressure further and may combine with your medication to cause unsafe drops. Talk with your doctor or pharmacist before starting — they can review your specific drug and decide if it's safe or if you need monitoring.
Is this safe to use while pregnant or breastfeeding?
L-Glutamine and Potassium are Likely Safe in pregnancy and lactation, but L-Arginine is only Possibly Safe in pregnancy with no lactation data, and several other ingredients (L-Tyrosine, Glycine, GABA, L-Lysine) lack enough safety information. Talk with your doctor or pharmacist before use — they can advise based on your individual situation.
What are the most common side effects?
The amino acids in this blend commonly cause gastrointestinal upset: bloating, constipation, nausea, diarrhea, and abdominal pain. L-Arginine may also cause headache and flushing. GABA can cause drowsiness. These effects are generally mild and often resolve with dose adjustment or discontinuation.
Will this help me build muscle or improve athletic performance?
L-Glutamine is Possibly Effective for recovery after surgery and certain illnesses, and L-Tyrosine is Possibly Effective for cognitive function. However, L-Tyrosine is rated Possibly Ineffective for athletic performance itself, and most other ingredients in this product do not have established effectiveness for muscle building or sports performance in our data.
Can I take this with my diabetes or blood sugar medication?
L-Arginine can theoretically lower blood sugar and add to the effects of diabetes drugs — a Moderate interaction. You'll need to talk with your doctor or pharmacist first to see if it's safe for you, and whether your blood sugar needs monitoring.
What is L-Arginine in this product supposed to do?
L-Arginine is an amino acid that the body uses to make nitric oxide, a chemical that relaxes blood vessels and improves blood flow. It may help lower blood pressure in some people and support sexual function, but it also carries Moderate interaction risks with several common medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Secretagogue-One Lemon Ice label
Go deeper

The Full Monographs Behind Secretagogue-One Lemon Ice’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph →
Sources

Sources & How We Checked

Secretagogue-One Lemon Ice's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 173 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
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Black Psyllium 18 references
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Lysine 7 references
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  7. Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5.

See these in context on the Lysine monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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