Selenium 50 mcg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Selenium 50 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Selenium 50 mcg is a dietary supplement by Wonder Laboratories with 1 active ingredient. Its ingredients are commonly taken for thyroid health support, antioxidant support, immune support.Based on those ingredients, 321 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Selenium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Selenium 50 mcg by Wonder Laboratories
Ask about any prescription or over-the-counter medication and we check it for interactions with Selenium 50 mcg by Wonder Laboratories — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Selenium 50 mcg by Wonder Laboratories
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: yeast-free selenium amino acid chelate, providing 50 micrograms of selenium per tablet. Selenium is a mineral your body needs in small amounts for thyroid function, antioxidant protection, and immune health.
The remaining ingredients are inactive — calcium carbonate, vegetable cellulose, vegetable stearic acid, vegetable magnesium silicate, silica, and vegetable magnesium stearate — they're fillers and binders that help form and stabilize the tablet.
Does it work?
Strong evidence
Selenium is likely effective for preventing and treating selenium deficiency. It's possibly effective for Kashin-Beck disease (a joint disorder), pre-eclampsia (a pregnancy complication), and autoimmune thyroiditis (an immune attack on the thyroid).
However, the evidence suggests it's ineffective for dyslipidemia (abnormal blood fat levels).
How safe is it?
Well-documented data
Selenium is generally well tolerated at recommended doses up to the tolerable upper limit of 400 mcg daily. The most common side effects at normal doses are gastric discomfort, headache, and rash.
Excess selenium — beyond recommended amounts — can cause hair loss, skin inflammation, fatigue, nail changes, nausea, vomiting, and weight loss. Rare serious effects from very high doses include liver damage and multi-organ failure.
Long-term high-dose exposure may increase the risk of motor nerve damage and possibly amyotrophic lateral sclerosis (ALS). Research also shows that supplementing with selenium increases the risk of squamous cell carcinoma and other non-melanoma skin cancers and does not prevent basal cell carcinoma.
Stay within the recommended dose and talk with your doctor if you're considering high-dose supplementation.
Meds to double-check
Moderate interaction found
Before taking this supplement, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (Moderate risk of increased bleeding), immunosuppressants (Moderate risk of reduced effectiveness), barbiturates (Moderate risk of prolonged sedation), or warfarin/Coumadin (Moderate risk of interference). Also mention oral contraceptives and niacin, which carry Minor interactions.
The bottom line
Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
This 50 mcg dose is appropriate if you have a selenium deficiency or want basic support for thyroid and immune function. If you take any blood thinners, immunosuppressants, barbiturates, warfarin, oral contraceptives, or niacin, check with your doctor or pharmacist before adding this supplement.
At recommended doses it's generally well tolerated, but avoid high-dose selenium without medical guidance.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 18, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Selenium 50 mcg, straight from the product label.
| Brand | Wonder Laboratories |
|---|---|
| Net contents | 100 Tablet(s) |
| Market status | On market |
| Date entered into DSLD | Dec 18, 2021 |
| DSLD ID | 262473 |
| Product type | Mineral |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Selenium 50 mcg by Wonder Laboratories, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Selenium | 50 mcg | 71% |
| yeast free Selenium Amino Acid Chelate | 25 mg | -- |
Other ingredients: Calcium Carbonate, Vegetable Cellulose, Vegetable Stearic Acid, Vegetable Magnesium Silicate, Silica, Vegetable Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions: As a dietary supplement, take one tablet daily.
Precautions
Tamper evident: Do not use this product if imprinted foil seal under cap is broken or missing.
Keep out of reach of children.
Caution: If you are pregnant or nursing, consult your physician before taking this product.
Formulation
Mfg. in an FDA Registered Facility using Good Manufacturing Practices (GMPs).
Conforms to USP <2091> for weight. Meets USP <2040> disintegration for maximum bioavailability.
"Yeast free"
Antioxidant and immune health Helps neutralize cell damaging free radicals
Gluten free
Made in USA
Storage
Keep tightly closed. Store at room temperature: 59 degrees – 86 degrees F (15 degrees – 30 degrees C).
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
General Statements
Formula 603
Formula
Amino acid chelated
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Selenium 50 mcg by Wonder Laboratories label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Selenium 50 mcg by Wonder Laboratories
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.
Selenium
Interacts with321 drugs
Selenium is an essential trace mineral your body needs in small amounts for thyroid function, antioxidant defense, and immune health. Most people who...
Selenium monograph & interactionsOther (inactive) ingredients: Calcium Carbonate, Vegetable Cellulose, Vegetable Stearic Acid, Vegetable Magnesium Silicate, Silica, Vegetable Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
Selenium 50 mcg by Wonder Laboratories Drug Interactions
HelloPharmacist Interaction Report
Wonder Laboratories Selenium 50 mcg interacts with several medication types through its yeast-free selenium amino acid chelate.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs — selenium may increase bleeding risk by enhancing antiplatelet effects and prolonging bleeding time.
Read the full breakdown — every affected drug type, severity by severity
Selenium may also interfere with immunosuppressants by potentially stimulating your immune system and reducing their effectiveness. It can prolong the sedating effects of barbiturates by slowing their breakdown in the liver.
Additionally, selenium might interfere with warfarin (Coumadin) activity through multiple mechanisms, including displacing it from protein binding sites and affecting vitamin K-dependent clotting factors. These are all Moderate-severity interactions.
Two Minor interactions are also documented: oral contraceptives might raise your selenium levels (though the clinical meaning isn't clear), and selenium might reduce niacin's beneficial effects on HDL cholesterol.
Altogether, these interactions span 321 individual medications. Use the medication checker below to verify your exact prescriptions before starting this supplement.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Selenium 50 mcg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Selenium 50 mcg interact with 321 drugs. Click any drug to see the details.
1 of the 1 ingredient in Selenium 50 mcg interact with drugs. Each result below shows which ingredient is responsible. Selenium
Inebilizumab-cdonUplizna
How Inebilizumab-cdon interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Inebilizumab-cdon interactionInfliximab-abdaRenflexis
How Infliximab-abda interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Infliximab-abda interactionInfliximab-dyybInflectra
How Infliximab-dyyb interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Infliximab-dyyb interactionInfliximab-qbtxIxifi
How Infliximab-qbtx interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Infliximab-qbtx interactionInfliximab-axxqAvsola
How Infliximab-axxq interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Infliximab-axxq interactionInotersenTegsedi
How Inotersen interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Inotersen interactionIxekizumabTaltz
How Ixekizumab interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Ixekizumab interactionKetoprofenOrudis, Oruvail Gel, Oruvail Injection, Powergel
How Ketoprofen interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Ketoprofen interactionLenalidomideRevlimid
How Lenalidomide interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Lenalidomide interactionLepirudinRefludan
How Lepirudin interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Lepirudin interactionLumateperoneCaplyta
How Lumateperone interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Lumateperone interactionLymphocyte Immune GlobulinAtgam
How Lymphocyte Immune Globulin interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Lymphocyte Immune Globulin interactionMephobarbitalMebaral
How Mephobarbital interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Yeast Free Selenium Amino Acid Chelate + Mephobarbital interactionMercaptopurinePurixan
How Mercaptopurine interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Mercaptopurine interactionMetharbitalGemonil
How Metharbital interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateBarbiturates Moderate
Interaction Summary
Theoretically, selenium might prolong the sedating effects of barbiturates.
Read the full Yeast Free Selenium Amino Acid Chelate + Metharbital interactionMethylprednisoloneMedrol, Medrol Dosepak
How Methylprednisolone interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Methylprednisolone interactionMinocyclineAcnamino MR, Aknemin, Amzeeq, Arestin Miscrosperes, Dynacin, Minocin +6 more
How Minocycline interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Minocycline interactionMirikizumab-mrkzOmvoh
How Mirikizumab-mrkz interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Mirikizumab-mrkz interactionMosunetuzumab-axgbLunsumio
How Mosunetuzumab-axgb interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Mosunetuzumab-axgb interactionMuromonab-cd3Orthoclone OKT3
How Muromonab-cd3 interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Muromonab-cd3 interactionMycophenolate MofetilCellCept
How Mycophenolate Mofetil interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Mycophenolate Mofetil interactionNadroparinFraxiparine
How Nadroparin interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Nadroparin interactionNaproxenAleve, Anaprox, Anaprox DS, Arthroxen, EC-Naprosyn, Naprelan +7 more
How Naproxen interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Naproxen interactionNaproxen SodiumMidol Extended Relief
How Naproxen Sodium interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Naproxen Sodium interactionNaproxen, PseudoephedrineAleve Cold and Sinus
How Naproxen, Pseudoephedrine interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Naproxen, Pseudoephedrine interactionNaproxen, SumatriptanTreximet
How Naproxen, Sumatriptan interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Naproxen, Sumatriptan interactionNatalizumabTysabri
How Natalizumab interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Natalizumab interactionNelarabineAtriance
How Nelarabine interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateImmunosuppressants Moderate
Interaction Summary
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
Read the full Yeast Free Selenium Amino Acid Chelate + Nelarabine interactionNintedanib EsylateOfev
How Nintedanib Esylate interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Nintedanib Esylate interactionNusinersen SodiumSpinraza
How Nusinersen Sodium interacts with Selenium 50 mcg — through 1 ingredient. Tap an ingredient for the detail:
Yeast Free Selenium Amino Acid ChelateAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Yeast Free Selenium Amino Acid Chelate + Nusinersen Sodium interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Selenium 50 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Selenium
Anticoagulant/Antiplatelet Drugs
Selenium may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Clinical research suggests that taking selenium 10 mcg/kg/day can increase bleeding times by increasing prostacyclin production, which inhibits platelet activity. Other clinical research suggests that taking selenium 75 mcg daily, in combination with ascorbic acid 600 mg, alpha-tocopherol 300 mg, and beta-carotene 27 mg, reduces platelet aggregation.
Barbiturates
Theoretically, selenium might prolong the sedating effects of barbiturates.
Laboratory research suggests that selenium can inhibit the hepatic metabolism of barbiturates. Selenium seems to prolong the sedative effect of pentobarbital in animal models.
Immunosuppressants
Theoretically, selenium supplementation may reduce the effectiveness of immunosuppressant therapy.
In vitro research and preliminary clinical evidence suggests that selenium may stimulate the immune system.
Warfarin (Coumadin)
Theoretically, selenium might interfere with warfarin activity.
Animal research suggests that selenium can increase warfarin activity. Selenium might interact with warfarin by displacing it from albumin binding sites, reducing its metabolism in the liver, or by decreasing production of vitamin K-dependent clotting factors. Selenium can also prolong bleeding times in humans by increasing prostacyclin production, which inhibits platelet activity.
Contraceptive Drugs
Contraceptive drugs might increase levels of selenium, although the clinical significance of this effect is unclear.
Some research suggests that oral contraceptives increase serum selenium levels in women taking oral contraceptives; however, other research shows no change in selenium levels. It is suggested that an increase could be due to increased carrier proteins, indicating a redistribution of selenium rather than a change in total body selenium.
Niacin
Selenium might reduce the beneficial effects of niacin on high-density lipoprotein (HDL) levels.
A combination of niacin and simvastatin (Zocor) effectively raises HDL cholesterol levels in patients with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50% in patients with coronary disease. It is not known whether this adverse effect is due to a single antioxidant such as selenium, or to the combination. It also is not known whether it will occur in other patient populations.
Brand information
Manufacturer and brand details for Selenium 50 mcg, from the product label.
Wonder Laboratories
See all Wonder Laboratories products- Name
- Wonder Laboratories
- Street Address
- 115 S.C.T. Ct.
- City
- White House
- State
- TN
- ZipCode
- 37188
Selenium 50 mcg by Wonder Laboratories: Common Questions
Does Selenium 50 mcg by Wonder Laboratories interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this work for my thyroid?
What if I take more than recommended?
Can I take this while pregnant?
Is this safe to breastfeed while taking?
What's the difference between this form and other selenium supplements?
Can this prevent skin cancer?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Selenium 50 mcg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Selenium 50 mcg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Selenium 50 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 36 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Selenium 36 references
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academy Press, 2000. Available at: http://www.nap.edu/books/0309069351/html/.
- Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med 2001;345:1583-93. DOI
- Trafikowska U, Zachara BA, Wiacek M, et al. Selenium supply and glutathione peroxidase activity in breastfed Polish infants. Acta Paediatr 1996;85:1143-5. PubMed
- Duffield-Lillico AJ, Slate EH, Reid ME, et al. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003;95:1477-81.. PubMed
- Cheung MC, Zhao XQ, Chait A, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol 2001;21:1320-6. PubMed
- Schiavon R, Freeman GE, Guidi GC, et al. Selenium enhances prostacyclin production by cultured endothelial cells: possible explanation for increased bleeding times in volunteers taking selenium as a dietary supplement. Thromb Res 1984;34:389-96. PubMed
- Davila JC, Edds GT, Osuna O, Simpson CF. Modification of the effects of aflatoxin B1 and warfarin in young pigs given selenium. Am J Vet Res 1983;44:1877-83. DOI
- Heese HD, Lawrence MA, Dempster WS, Pocock F. Reference concentrations of serum selenium and manganese in healthy nulliparas. S Afr Med J 1988;73:163-5.
- Lloyd B, Lloyd RS, Clayton BE. Effect of smoking, alcohol and other factors on the selenium status of a healthy population. J Epidemiol Commun Health 1983;37:213-7. PubMed
- Capel ID, Jenner M, Williams DC, et al. The effect of prolonged oral contraceptive steroid use on erythrocyte glutathione peroxidase activity. J Steroid Biochem 1981;14:729-32. PubMed
- Contempre B, Dumont JE, Ngo B, et al. Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium. J Clin Endocrinol PubMed
- Hofbauer LC, Spitzweg C, Magerstadt RA, Heufelder AE. Selenium-induced thyroid dysfunction. Postgrad Med J 1997;73:103-4. PubMed
- Debski B, Milner JA. Dietary selenium supplementation prolongs pentobarbital induced hypnosis. J Nutr Biochem 2004;15:548-53. PubMed
- Ishikawa M, Sasaki M, Koiwai K, et al. Inhibition of hepatic mixed-function oxidase enzymes in mice by acute and chronic treatment with selenium. J Pharmacobiodyn 1992;15:377-85. PubMed
- Lippmann SM, Klein EA, Goodman PJ, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the selenium and vitamin E cancer prevention trial (SELECT). JAMA 2009;301:39-51. DOI
- Reid SM, Middleton P, Cossich MC, Crowther CA. Interventions for clinical and subclinical hypothyroidism in pregnancy. Cochrane Database Syst Rev 2010;(7):CD007752. PubMed
- Vinceti, M., Wei, E. T., Malagoli, C., Bergomi, M., and Vivoli, G. Adverse health effects of selenium in humans. Rev.Environ.Health 2001;16(4):233-251. PubMed
- Abrams, C. K., Siram, S. M., Galsim, C., Johnson-Hamilton, H., Munford, F. L., and Mezghebe, H. Selenium deficiency in long-term total parenteral nutrition. Nutr Clin Pract 1992;7(4):175-178. PubMed
- Spiller, H. A. and Pfiefer, E. Two fatal cases of selenium toxicity. Forensic Sci Int 8-24-2007;171(1):67-72. PubMed
- Negro, R., Greco, G., Mangieri, T., Pezzarossa, A., Dazzi, D., and Hassan, H. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol.Metab 2007;92(4):1263-1268. PubMed
- Alexander, J. Selenium. Novartis.Found.Symp 2007;282:143-149.
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- Kupka, R., Mugusi, F., Aboud, S., Msamanga, G. I., Finkelstein, J. L., Spiegelman, D., and Fawzi, W. W. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and chil
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